C H Hennekens

Summary

Affiliation: St. John's Mercy Medical Center
Country: USA

Publications

  1. doi request reprint Aspirin in the treatment and prevention of cardiovascular disease: past and current perspectives and future directions
    Charles H Hennekens
    Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton Electronic address
    Am J Med 126:373-8. 2013
  2. ncbi request reprint Increasing global burden of cardiovascular disease in general populations and patients with schizophrenia
    Charles H Hennekens
    Department of Biomedical Sciences, Center of Excellence, Florida Atlantic University, Boca Raton Nova Southeastern University, Fort Lauderdale and University of Miami Miller School of Medicine, Miami, Fla, USA
    J Clin Psychiatry 68:4-7. 2007
  3. ncbi request reprint Current perspectives on lipid lowering with statins to decrease risk of cardiovascular disease
    C H Hennekens
    Mount Sinai Medical Center Miami Heart Institute and Department of Medicine, Epidemiology, and Public Health, University of Miami School of Medicine, Miami Beach, Florida 33140, USA
    Clin Cardiol 24:II-2-5. 2001
  4. ncbi request reprint Schizophrenia and increased risks of cardiovascular disease
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence in Biomedical and Marine Biotechnology, Florida Atlantic University, FL, USA
    Am Heart J 150:1115-21. 2005
  5. doi request reprint A randomized trial of aspirin at clinically relevant doses and nitric oxide formation in humans
    Charles H Hennekens
    Charles E Schmidt College of Biomedical Science, Department of Clinical Science and Medical Education and Center of Excellence, Florida Atlantic University, Boca Raton, FL, USA
    J Cardiovasc Pharmacol Ther 15:344-8. 2010
  6. doi request reprint Hypothesis formulation from subgroup analyses: nonadherence or nonsteroidal anti-inflammatory drug use explains the lack of clinical benefit of aspirin on first myocardial infarction attributed to "aspirin resistance"
    Charles H Hennekens
    Florida Atlantic University, Boca Raton, 33431 0991, USA
    Am Heart J 159:744-8. 2010
  7. ncbi request reprint Lack of deleterious interaction between angiotensin receptor blockers and beta-blockers in the treatment of patients with heart failure
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence, Florida Atlantic University, 2800 South Ocean Boulevard, Boca Raton, FL 33432, USA
    J Cardiovasc Pharmacol Ther 11:149-52. 2006
  8. ncbi request reprint Use of aspirin to reduce risks of cardiovascular disease in patients with diabetes: clinical and research challenges
    Charles H Hennekens
    Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    Diabetes Care 27:2752-4. 2004
  9. pmc Update for primary healthcare providers: recent statin trials and revised National Cholesterol Education Program III guidelines
    Charles H Hennekens
    Miller School of Medicine, University of Miami, Miami, Florida, USA
    MedGenMed 8:54. 2006
  10. ncbi request reprint Obesity in childhood: introduction and general considerations
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence, FL Atlantic University, Boca Raton, FL 33431, USA
    Pediatr Res 61:634-5. 2007

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint Aspirin in the treatment and prevention of cardiovascular disease: past and current perspectives and future directions
    Charles H Hennekens
    Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton Electronic address
    Am J Med 126:373-8. 2013
    ....
  2. ncbi request reprint Increasing global burden of cardiovascular disease in general populations and patients with schizophrenia
    Charles H Hennekens
    Department of Biomedical Sciences, Center of Excellence, Florida Atlantic University, Boca Raton Nova Southeastern University, Fort Lauderdale and University of Miami Miller School of Medicine, Miami, Fla, USA
    J Clin Psychiatry 68:4-7. 2007
    ..Primary prevention strategies should include the choice of antipsychotic drug regimens that do not adversely affect the major risk factors for CVD...
  3. ncbi request reprint Current perspectives on lipid lowering with statins to decrease risk of cardiovascular disease
    C H Hennekens
    Mount Sinai Medical Center Miami Heart Institute and Department of Medicine, Epidemiology, and Public Health, University of Miami School of Medicine, Miami Beach, Florida 33140, USA
    Clin Cardiol 24:II-2-5. 2001
    ..Despite widespread acknowledgment of the very favorable benefit-to-risk ratio of the statins, most at-risk patients either are not being treated or are not at the goals defined by the National Cholesterol Education Program...
  4. ncbi request reprint Schizophrenia and increased risks of cardiovascular disease
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence in Biomedical and Marine Biotechnology, Florida Atlantic University, FL, USA
    Am Heart J 150:1115-21. 2005
    ..The aim of the study is to review the absolute and relative impacts of the major causes for premature mortality among patients with schizophrenia...
  5. doi request reprint A randomized trial of aspirin at clinically relevant doses and nitric oxide formation in humans
    Charles H Hennekens
    Charles E Schmidt College of Biomedical Science, Department of Clinical Science and Medical Education and Center of Excellence, Florida Atlantic University, Boca Raton, FL, USA
    J Cardiovasc Pharmacol Ther 15:344-8. 2010
    ..we performed the first test in humans of whether aspirin at clinically relevant doses increases nitric oxide (NO) formation...
  6. doi request reprint Hypothesis formulation from subgroup analyses: nonadherence or nonsteroidal anti-inflammatory drug use explains the lack of clinical benefit of aspirin on first myocardial infarction attributed to "aspirin resistance"
    Charles H Hennekens
    Florida Atlantic University, Boca Raton, 33431 0991, USA
    Am Heart J 159:744-8. 2010
    ..One major analytic study suggesting that "aspirin resistance" is a clinical reality was unable to control for confounding by nonadherence or nonsteroidal anti-inflammatory drugs (NSAIDs)...
  7. ncbi request reprint Lack of deleterious interaction between angiotensin receptor blockers and beta-blockers in the treatment of patients with heart failure
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence, Florida Atlantic University, 2800 South Ocean Boulevard, Boca Raton, FL 33432, USA
    J Cardiovasc Pharmacol Ther 11:149-52. 2006
    ..These considerations have great clinical and public health importance given the increasing numbers of patients with heart failure, their high morbidity and mortality, and the relatively limited number of effective drug therapies...
  8. ncbi request reprint Use of aspirin to reduce risks of cardiovascular disease in patients with diabetes: clinical and research challenges
    Charles H Hennekens
    Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    Diabetes Care 27:2752-4. 2004
  9. pmc Update for primary healthcare providers: recent statin trials and revised National Cholesterol Education Program III guidelines
    Charles H Hennekens
    Miller School of Medicine, University of Miami, Miami, Florida, USA
    MedGenMed 8:54. 2006
    ..Together, these recent statin trials and the NCEP ATP III revised guidelines, if implemented by primary healthcare providers, would result in many more patients receiving statins of proven benefit and reassuring adverse event profile...
  10. ncbi request reprint Obesity in childhood: introduction and general considerations
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence, FL Atlantic University, Boca Raton, FL 33431, USA
    Pediatr Res 61:634-5. 2007
  11. ncbi request reprint Terms and conditions: semantic complexity and aspirin resistance
    Charles H Hennekens
    Department of Medicine and Epidemiology and Public Health, University of Miami School of Medicine, Miami, USA
    Circulation 110:1706-8. 2004
  12. ncbi request reprint Dose of aspirin in the treatment and prevention of cardiovascular disease: current and future directions
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence, Florida Atlantic University, Boca Raton, Florida, USA
    J Cardiovasc Pharmacol Ther 11:170-6. 2006
    ..Direct comparisons of higher doses may yield additional cardiovascular benefits. At present, daily doses of 75 to 325 mg aspirin are sufficient for long-term treatment and prevention of cardiovascular disease...
  13. ncbi request reprint The ALLHAT-LLT and ASCOT-LLA trials: are the discrepancies more apparent than real?
    Charles H Hennekens
    Department of Medicine, 2800 South Ocean Boulevard, PH A, Boca Raton, FL 33432, USA
    Curr Atheroscler Rep 6:9-11. 2004
    ..The totality of evidence on statins continues to strongly support their benefits in a wide range of patients on a large number of cardiovascular disease endpoints...
  14. ncbi request reprint Additive benefits of pravastatin and aspirin to decrease risks of cardiovascular disease: randomized and observational comparisons of secondary prevention trials and their meta-analyses
    Charles H Hennekens
    Mount Sinai Medical Center Miami Heart Institute, Department of Medicine and Epidemiology and Public Health, University of Miami School of Medicine, Boca Raton, FL 33432, USA
    Arch Intern Med 164:40-4. 2004
    ..Pravastatin has a predominantly delayed antiatherogenic effect, and aspirin has an immediate antiplatelet effect, raising the possibility of additive clinical benefits...
  15. ncbi request reprint Aspirin in the treatment and prevention of cardiovascular disease: current perspectives and future directions
    Charles H Hennekens
    Curr Atheroscler Rep 9:409-16. 2007
    ..Worldwide, aspirin used more widely and appropriately would avoid many premature deaths in secondary prevention, during acute MI, and during acute stroke, as well as many first MI in primary prevention...
  16. ncbi request reprint Sex-related differences in response to aspirin in cardiovascular disease: an untested hypothesis
    Charles H Hennekens
    Center of Excellence, Florida Atlantic University, USA
    Nat Clin Pract Cardiovasc Med 3:4-5. 2006
  17. ncbi request reprint Alcohol consumption and risk of coronary heart disease by diabetes status
    U A Ajani
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Circulation 102:500-5. 2000
    ..To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and without diabetes mellitus in a prospective cohort study...
  18. pmc Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
    J W Rich-Edwards
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    BMJ 315:396-400. 1997
    ..To examine the association between birth weight and non-fatal adult cardiovascular disease while controlling for potential confounders such as socioeconomic group and adult lifestyle...
  19. ncbi request reprint Light-to-moderate alcohol consumption and mortality in the Physicians' Health Study enrollment cohort
    J M Gaziano
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215 1204, USA
    J Am Coll Cardiol 35:96-105. 2000
    ..This study examined the relationship between light-to-moderate alcohol consumption and cause-specific mortality...
  20. ncbi request reprint Exercise and risk of stroke in male physicians
    I M Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215, USA
    Stroke 30:1-6. 1999
    ..However, epidemiological studies of physical activity and stroke risk have yielded divergent findings. We therefore sought to examine the association between exercise and stroke risk...
  21. ncbi request reprint Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
    ..Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown...
  22. ncbi request reprint A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women
    J E Manson
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 341:650-8. 1999
    ..The role of walking, as compared with vigorous exercise, in the prevention of coronary heart disease remains controversial, and data for women on this topic are sparse...
  23. ncbi request reprint Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States)
    N R Cook
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Cancer Causes Control 11:617-26. 2000
    ..This report updates results for beta-carotene and examines effect modification by baseline characteristics...
  24. ncbi request reprint Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians
    C M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Circulation 100:944-50. 1999
    ..Individuals who consume high amounts of alcohol (>5 drinks/d) have increased risks of ventricular arrhythmia and sudden cardiac death (SCD). However, the relationship is less clear for drinkers of light-to-moderate amounts...
  25. ncbi request reprint Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study
    I M Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, and Boston, MA 02215, USA
    J Natl Cancer Inst 91:2102-6. 1999
    ..However, the few randomized trials of beta-carotene supplementation show no overall benefits; some even suggest harm. This trial was designed to test the effects of beta-carotene supplementation in women...
  26. ncbi request reprint Aspirin use and risk of cataract in posttrial follow-up of Physicians' Health Study I
    W G Christen
    Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215-1204, USA
    Arch Ophthalmol 119:405-12. 2001
    ....
  27. ncbi request reprint A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  28. ncbi request reprint Abdominal adiposity and coronary heart disease in women
    K M Rexrode
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215, USA
    JAMA 280:1843-8. 1998
    ..Obesity is a well-established risk factor for coronary heart disease (CHD), but whether regional fat distribution contributes independently to risk remains unclear...
  29. ncbi request reprint Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke
    R Y Zee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 99:340-3. 1999
    ..We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study...
  30. ncbi request reprint The need for wider and appropriate utilization of aspirin and statins in the treatment and prevention of cardiovascular disease
    Charles H Hennekens
    Department of Clinical Science and Medical Education, Florida Atlantic University, Boca Raton, FL 33431, USA
    Expert Rev Cardiovasc Ther 6:95-107. 2008
    ..At present, the wider and more appropriate use of aspirin and statins will reduce premature MI, stroke and CVD death...
  31. ncbi request reprint Self-selected posttrial aspirin use and subsequent cardiovascular disease and mortality in the physicians' health study
    N R Cook
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    Arch Intern Med 160:921-8. 2000
    ..00001) 44% reduction of first myocardial infarction (MI) among those assigned to aspirin. As a result, there were insufficient numbers of strokes or cardiovascular disease (CVD)-related deaths to evaluate these end points definitively...
  32. ncbi request reprint Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke
    P M Ridker
    Divisions of Preventive Medicine, Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 98:2796-9. 1998
    ..However, prospective data relating evidence of prior exposure to these agents with risks of future myocardial infarction (MI) and stroke are sparse...
  33. ncbi request reprint Physical activity and breast cancer risk: the Women's Health Study (United States)
    I M Lee
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Cancer Causes Control 12:137-45. 2001
    ..We therefore examined physical activity and breast cancer risk in the Women's Health Study...
  34. ncbi request reprint Prospective study of Chlamydia pneumoniae IgG seropositivity and risks of future myocardial infarction
    P M Ridker
    Divisions of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 99:1161-4. 1999
    ..Chlamydia pneumoniae has been hypothesized to play a role in atherothrombosis. However, prospective data relating exposure to Chlamydia pneumoniae and risks of future myocardial infarction (MI) are sparse...
  35. ncbi request reprint Age-related maculopathy in a randomized trial of low-dose aspirin among US physicians
    W G Christen
    Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215-1204, USA
    Arch Ophthalmol 119:1143-9. 2001
    ..However, a smaller, but potentially important, beneficial effect cannot be ruled out and would require testing in randomized trials of adequate size and duration...
  36. ncbi request reprint Vasectomy and subsequent cardiovascular disease in US physicians
    J E Manson
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Contraception 59:181-6. 1999
    ..12 (0.94-1.35) for angina/revascularization. These results provide reassuring evidence that vasectomy does not materially increase the risk of subsequent cardiovascular disease, even 15 or more years following the procedure...
  37. ncbi request reprint The CHARM program: study design leads to findings of clinical and public health importance
    Charles H Hennekens
    Florida Atlantic University, Boca Raton, Florida, and Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Pharmacol Ther 12:124-6. 2007
    ..Such patients have a 50% mortality rate at 5 years, and heart failure is the leading cause of hospitalization for patients 65 years of age and older...
  38. ncbi request reprint Time urgency and risk of non-fatal myocardial infarction
    S R Cole
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA02215, USA
    Int J Epidemiol 30:363-9. 2001
    ....
  39. ncbi request reprint Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
    S Liu
    Division of Preventive Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 70:412-9. 1999
    ..Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to the risk of CHD are sparse...
  40. ncbi request reprint Triggering of sudden death from cardiac causes by vigorous exertion
    C M Albert
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 343:1355-61. 2000
    ..However, the role of physical activity in precipitating or preventing sudden death has not been assessed prospectively in a large number of subjects...
  41. ncbi request reprint Active and passive smoking and risk of colds in women
    I M Bensenor
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Ann Epidemiol 11:225-31. 2001
    ..To evaluate the association between active and passive smoking and frequency of colds in women...
  42. ncbi request reprint An update on aspirin in the primary prevention of cardiovascular disease
    Rachel S Eidelman
    Division of Cardiovascular Research, Mount Sinai Medical Center Miami Heart Institute, Miami Beach, Fla, USA
    Arch Intern Med 163:2006-10. 2003
    ..Since that time, 3 additional randomized trials (which included men and women) of aspirin in the primary prevention of MI have been published...
  43. ncbi request reprint Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians
    C J O'Donnell
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:1132-7. 1997
    ..The objective of this study was to examine whether definite hypertension and borderline isolated systolic hypertension predict subsequent cardiovascular disease and mortality...
  44. ncbi request reprint Current issues concerning thrombolytic therapy for acute myocardial infarction
    C H Hennekens
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 25:18S-22S. 1995
    ..Whether or not accelerated t-PA has a small advantage for mortality is less conclusive.(ABSTRACT TRUNCATED AT 250 WORDS)..
  45. ncbi request reprint Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians
    U A Ajani
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass, USA
    Arch Intern Med 160:1025-30. 2000
    ..To examine the association between low to moderate alcohol consumption and the incidence of type 2 diabetes mellitus (DM) in men...
  46. ncbi request reprint C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 97:2007-11. 1998
    ..However, whether measurement of CRP adds to the predictive value of total cholesterol (TC) and HDL cholesterol (HDL-C) in determining risk is uncertain...
  47. ncbi request reprint Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women
    H Iso
    Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:856-63. 2001
    ..The increased risk with low intake of saturated fat and trans unsaturated fat is compatible with the reported association between low serum total cholesterol and risk...
  48. ncbi request reprint Increased pulse pressure and risk of heart failure in the elderly
    C U Chae
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    JAMA 281:634-9. 1999
    ..Arterial stiffness increases with age. Thus, pulse pressure, an index of arterial stiffening, may predict congestive heart failure (CHF) in the elderly...
  49. ncbi request reprint The role of aspirin in cardiovascular diseases--forgotten benefits?
    Adam Williams
    University of Miami School of Medicine, Miami, FL, USA
    Expert Opin Pharmacother 5:109-15. 2004
    ..The more widespread and appropriate use of aspirin will avoid many premature deaths in secondary prevention and MIs in primary prevention...
  50. ncbi request reprint A randomized trial of beta carotene and age-related cataract in US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Third Floor, Boston, MA 02215 1204, USA
    Arch Ophthalmol 121:372-8. 2003
    ..To examine the development of age-related cataract in a trial of beta carotene supplementation in men...
  51. ncbi request reprint Update on aspirin in the treatment and prevention of cardiovascular disease
    Charles H Hennekens
    University of Miami School of Medicine, Florida, USA
    Am J Manag Care 8:S691-700. 2002
    ..In all these patient categories, including secondary prevention, acute MI and acute occlusive stroke, as well as primary prevention, increased and appropriate use of aspirin will prevent large numbers of premature deaths and MIs...
  52. ncbi request reprint The new National Cholesterol Education Program guidelines: clinical challenges for more widespread therapy of lipids to treat and prevent coronary heart disease
    Rachel S Eidelman
    Mount Sinai Medical Center, Cardiology Research, 4300 Alton Rd, Suite 207A, Miami Beach, FL 33140, USA
    Arch Intern Med 162:2033-6. 2002
  53. ncbi request reprint Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Control Clin Trials 23:686-702. 2002
    ..In contrast, diseases and risk factors explain some, but not all, of the lower mortality rates of physicians based on eligibility status and their ability to complete a run-in phase...
  54. ncbi request reprint G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men
    P M Ridker
    Divisions of Preventive Medicine and Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 99:999-1004. 1999
    ..Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial...
  55. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
    ..We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study...
  56. ncbi request reprint Serologic evaluations of women exposed to breast implants
    E W Karlson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Rheumatol 28:1523-30. 2001
    ..We conducted laboratory tests in a large number of women with and without breast implants, and in diabetic patients with presumed silicone exposure via insulin syringes...
  57. ncbi request reprint Combining annual blood pressure measurements in childhood to improve prediction of young adult blood pressure
    N R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Stat Med 19:2625-40. 2000
    ..These results suggest that averaging BP over at least two years during childhood increases tracking correlations and improves the prediction of adult values from childhood levels...
  58. ncbi request reprint The renin-angiotensin system: the role of inhibitors, blockers, and genetic polymorphisms in the treatment and prevention of heart failure
    Patricia R Hebert
    Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Curr Vasc Pharmacol 1:33-9. 2003
    ....
  59. ncbi request reprint Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
    ..Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons...
  60. doi request reprint Cyclooxygenase-2 inhibitors and most traditional nonsteroidal anti-inflammatory drugs cause similar moderately increased risks of cardiovascular disease
    Charles H Hennekens
    Department of Clinical Science and Medical Education and Center of Excellence, Charles E Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431 0991, USA
    J Cardiovasc Pharmacol Ther 13:41-50. 2008
    ....
  61. ncbi request reprint Hypothesis: atorvastatin has pleiotropic effects that translate into early clinical benefits on cardiovascular disease
    Cristina Novela
    Department of Medicine, Mount Sinai Medical Center Miami Heart Institute, Miami Beach, Florida, USA
    J Cardiovasc Pharmacol Ther 9:61-3. 2004
    ..These and other considerations contribute to the hypothesis that atorvastatin has pleiotropic effects that translate into early clinical benefits on cardiovascular disease...
  62. ncbi request reprint CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U.S. physicians
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Prostate 39:130-4. 1999
    ..Because benign prostatic hyperplasia (BPH) is an androgen-dependent condition, we examined the hypothesis that a shorter AR gene CAG repeat length increases the risk of developing of BPH...
  63. ncbi request reprint Low-dose aspirin for migraine prophylaxis in women
    I M Bensenor
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215 1204, USA
    Cephalalgia 21:175-83. 2001
    ..These reductions were not, however, statistically significant. These data are compatible with a small treatment effect of low-dose aspirin in the prophylaxis of migraine among middle-aged women...
  64. ncbi request reprint Analgesic use and risk of subsequent hypertension in apparently healthy men
    Tobias Kurth
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 165:1903-9. 2005
    ..We tested whether apparently healthy male physicians who reported analgesic use had an increased risk of subsequent hypertension...
  65. ncbi request reprint A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 161:469-74. 2002
    ..However, whether this polymorphism is associated with risk of myocardial infarction (MI) is uncertain...
  66. pmc Use of aspirin among diabetics in the primary prevention of cardiovascular disease: need for reliable randomized evidence and astute clinical judgment
    Patricia R Hebert
    Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
    J Gen Intern Med 24:1248-50. 2009
    ..The American Heart Association Guidelines recommend aspirin for all apparently healthy individuals whose 10-year risk of a first coronary heart disease (CHD) event is >10%...
  67. ncbi request reprint Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease
    Rachel S Eidelman
    Agatston Research Institute, Miami Beach, FL, USA
    Arch Intern Med 164:1552-6. 2004
    ..Before the availability of randomized evidence, about 1 in 4 adults was taking vitamin E supplements in the United States...
  68. ncbi request reprint Fixed-dose combination therapy with statins: strengths, limitations, and clinical and regulatory considerations
    Charles H Hennekens
    Department of Clinical Science and Medical Education and Center of Excellence, Charles E Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33434, USA
    Am J Cardiovasc Drugs 8:155-60. 2008
    ....
  69. ncbi request reprint Inhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugs
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Circulation 108:1191-5. 2003
    ..Recent data also suggest that other nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with this benefit of aspirin...
  70. ncbi request reprint Use of a marginal structural model to determine the effect of aspirin on cardiovascular mortality in the Physicians' Health Study
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 155:1045-53. 2002
    ..65, 1.25). Although the numbers of cardiovascular deaths were insufficient to evaluate this endpoint definitively, use of such methods holds much potential for controlling time-varying confounders affected by previous exposure...
  71. pmc Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Ophthalmol 125:333-9. 2007
    ..To test whether beta carotene supplementation affects the incidence of age-related maculopathy (ARM) in a large-scale randomized trial...
  72. ncbi request reprint Series introduction and cardiovascular disease in patients with schizophrenia
    Charles H Hennekens
    Center of Excellence and Department of Biomedical Science, Florida Atlantic University, Boca Raton, Fla, USA
    J Clin Psychiatry 68:e12. 2007
  73. ncbi request reprint Prevention of premature mortality among patients with schizophrenia: the need for primary prevention efforts in cardiovascular disease
    Charles H Hennekens
    Center of Excellence, Florida Atlantic University, Boca Raton, FL, USA
    CNS Spectr 13:9-10. 2008
  74. ncbi request reprint Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
    ..Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer...
  75. ncbi request reprint Impact of diabetes on mortality in patients with myocardial infarction and left ventricular dysfunction
    Alvaro M Murcia
    Mount Sinai Medical Center and Miami Heart Institute, Miami Beach, Fla, USA
    Arch Intern Med 164:2273-9. 2004
    ..We evaluated the effects of diabetes in post-MI patients with left ventricular dysfunction on cardiovascular events and death...
  76. ncbi request reprint Hypertension: trends, risks, drug therapies and clinical challenges in African Americans
    Danielle Hollar
    Agatston Research Institute, Miami Beach, Florida, USA
    Ethn Dis 14:S2-23-5. 2004
    ..Effective strategies to encourage widespread use of these therapies of proven benefit would provide progress toward decreasing the adverse mortality experiences, especially CVD, among African Americans...
  77. ncbi request reprint Brain natriuretic peptide and HIV-related cardiomyopathy
    Rodolfo Carrillo-Jimenez
    Division of Cardiology, Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA
    AIDS Read 12:501-3, 508. 2002
    ..Further basic and epidemiologic research on BNP measurement for the detection of HIV-related cardiomyopathy is needed to support these findings, which if confirmed, could have important clinical and public health implications...
  78. ncbi request reprint Brain natriuretic peptide: clinical and research challenges
    Rodolfo Carrillo-Jimenez
    Bethesda Memorial Hospital, Boynton Beach, and Nova Southeastern College of Medicine, Ft Lauderdale, FL, USA
    J Cardiovasc Pharmacol Ther 12:85-8. 2007
    ..Less is known about serial peptide measurements for guiding treatment strategies in heart failure. The authors review the uses, pitfalls, and practical points for using natriuretic peptides clinically...
  79. ncbi request reprint High-risk African Americans with multiple risk factors for cardiovascular disease: challenges in prevention, diagnosis, and treatment
    Richard Allen Williams
    Department of Medicine, The David Geffen School of Medicine at UCLA, Minority Health Institute, Los Angeles, California, USA
    Ethn Dis 16:633-9. 2006
    ..quot; The AAMRP poses clinical and public health challenges for healthcare providers. We provide clinical and public health strategies for early detection and aggressive management of AAMRP...
  80. pmc Aspirin and decreased adult-onset asthma: randomized comparisons from the physicians' health study
    R Graham Barr
    Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY, USA
    Am J Respir Crit Care Med 175:120-5. 2007
    ..In an observational cohort study, women who self-selected for frequent aspirin use developed less newly diagnosed asthma than women who did not take aspirin...
  81. ncbi request reprint Prolonged QTc interval and risks of total and cardiovascular mortality and sudden death in the general population: a review and qualitative overview of the prospective cohort studies
    Alicia Montanez
    Division of Cardiovascular Research, Mount Sinai Medical Center and Miami Heart Institute, Miami Beach, FL, USA
    Arch Intern Med 164:943-8. 2004
    ..Nonetheless, whether modest prolongation of the QTc interval in the general population has clinical importance remains unclear...
  82. ncbi request reprint Prevalence and clinical correlates of mitral annulus calcification in Hispanics and non-Hispanic whites
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Echocardiogr 20:191-6. 2007
    ..Data about mitral annulus calcification (MAC) are sparse in Hispanics. We compare prevalence and clinical correlates of MAC in Hispanics and non-Hispanic whites...
  83. ncbi request reprint N-acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials
    Axel Zagler
    Division of Cardiology, Mount Sinai Medical Center Miami Heart Institute, Miami Beach, FL, USA
    Am Heart J 151:140-5. 2006
    ..Contrast-induced nephropathy (CIN) following coronary angiography increases morbidity and mortality. Randomized trials of small sample size have evaluated whether N-acetylcysteine (NAC) prevents CIN in patients with renal dysfunction...
  84. ncbi request reprint An update on clinical trials in pacing: is dual chamber pacing better?
    Steven J Hussein
    Cardiovascular Research Institute, Mount Sinai Medical Center and Miami Heart Institute, Miami Beach, Florida 33140, USA
    Curr Opin Cardiol 19:12-8. 2004
    ..As pacemaker technology has increased in complexity and now offers a variety of additional capabilities, there is uncertainty as to which pacing mode offers more benefit-dual-chamber or single-chamber...
  85. doi request reprint Modest dietary reductions in blood cholesterol have important public health benefits
    Charles H Hennekens
    Florida Atlantic University, Boca Raton 33431, USA
    J Cardiovasc Pharmacol Ther 14:85-8. 2009
    ....
  86. ncbi request reprint Guidelines for management of high-risk African Americans with multiple cardiovascular risk factors: recommendations of an expert consensus panel
    Richard Allen Williams
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Ethn Dis 17:214-20. 2007
    ..For dyslipidemia, statins alone will generally reach the goal, but for hypertension, multiple drugs are usually necessary. We conclude that further research in African Americans is necessary to complete the totality of evidence...
  87. ncbi request reprint Pacemaker mode selection: the evidence from randomized trials
    Alicia Montanez
    Division of Cardiology, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    Pacing Clin Electrophysiol 26:1270-82. 2003
    ..The availability of data from ongoing randomized trials and their meta analysis should complete the totality of evidence during the next several years...
  88. ncbi request reprint The national cholesterol education program diet vs a diet lower in carbohydrates and higher in protein and monounsaturated fat: a randomized trial
    Y Wady Aude
    Agatston Research Institute, Miami Beach, FL, USA
    Arch Intern Med 164:2141-6. 2004
    ....
  89. ncbi request reprint Brain natriuretic peptide: a potential marker for mortality in septic shock
    Jose R Castillo
    Department of Medicine, Mount Sinai Medical Center Miami Heart Institute, Miami, FL 33140, USA
    Int J Infect Dis 8:271-4. 2004
    ..However, growing evidence supports the hypothesis that BNP could be an early predictor of mortality in septic shock. If proven, the hypothesis would have important clinical and public health implications...
  90. ncbi request reprint Are antiplatelet effects of clopidogrel inhibited by atorvastatin? A research question formulated but not yet adequately tested
    Victor L Serebruany
    Circulation 107:1568-9. 2003
  91. ncbi request reprint Severe mental illness and risk of cardiovascular disease
    John W Newcomer
    Department of Psychiatry, and the Center for Clinical Studies, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 298:1794-6. 2007
  92. ncbi request reprint Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits
    Victor L Serebruany
    Johns Hopkins University, Baltimore, Maryland, USA
    J Cardiovasc Pharmacol 43:677-84. 2004
    ..Whether valsartan reduces vascular ischemic events via additional pathways of platelet inhibition in patients with myocardial infarction and ischemic stroke requires further clinical research...
  93. ncbi request reprint Use of statins and aspirin to reduce risks of cardiovascular disease
    Patricia R Hebert
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cardiovasc Pharmacol Ther 7:77-80. 2002
  94. doi request reprint Bleeding risks of combination vs. single antiplatelet therapy: a meta-analysis of 18 randomized trials comprising 129,314 patients
    Victor L Serebruany
    HeartDrug Research Laboratories, Johns Hopkins University, Baltimore, MD, USA
    Fundam Clin Pharmacol 22:315-21. 2008
    ..This excess risk should be considered when choosing the optimal antiplatelet strategy for long-term treatment of patients with prior occlusive vascular events or those at high risk of developing occlusive vascular disease...
  95. ncbi request reprint Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challenges
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    J Clin Psychiatry 69:514-9. 2008
    ....
  96. ncbi request reprint Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy
    Victor L Serebruany
    Internal Medicine, Johns Hopkins University, 7600 Osler Drive, Ste 307, Baltimore, MD 21204, USA
    Thromb Res 113:197-204. 2004
    ..Although aspirin reduces risks of myocardial infarction, stroke and cardiovascular death, the extent of platelet action and the effect of aspirin on platelet function in patients recovering from stroke remain unclear...
  97. ncbi request reprint The data monitoring experience in the Candesartan in Heart Failure Assessment of Reduction in Mortality and morbidity (CHARM) program
    Stuart Pocock
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am Heart J 149:939-43. 2005
    ..40; (2) were on angiotensin-converting enzyme inhibitor and had LVEF < or =0.40; or (3) had LVEF >0.40. CHARM provides an interesting example of the challenges faced by a Data and Safety Monitoring Committee (DSMC)...
  98. ncbi request reprint Valsartan inhibits platelet activity at different doses in mild to moderate hypertensives: Valsartan Inhibits Platelets (VIP) trial
    Victor L Serebruany
    HeartDrug Research Laboratories, Johns Hopkins University, Baltimore, MD, USA
    Am Heart J 151:92-9. 2006
    ..To test whether valsartan inhibits platelet activity in mild to moderate hypertensives we conducted the randomized Valsartan Inhibits Platelets (VIP) trial...
  99. ncbi request reprint Absence of interaction between atorvastatin or other statins and clopidogrel: results from the interaction study
    Victor L Serebruany
    HeartDrug Research, LLC, Baltimore, MD, USA
    Arch Intern Med 164:2051-7. 2004
    ..We sought to address this issue prospectively by performing serial measurements of 19 platelet characteristics using conventional aggregometry, rapid analyzers, and flow cytometry...
  100. ncbi request reprint Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial
    Victor L Serebruany
    HeartDrug Research Laboratories, 7600 Osler Drive, Ste 307, Towson, MD 21204, USA
    Eur J Pharmacol 499:315-24. 2004
    ..Aggrenox was associated with a profound reduction of PAR-1 receptors, an observation that may be related to the greater clinical benefit of Aggrenox compared with Aspirin in preventing recurrent stroke...
  101. ncbi request reprint Aspirin, NSAIDs, and COX-2 inhibitors in cardiovascular disease: possible interactions and implications for treatment of rheumatoid arthritis
    Tobias Kurth
    Brigham and Women s Hospital, Division of Aging, 1620 Tremont Street, Boston, MA 02120, USA
    Curr Rheumatol Rep 6:351-6. 2004
    ..The more widespread and appropriate use of aspirin in patients with rheumatoid arthritis will avoid many premature deaths in secondary prevention for CVD and first myocardial infarctions in primary prevention...