Jane S Hankins

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Chemical and functional analysis of generic hydroxyurea formulations
    Virginia L Harrod
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Hematol Oncol 25:423-9. 2008
  2. doi request reprint A transition pilot program for adolescents with sickle cell disease
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Health Care 26:e45-9. 2012
  3. pmc Patterns of liver iron accumulation in patients with sickle cell disease and thalassemia with iron overload
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Eur J Haematol 85:51-7. 2010
  4. pmc R2* magnetic resonance imaging of the liver in patients with iron overload
    Jane S Hankins
    Departments of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Blood 113:4853-5. 2009
  5. pmc Pharmacotherapy in sickle cell disease--state of the art and future prospects
    Jane Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 145:296-308. 2009
  6. pmc Ventricular diastolic dysfunction in sickle cell anemia is common but not associated with myocardial iron deposition
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 55:495-500. 2010
  7. doi request reprint The natural history of conditional transcranial Doppler flow velocities in children with sickle cell anaemia
    Jane S Hankins
    Department of Hematology, Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 142:94-9. 2008
  8. ncbi request reprint Therapy preference and decision-making among patients with severe sickle cell anemia and their families
    Jane Hankins
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 48:705-10. 2007
  9. ncbi request reprint Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia
    Jane S Hankins
    Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 140:80-5. 2008
  10. ncbi request reprint Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea
    Jane S Hankins
    Department of Hematology, Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 50:293-7. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Chemical and functional analysis of generic hydroxyurea formulations
    Virginia L Harrod
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Hematol Oncol 25:423-9. 2008
    ..Generic hydroxyurea formulations represent a potent yet inexpensive therapeutic option for children with SCA worldwide...
  2. doi request reprint A transition pilot program for adolescents with sickle cell disease
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Health Care 26:e45-9. 2012
    ..We describe a pilot program created to facilitate transition from pediatric to adult care by helping adolescents with SCD identify an adult medical home...
  3. pmc Patterns of liver iron accumulation in patients with sickle cell disease and thalassemia with iron overload
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Eur J Haematol 85:51-7. 2010
    ..Pathophysiological and genetic differences affecting iron deposition and accumulation in SCD and TM warrants further investigation...
  4. pmc R2* magnetic resonance imaging of the liver in patients with iron overload
    Jane S Hankins
    Departments of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Blood 113:4853-5. 2009
    ..98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038...
  5. pmc Pharmacotherapy in sickle cell disease--state of the art and future prospects
    Jane Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 145:296-308. 2009
    ....
  6. pmc Ventricular diastolic dysfunction in sickle cell anemia is common but not associated with myocardial iron deposition
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 55:495-500. 2010
    ....
  7. doi request reprint The natural history of conditional transcranial Doppler flow velocities in children with sickle cell anaemia
    Jane S Hankins
    Department of Hematology, Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 142:94-9. 2008
    ..Our data document a high conversion rate to abnormal velocities among untreated children with SCA. Therapy should be considered for the prevention of conversion to abnormal TCD velocities...
  8. ncbi request reprint Therapy preference and decision-making among patients with severe sickle cell anemia and their families
    Jane Hankins
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 48:705-10. 2007
    ..We explored factors that influenced making decisions regarding interventions and examined the relations between treatment preference and health-related quality of life (HRQOL)...
  9. ncbi request reprint Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia
    Jane S Hankins
    Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Br J Haematol 140:80-5. 2008
    ..KCl co-transporter activity declined after 3 months of magnesium pidolate (P = 0.02). A phase II study is needed to investigate the efficacy of this drug combination...
  10. ncbi request reprint Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea
    Jane S Hankins
    Department of Hematology, Comprehensive Sickle Cell Center, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 50:293-7. 2008
    ..Chronic organ damage is an insidious process in patients with sickle cell anemia (SCA). Although hydroxyurea prevents acute vaso-occlusive events, its effects on the preservation of organ function remain undefined...
  11. pmc Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
    Jane S Hankins
    St Jude Comprehensive Sickle Cell Center, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 106:2269-75. 2005
    ..Infants with SCA tolerate prolonged hydroxyurea therapy with sustained hematologic benefits, fewer ACS events, improved growth, and possibly preserved organ function...
  12. pmc "It's our job": qualitative study of family responses to ableism
    Susan L Neely-Barnes
    College of Social Work, University of Tennessee, Memphis, TN 38163, USA
    Intellect Dev Disabil 48:245-58. 2010
    ..The relationship between themes is presented, and the relationship between themes and parent empowerment is discussed as well as the ways in which the themes reflect underlying ableism...
  13. doi request reprint Hydroxyurea treatment decreases glomerular hyperfiltration in children with sickle cell anemia
    Banu Aygun
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Am J Hematol 88:116-9. 2013
    ..042) and decrease in lactate dehydrogenase levels (P = 0.035). Urine microalbumin and cystatin C levels did not change significantly. Hydroxyurea at MTD is associated with a decrease in hyperfiltration in young children with SCA...
  14. pmc Comparison of whole liver and small region-of-interest measurements of MRI liver R2* in children with iron overload
    M Beth McCarville
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 210, Memphis, TN 38105, USA
    Pediatr Radiol 40:1360-7. 2010
    ..A systematic investigation of the influence of the region-of-interest size and placement has not been conducted...
  15. pmc Automated T(2) * measurements using supplementary field mapping to assess cardiac iron content
    Brian A Taylor
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Magn Reson Imaging 38:441-7. 2013
    ..To develop and evaluate an algorithm that automatically identifies high-susceptibility areas and excludes them from T(2) * measurements in the left ventricle (LV) for myocardial iron measurements...
  16. pmc Hydroxyurea use and hospitalization trends in a comprehensive pediatric sickle cell program
    Kerri A Nottage
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 8:e72077. 2013
    ..This analysis evaluates the impact of increasing usage of HU on trends in hospitalizations and blood transfusions within a large SCD treatment program...
  17. doi request reprint Protection from sickle cell retinopathy is associated with elevated HbF levels and hydroxycarbamide use in children
    Jeremie H Estepp
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 161:402-5. 2013
    ..16%; P = 0.005). We report a protective benefit of elevated HbF regarding retinopathy, and our data suggests induction of HbF with hydroxycarbamide may prevent retinopathy in children...
  18. pmc Simultaneous field and R2 mapping to quantify liver iron content using autoregressive moving average modeling
    Brian A Taylor
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Magn Reson Imaging 35:1125-32. 2012
    ....
  19. doi request reprint Microarray analysis of liver gene expression in iron overloaded patients with sickle cell anemia and beta-thalassemia
    Jonathan M Flanagan
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Am J Hematol 84:328-34. 2009
    ....
  20. doi request reprint The clinical and laboratory spectrum of Hb C [β6(A3)Glu→Lys, GAG>AAG] disease
    Cathleen M Cook
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Hemoglobin 37:16-25. 2013
    ..Accurate diagnosis and understanding of Hb C-related disorders helped to avoid confusion with sickle hemoglobinopathies and aided in proper clinical management...
  21. doi request reprint Neurocognitive screening with the Brigance preschool screen-II in 3-year-old children with sickle cell disease
    Banu Aygun
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Pediatr Blood Cancer 56:620-4. 2011
    ..However, the age of onset and factors contributing to this problem have not been well studied. We hypothesized that in children with SCD the failure rate with Brigance screening would be higher than in the normal population...
  22. pmc Glomerular hyperfiltration and albuminuria in children with sickle cell anemia
    Banu Aygun
    Department of Hematology, St Jude Children s Research Hospital, 262 Danny Thomas Place, MS 800, Memphis, TN 38105 3678, USA
    Pediatr Nephrol 26:1285-90. 2011
    ..Cystatin C levels inversely reflect GFR changes and are associated with albuminuria; serial monitoring may provide a sensitive and accurate marker of nephropathy in children with SCA...
  23. doi request reprint Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 52:85-91. 2009
    ..Recent studies have documented elevated gray matter (GM) CBF in untreated children with SCA, but no measurements of white matter (WM) CBF have been reported...
  24. ncbi request reprint Assessment of sleep-related disorders in children with sickle cell disease
    Jane S Hankins
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Hemoglobin 38:244-51. 2014
    ..Survey-reported symptoms of SRDs were significantly higher than that reported in the general pediatric population. A fast and simplified SRD survey is feasible and suggests a high prevalence of SRDs in children with sickle cell disease. ..
  25. pmc Trends in transfusion burden among long-term survivors of childhood hematological malignancies
    Kerri Nottage
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Leuk Lymphoma 54:1719-23. 2013
    ..5-2.8). Those with higher ITR-3 scores and more recent decades of treatment had a higher transfusional burden. Comprehensive transfusion histories are useful in identifying those at highest risk for iron overload...
  26. doi request reprint Phenocopy of warfarin syndrome in an infant born to a mother with sickle cell anemia and severe transfusional iron overload
    Yi Xie
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105 3678, USA
    J Pediatr Hematol Oncol 35:e265-8. 2013
    ..Treatment of iron overload among women with sickle cell anemia of childbearing potential is important to avoid possible CDP in newborns. ..
  27. doi request reprint Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease
    Amber Mayfield Yates
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 53:479-81. 2009
    ..Our cases suggest that older children with SCD and acute parvovirus infection should be monitored closely for splenomegaly and multi-system dysfunction...
  28. doi request reprint The impact of preparation and support procedures for children with sickle cell disease undergoing MRI
    Katherine R Cejda
    Child Life Program, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 121, Memphis, TN 38105, USA
    Pediatr Radiol 42:1223-8. 2012
    ..To improve children's ability to cope with MRI examinations and avoid sedation, our institution established preparation and support procedures (PSP)...
  29. doi request reprint The diagnostic dilemma of congenital unstable hemoglobinopathies
    Amber M Yates
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 55:1393-5. 2010
    ....
  30. pmc Exploring parent-sibling communication in families of children with sickle cell disease
    J Carolyn Graff
    University of Tennessee Health Science Center, College of Nursing and Boling Center for Developmental Disabilities, Memphis, TN 38105, USA
    Issues Compr Pediatr Nurs 33:101-23. 2010
    ..Communication within families of children with sickle cell disease is important yet has not been adequately investigated...
  31. doi request reprint Transition from pediatric to adult care in sickle cell disease: perspectives on the family role
    Jerlym S Porter
    St Jude Children s Research Hospital, Memphis, TN Electronic address
    J Pediatr Nurs 29:158-67. 2014
    ..Family members' perspectives are valuable in informing transition planning. Family-focused interventions designed to prepare and support families during transition are necessary...
  32. doi request reprint Effects of adenotonsillectomy on polysomnographic parameters in children with sickle cell disease
    Paul Finch
    Department of Pediatrics Otolaryngology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Pediatr Blood Cancer 60:E26-8. 2013
    ..Adenotonsillectomy promotes improvement in sleep quality in children with SCD and PSG-confirmed OSA...
  33. doi request reprint Fetal haemoglobin levels and haematological characteristics of compound heterozygotes for haemoglobin S and deletional hereditary persistence of fetal haemoglobin
    Duyen A Ngo
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Br J Haematol 156:259-64. 2012
    ..Despite having a much higher HbF level, patients with HbS-HPFH have a similar age-related pattern of HbF decline and associations as patients with sickle cell anaemia or HbS-β(0) thalassaemia...
  34. ncbi request reprint Biloma and pneumobilia in sickle cell disease
    Jeffrey Lebensburger
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 51:288-90. 2008
    ..Although hepatobiliary complications are common in SCD, we report on biloma and pneumobilia in a young patient with this condition...
  35. ncbi request reprint Chronic transfusion therapy for children with sickle cell disease and recurrent acute chest syndrome
    Jane Hankins
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr Hematol Oncol 27:158-61. 2005
    ..The effectiveness of CTX should be prospectively compared with that of hydroxyurea and stem cell transplantation...