RICHARD JAMES GILBERTSON

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Paediatric embryonic brain tumours. biological and clinical relevance of molecular genetic abnormalities
    R Gilbertson
    Department of Developmental Neurobiology, Room D2006G, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Eur J Cancer 38:675-85. 2002
  2. ncbi Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma
    R Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Chromosomes Cancer 31:288-94. 2001
  3. ncbi The origins of medulloblastoma subtypes
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pathol 3:341-65. 2008
  4. ncbi Making a tumour's bed: glioblastoma stem cells and the vascular niche
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nat Rev Cancer 7:733-6. 2007
  5. ncbi Mapping cancer origins
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cell 145:25-9. 2011
  6. ncbi High-grade glioma: can we teach an old dogma new tricks?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 9:147-8. 2006
  7. ncbi Brain tumors provide new clues to the source of cancer stem cells: does oncology recapitulate ontogeny?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennesee 38105, USA
    Cell Cycle 5:135-7. 2006
  8. ncbi ERBB2 in pediatric cancer: innocent until proven guilty
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee 38105, USA
    Oncologist 10:508-17. 2005
  9. ncbi Medulloblastoma: signalling a change in treatment
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 5:209-18. 2004
  10. ncbi ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma
    Richard J Gilbertson
    Brain Tumor Program, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 9:3620-4. 2003

Research Grants

  1. An investigation of radial glia as the source of ependymoma stem cells
    Richard Gilbertson; Fiscal Year: 2007
  2. An investigation of radial glia as the source of ependymoma stem cells
    RICHARD JAMES GILBERTSON; Fiscal Year: 2010

Collaborators

Detail Information

Publications35

  1. ncbi Paediatric embryonic brain tumours. biological and clinical relevance of molecular genetic abnormalities
    R Gilbertson
    Department of Developmental Neurobiology, Room D2006G, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Eur J Cancer 38:675-85. 2002
    ..This review focuses on the principal molecular genetic abnormalities so far identified in embryonal brain tumours and discusses their biological and clinical relevance...
  2. ncbi Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma
    R Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Chromosomes Cancer 31:288-94. 2001
    ..This demonstrated the four ERBB4 JM variants to be encoded by two short exons containing the JMb and JMa sequences positioned in the order 5' to 3' and separated by a 121 bp intron...
  3. ncbi The origins of medulloblastoma subtypes
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pathol 3:341-65. 2008
    ..Definitive characterization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provide important insights to the origins of cancer...
  4. ncbi Making a tumour's bed: glioblastoma stem cells and the vascular niche
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nat Rev Cancer 7:733-6. 2007
    ..These data have direct implications for cancer, highlighting the similarity between normal and malignant stem cells and identifying the tumour microenvironment as a target for new therapies...
  5. ncbi Mapping cancer origins
    Richard J Gilbertson
    Department of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cell 145:25-9. 2011
    ..5 million people each year. Poor understanding of cancer's diversity currently thwarts our goal of a cure for every patient, but recent integration of genomic and stem cell technologies promises a route through this impasse...
  6. ncbi High-grade glioma: can we teach an old dogma new tricks?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 9:147-8. 2006
    ..report an extensive study of the gene expression profiles of a large cohort of HGG. Their data provide new clues to the origins of this disease and suggest potential targets for novel therapies...
  7. ncbi Brain tumors provide new clues to the source of cancer stem cells: does oncology recapitulate ontogeny?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennesee 38105, USA
    Cell Cycle 5:135-7. 2006
    ..These data suggest strongly that ependymomas arise directly from transformed radial glia and they provide a novel method that could be used to map the cell of origin of other types of cancer...
  8. ncbi ERBB2 in pediatric cancer: innocent until proven guilty
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, Tennessee 38105, USA
    Oncologist 10:508-17. 2005
    ..This review addresses the issues surrounding the identification of molecular targets in pediatric cancers by focusing on studies of the ERBB2 oncogene...
  9. ncbi Medulloblastoma: signalling a change in treatment
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 5:209-18. 2004
    ..Several pathways have been implicated in medulloblastoma formation, and knowledge of these is now being used to develop new ways of treating children with medulloblastoma...
  10. ncbi ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma
    Richard J Gilbertson
    Brain Tumor Program, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 9:3620-4. 2003
    ....
  11. ncbi Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
    ..ERBB2 expression and clinical risk factors together constitute a highly accurate disease risk stratification tool...
  12. ncbi Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4221-7. 2010
    ....
  13. ncbi ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma
    Roberto Hernan
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:140-8. 2003
    ..These data identify an ERBB2 driven prometastatic pathway that may provide a novel target for therapeutic intervention in metastatic medulloblastoma...
  14. ncbi A molecular fingerprint for medulloblastoma
    Youngsoo Lee
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:5428-37. 2003
    ..Coordinated deregulation of these same genes also occurred in a large subset of human medulloblastomas. These data identify a group of genes that is central to medulloblastoma tumorigenesis...
  15. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  16. ncbi Phase I study of everolimus in pediatric patients with refractory solid tumors
    Maryam Fouladi
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 25:4806-12. 2007
    ....
  17. ncbi Molecular profiling of pediatric brain tumors: insight into biology and treatment
    Robert Johnson
    Departments of Developmental Neurobiology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Oncol Rep 11:68-72. 2009
    ....
  18. ncbi Cross-species genomics matches driver mutations and cell compartments to model ependymoma
    Robert A Johnson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 466:632-6. 2010
    ..Our data demonstrate the power of cross-species genomics to meticulously match subgroup-specific driver mutations with cellular compartments to model and interrogate cancer subgroups...
  19. ncbi Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
    ....
  20. ncbi Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Acta Neuropathol 121:381-96. 2011
    ....
  21. ncbi ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA Richard
    Clin Cancer Res 8:3054-64. 2002
    ..Functional assessment of ERBB-dependent cell signaling and proliferation, in addition to novel therapeutic inhibition of these processes, was conducted using short-term cultures of human ependymoma cells...
  22. ncbi Tumorigenesis in the brain: location, location, location
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 67:5579-82. 2007
    ..These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors...
  23. ncbi Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  24. ncbi Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    Margaret C Thompson
    St Jude Children's Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 24:1924-31. 2006
    ..This approach may assist ultimately in the selection of patients for future clinical trials of molecular targeted therapies...
  25. ncbi Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    Frederique Zindy
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 67:2676-84. 2007
    ..These results underscore the functional interplay between a network of specific genes that recurrently contribute to medulloblastoma formation...
  26. ncbi Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:3623-9. 2010
    ....
  27. ncbi Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature
    Paxton V Dickson
    Department of Surgery, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Mol Cancer Res 5:531-42. 2007
    ..These results have significant implications for the planning of combination anticancer therapy...
  28. ncbi Molecular biology of medulloblastoma: will it ever make a difference to clinical management?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    J Neurooncol 75:273-8. 2005
    ..We review some of the reasons we have failed to translate knowledge of medulloblastoma disease biology to the clinic and look forward to the next generation of clinical and molecular studies that are seeking to correct this...
  29. ncbi Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology-Oncology, Mail Stop 260, St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..ATRT presenting in older patients can be cured using a combination of radiation and high-dose alkylating therapy. Older patients with relapsed ATRT can have salvage treatment using ICE chemotherapy...
  30. ncbi Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009
    ..Our data indicate that Prom1 marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1(+) tumour cells...
  31. ncbi A perivascular niche for brain tumor stem cells
    Christopher Calabrese
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 11:69-82. 2007
    ..We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches...
  32. ncbi Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma
    Richard J Gilbertson
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
    Eur J Cancer 42:646-9. 2006
    ....
  33. ncbi The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    Tamar Uziel
    Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
    Genes Dev 19:2656-67. 2005
    ..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children...
  34. ncbi Radial glia cells are candidate stem cells of ependymoma
    Michael D Taylor
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 8:323-35. 2005
    ....
  35. ncbi The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma
    Tamar Uziel
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:2812-7. 2009
    ..Our findings suggest a functional collaboration between the miR-17 approximately 92 cluster and the SHH signaling pathway in the development of MBs in mouse and man...

Research Grants4

  1. An investigation of radial glia as the source of ependymoma stem cells
    Richard Gilbertson; Fiscal Year: 2007
    ....
  2. An investigation of radial glia as the source of ependymoma stem cells
    RICHARD JAMES GILBERTSON; Fiscal Year: 2010
    ....