A Gajjar

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Atypical teratoid rhabdoid tumor: current therapy and future directions
    Kevin F Ginn
    Division of Neuro Oncology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Oncol 2:114. 2012
  2. doi request reprint Children's Oncology Group's 2013 blueprint for research: central nervous system tumors
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Blood Cancer 60:1022-6. 2013
  3. ncbi request reprint Low-grade astrocytoma: a decade of experience at St. Jude Children's Research Hospital
    A Gajjar
    St Jude Children s Research Hospital Le Bonheur Children s Medical Center Brain Tumor Team, Memphis, TN 38105 2794, USA
    J Clin Oncol 15:2792-9. 1997
  4. ncbi request reprint Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
  5. ncbi request reprint Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy
    Amar Gajjar
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2374-80. 2003
  6. ncbi request reprint Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia
    A Gajjar
    Departments of Hematology Oncology, Biostatistics and Epidemiology, Pharmaceutical Sciences, and Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 96:3381-4. 2000
  7. ncbi request reprint Comparison of lumbar and shunt cerebrospinal fluid specimens for cytologic detection of leptomeningeal disease in pediatric patients with brain tumors
    A Gajjar
    Departments of Hematology Oncology, Radiation Oncology, Pathology and Laboratory Medicine, and Biostatistics and Epidemiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 17:1825-8. 1999
  8. ncbi request reprint Medulloblastoma with brain stem involvement: the impact of gross total resection on outcome
    A Gajjar
    Le Bonheur Children s Medical Center, Brain Tumor Team, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38101 0318, USA
    Pediatr Neurosurg 25:182-7. 1996
  9. ncbi request reprint Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor
    M Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 17:3234-7. 1999
  10. ncbi request reprint Survival and neurodevelopmental outcome of young children with medulloblastoma at St Jude Children's Research Hospital
    A W Walter
    Departments of Hematology Oncology, Behavioral Medicine, Radiation Oncology, and Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 17:3720-8. 1999

Detail Information

Publications104 found, 100 shown here

  1. pmc Atypical teratoid rhabdoid tumor: current therapy and future directions
    Kevin F Ginn
    Division of Neuro Oncology, St Jude Children s Research Hospital Memphis, TN, USA
    Front Oncol 2:114. 2012
    ..There has been significant interest in identifying and testing therapeutic agents that target these pathways...
  2. doi request reprint Children's Oncology Group's 2013 blueprint for research: central nervous system tumors
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Blood Cancer 60:1022-6. 2013
    ..Phase III trials will explore risk-based therapy stratification guided by molecular and clinical traits of children with medulloblastoma or ependymoma...
  3. ncbi request reprint Low-grade astrocytoma: a decade of experience at St. Jude Children's Research Hospital
    A Gajjar
    St Jude Children s Research Hospital Le Bonheur Children s Medical Center Brain Tumor Team, Memphis, TN 38105 2794, USA
    J Clin Oncol 15:2792-9. 1997
    ..To evaluate the impact of primary tumor site, age at diagnosis, extent of resection, and histology on progression-free survival (PFS) in pediatric low-grade astrocytoma...
  4. ncbi request reprint Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  5. ncbi request reprint Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy
    Amar Gajjar
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2374-80. 2003
    ..The type and grade of toxicity did not differ between the two patient groups. Increasing the dosage of irinotecan increased the SN-38 AUC in some patients who received concomitant EIA therapy...
  6. ncbi request reprint Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia
    A Gajjar
    Departments of Hematology Oncology, Biostatistics and Epidemiology, Pharmaceutical Sciences, and Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 96:3381-4. 2000
    ..These data indicate that contamination of CSF with circulating leukemic blast cells during diagnostic lumbar puncture can adversely affect the treatment outcome of children with ALL and is an indication to intensify intrathecal therapy...
  7. ncbi request reprint Comparison of lumbar and shunt cerebrospinal fluid specimens for cytologic detection of leptomeningeal disease in pediatric patients with brain tumors
    A Gajjar
    Departments of Hematology Oncology, Radiation Oncology, Pathology and Laboratory Medicine, and Biostatistics and Epidemiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 17:1825-8. 1999
    ....
  8. ncbi request reprint Medulloblastoma with brain stem involvement: the impact of gross total resection on outcome
    A Gajjar
    Le Bonheur Children s Medical Center, Brain Tumor Team, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38101 0318, USA
    Pediatr Neurosurg 25:182-7. 1996
    ..Although there was no operative mortality, the frequency of the posterior fossa syndrome is of concern and emphasizes the need for careful consideration of the risk/benefit ratio in the surgical approach to this subgroup of patients...
  9. ncbi request reprint Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor
    M Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 17:3234-7. 1999
    ..To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET...
  10. ncbi request reprint Survival and neurodevelopmental outcome of young children with medulloblastoma at St Jude Children's Research Hospital
    A W Walter
    Departments of Hematology Oncology, Behavioral Medicine, Radiation Oncology, and Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 17:3720-8. 1999
    ..This study sought to assess the relationship, if any, between patient outcome and M stage. Neuropsychologic and endocrine outcomes were also assessed...
  11. ncbi request reprint Bithalamic involvement predicts poor outcome among children with thalamic glial tumors
    D A Reardon
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Neurosurg 29:29-35. 1998
    ....
  12. ncbi request reprint Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 65:210-21. 2006
    ..Model the effects of radiation dosimetry on IQ among pediatric patients with central nervous system (CNS) tumors...
  13. doi request reprint High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors
    Chie Schin Shih
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 112:1345-53. 2008
    ..High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies...
  14. ncbi request reprint Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss
    R K Mulhern
    Division of Behavioral Medicine and Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 19:472-9. 2001
    ....
  15. ncbi request reprint Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation
    W E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN, USA
    Magn Reson Imaging 18:787-93. 2000
    ..Serial quantitative MR measures of NAWMV may provide a neuroanatomical substrate for assessing functional impact of CSI on normal brain function following treatment for medulloblastoma...
  16. ncbi request reprint Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse
    N Hijiya
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Leukemia 18:1581-6. 2004
    ..0+/-9.6% for those with late relapse and 20.0+/-8.0% for those with early relapse. We conclude that low-dose etoposide administered orally has a cytoreductive effect in relapsed ALL...
  17. ncbi request reprint Safety of lumbar puncture for children with acute lymphoblastic leukemia and thrombocytopenia
    S C Howard
    Department of Hematology Oncology, ALSAC Bldg, Room C6005, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    JAMA 284:2222-4. 2000
    ..Patients with thrombocytopenia are at risk for spontaneous or procedure-related hemorrhage. Whether such patients can safely undergo lumbar puncture (LP) without prophylactic platelet transfusion is unknown...
  18. ncbi request reprint Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma
    Raymond K Mulhern
    Division of Behavioral Medicine, Department of Biostatistics, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:5511-9. 2005
    ....
  19. ncbi request reprint Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
    ..To assess the feasibility of performing central molecular analyses of fresh medulloblastomas obtained from multiple institutions and using these data to identify prognostic markers for contemporaneously treated patients...
  20. pmc Comparison of native E. coli and PEG asparaginase pharmacokinetics and pharmacodynamics in pediatric acute lymphoblastic leukemia
    J C Panetta
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 86:651-8. 2009
    ..At relapse, there were significant pharmacokinetic and pharmacodynamic differences attributable to ASP preparation and antibody status...
  21. ncbi request reprint Immediate neurocognitive effects of methylphenidate on learning-impaired survivors of childhood cancer
    S J Thompson
    Division of Neurology, Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Oncol 19:1802-8. 2001
    ..No significant side effects from MPH were observed. CONCLUSION: MPH resulted in a statistically significant improvement on measures of attention abilities that cannot be explained by placebo or practice effects...
  22. ncbi request reprint Diffusion tensor imaging of intraaxial tumors at the cervicomedullary and pontomedullary junctions. Report of two cases
    Nicholas S Phillips
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosurg 103:557-62. 2005
    ....
  23. ncbi request reprint Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation
    Bonnie J Nagel
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN, USA
    AJNR Am J Neuroradiol 25:1575-82. 2004
    ..Therefore, we hypothesized that longitudinal hippocampal volume measurements are abnormal in patients with medulloblastoma and thereby provide a possible substrate for explaining memory dysfunction...
  24. doi request reprint Role of high-dose chemotherapy for recurrent medulloblastoma and other CNS primitive neuroectodermal tumors
    Amar Gajjar
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 54:649-51. 2010
    ..2% were event free survivors. The outlook for previously irradiated patients with recurrent PNETs remains extremely poor and more effective therapeutic approaches are needed...
  25. pmc Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection
    M Fouladi
    Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    Neuro Oncol 3:184-92. 2001
    ..Gross total resection without adjuvant therapy provides prolonged disease control, as seen in 6 of 7 patients (85%) in our series...
  26. ncbi request reprint Attention and memory functioning among pediatric patients with medulloblastoma
    Cara B Reeves
    Division of Behavioral Medicine, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    J Pediatr Psychol 31:272-80. 2006
    ..To test the hypotheses that memory and attention deficits are prevalent in survivors of childhood medulloblastoma (MB) and that these deficits are associated with problems with academic achievement...
  27. ncbi request reprint Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor
    Clinton F Stewart
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:3357-65. 2004
    ....
  28. pmc Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4221-7. 2010
    ....
  29. ncbi request reprint Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors
    John C Panetta
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Cancer Chemother Pharmacol 52:435-41. 2003
    ..To construct a population pharmacokinetic model for temozolomide (TMZ), a novel imidazo-tetrazine methylating agent and its metabolites MTIC and AIC in infants and children with primary central nervous system tumors...
  30. pmc Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy
    N D Sabin
    Department of Radiological Sciences, St Jude s Children s Research Hospital, Memphis, Tennessee 38105, USA
    AJNR Am J Neuroradiol 34:446-50. 2013
    ..Radiologists should be aware of these findings in children who receive PT after chemotherapy. In this report, we describe the time course of these PT-related imaging findings and correlate them with treatment and clinical outcomes...
  31. pmc Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors
    N G Miller
    Department of Radiological Sciences, St Jude Children s Research Hostpital, Memphis, TN 38105, USA
    AJNR Am J Neuroradiol 31:288-94. 2010
    ....
  32. ncbi request reprint Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH)...
  33. pmc Chemotherapy for malignant brain tumors of childhood
    Nicholas G Gottardo
    Department of Hematology Oncology, Division of Neuro Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Child Neurol 23:1149-59. 2008
    ..These selective agents are likely to be less toxic to normal cells and more effective...
  34. ncbi request reprint Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis
    S L Palmer
    Division of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
    J Clin Oncol 19:2302-8. 2001
    ....
  35. ncbi request reprint Chemotherapy of medulloblastoma
    A Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2729, USA
    Childs Nerv Syst 15:554-62. 1999
    ..Further areas of basic research and evolving data on studies in relapsed patients are also briefly discussed...
  36. ncbi request reprint Algorithm for nutritional support: experience of the Metabolic and Infusion Support Service of St. Jude Children's Research Hospital
    L C Bowman
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Cancer Suppl 11:76-80. 1998
    ..Our current emphasis is to define the time points in therapy at which nutritional intervention is most warranted...
  37. ncbi request reprint Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 107:2291-7. 2006
    ....
  38. ncbi request reprint Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Clin Cancer Res 13:6712-8. 2007
    ..To estimate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of escalating doses of temozolomide combined with O(6)-benzylguanine in patients < or =21 years with recurrent brain tumors...
  39. ncbi request reprint UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan
    Clinton F Stewart
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:2594-600. 2007
    ....
  40. ncbi request reprint High-grade astrocytoma in very young children
    Robert P Sanders
    Division of Neuro Oncology, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 49:888-93. 2007
    ..High-grade astrocytomas are rare in young children, but have been reported to have a better prognosis than similar tumors in older patients...
  41. ncbi request reprint Survival and late mortality in long-term survivors of pediatric CNS tumors
    E Brannon Morris
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:1532-8. 2007
    ..To describe the pattern of survival and late mortality among contemporary long-term survivors of pediatric CNS tumor...
  42. doi request reprint Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosurg Pediatr 1:270-6. 2008
    ..The authors sought to determine whether DT imaging and white matter tractography could detect axonal degeneration in patients with brainstem tumors...
  43. doi request reprint Young age may predict a better outcome for children with diffuse pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 113:566-72. 2008
    ..Because diffuse pontine glioma (DPG) is rare among young children, the outcome of affected patients is unknown...
  44. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  45. pmc Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma
    Thomas E Merchant
    Department of Radiological Sciences, Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 70:782-7. 2008
    ..Conformal RT to less than the entire posterior fossa (PF) after craniospinal irradiation might reduce neurocognitive sequelae and requires evaluation...
  46. pmc M1 Medulloblastoma: high risk at any age
    Robert P Sanders
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 90:351-5. 2008
    ..The prognosis for children with M1 medulloblastoma (positive CSF cytology) has not been well-defined...
  47. pmc Regional white matter anisotropy and reading ability in patients treated for pediatric embryonal tumors
    Shawna L Palmer
    St Jude Children s Research Hospital, Memphis, TN, USA
    Brain Imaging Behav 4:132-40. 2010
    ..The integrity of the white matter in these regions may affect communication among visual, auditory, and language cortical areas that are engaged during reading...
  48. pmc Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma
    Shawna L Palmer
    Department of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Neuro Oncol 12:1311-7. 2010
    ..This study highlights the need for careful follow-up with neuropsychological evaluation and for obtaining critical support for patients and their families...
  49. pmc Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database
    Ibrahim Qaddoumi
    Department of Oncology, Division of Neuro Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Cancer 115:5761-70. 2009
    ..Pediatric gliomas are rare and heterogeneous tumors. The Surveillance, Epidemiology, and End Results (SEER) database allows a large-scale analysis of the clinical characteristics and prognostic features of these tumors...
  50. pmc Proximal dentatothalamocortical tract involvement in posterior fossa syndrome
    E Brannon Morris
    Department of Oncology, Division of Cancer Survivorship, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    Brain 132:3087-95. 2009
    ....
  51. pmc Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
    ....
  52. pmc Fanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor
    Mariko D Dewire
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 53:1140-2. 2009
    ....
  53. pmc Survival and long-term health and cognitive outcomes after low-grade glioma
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN 38105, USA
    Neuro Oncol 13:223-34. 2011
    ..Survivors of childhood LGG experience substantial long-term adverse effects that continue to increase well beyond the 5-year survival time point...
  54. pmc Successful treatment of early detected trilateral retinoblastoma using standard infant brain tumor therapy
    Karen D Wright
    Department of Oncology, Division of Neuro Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Pediatr Blood Cancer 55:570-2. 2010
    ..Early diagnosis of trilateral retinoblastoma may facilitate the use of less intensive therapeutic approaches and result in excellent outcomes in these patients...
  55. pmc Abnormal timing of menarche in survivors of central nervous system tumors: A report from the Childhood Cancer Survivor Study
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 115:2562-70. 2009
    ..To the authors' knowledge, data regarding the risk of altered timing of menarche after higher dose radiotherapy (RT), as used in the treatment of central nervous system (CNS) tumors, are limited...
  56. pmc New chemotherapy strategies and biological agents in the treatment of childhood ependymoma
    Karen D Wright
    Division of Neuro Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mailstop 260, Memphis, TN 38105, USA
    Childs Nerv Syst 25:1275-82. 2009
    ..With the limited role of current treatment regimens and potential associated side effects of radiation in young children with ependymoma, considerable effort is being focused on new chemotherapeutic strategies and biologic agents...
  57. pmc Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
    ....
  58. pmc The use of bone age for bone mineral density interpretation in a cohort of pediatric brain tumor patients
    E Brannon Morris
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Pediatr Radiol 38:1285-92. 2008
    ..Previous investigators have proposed using bone age (BA) rather than chronological age (CA) when interpreting bone mineral density (BMD) values in children...
  59. pmc Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Cancer 116:4632-7. 2010
    ..A prospective, multicenter study was conducted to assess the feasibility of tissue collection at autopsy and its suitability for molecular analyses in children with diffuse intrinsic pontine glioma...
  60. ncbi request reprint Quantitative morphologic evaluation of white matter in survivors of childhood medulloblastoma
    Zuyao Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences MS212, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Magn Reson Imaging 24:1015-22. 2006
    ..We conclude that fractal geometry can be used to monitor the morphologic effects of neurotoxicity in brain tumor survivors...
  61. ncbi request reprint Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia
    John T Sandlund
    Department of Hematology Oncology, St Jude Children s Research Hospital, and the University of Tennessee, College of Medicine, Memphis, TN 38105, USA
    Blood 100:43-7. 2002
    ....
  62. ncbi request reprint Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist
    Alberto Broniscer
    Division of Neuro Oncology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Oncologist 9:197-206. 2004
    ..Because the outcome for patients with either type of tumor is poor when standard multimodality therapy is used, these children are ideal candidates for innovative treatment approaches...
  63. pmc Atypical white matter volume development in children following craniospinal irradiation
    Wilburn E Reddick
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuro Oncol 7:12-9. 2005
    ..Therefore, volumetric monitoring of brain development can be used to guide the care of survivors, assess the toxicity of previous and current clinical trials, and aid in the design of therapies that minimize toxicity...
  64. ncbi request reprint A knowledge-guided active contour method of segmentation of cerebella on MR images of pediatric patients with medulloblastoma
    Zu Y Shan
    Division of Translational Imaging Research, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Magn Reson Imaging 21:1-11. 2005
    ..To develop an automated method for identification of the cerebella on magnetic resonance (MR) images of patients with medulloblastoma...
  65. ncbi request reprint Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 13:1511-5. 2007
    ..To report cerebrospinal fluid (CSF) penetration of erlotinib and its metabolite OSI-420...
  66. ncbi request reprint Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98)
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 103:133-9. 2005
    ..The role of chemotherapy in the treatment of children with newly diagnosed diffuse brainstem glioma is uncertain. In the current study, the authors tested the efficacy of temozolomide treatment after radiotherapy (RT) in this setting...
  67. ncbi request reprint White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:4551-60. 2004
    ....
  68. ncbi request reprint Late neurocognitive sequelae in survivors of brain tumours in childhood
    Raymond K Mulhern
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Lancet Oncol 5:399-408. 2004
    ..Further efforts to limit neurocognitive sequelae have included design of clinical trials to test the effectiveness of cognitive, behavioural, and pharmacological interventions...
  69. ncbi request reprint Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 100:2246-52. 2004
    ..Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. The goal of the current study was to investigate and characterize these rare SNs...
  70. ncbi request reprint Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 98:2232-44. 2003
    ..Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma...
  71. ncbi request reprint Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Neuropsychology 17:548-55. 2003
    ..A steeper decline was found for those with higher baseline performance. Clinicians may use the proposed predictive model to identify those patients who are at risk of significant intellectual decline...
  72. ncbi request reprint ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma
    Richard J Gilbertson
    Brain Tumor Program, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 9:3620-4. 2003
    ....
  73. ncbi request reprint Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors
    Wilburn E Reddick
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:2512-9. 2003
    ....
  74. ncbi request reprint A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors
    Victor M Santana
    Department of Hematology, St Jude Children s Research Hospital, University of Tennessee, Memphis, Tennessee 38103, USA
    Clin Cancer Res 9:633-40. 2003
    ..To assess the use of a pharmacokinetically guided topotecan strategy and evaluate the toxicity of protracted i.v. topotecan in children with recurrent solid tumors...
  75. ncbi request reprint Survival and functional outcome of children with hypothalamic/chiasmatic tumors
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 97:1084-92. 2003
    ..We evaluated the impact of clinical and neuroimaging parameters and primary therapy on overall (OS) and progression-free (PFS) survival and on neuroendocrine and neurocognitive outcome in children with H and/or C tumors...
  76. ncbi request reprint Seizures in children with primary brain tumors: incidence and long-term outcome
    Raja B Khan
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Epilepsy Res 64:85-91. 2005
    ..To estimate the incidence and long-term outcome of brain tumor related seizures in children and to identify risk factors for adverse seizure outcome...
  77. ncbi request reprint Ocular neuromyotonia: video case report
    E Brannon Morris
    Neurology 66:E27. 2006
  78. ncbi request reprint Medulloblastoma metastatic to the suprasellar region at diagnosis: a report of six cases with clinicopathologic correlation
    Kathleen J Helton
    St Jude Children s Research Hospital, Semmes Murphy Clinic, Memphis, TN 38105, USA
    Pediatr Neurosurg 37:111-7. 2002
    ..8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site...
  79. ncbi request reprint Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer 106:1364-71. 2006
    ..In the current study, the authors assessed the characteristics and estimated the cumulative incidence of IH among children with BSG...
  80. pmc Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma
    Trevor McKibbin
    Department of Clinical Pharmacy and Pharmaceutical Sciences, University of Tennessee, TN, USA
    Clin Cancer Res 16:1049-57. 2010
    ....
  81. ncbi request reprint Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 76:313-9. 2006
    ..Although the heterogeneity of prognostic factors in our patients made assessment of treatment outcome more difficult, the addition of 6 cycles of temozolomide after radiotherapy did not seem to alter the poor outcome of these patients...
  82. ncbi request reprint Molecular biology of medulloblastoma: will it ever make a difference to clinical management?
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    J Neurooncol 75:273-8. 2005
    ..We review some of the reasons we have failed to translate knowledge of medulloblastoma disease biology to the clinic and look forward to the next generation of clinical and molecular studies that are seeking to correct this...
  83. ncbi request reprint Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 23:7152-60. 2005
    ....
  84. ncbi request reprint Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse
    E Coustan-Smith
    Department of Hematology Oncology, Children s Research Hospital, Memphis, TN, USA
    Leukemia 18:499-504. 2004
    ..We conclude that MRD assays should be used to guide the selection of postremission therapy in patients with ALL in first relapse...
  85. pmc Clinical, radiological, histological and molecular characteristics of paediatric epithelioid glioblastoma
    A Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Neuropathol Appl Neurobiol 40:327-36. 2014
    ..We evaluated clinical, radiological, histological and molecular characteristics in the largest series to date of paediatric e-GB...
  86. pmc The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer
    J J Yang
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 94:252-9. 2013
    ..In conclusion, our results indicated that TPMT or COMT genetic variation was not related to cisplatin ototoxicity in children with cancer and did not influence cisplatin-induced hearing damage in laboratory models. ..
  87. ncbi request reprint What's new in neuro-oncology? Recent advances in medulloblastoma
    David W Ellison
    The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Paediatr Neurol 7:53-66. 2003
  88. ncbi request reprint Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia
    Mathew J Edick
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, and College of Pharmacy, The University of Tennessee, Memphis 38105, USA
    J Clin Oncol 21:1340-6. 2003
    ..To study the pharmacokinetics and pharmacodynamics of once- versus twice-daily oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia (ALL)...
  89. ncbi request reprint Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    J Clin Oncol 24:4202-8. 2006
    ..To determine the event-free survival (EFS) and overall survival of children with average-risk medulloblastoma and treated with reduced-dose craniospinal radiotherapy (CSRT) and one of two postradiotherapy chemotherapies...
  90. ncbi request reprint Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia
    Gaston K Rivera
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 103:368-76. 2005
    ..The authors studied the clinical outcome of 106 children with acute lymphoblastic leukemia (ALL) who developed a bone marrow recurrence as the first adverse event after contemporary intensified therapy...
  91. ncbi request reprint Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group
    Patricia L Robertson
    Department of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan 48109 0203, USA
    J Neurosurg 105:444-51. 2006
    ..Most descriptions have been limited to small institutional series using a retrospective chart review methodology...
  92. ncbi request reprint Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes
    Christine Fuller
    Department of Pathology, St Jude Children s, Research Hospital, Memphis, TN, USA
    Am J Clin Pathol 126:277-83. 2006
    ..No deletions of INI1 or amplifications of MYC or MYCN were detected. This report adds 2 cases to our experience of PNTANTR and is the first to demonstrate isochromosome 17q, a molecular alteration typical of medulloblastomas...
  93. ncbi request reprint Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy
    Kristine R Crews
    Departments of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 8:2202-9. 2002
    ..The purpose of this study was to determine the effect of enzyme-inducing anticonvulsants (EIAs) on the disposition of irinotecan and metabolites in pediatric patients with high-grade glioma...
  94. ncbi request reprint Decline in corpus callosum volume among pediatric patients with medulloblastoma: longitudinal MR imaging study
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, TN 38105 2794, USA
    AJNR Am J Neuroradiol 23:1088-94. 2002
    ....
  95. ncbi request reprint Understanding the cognitive impact on children who are treated for medulloblastoma
    Shawna L Palmer
    Division of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Psychol 32:1040-9. 2007
    ..Despite these important steps to reduce radiation dose exposure, an overwhelming majority of medulloblastoma survivors continue to experience academic failure and significant learning delays...
  96. doi request reprint Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial
    Stephen J Laughton
    Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:1112-8. 2008
    ....
  97. pmc Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma
    Maryam Fouladi
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 26:3749-55. 2008
    ....
  98. doi request reprint High-dose chemotherapy for recurrent medulloblastoma: time for a reappraisal
    Amar Gajjar
    Cancer 112:1643-5. 2008
  99. ncbi request reprint Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001)
    Susan M Blaney
    Texas Children s Cancer Center, 6621 Fannin, CC 1410 00, Houston, TX 77030, USA
    J Clin Oncol 23:525-31. 2005
    ....
  100. ncbi request reprint Population pharmacokinetic analysis of topotecan in pediatric cancer patients
    Paula Schaiquevich
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Clin Cancer Res 13:6703-11. 2007
    ..A population approach via nonlinear mixed effects modeling was used to conduct the analysis...
  101. pmc Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma
    Burgess B Freeman
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis TN 38105 2794, USA
    Neuro Oncol 8:89-95. 2006
    ..We demonstrated that a plasma PK model could estimate vCSF TPT concentrations. Further, our results indicate that the TPT vCSF EDT can be achieved in more than 80% of studies targeted to a plasma TPT AUC of 120 ng/ml-h...