Christine Fuller

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Polar spongioblastoma of the spinal cord: a case report
    Christine Fuller
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Dev Pathol 9:75-80. 2006
  2. ncbi Molecular diagnostics in central nervous system tumors
    Christine E Fuller
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, and Division of Neuropathology, Washington University School of Medicine, St Louis, MO, USA
    Adv Anat Pathol 12:180-94. 2005
  3. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features
    Christine E Fuller
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 62:1118-28. 2003
  4. ncbi Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
    Ken Sasai
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4215-22. 2006
  5. ncbi Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes
    Christine Fuller
    Department of Pathology, St Jude Children s, Research Hospital, Memphis, TN, USA
    Am J Clin Pathol 126:277-83. 2006
  6. ncbi Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    Margaret C Thompson
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 24:1924-31. 2006
  7. ncbi Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 98:2232-44. 2003
  8. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
  9. ncbi Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Cancer 101:1445-54. 2004
  10. ncbi The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital Experience
    Lisa M McGregor
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer 104:2837-46. 2005

Detail Information

Publications46

  1. ncbi Polar spongioblastoma of the spinal cord: a case report
    Christine Fuller
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Dev Pathol 9:75-80. 2006
    ..Discrimination of these rare aggressive lesions from other CNS tumors with focal palisaded architecture is crucial as the treatment and prognosis of the latter may differ significantly...
  2. ncbi Molecular diagnostics in central nervous system tumors
    Christine E Fuller
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, and Division of Neuropathology, Washington University School of Medicine, St Louis, MO, USA
    Adv Anat Pathol 12:180-94. 2005
    ....
  3. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features
    Christine E Fuller
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 62:1118-28. 2003
    ..We conclude that 1) distinct genetic subsets are identifiable by FISH in morphologically ambiguous gliomas, and 2) both histological grading and molecular analysis yield prognostically useful information...
  4. ncbi Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
    Ken Sasai
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4215-22. 2006
    ....
  5. ncbi Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes
    Christine Fuller
    Department of Pathology, St Jude Children s, Research Hospital, Memphis, TN, USA
    Am J Clin Pathol 126:277-83. 2006
    ..No deletions of INI1 or amplifications of MYC or MYCN were detected. This report adds 2 cases to our experience of PNTANTR and is the first to demonstrate isochromosome 17q, a molecular alteration typical of medulloblastomas...
  6. ncbi Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    Margaret C Thompson
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 24:1924-31. 2006
    ..We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities...
  7. ncbi Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 98:2232-44. 2003
    ..Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma...
  8. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  9. ncbi Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Cancer 101:1445-54. 2004
    ..Medullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components...
  10. ncbi The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital Experience
    Lisa M McGregor
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer 104:2837-46. 2005
    ..It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients...
  11. ncbi A perivascular niche for brain tumor stem cells
    Christopher Calabrese
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 11:69-82. 2007
    ..We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches...
  12. ncbi Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium study
    Maryam Fouladi
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 107:2291-7. 2006
    ....
  13. ncbi Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma
    Richard J Gilbertson
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Eur J Cancer 42:646-9. 2006
    ....
  14. ncbi Intracranial infantile myofibromatosis with intraparenchymal involvement
    Stuart S Kaplan
    Department of Neurological Surgery, Washington University School of Medicine and St Louis Children s Hospital, One Children s Place, Suite 4S20, St Louis, MO 63110, USA
    Pediatr Neurosurg 36:214-7. 2002
    ..The patient underwent suboccipital craniotomy and resection of the lesion. This is the first report of the surgical removal of an intraparenchymal infantile myofibroma...
  15. ncbi Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
    Amar Gajjar
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 22:984-93. 2004
    ..To assess the feasibility of performing central molecular analyses of fresh medulloblastomas obtained from multiple institutions and using these data to identify prognostic markers for contemporaneously treated patients...
  16. ncbi Radial glia cells are candidate stem cells of ependymoma
    Michael D Taylor
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 8:323-35. 2005
    ....
  17. doi Intraventricular twin fetuses in fetu
    Lauren N Huddle
    Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0662, USA
    J Neurosurg Pediatr 9:17-23. 2012
    ..This is the first report of a rare example of intracranial intraventricular twin fetuses in fetu for which a genome-wide single nucleotide polymorphism assay has confirmed their genetic identity...
  18. ncbi Treatment of metastatic rhabdoid tumor of the kidney
    Lars Wagner
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Pediatr Hematol Oncol 24:385-8. 2002
    ..Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials...
  19. ncbi Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
    Justyna T Romer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 6:229-40. 2004
    ..Long-term treatment with HhAntag prolonged medulloblastoma-free survival. These findings support the development of Shh antagonists for the treatment of medulloblastoma...
  20. ncbi Inactivation of the p53 pathway in retinoblastoma
    Nikia A Laurie
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 444:61-6. 2006
    ..In addition, they support the idea that MDMX is a specific chemotherapeutic target for treating retinoblastoma...
  21. ncbi Gliomatosis cerebri
    Stuart S Kaplan
    Department of Neurological Surgery, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatr Neurosurg 36:111-2. 2002
  22. doi Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization
    Shengle Zhang
    Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Diagn Mol Pathol 19:151-6. 2010
    ..Tissue heterogeneity for TMPRSS2 alterations is common, and it should be considered when sampling and evaluating biopsy specimens...
  23. pmc Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma
    Dong Chen
    Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Clin Cancer Res 17:6693-701. 2011
    ..The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function...
  24. ncbi Aggressive bladder carcinoma in a child
    Pablo Lezama-del Valle
    Department of Surgery, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 43:285-8. 2004
    ..Although rare, most malignant bladder neoplasms in children are low grade and present in early stages. Sarcomatoid differentiation in the setting of high-grade urothelial carcinoma portends a poor prognosis...
  25. ncbi Primary cutaneous ALCL with phosphorylated/activated cytoplasmic ALK and novel phenotype: EMA/MUC1+, cutaneous lymphocyte antigen negative
    Marshall E Kadin
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Am J Surg Pathol 32:1421-6. 2008
    ..Primary cutaneous ALCL of this novel subtype should be distinguished from systemic ALCL to ensure proper clinical management...
  26. ncbi Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer
    Sheri L Spunt
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 107:201-6. 2006
    ..ESFT arising as a second cancer was reviewed and characterized at our childhood cancer center...
  27. ncbi Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  28. ncbi Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Neuropathol Exp Neurol 61:702-9. 2002
    ..001). Thus, FISH analysis identifies relatively specific genetic patterns that may be useful in selected cases, for which the differential diagnosis includes low- or high-grade MPNST...
  29. ncbi Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors
    Matthew J Krasin
    Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 43:229-36. 2004
    ..Local failure rates for patients who received combined surgery and RT were reviewed to determine outcome and prognostic factors...
  30. ncbi Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features
    Sue C Kaste
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 47:152-62. 2006
    ..Osteosarcoma (OS) arising from the surface of bone is far less common than its intramedullary counterpart. Although surface OSs share some radiographic and clinical features, they can be divided into three distinct histologic subtypes...
  31. ncbi Differential involvement of protein 4.1 family members DAL-1 and NF2 in intracranial and intraspinal ependymomas
    Pratima K Singh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 10963, USA
    Mod Pathol 15:526-31. 2002
    ....
  32. ncbi Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Front Biosci 8:a1-9. 2003
    ....
  33. ncbi High-throughput molecular profiling of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH)
    Christine E Fuller
    Division of Neuropathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 61:1078-84. 2002
    ..The overall concordance rate between paired tumor core samples was 93%. We conclude that TMA-FISH is an efficient and reliable method for detecting molecular alterations in high-grade astrocytomas...
  34. ncbi Primary perineal alveolar rhabdomyosarcoma metastatic to an extraocular muscle
    Melanie L McCarty
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Ophthal Plast Reconstr Surg 19:333-5. 2003
    ..Alveolar rhabdomyosarcoma from distant sites rarely metastasizes to the extraocular muscles. However, our case shows that alveolar rhabdomyosarcoma may metastasize to the orbit and involve a single muscle...
  35. ncbi Clinical and pathological features of intracranial chordoma with orbital involvement in a child
    Rebecca A Fleming
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis 38163, USA
    Ophthal Plast Reconstr Surg 19:240-2. 2003
    ..Intracranial chordoma should be considered in the differential diagnosis of children with orbital lesions. Immunohistochemistry is helpful in differentiating chordomas from other primitive round-cell or spindle-cell tumors...
  36. ncbi Primary pelvic telangiectatic osteosarcoma metastatic to both orbits
    Yasaman Mohadjer
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, U S A
    Ophthal Plast Reconstr Surg 20:77-9. 2004
    ..However, patients with this disease have a poor prognosis...
  37. ncbi Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathology
    Christine E Fuller
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Pathol 12:67-86. 2002
    ..In this review, we highlight the advantages and disadvantages of FISH and familiarize the reader with current applications in diagnostic and investigative neuropathology...
  38. ncbi The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma
    Adrian J Frank
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Brain Res Mol Brain Res 121:137-40. 2004
    ..Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma...
  39. ncbi Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 100:2246-52. 2004
    ..Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. The goal of the current study was to investigate and characterize these rare SNs...
  40. ncbi Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH)...
  41. ncbi INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
    Mod Pathol 18:951-8. 2005
    ..Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor...
  42. ncbi Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors
    Matthew J Krasin
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 104:367-73. 2005
    ....
  43. ncbi Percutaneous biopsy of pediatric solid tumors
    Kevin M Garrett
    Department of Radiological Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    Cancer 104:644-52. 2005
    ..The objective of the current study was to determine the diagnostic accuracy of percutaneous biopsy of pediatric solid tumors, a procedure that is less invasive than open biopsy...
  44. ncbi Status of the NF1 tumor suppressor locus in uveal melanoma
    William J Foster
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 121:1311-5. 2003
    ..A clinical association has been observed between uveal melanoma and neurofibromatosis type 1 (NF1). This study aims to determine whether the NF1 tumor suppressor gene is mutated in uveal melanoma...
  45. ncbi Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma
    Ramapriya Ganti
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mod Pathol 19:1213-20. 2006
    ..Notably, expression of EGFR correlates with the embryonal subtype, which is also more likely to coexpress EGFR and ErbB-2...
  46. ncbi Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumors
    Lars M Wagner
    Division of Pediatric Hematology Oncology, University of Utah Primary Children s Medical Center, Salt Lake City, Utah, USA
    Clin Cancer Res 10:840-8. 2004
    ..The purpose is to estimate the maximum-tolerated dose (MTD) of temozolomide and irinotecan given on a protracted schedule in 28-day courses to pediatric patients with refractory solid tumors...