Research Topics
Genomes and Genes | Christine FullerSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
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Publications
Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic featuresChristine E Fuller
Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
J Neuropathol Exp Neurol 62:1118-28. 2003..We conclude that 1) distinct genetic subsets are identifiable by FISH in morphologically ambiguous gliomas, and 2) both histological grading and molecular analysis yield prognostically useful information...- Molecular diagnostics in central nervous system tumorsChristine E Fuller
Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, and Division of Neuropathology, Washington University School of Medicine, St Louis, MO, USA
Adv Anat Pathol 12:180-94. 2005.... - Polar spongioblastoma of the spinal cord: a case reportChristine Fuller
Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
Pediatr Dev Pathol 9:75-80. 2006..Discrimination of these rare aggressive lesions from other CNS tumors with focal palisaded architecture is crucial as the treatment and prognosis of the latter may differ significantly... - Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studiesKen Sasai
Department of Developmental Neurobiology, Saint Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 66:4215-22. 2006.... - Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettesChristine Fuller
Department of Pathology, St Jude Children's, Research Hospital, Memphis, TN, USA
Am J Clin Pathol 126:277-83. 2006..No deletions of INI1 or amplifications of MYC or MYCN were detected. This report adds 2 cases to our experience of PNTANTR and is the first to demonstrate isochromosome 17q, a molecular alteration typical of medulloblastomas... - Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsMargaret C Thompson
St Jude Children's Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 24:1924-31. 2006..This approach may assist ultimately in the selection of patients for future clinical trials of molecular targeted therapies... - Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patientsMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 98:2232-44. 2003..Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma... - Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literatureKathleen J Helton
Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Cancer 101:1445-54. 2004..Medullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components... - The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital ExperienceLisa M McGregor
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cancer 104:2837-46. 2005..It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients... - Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trialAmar Gajjar
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Lancet Oncol 7:813-20. 2006..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma... - A perivascular niche for brain tumor stem cellsChristopher Calabrese
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
Cancer Cell 11:69-82. 2007..We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches... - Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium studyMaryam Fouladi
St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 107:2291-7. 2006.... - Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastomaRichard J Gilbertson
Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Eur J Cancer 42:646-9. 2006.... - Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastomaAmar Gajjar
St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
J Clin Oncol 22:984-93. 2004..ERBB2 expression and clinical risk factors together constitute a highly accurate disease risk stratification tool... - Radial glia cells are candidate stem cells of ependymomaMichael D Taylor
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
Cancer Cell 8:323-35. 2005.... - Inactivation of the p53 pathway in retinoblastomaNikia A Laurie
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nature 444:61-6. 2006..In addition, they support the idea that MDMX is a specific chemotherapeutic target for treating retinoblastoma... - Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) miceJustyna T Romer
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cancer Cell 6:229-40. 2004..Long-term treatment with HhAntag prolonged medulloblastoma-free survival. These findings support the development of Shh antagonists for the treatment of medulloblastoma... 
Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridizationShengle Zhang
Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Diagn Mol Pathol 19:151-6. 2010..Tissue heterogeneity for TMPRSS2 alterations is common, and it should be considered when sampling and evaluating biopsy specimens...- Intraventricular twin fetuses in fetuLauren N Huddle
Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0662, USA
J Neurosurg Pediatr 9:17-23. 2012..This is the first report of a rare example of intracranial intraventricular twin fetuses in fetu for which a genome-wide single nucleotide polymorphism assay has confirmed their genetic identity... 
Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinomaDong Chen
Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
Clin Cancer Res 17:6693-701. 2011..The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function...- Aggressive bladder carcinoma in a childPablo Lezama-del Valle
Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Pediatr Blood Cancer 43:285-8. 2004..Although rare, most malignant bladder neoplasms in children are low grade and present in early stages. Sarcomatoid differentiation in the setting of high-grade urothelial carcinoma portends a poor prognosis... - Treatment of metastatic rhabdoid tumor of the kidneyLars Wagner
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
J Pediatr Hematol Oncol 24:385-8. 2002..Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials... - INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomasArie Perry
Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
Mod Pathol 18:951-8. 2005..Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor... - Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathologyChristine E Fuller
Division of Neuropathology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
Brain Pathol 12:67-86. 2002..In this review, we highlight the advantages and disadvantages of FISH and familiarize the reader with current applications in diagnostic and investigative neuropathology... - Clinical and pathological features of intracranial chordoma with orbital involvement in a childRebecca A Fleming
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis 38163, USA
Ophthal Plast Reconstr Surg 19:240-2. 2003..Intracranial chordoma should be considered in the differential diagnosis of children with orbital lesions. Immunohistochemistry is helpful in differentiating chordomas from other primitive round-cell or spindle-cell tumors... - Primary perineal alveolar rhabdomyosarcoma metastatic to an extraocular muscleMelanie L McCarty
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Ophthal Plast Reconstr Surg 19:333-5. 2003..Alveolar rhabdomyosarcoma from distant sites rarely metastasizes to the extraocular muscles. However, our case shows that alveolar rhabdomyosarcoma may metastasize to the orbit and involve a single muscle... - Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimicsArie Perry
Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Front Biosci 8:a1-9. 2003.... - High-throughput molecular profiling of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH)Christine E Fuller
Division of Neuropathology, Barnes-Jewish Hospital, Washington University Medical Center, St. Louis, Missouri 63110, USA
J Neuropathol Exp Neurol 61:1078-84. 2002..The overall concordance rate between paired tumor core samples was 93%. We conclude that TMA-FISH is an efficient and reliable method for detecting molecular alterations in high-grade astrocytomas... - Clinical and molecular characteristics of malignant transformation of low-grade glioma in childrenAlberto Broniscer
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 25:682-9. 2007..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children... - Primary cutaneous ALCL with phosphorylated/activated cytoplasmic ALK and novel phenotype: EMA/MUC1+, cutaneous lymphocyte antigen negativeMarshall E Kadin
Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
Am J Surg Pathol 32:1421-6. 2008..Primary cutaneous ALCL of this novel subtype should be distinguished from systemic ALCL to ensure proper clinical management... - Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasmsArie Perry
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
J Neuropathol Exp Neurol 61:702-9. 2002..001). Thus, FISH analysis identifies relatively specific genetic patterns that may be useful in selected cases, for which the differential diagnosis includes low- or high-grade MPNST... - Differential involvement of protein 4.1 family members DAL-1 and NF2 in intracranial and intraspinal ependymomasPratima K Singh
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110-10963, USA
Mod Pathol 15:526-31. 2002.... - Ewing sarcoma-family tumors that arise after treatment of primary childhood cancerSheri L Spunt
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 107:201-6. 2006..ESFT arising as a second cancer was reviewed and characterized at our childhood cancer center... - Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapyTanya M Tekautz
Department of Hematology-Oncology, Mail Stop 260, St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
J Clin Oncol 23:1491-9. 2005..ATRT presenting in older patients can be cured using a combination of radiation and high-dose alkylating therapy. Older patients with relapsed ATRT can have salvage treatment using ICE chemotherapy... - Percutaneous biopsy of pediatric solid tumorsKevin M Garrett
Department of Radiological Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA
Cancer 104:644-52. 2005..CONCLUSIONS: Image-guided percutaneous biopsy was highly accurate and safe in the diagnosis of pediatric malignant solid tumors. This technique may be able to supplant diagnostic open biopsy... - Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumorsMatthew J Krasin
Division of Radiation Oncology, Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Pediatr Blood Cancer 43:229-36. 2004..Local failure rates for patients who received combined surgery and RT were reviewed to determine outcome and prognostic factors... - Pediatric surface osteosarcoma: clinical, pathologic, and radiologic featuresSue C Kaste
Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Pediatr Blood Cancer 47:152-62. 2006..Osteosarcoma (OS) arising from the surface of bone is far less common than its intramedullary counterpart. Although surface OSs share some radiographic and clinical features, they can be divided into three distinct histologic subtypes... - Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experienceAlberto Broniscer
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 100:2246-52. 2004..Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. The goal of the current study was to investigate and characterize these rare SNs... - Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factorsMatthew J Krasin
Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 104:367-73. 2005.... - The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastomaAdrian J Frank
Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Brain Res Mol Brain Res 121:137-40. 2004..Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma... - Primary pelvic telangiectatic osteosarcoma metastatic to both orbitsYasaman Mohadjer
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A
Ophthal Plast Reconstr Surg 20:77-9. 2004..However, patients with this disease have a poor prognosis... - Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumorsLars M Wagner
Division of Pediatric Hematology Oncology, University of Utah Primary Children s Medical Center, Salt Lake City, Utah, USA
Clin Cancer Res 10:840-8. 2004..The purpose is to estimate the maximum-tolerated dose (MTD) of temozolomide and irinotecan given on a protracted schedule in 28-day courses to pediatric patients with refractory solid tumors... - Status of the NF1 tumor suppressor locus in uveal melanomaWilliam J Foster
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Arch Ophthalmol 121:1311-5. 2003..A clinical association has been observed between uveal melanoma and neurofibromatosis type 1 (NF1). This study aims to determine whether the NF1 tumor suppressor gene is mutated in uveal melanoma... - Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcomaRamapriya Ganti
Department of Pathology and Laboratory Medicine, St Jude Children's Research Hospital, Memphis, TN 38105, USA
Mod Pathol 19:1213-20. 2006..Notably, expression of EGFR correlates with the embryonal subtype, which is also more likely to coexpress EGFR and ErbB-2...