Research Topics

Naoaki Fujii


Affiliation: St. Jude Children's Research Hospital
Country: USA


  1. Evison B, Actis M, Wu S, Shao Y, Heath R, Yang L, et al. A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA). Bioorg Med Chem. 2014;22:6333-43 pubmed publisher
    ..The discovery of T2Pt represents an original effort directed at the development of irreversible PCNA inhibitors and sets the stage for the discovery of analogues more selective for PCNA over other cellular nucleophiles. ..
  2. Fujii N, Evison B, Actis M, Inoue A. A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair. Bioorg Med Chem. 2015;23:6912-21 pubmed publisher
    ..The assay approach could identify other molecules essential for ICLR in quantitative and flexible manner. ..
  3. Evison B, Actis M, Fujii N. A clickable psoralen to directly quantify DNA interstrand crosslinking and repair. Bioorg Med Chem. 2016;24:1071-8 pubmed publisher
    ..The post-labeling strategy applied in this study is inexpensive, rapid and highly modular in nature with the potential for multiple applications in DNA repair studies. ..
  4. Vanarotti M, Evison B, Actis M, Inoue A, McDonald E, Shao Y, et al. Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance. Bioorg Med Chem. 2018;26:2345-2353 pubmed publisher
    ..This study demonstrates the potential utility of a small-molecule REV1 UBM2 inhibitor for preventing DDT. ..