W E Evans

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Pharmacogenomics: translating functional genomics into rational therapeutics
    W E Evans
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 286:487-91. 1999
  2. pmc Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
    C H Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 24:371-82. 2010
  3. ncbi request reprint Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    M V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Natl Cancer Inst 91:2001-8. 1999
  4. pmc Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity
    S H Chen
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 88:191-6. 2010
  5. pmc Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1
    S Jeha
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1406-9. 2009
  6. ncbi request reprint Polymorphism of the thiopurine S-methyltransferase gene in African-Americans
    Y Y Hon
    Pharmaceutical and Hematology Oncology Departments, St Jude Children s Research Hospital, 332 North Lauderdale, PO Box 318, Memphis, TN 38101 0318, USA
    Hum Mol Genet 8:371-6. 1999
  7. ncbi request reprint Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance
    C R Yates
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Ann Intern Med 126:608-14. 1997
  8. ncbi request reprint Late effects of treatment in survivors of childhood acute myeloid leukemia
    W Leung
    After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 18:3273-9. 2000
  9. ncbi request reprint Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia
    M V Relling
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 356:285-90. 2000
  10. ncbi request reprint Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia
    C H Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 16:3768-73. 1998

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Pharmacogenomics: translating functional genomics into rational therapeutics
    W E Evans
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 286:487-91. 1999
    ....
  2. pmc Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
    C H Pui
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 24:371-82. 2010
    ..The next main challenge is to further increase cure rates while improving quality of life for all patients...
  3. ncbi request reprint Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    M V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Natl Cancer Inst 91:2001-8. 1999
    ..We studied the metabolism, dose requirements, and tolerance of 6-mercaptopurine among patients with different TPMT phenotypes...
  4. pmc Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity
    S H Chen
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 88:191-6. 2010
    ..05) in both cohorts. Chromosome 5q33 has previously been associated with asthma and atopy. These data contribute to the growing body of evidence that there is an inherited component to predisposition to drug allergy...
  5. pmc Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1
    S Jeha
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 23:1406-9. 2009
    ..These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse...
  6. ncbi request reprint Polymorphism of the thiopurine S-methyltransferase gene in African-Americans
    Y Y Hon
    Pharmaceutical and Hematology Oncology Departments, St Jude Children s Research Hospital, 332 North Lauderdale, PO Box 318, Memphis, TN 38101 0318, USA
    Hum Mol Genet 8:371-6. 1999
    ..These data indicate that the same TPMT mutant alleles are found in American black and white populations, but that the predominant mutant alleles differ in these two ethnic groups...
  7. ncbi request reprint Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance
    C R Yates
    St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Ann Intern Med 126:608-14. 1997
    ....
  8. ncbi request reprint Late effects of treatment in survivors of childhood acute myeloid leukemia
    W Leung
    After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 18:3273-9. 2000
    ..To investigate the incidence of and risk factors for late sequelae of treatment in patients who survived for more than 10 years after the diagnosis of childhood acute myeloid leukemia (AML)...
  9. ncbi request reprint Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia
    M V Relling
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet 356:285-90. 2000
    ..Most anticonvulsant drugs induce drug-metabolising enzymes and thereby increase the clearance of anticancer agents. We investigated whether anticonvulsants compromise the efficacy of cancer chemotherapy...
  10. ncbi request reprint Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia
    C H Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 16:3768-73. 1998
    ..To reassess the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia (ALL)...
  11. ncbi request reprint Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia
    A Gajjar
    Departments of Hematology Oncology, Biostatistics and Epidemiology, Pharmaceutical Sciences, and Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 96:3381-4. 2000
    ..These data indicate that contamination of CSF with circulating leukemic blast cells during diagnostic lumbar puncture can adversely affect the treatment outcome of children with ALL and is an indication to intensify intrathecal therapy...
  12. ncbi request reprint A novel protein complex distinct from mismatch repair binds thioguanylated DNA
    E Y Krynetski
    Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38163, USA
    Mol Pharmacol 59:367-74. 2001
    ....
  13. ncbi request reprint Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library
    E Y Krynetski
    Dept of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38101, USA
    Pharm Res 14:1672-8. 1997
    ..To isolate and characterize the polymorphic human thiopurine S-methyltransferase (TPMT) gene...
  14. pmc A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity
    S H Chen
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 25:66-74. 2011
    ..5 × 10(-5)). Our genome-wide interrogation of CEU cell lines and primary ALL blasts revealed that inherited genomic interindividual variation in a plausible candidate pathway can contribute to asparaginase sensitivity...
  15. pmc Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia
    C Liu
    Department of Pharmaceutical Sciences, Memphis, TN, USA
    Leukemia 26:2303-9. 2012
    ..83; 95% confidence interval, 0.78-0.89; P=0.007). Antibodies were related to clinical allergy and to low systemic exposure to asparaginase, leading to lower risk of some adverse effects of therapy...
  16. pmc ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy
    D Bhojwani
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Leukemia 26:265-70. 2012
    ....
  17. ncbi request reprint Second malignancy after treatment of childhood non-Hodgkin lymphoma
    W Leung
    St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Cancer 92:1959-66. 2001
    ....
  18. pmc Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
    G Stocco
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 85:164-72. 2009
    ....
  19. pmc Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity
    H L Tai
    St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38101, USA
    Proc Natl Acad Sci U S A 94:6444-9. 1997
    ..These studies establish enhanced degradation of TPMT proteins encoded by TPMT*2 and TPMT*3A as mechanisms for lower TPMT protein and catalytic activity inherited by the predominant mutant alleles at the human TPMT locus...
  20. pmc A health-care system perspective on implementing genomic medicine: pediatric acute lymphoblastic leukemia as a paradigm
    W E Evans
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 94:224-9. 2013
    ..Here, we illustrate how genomics has been deployed to advance the treatment of childhood leukemia. ..
  21. pmc Pharmacogenomics and individualized medicine: translating science into practice
    K R Crews
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 92:467-75. 2012
    ....
  22. ncbi request reprint Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)
    M Y Fessing
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    FEBS Lett 424:143-5. 1998
    ..The expression product of the murine cDNA in rabbit reticulocyte and wheat germ lysate coupled transcription-translation systems showed TPMT enzymatic activity. We conclude that the isolated cDNA clone represents the murine TPMT cDNA...
  23. pmc Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing
    M V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 89:387-91. 2011
    ..We provide dosing recommendations (updates at http://www.pharmgkb.org) for azathioprine, mercaptopurine (MP), and thioguanine based on TPMT genotype...
  24. ncbi request reprint Pharmacogenomics: the inherited basis for interindividual differences in drug response
    W E Evans
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Genomics Hum Genet 2:9-39. 2001
    ..This chapter provides an overview of the current pharmacogenomics literature and offers insights for the potential impact of this field on the safe and effective use of medications...
  25. pmc Pharmacogenomics: marshalling the human genome to individualise drug therapy
    W E Evans
    St Jude Children s Research Hospital, Memphis, TN 38101 0318, USA
    Gut 52:ii10-8. 2003
    ..It seems that this field is at the early stages of developing a powerful set of molecular diagnostics that will have profound utility in optimising drug therapy for individual patients...
  26. ncbi request reprint Second malignancy after treatment of childhood acute myeloid leukemia
    W Leung
    Department of Hematology-Oncology, St Jude Children's Research Hospital, and University of Tennessee, College of Medicine, Memphis, USA
    Leukemia 15:41-5. 2001
    ..Future studies should focus on improving treatments for primary AML while preventing second malignancies...
  27. pmc The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer
    J J Yang
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 94:252-9. 2013
    ..In conclusion, our results indicated that TPMT or COMT genetic variation was not related to cisplatin ototoxicity in children with cancer and did not influence cisplatin-induced hearing damage in laboratory models. ..
  28. pmc Concordance of DMET plus genotyping results with those of orthogonal genotyping methods
    C A Fernandez
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 92:360-5. 2012
    ..96%. We conclude that the DMET Plus array performs well with primary patient samples, with the results in good concordance with those of several lower-throughput genotyping methods...
  29. ncbi request reprint Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism
    T S Jones
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, and College of Pharmacy, University of Tennessee, Memphis, TN, USA
    Clin Pharmacol Ther 81:729-34. 2007
    ..Our findings show that HapMap resources are useful for pharmacogenetic discovery when the candidate gene is known, but challenges remain for definitive gene identification when a genome-wide agnostic approach is employed...
  30. ncbi request reprint Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug
    N F Krynetskaia
    St. Jude Children's Research Hospital, 332 N. Lauderdale St, Memphis, TN 38105, USA
    FASEB J 15:1902-8. 2001
    ..Thus, thiopurines are novel anti-retroviral agents that alter the DNA-RNA substrates for HIV RNaseH, thereby abrogating early stages of HIV replication...
  31. ncbi request reprint Childhood acute lymphoblastic leukaemia--current status and future perspectives
    C H Pui
    Leukaemia Lymphoma Division, Fahad Nassar Al Rashid Chair of Leukaemia Research at St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 2:597-607. 2001
    ..Ultimately, treatment based on biological features of leukaemic cells, host genetics, and the amount of residual disease should improve cure rates further...
  32. ncbi request reprint Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia
    C H Pui
    Dept of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Ann Hematol 83:S124-6. 2004
    ....
  33. ncbi request reprint Ponte di Legno Working Group: statement on the right of children with leukemia to have full access to essential treatment and report on the Sixth International Childhood Acute Lymphoblastic Leukemia Workshop
    C H Pui
    St Jude Children s Research Hospital, Memphis, TN, USA
    Leukemia 18:1043-53. 2004
  34. pmc Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells
    J C Panetta
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
    Br J Cancer 94:93-100. 2006
    ..In summary, the mathematical model provides a quantitative assessment to compare the cell cycle effects of MP in cells with varying degrees of MP resistance...
  35. ncbi request reprint Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
    C H Pui
    St Jude Chidren s Research Hospital and University of Tennessee, Memphis, 38105, USA
    Leukemia 17:700-6. 2003
    ....
  36. pmc Ligation of CD38 suppresses human B lymphopoiesis
    M Kumagai
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    J Exp Med 181:1101-10. 1995
    ....
  37. ncbi request reprint Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children
    W E Evans
    Pharmacokinetics and Pharmacodynamics Section, St Jude Children s Research Hospital, Memphis, TN 38101 0318
    Clin Pharmacol Ther 45:568-73. 1989
    ....
  38. ncbi request reprint Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms
    E Y Krynetski
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pharmacogenetics 6:279-90. 1996
    ..Together, these advances bold the promise of improving the safety and efficacy of thiopurine therapy...
  39. pmc A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
    P Fernandez-Salguero
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 57:651-60. 1995
    ..The allelic frequencies of CYP2A6v1 and CYP2A6v2 differed significantly between Caucasian, Asian, and African-American populations. These studies establish the existence of a new cytochrome P450 genetic polymorphism...
  40. ncbi request reprint Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance
    N L Ramakers-van Woerden
    Leukemia 16:949-51. 2002
  41. ncbi request reprint Statement by members of the Ponte di Legno group on the right of children with leukemia to have full access to essential treatment for acute lymphoblastic leukemia
    G Tognoni
    Ann Oncol 16:169-70. 2005
  42. ncbi request reprint Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype
    R Saxena
    Department of Human Genetics and Molecular Biology, Collaborative Research, Inc, Waltham, MA 02154
    Hum Mol Genet 3:923-6. 1994
    ..The frequency of the D6(T) allele among Caucasian controls of the case-control study was 1.8% (4/220 chromosomes)...
  43. pmc Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    H L Tai
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Am J Hum Genet 58:694-702. 1996
    ....
  44. ncbi request reprint Molecular cloning of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) gene
    K E White
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Gene 246:347-56. 2000
    ..In summary, these studies identified the human GalNAc-T8 gene, as well as multiple genomic polymorphisms that will be useful for further understanding the structure-function relations of the ppGaNTases...