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Genomes and Genes | W E EvansSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
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Publications
Pharmacogenomics: translating functional genomics into rational therapeuticsW E Evans
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Science 286:487-91. 1999....
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemiaC H Pui
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Leukemia 24:371-82. 2010..The next main challenge is to further increase cure rates while improving quality of life for all patients...- Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locusM V Relling
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Natl Cancer Inst 91:2001-8. 1999..We studied the metabolism, dose requirements, and tolerance of 6-mercaptopurine among patients with different TPMT phenotypes... - Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivityS H Chen
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Clin Pharmacol Ther 88:191-6. 2010..05) in both cohorts. Chromosome 5q33 has previously been associated with asthma and atopy. These data contribute to the growing body of evidence that there is an inherited component to predisposition to drug allergy... - Polymorphism of the thiopurine S-methyltransferase gene in African-AmericansY Y Hon
Pharmaceutical and Hematology Oncology Departments, St Jude Children s Research Hospital, 332 North Lauderdale, PO Box 318, Memphis, TN 38101 0318, USA
Hum Mol Genet 8:371-6. 1999..These data indicate that the same TPMT mutant alleles are found in American black and white populations, but that the predominant mutant alleles differ in these two ethnic groups... - Late effects of treatment in survivors of childhood acute myeloid leukemiaW Leung
After Completion of Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 18:3273-9. 2000..To investigate the incidence of and risk factors for late sequelae of treatment in patients who survived for more than 10 years after the diagnosis of childhood acute myeloid leukemia (AML)... - Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intoleranceC R Yates
St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Ann Intern Med 126:608-14. 1997.... - Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemiaA Gajjar
Departments of Hematology Oncology, Biostatistics and Epidemiology, Pharmaceutical Sciences, and Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
Blood 96:3381-4. 2000..These data indicate that contamination of CSF with circulating leukemic blast cells during diagnostic lumbar puncture can adversely affect the treatment outcome of children with ALL and is an indication to intensify intrathecal therapy... - Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemiaC H Pui
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 16:3768-73. 1998..To reassess the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia (ALL)... - Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemiaM V Relling
St Jude Children s Research Hospital, Memphis, TN 38105, USA
Lancet 356:285-90. 2000..Most anticonvulsant drugs induce drug-metabolising enzymes and thereby increase the clearance of anticancer agents. We investigated whether anticonvulsants compromise the efficacy of cancer chemotherapy... - Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic libraryE Y Krynetski
Dept of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38101, USA
Pharm Res 14:1672-8. 1997..To isolate and characterize the polymorphic human thiopurine S-methyltransferase (TPMT) gene... - A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivityS H Chen
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Leukemia 25:66-74. 2011..5 × 10(-5)). Our genome-wide interrogation of CEU cell lines and primary ALL blasts revealed that inherited genomic interindividual variation in a plausible candidate pathway can contribute to asparaginase sensitivity... - ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapyD Bhojwani
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Leukemia 26:265-70. 2012.... - Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemiaG Stocco
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Clin Pharmacol Ther 85:164-72. 2009.... - A novel protein complex distinct from mismatch repair binds thioguanylated DNAE Y Krynetski
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38163, USA
Mol Pharmacol 59:367-74. 2001.... - Second malignancy after treatment of childhood non-Hodgkin lymphomaW Leung
St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
Cancer 92:1959-66. 2001.... - Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activityH L Tai
St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38101, USA
Proc Natl Acad Sci U S A 94:6444-9. 1997..These studies establish enhanced degradation of TPMT proteins encoded by TPMT*2 and TPMT*3A as mechanisms for lower TPMT protein and catalytic activity inherited by the predominant mutant alleles at the human TPMT locus... - Pharmacogenomics and individualized medicine: translating science into practiceK R Crews
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Clin Pharmacol Ther 92:467-75. 2012.... - Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1S Jeha
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Leukemia 23:1406-9. 2009..These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse... - Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosingM V Relling
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Clin Pharmacol Ther 89:387-91. 2011..We provide dosing recommendations (updates at http://www.pharmgkb.org) for azathioprine, mercaptopurine (MP), and thioguanine based on TPMT genotype... - Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)M Y Fessing
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
FEBS Lett 424:143-5. 1998..The expression product of the murine cDNA in rabbit reticulocyte and wheat germ lysate coupled transcription-translation systems showed TPMT enzymatic activity. We conclude that the isolated cDNA clone represents the murine TPMT cDNA... - Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemiaC Liu
Department of Pharmaceutical Sciences, Memphis, TN, USA
Leukemia 26:2303-9. 2012..83; 95% confidence interval, 0.78-0.89; P=0.007). Antibodies were related to clinical allergy and to low systemic exposure to asparaginase, leading to lower risk of some adverse effects of therapy... - Pharmacogenomics: marshalling the human genome to individualise drug therapyW E Evans
St Jude Children s Research Hospital, Memphis, TN 38101 0318, USA
Gut 52:ii10-8. 2003..It seems that this field is at the early stages of developing a powerful set of molecular diagnostics that will have profound utility in optimising drug therapy for individual patients... - Pharmacogenomics: the inherited basis for interindividual differences in drug responseW E Evans
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Annu Rev Genomics Hum Genet 2:9-39. 2001..This chapter provides an overview of the current pharmacogenomics literature and offers insights for the potential impact of this field on the safe and effective use of medications... - Concordance of DMET plus genotyping results with those of orthogonal genotyping methodsC A Fernandez
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Clin Pharmacol Ther 92:360-5. 2012..96%. We conclude that the DMET Plus array performs well with primary patient samples, with the results in good concordance with those of several lower-throughput genotyping methods... - Childhood acute lymphoblastic leukaemia--current status and future perspectivesC H Pui
Leukaemia Lymphoma Division, Fahad Nassar Al Rashid Chair of Leukaemia Research at St Jude Children s Research Hospital, Memphis, TN 38105, USA
Lancet Oncol 2:597-607. 2001..Ultimately, treatment based on biological features of leukaemic cells, host genetics, and the amount of residual disease should improve cure rates further... - Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphismT S Jones
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, and College of Pharmacy, University of Tennessee, Memphis, TN, USA
Clin Pharmacol Ther 81:729-34. 2007..Our findings show that HapMap resources are useful for pharmacogenetic discovery when the candidate gene is known, but challenges remain for definitive gene identification when a genome-wide agnostic approach is employed... - Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drugN F Krynetskaia
St. Jude Children's Research Hospital, 332 N. Lauderdale St, Memphis, TN 38105, USA
FASEB J 15:1902-8. 2001..Thus, thiopurines are novel anti-retroviral agents that alter the DNA-RNA substrates for HIV RNaseH, thereby abrogating early stages of HIV replication... - Second malignancy after treatment of childhood acute myeloid leukemiaW Leung
Department of Hematology-Oncology, St Jude Children's Research Hospital, and University of Tennessee, College of Medicine, Memphis, USA
Leukemia 15:41-5. 2001..Future studies should focus on improving treatments for primary AML while preventing second malignancies... - Ligation of CD38 suppresses human B lymphopoiesisM Kumagai
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38101
J Exp Med 181:1101-10. 1995.... - Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in childrenW E Evans
Pharmacokinetics and Pharmacodynamics Section, St Jude Children s Research Hospital, Memphis, TN 38101 0318
Clin Pharmacol Ther 45:568-73. 1989.... - Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemiaC H Pui
Dept. of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Ann Hematol 83:S124-6. 2004.... - Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanismsE Y Krynetski
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Pharmacogenetics 6:279-90. 1996..Together, these advances bold the promise of improving the safety and efficacy of thiopurine therapy... - Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cellsJ C Panetta
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105, USA
Br J Cancer 94:93-100. 2006..In summary, the mathematical model provides a quantitative assessment to compare the cell cycle effects of MP in cells with varying degrees of MP resistance... - Ponte di Legno Working Group: statement on the right of children with leukemia to have full access to essential treatment and report on the Sixth International Childhood Acute Lymphoblastic Leukemia WorkshopC-H Pui
St Jude Children's Research Hospital, Memphis, TN, USA
Leukemia 18:1043-53. 2004 - Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangementsC-H Pui
St. Jude Chidren's Research Hospital and University of Tennessee, Memphis, 38105, USA
Leukemia 17:700-6. 2003.... - Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistanceN L Ramakers-van Woerden
Leukemia 16:949-51. 2002 - A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 allelesP Fernandez-Salguero
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 57:651-60. 1995..The allelic frequencies of CYP2A6v1 and CYP2A6v2 differed significantly between Caucasian, Asian, and African-American populations. These studies establish the existence of a new cytochrome P450 genetic polymorphism... - Statement by members of the Ponte di Legno group on the right of children with leukemia to have full access to essential treatment for acute lymphoblastic leukemiaG Tognoni
Ann Oncol 16:169-70. 2005 - Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotypeR Saxena
Department of Human Genetics and Molecular Biology, Collaborative Research, Inc, Waltham, MA 02154
Hum Mol Genet 3:923-6. 1994..The frequency of the D6(T) allele among Caucasian controls of the case-control study was 1.8% (4/220 chromosomes)... - Molecular cloning of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) geneK E White
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Gene 246:347-56. 2000..In summary, these studies identified the human GalNAc-T8 gene, as well as multiple genomic polymorphisms that will be useful for further understanding the structure-function relations of the ppGaNTases... - Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in CaucasiansH L Tai
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Am J Hum Genet 58:694-702. 1996....