David W Ellison

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Maximum likelihood estimation of reviewers' acumen in central review setting: categorical data
    Wei Zhao
    MedImmune LLC, Gaithersburg, MD 20878, USA
    Theor Biol Med Model 8:3. 2011
  2. pmc Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma
    Emmanuel Rousseau
    Laboratory of Pathology, Universite Catholique de Louvain, Bruxelles, Belgium
    Mol Cancer 6:47. 2007
  3. pmc Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Acta Neuropathol 121:381-96. 2011
  4. pmc Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Clin Oncol 29:1400-7. 2011
  5. doi request reprint Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease
    David W Ellison
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38103, USA
    Acta Neuropathol 120:305-16. 2010
  6. pmc Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts
    David W Ellison
    Dept, of Pathology, St, Jude Children s Research Hospital, Memphis, USA
    J Negat Results Biomed 10:7. 2011
  7. pmc Novel mutations target distinct subgroups of medulloblastoma
    Giles Robinson
    St Jude Children s Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA
    Nature 488:43-8. 2012
  8. pmc Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    Jinghui Zhang
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:602-12. 2013
  9. pmc A mouse model of the most aggressive subgroup of human medulloblastoma
    Daisuke Kawauchi
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 21:168-80. 2012
  10. pmc Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 19:305-16. 2011

Detail Information

Publications34

  1. pmc Maximum likelihood estimation of reviewers' acumen in central review setting: categorical data
    Wei Zhao
    MedImmune LLC, Gaithersburg, MD 20878, USA
    Theor Biol Med Model 8:3. 2011
    ..The result of the anesthetist data set by the new method is more convincing...
  2. pmc Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma
    Emmanuel Rousseau
    Laboratory of Pathology, Universite Catholique de Louvain, Bruxelles, Belgium
    Mol Cancer 6:47. 2007
    ..These altered chromosomal regions are indicative of genes and pathways involved in trisomy 19 ependymoma tumorigenesis. Recognition of this genetico-histological entity allows better understanding and dissection of ependymal tumors...
  3. pmc Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Acta Neuropathol 121:381-96. 2011
    ....
  4. pmc Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Clin Oncol 29:1400-7. 2011
    ..Developing a practical therapeutic stratification that allows accurate identification of disease risk offers the potential to individualize adjuvant therapy and to minimize long-term adverse effects in a subgroup of survivors...
  5. doi request reprint Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease
    David W Ellison
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38103, USA
    Acta Neuropathol 120:305-16. 2010
    ....
  6. pmc Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts
    David W Ellison
    Dept, of Pathology, St, Jude Children s Research Hospital, Memphis, USA
    J Negat Results Biomed 10:7. 2011
    ....
  7. pmc Novel mutations target distinct subgroups of medulloblastoma
    Giles Robinson
    St Jude Children s Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA
    Nature 488:43-8. 2012
    ..These data provide important new insights into the pathogenesis of medulloblastoma subgroups and highlight targets for therapeutic development...
  8. pmc Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    Jinghui Zhang
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:602-12. 2013
    ..Focusing on the therapeutically challenging diffuse LGGs, our study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric LGGs and LGGNTs...
  9. pmc A mouse model of the most aggressive subgroup of human medulloblastoma
    Daisuke Kawauchi
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 21:168-80. 2012
    ..This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis...
  10. pmc Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 19:305-16. 2011
    ..Gene expression profiling revealed striking similarities to subclasses of human diffuse astrocytoma. Astrocytomas were found within and outside of proliferative niches in the adult brain...
  11. pmc Cross-species genomics matches driver mutations and cell compartments to model ependymoma
    Robert A Johnson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 466:632-6. 2010
    ..Our data demonstrate the power of cross-species genomics to meticulously match subgroup-specific driver mutations with cellular compartments to model and interrogate cancer subgroups...
  12. pmc Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 29:3999-4006. 2011
    ..We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG...
  13. pmc MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas
    Ruth G Tatevossian
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Acta Neuropathol 120:731-43. 2010
    ..Our data suggest that MYB may have a role in a subset of pediatric gliomas, through a variety of mechanisms in addition to MYB amplification and deletion...
  14. pmc Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model
    Raelene Endersby
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 71:4106-16. 2011
    ..Taken together, these results indicate context-dependent roles for individual Akt isoforms and suggest that there may be heterogeneous tumor response to isoform-specific inhibitors...
  15. pmc Isochromosome 17q, MYC amplification and large cell/anaplastic phenotype in a case of medullomyoblastoma with extracranial metastases
    Karen D Wright
    Department of Oncology, Division of Neuro Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Pediatr Blood Cancer 59:561-4. 2012
    ..Here, we present the clinical course and treatment of an almost 4-year-old girl with MMB that was characterized by MYC amplification, isochromosome 17q and large cell/anaplastic histopathology...
  16. pmc Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
    ....
  17. pmc An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma
    Jennifer M Atkinson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 20:384-99. 2011
    ..g., 5-fluorouracil. Our comprehensive approach advances understanding of the biology and treatment of ependymoma including the discovery of several treatment leads for immediate clinical translation...
  18. doi request reprint C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma
    Matthew Parker
    1 St Jude Children s Research Hospital Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA 2 Department of Computational Biology and Bioinformatics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA 3
    Nature 506:451-5. 2014
    ..Our data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95-RELA fusion protein as a potential therapeutic target in supratentorial ependymoma...
  19. pmc Subtypes of medulloblastoma have distinct developmental origins
    Paul Gibson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 468:1095-9. 2010
    ..Our data provide an explanation for the marked molecular and clinical differences between SHH- and WNT-subtype medulloblastomas and have profound implications for future research and treatment of this important childhood cancer...
  20. pmc Dysembryoplastic neuroepithelial tumors and cognitive outcome: cure at a price?
    Ibrahim Qaddoumi
    Division of Neuro Oncology, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 116:5461-9. 2010
    ..Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection...
  21. doi request reprint The genomic landscape of hypodiploid acute lymphoblastic leukemia
    Linda Holmfeldt
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:242-52. 2013
    ....
  22. pmc Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    Gang Wu
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 44:251-3. 2012
    ..3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration...
  23. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  24. pmc Survival and long-term health and cognitive outcomes after low-grade glioma
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN 38105, USA
    Neuro Oncol 13:223-34. 2011
    ..Survivors of childhood LGG experience substantial long-term adverse effects that continue to increase well beyond the 5-year survival time point...
  25. pmc Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study
    Amar Gajjar
    Authors Affiliations Departments of Oncology, Pharmaceutical Sciences, Pathology, Radiological Sciences, Biostatistics, and Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee Center for Neuroscience Research, Children s National Medical Center, Washington, DC Division of Hematology Oncology, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, Illinois Department of Pediatrics, Texas Children s Hospital, Houston, Texas Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland and Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Clin Cancer Res 19:6305-12. 2013
    ..Immunohistochemical analysis was done to identify patients with Sonic Hedgehog (SHH)-subtype medulloblastoma...
  26. ncbi request reprint The origins of medulloblastoma subtypes
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pathol 3:341-65. 2008
    ..Definitive characterization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provide important insights to the origins of cancer...
  27. pmc Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 28:3061-8. 2010
    ..To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG)...
  28. pmc Fanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor
    Mariko D Dewire
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Pediatr Blood Cancer 53:1140-2. 2009
    ....
  29. doi request reprint Young age may predict a better outcome for children with diffuse pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 113:566-72. 2008
    ..Because diffuse pontine glioma (DPG) is rare among young children, the outcome of affected patients is unknown...
  30. doi request reprint Pituitary adenoma causing visual disturbances in a 6-year-old girl
    Thomas Adam Oliver
    Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA
    J AAPOS 15:495-8. 2011
    ..The tumor was resected, but 22 months later she developed recurrence with malignant transformation...
  31. doi request reprint Angiocentric glioma-induced seizures in a 2-year-old child
    Stephen P Fulton
    Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, TN 38105, USA
    J Child Neurol 24:852-6. 2009
    ..Lesionectomy permitted sparing of adjacent areas of eloquent cortex, and the child is now seizure-free on monotherapy...
  32. pmc Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009
    ..Our data indicate that Prom1 marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1(+) tumour cells...
  33. pmc Disseminated carcinoma ex pleomorphic adenoma in an adolescent confirmed by application of PLAG1 immunohistochemistry and FISH for PLAG1 rearrangement
    Armita Bahrami
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Head Neck Pathol 6:377-83. 2012
    ....
  34. ncbi request reprint ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA Richard
    Clin Cancer Res 8:3054-64. 2002
    ..Functional assessment of ERBB-dependent cell signaling and proliferation, in addition to novel therapeutic inhibition of these processes, was conducted using short-term cultures of human ependymoma cells...