Peter Doherty

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint Tuning into immunological dissonance: an experimental model for infectious mononucleosis
    P C Doherty
    Department of lmmunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Curr Opin Immunol 9:477-83. 1997
  2. pmc Toward a broadly protective influenza vaccine
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Clin Invest 118:3273-5. 2008
  3. ncbi request reprint The challenge of viral immunity
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, VIC 3010, Australia
    Immunity 27:363-5. 2007
  4. ncbi request reprint The pas de deux of viruses and CD8 T cells
    Peter C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunol Rev 185:39-49. 2002
  5. ncbi request reprint Challenged by complexity: my twentieth century in immunology
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    Annu Rev Immunol 25:1-19. 2007
  6. pmc Dissecting the host response to a gamma-herpesvirus
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Philos Trans R Soc Lond B Biol Sci 356:581-93. 2001
  7. pmc Quantitative analysis of the CD8+ T-cell response to readily eliminated and persistent viruses
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    Philos Trans R Soc Lond B Biol Sci 355:1093-101. 2000
  8. ncbi request reprint Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections
    P C Doherty
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunol Rev 159:105-17. 1997
  9. ncbi request reprint The new numerology of immunity mediated by virus-specific CD8(+) T cells
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Curr Opin Microbiol 1:419-22. 1998
  10. doi request reprint Burnet, chick embryos, viruses, clones and quantitative biology
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Immunol Cell Biol 86:119-23. 2008

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Tuning into immunological dissonance: an experimental model for infectious mononucleosis
    P C Doherty
    Department of lmmunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Curr Opin Immunol 9:477-83. 1997
    ....
  2. pmc Toward a broadly protective influenza vaccine
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Clin Invest 118:3273-5. 2008
    ..These peptides could be used to add a CD8+ T cell component to current antibody-focused vaccine strategies with a view to reducing the impact of infection with novel influenza A viruses...
  3. ncbi request reprint The challenge of viral immunity
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, VIC 3010, Australia
    Immunity 27:363-5. 2007
    ....
  4. ncbi request reprint The pas de deux of viruses and CD8 T cells
    Peter C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunol Rev 185:39-49. 2002
    ..Virus infections, particularly HIV, pose enormous challenges for the future. It is generally helpful to know a little of what went before...
  5. ncbi request reprint Challenged by complexity: my twentieth century in immunology
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    Annu Rev Immunol 25:1-19. 2007
    ..Part of my focus since then has been to communicate the societal value and power of science to the broader community. As my scientific life is not yet over, I confine the present historical account to the twentieth century...
  6. pmc Dissecting the host response to a gamma-herpesvirus
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Philos Trans R Soc Lond B Biol Sci 356:581-93. 2001
    ..Perhaps the main lesson learned to date is that all the components of immunity are likely to be important for the control of these complex viruses...
  7. pmc Quantitative analysis of the CD8+ T-cell response to readily eliminated and persistent viruses
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    Philos Trans R Soc Lond B Biol Sci 355:1093-101. 2000
    ....
  8. ncbi request reprint Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections
    P C Doherty
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunol Rev 159:105-17. 1997
    ..Thus, the evidence to date supports a very traditional view; CD8+ T cells function mainly as killers and the CD4+ T cells as helpers in these respiratory virus infections...
  9. ncbi request reprint The new numerology of immunity mediated by virus-specific CD8(+) T cells
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Curr Opin Microbiol 1:419-22. 1998
    ..These techniques are, for the first time, putting the analysis of T-cell-mediated immunity on a quantitative basis...
  10. doi request reprint Burnet, chick embryos, viruses, clones and quantitative biology
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Immunol Cell Biol 86:119-23. 2008
  11. ncbi request reprint Burnet Oration: living in the Burnet lineage
    P C Doherty
    Department of Immunolgy, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Immunol Cell Biol 77:167-76. 1999
    ....
  12. ncbi request reprint Accessing complexity: the dynamics of virus-specific T cell responses
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Immunol 18:561-92. 2000
    ..Though these are early days and there is an enormous amount to be done, our perceptions of the shape of virus-specific cell-mediated immunity are changing rapidly...
  13. ncbi request reprint Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    J Immunol 172:5553-60. 2004
    ....
  14. pmc Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:12388-93. 2002
    ..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
  15. doi request reprint Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells
    Sophie A Valkenburg
    Department of Microbiology and Immunology, University of Melbourne, VIC 3010, Australia
    Eur J Immunol 40:2470-81. 2010
    ..Even "sub-optimal" TCR alpha beta pairs can operate effectively when exposed in a milieu of high virus load. Thus, TCR beta diversity is important for optimal TCR alpha beta pairing and function when TCR alpha is limiting...
  16. pmc Transience of MHC Class I-restricted antigen presentation after influenza A virus infection
    Justine D Mintern
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Proc Natl Acad Sci U S A 106:6724-9. 2009
    ..Molecular profiles identified in antigen-specific T cells at this time may thus be considered to reflect established immunologic memory and not recent CTL activation from a persistent pMHCI pool...
  17. ncbi request reprint The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8+ T cells
    E Bridie Day
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 179:2187-94. 2007
    ..Furthermore, factors that impact the quality of immunity are discussed. These factors are important considerations when evaluating the efficacy of novel vaccine strategies that target dendritic cells for eliciting cellular immunity...
  18. pmc An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions
    Mark Y Sangster
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Exp Med 198:1011-21. 2003
    ..Our study demonstrates a CD4+ T cell-dependent, antiviral IgA response that is generated in the absence of B cell signaling via MHC II or CD40, and is restricted exclusively to virus-specific B cells...
  19. pmc Quantitative analysis of long-term virus-specific CD8+-T-cell memory in mice challenged with unrelated pathogens
    Haiyan Liu
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Virol 77:7756-63. 2003
    ....
  20. doi request reprint Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination
    Annett Miller
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Vaccine 26:5641-8. 2008
    ..This demonstrated the dose-sparing capacity of the SIN vector system and its ability to stimulate long-term memory responses, properties that are highly desirable in any vaccine formulation...
  21. pmc An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:2764-9. 2006
    ..These findings suggest intriguing possibilities for vaccination and, at the same time, emphasize that engineered modifications in viruses may have unintended immunological consequences...
  22. ncbi request reprint An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells
    John Stambas
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    J Immunol 178:1285-92. 2007
    ..These experiments provide insights that may be of value for adoptive immunotherapy, where careful consideration of both the activation state and the number of effector cells is required...
  23. pmc Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 104:9782-7. 2007
    ..It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory...
  24. ncbi request reprint Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL
    Misty R Jenkins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Immunol 179:64-70. 2007
    ..This analysis thus defines how naive, effector, and memory T cells differ in cytotoxic potential and provides novel insight into the molecular signatures of effector molecules observed at various stages after infection...
  25. pmc A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Proc Natl Acad Sci U S A 103:994-9. 2006
    ..Thus, this immunodominance hierarchy is a direct function of antigen dose and T cell numbers...
  26. ncbi request reprint Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells
    Misty R Jenkins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 181:3818-22. 2008
    ..Thus, while effector gene expression can be acquired early, maturation of cytotoxic capacity requires extended differentiation...
  27. pmc Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells
    Stephen J Turner
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 101:3545-50. 2004
    ..Therefore, the massive difference in magnitude for the secondary, although not the primary, response to these D(b)NP(366) and D(b)PA(224) epitopes cannot be considered to reflect differential TNFR2-mediated T cell editing...
  28. pmc TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    Jerry R Aldridge
    Division of Virology, Department of Infectious Diseases, and Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:5306-11. 2009
    ..Targeting the tipDCs in this way thus offers possibilities for therapeutic intervention in the face of a catastrophic pandemic...
  29. ncbi request reprint Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance
    Justine D Mintern
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 179:7220-4. 2007
    ..Therefore, both lymphoid and tissue-resident memory CTL down-regulate cytolytic molecule transcription following virus clearance unless localized Ag is present...
  30. ncbi request reprint Homogenization of TCR repertoires within secondary CD62Lhigh and CD62Llow virus-specific CD8+ T cell populations
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    J Immunol 180:7938-47. 2008
    ..A better understanding of TCR selection and maintenance has implications for improved vaccine and immunotherapy protocols...
  31. doi request reprint Multiplexed combinatorial tetramer staining in a mouse model of virus infection
    Tania Cukalac
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    J Immunol Methods 360:157-61. 2010
    ....
  32. ncbi request reprint Addition of a prominent epitope affects influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting
    Misty Rayna Jenkins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 177:2917-25. 2006
    ....
  33. pmc Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 181:2556-62. 2008
    ..The key finding is thus that the role of TdT in ensuring enhanced diversity and the selection of private TCR repertoires promotes optimal CD8(+) T cell immunity, both within individuals and across the species as a whole...
  34. doi request reprint The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells
    Matthew R Olson
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    IUBMB Life 62:519-26. 2010
    ..This review focuses on how CD8(+) T cells acquire and regulate effector functions and how the capacity to produce effector molecules is maintained into memory...
  35. pmc Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses
    Samita S Andreansky
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 79:4329-39. 2005
    ..A possible explanation is that novel, as yet undetected epitopes emerge following primary exposure to the -NP-PA deletion viruses. These findings have implications for both natural infections and vaccines...
  36. ncbi request reprint Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection
    Stephen J Turner
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
    Semin Immunol 16:179-84. 2004
    ..The approach offers novel insights into the factors determining the selection of immune repertoires, and their functional consequences for CD8(+) T cell-mediated immunity...
  37. ncbi request reprint Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Gen Virol 84:337-41. 2003
    ..Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication...
  38. ncbi request reprint Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses
    Aleksandr S Lipatov
    Department of Infectious Diseases Division of Virology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105 2794, USA
    J Gen Virol 86:1121-30. 2005
    ..This cytokine imbalance is reminiscent of the clinical findings in two humans who died of H5N1/97 infection and may explain the unusual severity of the disease...
  39. ncbi request reprint Analysis of clonotype distribution and persistence for an influenza virus-specific CD8+ T cell response
    Stephen J Turner
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Immunity 18:549-59. 2003
    ..The long-term distribution of memory T cells seemed to be essentially random...
  40. pmc Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    J Immunol Methods 336:71-7. 2008
    ....
  41. ncbi request reprint Establishment and recall of CD8+ T-cell memory in a model of localized transient infection
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    Immunol Rev 211:133-45. 2006
    ....
  42. ncbi request reprint Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
    Stephen J Turner
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Immunol 6:382-9. 2005
    ..Thus, the lack of prominent features in an antigenic complex of peptide and major histocompatibility complex class I is associated with a diminished spectrum of TCR usage...
  43. pmc A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein
    Scott A Brown
    Department of Immunology, Memphis, TN 38105, USA
    J Virol 81:12535-42. 2007
    ....
  44. pmc Protective memory responses are modulated by priming events prior to challenge
    John A Rutigliano
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 84:1047-56. 2010
    ....
  45. doi request reprint Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection
    Jessica M Moffat
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Immunol 39:1203-10. 2009
    ..Analysis of CTL grzA expression during influenza virus immunity has enabled a more detailed insight into the cytolytic mechanisms of virus elimination...
  46. pmc Protection and compensation in the influenza virus-specific CD8+ T cell response
    Richard J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 100:7235-40. 2003
    ..It seems that the relationship between protective humoral and cellular immunity is neither simple nor readily predicted...
  47. pmc The limits of protection by "memory" T cells in Ig-/- mice persistently infected with a gamma-herpesvirus
    Samita Andreansky
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 101:2017-22. 2004
    ..Memory CD4(+) and CD8(+) T cells thus act together to limit gammaHV68 infection but are unable to provide absolute protection against a high-dose, homologous challenge...
  48. ncbi request reprint The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection
    Steven J Ray
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
    Immunity 20:167-79. 2004
    ..This suggests that VLA-1 is responsible for retaining protective memory CD8 T cells in the lung and other tissues via attachment to the extracellular matrix...
  49. ncbi request reprint Memories of virus-specific CD8+ T cells
    Peter C Doherty
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    Immunol Cell Biol 82:136-40. 2004
    ..The progress has been enormous, but there is a great deal still to be learned. A particular challenge is to use what we know for human benefit...
  50. pmc Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 184:1721-7. 2010
    ..Taken together, significant expansion was not a feature of these secondary influenza-specific CD4 T cell responses and the recall of memory did not enhance recovery...
  51. ncbi request reprint Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 178:3091-8. 2007
    ..Overall, these findings suggest that vaccine approaches using virus vectors to deliver an Ag may be optimized by disrupting key peptides in the normal CD8+ T cell response associated with common HLA types...
  52. ncbi request reprint Virus-specific CD8+ T cells in the liver: armed and ready to kill
    Rachael Keating
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 178:2737-45. 2007
    ..Together, these results show clearly that the liver is not a "graveyard" for influenza virus-specific CD8+ T cells...
  53. pmc Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy
    Katherine Kedzierska
    Department of Microbiology and Immunology, The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 105:19408-13. 2008
    ....
  54. pmc Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression
    Dana R Marshall
    Department of Immunology, Hartwell Center for Bioinformatics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 102:6074-9. 2005
    ....
  55. ncbi request reprint Reduced functional capacity of CD8+ T cells expanded by post-exposure vaccination of gamma-herpesvirus-infected CD4-deficient mice
    Haiyan Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 168:3477-83. 2002
    ....
  56. ncbi request reprint A question of self-preservation: immunopathology in influenza virus infection
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 85:85-92. 2007
    ....
  57. ncbi request reprint WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG
    Samita Andreansky
    Department of Immunology, St Jude Children s Hospital, Memphis, TN 38104, USA
    Exp Hematol 33:443-51. 2005
    ..To quantify the immune response of WASP- mice to three different pathogens: influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis...
  58. ncbi request reprint IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells
    Alice E Denton
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    Eur J Immunol 37:368-75. 2007
    ..Together, our results suggest that IL-18, but not IL-12, induces optimal, antigen-specific production of key cytokines by CD8+ T cells for the efficient clearance of influenza virus from the lungs of infected mice...
  59. doi request reprint Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice
    Misty R Jenkins
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Viral Immunol 21:341-6. 2008
    ..This suggests that grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B...
  60. ncbi request reprint CD8+ T-cells: are they sufficient to prevent, contain or eradicate HIV-1 infection?
    Scott A Brown
    Deparment of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Drug Targets Infect Disord 5:113-9. 2005
    ..Since CTL contribute to the success of vaccines in other model systems, an understanding of the strengths and possible limitations of these cells may be critical to future successes in the HIV-1 vaccine field...
  61. ncbi request reprint Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity
    Scott A Brown
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 171:4140-8. 2003
    ..To explain the clustering of Th cell epitopes, we propose that localization of peptide on exposed envelope surfaces facilitates proteolytic activity and preferential peptide shuttling through the Ag processing pathway...
  62. ncbi request reprint HIV vaccine rationale, design and testing
    Karen S Slobod
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Curr HIV Res 3:107-12. 2005
    ..Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific B-cell and T-cell responses, are reviewed...
  63. pmc Cell-mediated protection in influenza infection
    Paul G Thomas
    St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Emerg Infect Dis 12:48-54. 2006
    ..We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure...
  64. pmc Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 103:9184-9. 2006
    ..Hence, our analysis suggests that early establishment of influenza-specific memory within the CD8(+)CD62L(hi) subset preserves clonal diversity and prevents "overdominance" by a few public, or shared, clones...
  65. pmc Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity
    Carole Guillonneau
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 106:3330-5. 2009
    ....
  66. ncbi request reprint Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling
    Stephen J Turner
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 178:7616-22. 2007
    ..The present analysis is the first comprehensive demonstration that IFN-gamma signaling can differentially regulate both Ag-specific CTL homeostasis in secondary lymphoid organs and trafficking to a site of virus-induced pathology...
  67. ncbi request reprint A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    Eur J Immunol 36:2951-9. 2006
    ..Furthermore, this study shows that different indicators of avidity do not necessarily provide similar information and should be used in combination to obtain an overall picture of the characteristics of TCR binding...
  68. doi request reprint Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env(311-320) virus
    Tania Cukalac
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia
    Vaccine 27:6755-61. 2009
    ..1/8.2 D(d)Env(311) TCR repertoire diversity. This work further emphasizes the importance of understanding vaccine-induced CD8+ T cell responses...
  69. ncbi request reprint Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells
    Ted S Strom
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 102:3108-16. 2003
    ..The defective secondary T-cell response to influenza virus was also improved in gene-corrected animals...
  70. ncbi request reprint A five-residue HIV envelope helper T cell determinant: does this peptide-MHC interaction leave the binding groove half empty?
    Timothy D Lockey
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    AIDS Res Hum Retroviruses 18:1141-4. 2002
    ..The remaining positions may be empty, or may be associated with a second, perhaps unrelated, peptide moiety...
  71. pmc Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections
    Sherry R Crowe
    Trudeau Institute, P O Box 59, Saranac Lake, NY 12983, USA
    J Exp Med 198:399-410. 2003
    ..Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies...
  72. ncbi request reprint Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles
    Charani Ranasinghe
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 178:2370-9. 2007
    ..A greater understanding of these factors will be crucial for the development of effective vaccines in the future...
  73. ncbi request reprint Method for assessing the similarity between subsets of the T cell receptor repertoire
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital, Kensington NSW 2052, Australia
    J Immunol Methods 329:67-80. 2008
    ....
  74. pmc Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Mol Immunol 45:607-18. 2008
    ....
  75. ncbi request reprint Methods for comparing the diversity of samples of the T cell receptor repertoire
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital and, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    J Immunol Methods 321:182-95. 2007
    ..One example involves a comparison between the central and effector memory T cell subsets, defined on the basis of CD62L expression, and the other examines changes in the TCR repertoire over time...
  76. ncbi request reprint T cell epitope "hotspots" on the HIV Type 1 gp120 envelope protein overlap with tryptic fragments displayed by mass spectrometry
    Scott A Brown
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    AIDS Res Hum Retroviruses 21:165-70. 2005
    ..Results are consistent with the suggestion that gp120 peptide location influences antigen processing, which, in turn, influences the specificity of immunodominant T cells...
  77. pmc Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    Proc Natl Acad Sci U S A 103:18691-6. 2006
    ....
  78. pmc Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 102:11432-7. 2005
    ..Thus, whereas TCR sequence (or affinity) appears to contribute substantially to the avidity profile of diverse virus-specific CD8+ populations, other mechanisms may be prominent where the TCR spectrum is more limited...
  79. pmc Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Proc Natl Acad Sci U S A 101:4942-7. 2004
    ....
  80. pmc Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Victoria, Australia
    Proc Natl Acad Sci U S A 105:2034-9. 2008
    ..Thus, whereas a diverse repertoire may be important for recognition of epitope variants, its effect on the response to cognate pMHC recognition appears minimal...
  81. ncbi request reprint Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage
    Katherine Kedzierska
    Department of Microbiology and Immunology, The University of Melbourne, Parkeville, Victoria, Australia
    J Immunol 177:6705-12. 2006
    ..Therefore, even in CD8 T cell responses that appear to be oligoclonotypic, the total response is highly diverse...

Research Grants6

  1. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter Doherty; Fiscal Year: 2007
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..
  2. Protective Cell-Mediated Immunity Against Lethal H5N1 Influenza A Viruses
    Peter C Doherty; Fiscal Year: 2010
    ..These studies should allow us to develop a clear, mechanistic understanding of how to promote effective CMI against the H5N1 viruses. ..