Tom Curran

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint From bings to biology: taking a different path in cancer research
    Tom Curran
    St Jude Children s Research Hospital Memphis, Tennessee USA
    Cancer Biol Ther 2:456-9. 2003
  2. pmc BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system
    Susan Magdaleno
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, United States
    PLoS Biol 4:e86. 2006
  3. ncbi request reprint Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor
    Ken Sasai
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN, USA
    Cancer Res 67:3871-7. 2007
  4. ncbi request reprint A neurogenomics approach to gene expression analysis in the developing brain
    Patricia Jensen
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    Brain Res Mol Brain Res 132:116-27. 2004
  5. ncbi request reprint Radial glia cells are candidate stem cells of ependymoma
    Michael D Taylor
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 8:323-35. 2005
  6. doi request reprint Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    Hiromichi Kimura
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 13:249-60. 2008
  7. ncbi request reprint Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
    Ken Sasai
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4215-22. 2006
  8. ncbi request reprint Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics
    Justyna Romer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 65:4975-8. 2005
  9. ncbi request reprint Patched2 modulates tumorigenesis in patched1 heterozygous mice
    Youngsoo Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:6964-71. 2006
  10. ncbi request reprint Gli1 is important for medulloblastoma formation in Ptc1+/- mice
    Hiromichi Kimura
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Oncogene 24:4026-36. 2005

Collaborators

Detail Information

Publications26

  1. ncbi request reprint From bings to biology: taking a different path in cancer research
    Tom Curran
    St Jude Children s Research Hospital Memphis, Tennessee USA
    Cancer Biol Ther 2:456-9. 2003
  2. pmc BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system
    Susan Magdaleno
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, United States
    PLoS Biol 4:e86. 2006
  3. ncbi request reprint Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor
    Ken Sasai
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN, USA
    Cancer Res 67:3871-7. 2007
    ..We found that transplanted tumors were dramatically inhibited in mice treated for only 4 days with HhAntag. These findings suggest that HhAntag may be effective against tumors lacking mutations in known Shh pathway genes...
  4. ncbi request reprint A neurogenomics approach to gene expression analysis in the developing brain
    Patricia Jensen
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, United States
    Brain Res Mol Brain Res 132:116-27. 2004
    ..We propose that combining bioinformatics with the gene expression pattern is an effective strategy to identify genes that may play critical roles during brain development...
  5. ncbi request reprint Radial glia cells are candidate stem cells of ependymoma
    Michael D Taylor
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Cancer Cell 8:323-35. 2005
    ....
  6. doi request reprint Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    Hiromichi Kimura
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 13:249-60. 2008
    ..After drug removal, osteoblasts invaded the cartilage plate, mineralization occurred, and there was premature fusion of the growth plate resulting in permanent disruption of bone epiphyses...
  7. ncbi request reprint Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
    Ken Sasai
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:4215-22. 2006
    ....
  8. ncbi request reprint Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics
    Justyna Romer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 65:4975-8. 2005
    ..These and other findings suggest that inhibitors of Sonic Hedgehog signaling may offer an effective way to target some malignancies...
  9. ncbi request reprint Patched2 modulates tumorigenesis in patched1 heterozygous mice
    Youngsoo Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:6964-71. 2006
    ..Ptch1+/-Ptch2-/- and Ptch1+/-Ptch2+/- animals showed a higher incidence of tumors and a broader spectrum of tumor types compared with Ptch1+/- animals. Therefore, Ptch2 modulates tumorigenesis associated with Ptch1 haploinsufficiency...
  10. ncbi request reprint Gli1 is important for medulloblastoma formation in Ptc1+/- mice
    Hiromichi Kimura
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Oncogene 24:4026-36. 2005
    ..These results demonstrate that Gli1 plays a central role in medulloblastoma formation in Ptc1+/- mice and that Gli2 may also contribute to oncogenesis...
  11. pmc The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    Tamar Uziel
    Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
    Genes Dev 19:2656-67. 2005
    ..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children...
  12. ncbi request reprint Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
    Justyna T Romer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 6:229-40. 2004
    ..Long-term treatment with HhAntag prolonged medulloblastoma-free survival. These findings support the development of Shh antagonists for the treatment of medulloblastoma...
  13. ncbi request reprint Mouse embryos cloned from brain tumors
    Leyi Li
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:2733-6. 2003
    ..Thus, tumor cells can be epigenetically reprogrammed into normal cell types. This approach could lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis...
  14. ncbi request reprint A molecular fingerprint for medulloblastoma
    Youngsoo Lee
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:5428-37. 2003
    ..Coordinated deregulation of these same genes also occurred in a large subset of human medulloblastomas. These data identify a group of genes that is central to medulloblastoma tumorigenesis...
  15. ncbi request reprint ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA Richard
    Clin Cancer Res 8:3054-64. 2002
    ..Functional assessment of ERBB-dependent cell signaling and proliferation, in addition to novel therapeutic inhibition of these processes, was conducted using short-term cultures of human ependymoma cells...
  16. pmc Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality
    Yuehai Ke
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Mol Cell Biol 27:6706-17. 2007
    ..Together, these results identify Shp2 as a critical signaling molecule in coordinated regulation of progenitor cell proliferation and neuronal/astroglial cell differentiation...
  17. ncbi request reprint Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice
    Susan Magdaleno
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Neuron 33:573-86. 2002
    ..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning...
  18. ncbi request reprint The hedgehog pathway and neurological disorders
    Tammy Dellovade
    Curis, Inc, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:539-63. 2006
    ..We also describe the discovery and utility of small molecule agonists and antagonists of this pathway and their potential as novel types of therapeutics...
  19. pmc Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding
    Jared M Ordway
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 23:4257-66. 2003
    ....
  20. ncbi request reprint Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins
    Yongcheng Huang
    Division of Pharmacology, College of Pharmacy, The Ohio State University, 500 W 12th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 318:204-12. 2004
    ..Our results suggest that Crk family adapter proteins may play an important role in the Reelin signaling pathway during brain development...
  21. ncbi request reprint Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    Margaret C Thompson
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 24:1924-31. 2006
    ..We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities...
  22. ncbi request reprint Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma
    Wen Qing Yang
    Department of Oncology, University of Calgary and Tom Baker Cancer Centre, Calgary, Alberta, T2N 4N2 Canada
    Cancer Res 63:3162-72. 2003
    ..Its ability to reduce metastases to the spinal cord could allow a reduction in the dose/field of total neuroaxis cerebral-spinal radiotherapy currently used to treat/prevent cerebral spinal fluid dissemination...
  23. ncbi request reprint Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain
    Ramin Homayouni
    Department of Neurology, University of Tennessee, 855 Monroe Avenue, 416 Link Building, Memphis, TN 38163, USA
    Brain Res Mol Brain Res 115:121-9. 2003
    ..Our findings suggest that Dab2IP may function as a downstream effector in the Reelin signaling pathway that influences Ras signaling during brain development...
  24. ncbi request reprint Lost in translation: the future of cancer research?
    Tom Curran
    Clin Cancer Res 11:4644-5. 2005
  25. ncbi request reprint Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1
    Jared M Ordway
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Oncogene 23:3737-48. 2004
    ..The results emphasize the role of transcription repression in oncogenesis, and they provide insights into the potential common epigenetic mechanisms impacting cell transformation...
  26. ncbi request reprint Prediction of central nervous system embryonal tumour outcome based on gene expression
    Scott L Pomeroy
    Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:436-42. 2002
    ..We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis...