Research Topics
| Tom CurranSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
| Collaborators
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Detail Information
Publications
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous systemSusan Magdaleno
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States
PLoS Biol 4:e86. 2006
From bings to biology: taking a different path in cancer researchTom Curran
St. Jude Children's Research Hospital; Memphis, Tennessee USA
Cancer Biol Ther 2:456-9. 2003- Gli1 is important for medulloblastoma formation in Ptc1+/- miceHiromichi Kimura
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
Oncogene 24:4026-36. 2005..These results demonstrate that Gli1 plays a central role in medulloblastoma formation in Ptc1+/- mice and that Gli2 may also contribute to oncogenesis... - Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeuticsJustyna Romer
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 65:4975-8. 2005..These and other findings suggest that inhibitors of Sonic Hedgehog signaling may offer an effective way to target some malignancies... - Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) miceJustyna T Romer
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cancer Cell 6:229-40. 2004..Long-term treatment with HhAntag prolonged medulloblastoma-free survival. These findings support the development of Shh antagonists for the treatment of medulloblastoma... - A molecular fingerprint for medulloblastomaYoungsoo Lee
Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 63:5428-37. 2003..Coordinated deregulation of these same genes also occurred in a large subset of human medulloblastomas. These data identify a group of genes that is central to medulloblastoma tumorigenesis... - Patched2 modulates tumorigenesis in patched1 heterozygous miceYoungsoo Lee
Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 66:6964-71. 2006..Ptch1+/-Ptch2-/- and Ptch1+/-Ptch2+/- animals showed a higher incidence of tumors and a broader spectrum of tumor types compared with Ptch1+/- animals. Therefore, Ptch2 modulates tumorigenesis associated with Ptch1 haploinsufficiency... - Mouse embryos cloned from brain tumorsLeyi Li
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 63:2733-6. 2003..Thus, tumor cells can be epigenetically reprogrammed into normal cell types. This approach could lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis... - ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this diseaseRichard J Gilbertson
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA Richard
Clin Cancer Res 8:3054-64. 2002..Functional assessment of ERBB-dependent cell signaling and proliferation, in addition to novel therapeutic inhibition of these processes, was conducted using short-term cultures of human ependymoma cells... - The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formationTamar Uziel
Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
Genes Dev 19:2656-67. 2005..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children... - The hedgehog pathway and neurological disordersTammy Dellovade
Curis, Inc, Cambridge, Massachusetts 02138, USA
Annu Rev Neurosci 29:539-63. 2006..We also describe the discovery and utility of small molecule agonists and antagonists of this pathway and their potential as novel types of therapeutics... - Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studiesKen Sasai
Department of Developmental Neurobiology, Saint Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 66:4215-22. 2006.... - Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitorKen Sasai
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN, USA
Cancer Res 67:3871-7. 2007..We found that transplanted tumors were dramatically inhibited in mice treated for only 4 days with HhAntag. These findings suggest that HhAntag may be effective against tumors lacking mutations in known Shh pathway genes... - Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsMargaret C Thompson
St Jude Children's Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 24:1924-31. 2006..This approach may assist ultimately in the selection of patients for future clinical trials of molecular targeted therapies... - Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethalityYuehai Ke
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Mol Cell Biol 27:6706-17. 2007..Together, these results identify Shp2 as a critical signaling molecule in coordinated regulation of progenitor cell proliferation and neuronal/astroglial cell differentiation... - Radial glia cells are candidate stem cells of ependymomaMichael D Taylor
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
Cancer Cell 8:323-35. 2005.... - Lost in translation: the future of cancer research?Tom Curran
Clin Cancer Res 11:4644-5. 2005 - Prediction of central nervous system embryonal tumour outcome based on gene expressionScott L Pomeroy
Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 415:436-42. 2002..We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis... - Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteinsYongcheng Huang
Division of Pharmacology, College of Pharmacy, The Ohio State University, 500 W 12th Avenue, Columbus, OH 43210, USA
Biochem Biophys Res Commun 318:204-12. 2004..Our results suggest that Crk family adapter proteins may play an important role in the Reelin signaling pathway during brain development... - Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1Jared M Ordway
Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
Oncogene 23:3737-48. 2004..The results emphasize the role of transcription repression in oncogenesis, and they provide insights into the potential common epigenetic mechanisms impacting cell transformation... - Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brainRamin Homayouni
Department of Neurology, University of Tennessee, 855 Monroe Avenue, 416 Link Building, Memphis, TN 38163, USA
Brain Res Mol Brain Res 115:121-9. 2003..Our findings suggest that Dab2IP may function as a downstream effector in the Reelin signaling pathway that influences Ras signaling during brain development... - Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastomaWen Qing Yang
Department of Oncology, University of Calgary and Tom Baker Cancer Centre, Calgary, Alberta, T2N 4N2 Canada
Cancer Res 63:3162-72. 2003..Its ability to reduce metastases to the spinal cord could allow a reduction in the dose/field of total neuroaxis cerebral-spinal radiotherapy currently used to treat/prevent cerebral spinal fluid dissemination... - Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA bindingJared M Ordway
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Mol Cell Biol 23:4257-66. 2003.... - Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler miceSusan Magdaleno
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
Neuron 33:573-86. 2002..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning... 
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structureHiromichi Kimura
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
Cancer Cell 13:249-60. 2008..After drug removal, osteoblasts invaded the cartilage plate, mineralization occurred, and there was premature fusion of the growth plate resulting in permanent disruption of bone epiphyses...