Hongbo Chi

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Acetylation of MKP-1 and the control of inflammation
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Sci Signal 1:pe44. 2008
  2. pmc Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytokine 48:161-9. 2009
  3. doi request reprint Studies on MAP Kinase signaling in the immune system
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 661:471-80. 2010
  4. pmc Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:152-61. 2012
  5. pmc Regulation and function of mTOR signalling in T cell fate decisions
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 12:325-38. 2012
  6. pmc Sphingosine-1-phosphate and immune regulation: trafficking and beyond
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Trends Pharmacol Sci 32:16-24. 2011
  7. pmc Innate recognition of non-self nucleic acids
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Genome Biol 9:211. 2008
  8. pmc T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
    Kai Yang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 39:1043-56. 2013
  9. pmc mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    Hu Zeng
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 499:485-90. 2013
  10. pmc Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells
    Yanyan Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 110:E4894-903. 2013

Collaborators

Detail Information

Publications39

  1. pmc Acetylation of MKP-1 and the control of inflammation
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Sci Signal 1:pe44. 2008
    ..Acetylation of MKP-1 promotes the interaction of MKP-1 with its substrate p38 MAPK, which results in dephosphorylation of p38 MAPK and the inhibition of innate immunity...
  2. pmc Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytokine 48:161-9. 2009
    ..Here we discuss the recent advances in our understanding of these regulatory processes in MAPK signaling with a focus on their impacts on immune function...
  3. doi request reprint Studies on MAP Kinase signaling in the immune system
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Methods Mol Biol 661:471-80. 2010
    ..Specifically, we describe flow cytometry-based assays to analyze the roles of MAPKs in the development, homeostasis, proliferation, and apoptosis of murine T cells. We also describe methods to examine the activation of MAPKs in T cells...
  4. pmc Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:152-61. 2012
    ..Our results identify p38α signaling as a central pathway for the integration of instructive signals in DCs for T(H)17 differentiation and inflammation...
  5. pmc Regulation and function of mTOR signalling in T cell fate decisions
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 12:325-38. 2012
    ..This Review focuses on the signalling mechanisms of mTOR in T cell homeostatic and functional fates, and discusses the therapeutic implications of targeting mTOR in T cells...
  6. pmc Sphingosine-1-phosphate and immune regulation: trafficking and beyond
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Trends Pharmacol Sci 32:16-24. 2011
    ..I also describe strategies to target S1P and S1P receptors for immune-mediated diseases, particularly the immunosuppressant FTY720 (fingolimod), which has recently become the first oral therapy for relapsing multiple sclerosis...
  7. pmc Innate recognition of non-self nucleic acids
    Hongbo Chi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Genome Biol 9:211. 2008
    ..Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases...
  8. pmc T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
    Kai Yang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 39:1043-56. 2013
    ..Our studies identify a Raptor-mTORC1-dependent pathway linking signal-dependent metabolic reprogramming to quiescence exit, and this in turn coordinates lymphocyte activation and fate decisions in adaptive immunity...
  9. pmc mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    Hu Zeng
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 499:485-90. 2013
    ....
  10. pmc Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells
    Yanyan Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 110:E4894-903. 2013
    ..Our results demonstrate that the interplay between Tsc1-Rheb-mTORC1 signaling and Myc-dependent bioenergetic and biosynthetic activities constitutes a key metabolic checkpoint to orchestrate DC development. ..
  11. pmc Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function
    Yanyan Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 109:E343-52. 2012
    ..Therefore, TAK1 orchestrates a prosurvival checkpoint in DCs that affects the homeostasis and function of the immune system...
  12. pmc Control of T cell fates and immune tolerance by p38α signaling in mucosal CD103+ dendritic cells
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 191:650-9. 2013
    ..Our studies identify a key mechanism of DC-mediated coupling of T cell differentiation and trafficking that orchestrates mucosal immune tolerance. ..
  13. pmc The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
    ..Our studies establish an S1P(1)-mTOR axis that controls T cell lineage specification...
  14. pmc Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 35:45-58. 2011
    ....
  15. pmc Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells
    Lewis Zhichang Shi
    Department of Immunology and Hartwell Center for Bioinformatics and Biotechnology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 110:E3198-205. 2013
    ..Consistent with an inhibitory role of Gfi1 in this process, loss of Gfi1 dampens antitumor immunity. These data point to a previously unrecognized extrinsic control mechanism that negatively shapes thymic generation of nT(reg) cells...
  16. pmc Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
    Christopher Lupfer
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 14:480-8. 2013
    ..These results demonstrate a role for NOD2-RIPK2 signaling in protection against virally triggered immunopathology by negatively regulating activation of the NLRP3 inflammasome and production of IL-18 via ULK1-dependent mitophagy...
  17. pmc Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    J Immunol 184:4610-4. 2010
    ..We found that CD4(+) T cells deficient in ASC exhibited impaired survival; accordingly, ASC(-/-) mice had fewer myelin oligodendrocyte glycoprotein-specific T cells in the draining lymph nodes and CNS...
  18. pmc Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    Immunity 34:75-84. 2011
    ..Our results suggest that PGN in the CNS is involved in the pathogenesis of EAE through the activation of infiltrating dendritic cells via NOD1-, NOD2-, and RIP2-mediated pathways...
  19. pmc The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA Center for Brain Immunology and Glia BIG, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 42:654-64. 2015
    ..These results define an unexpected role for NLRP12 as an intrinsic negative regulator of T-cell-mediated immunity and identify altered NF-κB regulation and IL-4 production as key mediators of NLRP12-associated disease. ..
  20. pmc The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    Kai Yang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 12:888-97. 2011
    ..Therefore, Tsc1-dependent control of mTOR is crucial in actively maintaining the quiescence of naive T cells to facilitate adaptive immune function...
  21. pmc The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    Ruoning Wang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 35:871-82. 2011
    ..Therefore, a Myc-dependent global metabolic transcriptome drives metabolic reprogramming in activated, primary T lymphocytes. This may represent a general mechanism for metabolic reprogramming under patho-physiological conditions...
  22. pmc Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation
    Peer W F Karmaus
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105 3678, USA
    Cell Mol Life Sci 71:1893-906. 2014
    ..Our focus is on the molecular pathways that orchestrate DC life span, migration, antigen presentation, pattern recognition, and cytokine production and signaling. ..
  23. pmc Regulation of TH17 cell differentiation by innate immune signals
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Mol Immunol 9:287-95. 2012
    ..Here, we summarize the current knowledge on the mechanisms by which DC-derived innate immune signals drive T(H)17 cell differentiation...
  24. pmc Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 188:3107-15. 2012
    ..These findings highlight the importance of inflammasome-derived IL-1β and the IL-1R/MyD88 signaling axis in the regulation of GM-CSF production...
  25. pmc mTOR and lymphocyte metabolism
    Hu Zeng
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Immunol 25:347-55. 2013
    ..Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs. ..
  26. pmc Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
    Sharad Shrestha
    1 Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Nat Immunol 16:178-87. 2015
    ..Our studies establish a PTEN-mTORC2 axis that maintains Treg cell stability and coordinates Treg cell-mediated control of effector responses. ..
  27. pmc mTOR and metabolic pathways in T cell quiescence and functional activation
    Kai Yang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Semin Immunol 24:421-8. 2012
    ..In this review, we summarize the current advances on mTOR signaling and T cell metabolism in the control of development, homeostasis, activation and differentiation of T cells...
  28. pmc Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner
    Franz Kratochvill
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee
    Cancer Res 75:3054-64. 2015
    ..Manipulation of the p38α-TTP axis in macrophages has significant effects on the growth of tumors and therefore represents a means to manipulate inflammation in the tumor microenvironment...
  29. pmc The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 10:769-77. 2009
    ..Dynamic regulation of S1P1 contributed to lymphocyte priming and immune homeostasis. Thus, by antagonizing T(reg) cell-mediated immune suppression, the lipid-activated S1P1-Akt-mTOR pathway orchestrates adaptive immune responses...
  30. pmc Control of IL-17 receptor signaling and tissue inflammation by the p38α-MKP-1 signaling axis in a mouse model of multiple sclerosis
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Sci Signal 8:ra24. 2015
    ..Our results suggest that the p38α-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells...
  31. pmc The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus
    Rachael Keating
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 14:1266-76. 2013
    ..Our findings have implications for the design of a vaccine against influenza virus. ..
  32. pmc HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    Lewis Z Shi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Exp Med 208:1367-76. 2011
    ..Our studies demonstrate that HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of T(H)17 and T(reg) cells...
  33. pmc Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision
    Jun Wei
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Immunol 193:4297-301. 2014
    ..Our findings establish pivotal and unique roles for mTORC2 signaling, which is reciprocally regulated by Rictor and Pten, in NKT17 lineage determination. ..
  34. pmc Metabolic control of regulatory T cell development and function
    Hu Zeng
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN, USA
    Trends Immunol 36:3-12. 2015
    ..We review here the interplay between Tregs and metabolism, with a particular focus on how host, commensal, and cellular metabolism impinge upon Treg homeostasis and function. ..
  35. doi request reprint AMPK helps T cells survive nutrient starvation
    Kai Yang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 42:4-6. 2015
    ..Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo...
  36. ncbi request reprint Immunology: sensing the enemy within
    Hongbo Chi
    Nature 448:423-4. 2007
  37. pmc Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    Hongbo Chi
    Section of Immunobiology, Department of Pharmacology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:2274-9. 2006
    ..These results highlight the complex mechanisms by which the MAPKs regulate innate immunity...