Zhe Sheng Chen

Summary

Affiliation: St. John's University
Country: USA

Publications

  1. doi request reprint Masitinib Antagonizes ATP-Binding Cassette Subfamily C Member 10-Mediated Paclitaxel Resistance: A Preclinical Study
    Rishil J Kathawala
    Corresponding Authors Zhe Sheng Chen, Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439
    Mol Cancer Ther 13:714-23. 2014
  2. pmc Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells
    Xing Xiang Peng
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:110-8. 2012
  3. pmc Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
    Zhe Sheng Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    FEBS J 278:3226-45. 2011
  4. ncbi request reprint Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Cancer Res 67:11012-20. 2007
  5. pmc OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
    Ye Hong Kuang
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 84:766-74. 2012
  6. pmc Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Lett 328:307-17. 2013
  7. pmc Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10)
    Tong Shen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, United States of America
    PLoS ONE 4:e7520. 2009
  8. doi request reprint PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
    Atish Patel
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Chemother Pharmacol 72:189-99. 2013
  9. ncbi request reprint Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Cancer Sci 98:1373-80. 2007
  10. pmc PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter
    Jun Jiang Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, USA
    Cancer Sci 103:1531-7. 2012

Collaborators

  • Li Wu Fu
  • Tanaji T Talele
  • Xiang Chen
  • Susan E Bates
  • Dong Hua Yang
  • Gary D Kruh
  • Diaa T A Youssef
  • Tatsuhiko Furukawa
  • Vijaya L Damaraju
  • Shin ichi Akiyama
  • Amit K Tiwari
  • Kamlesh Sodani
  • Zhi Shi
  • Atish Patel
  • Yue Li Sun
  • Jun Jiang Chen
  • Rishil J Kathawala
  • Charles R Ashby
  • Ye Hong Kuang
  • Suresh V Ambudkar
  • Xing Xiang Peng
  • Ioana Abraham
  • Satyakam Singh
  • Chun Ling Dai
  • Tong Shen
  • Zhi jie Xiao
  • Robert W Robey
  • Ying Zhou
  • In Wha Kim
  • Si dong Chen
  • Wen Qi Jiang
  • Jay P Patel
  • Pei Rong Ding
  • Xin An
  • Khalid El Sayed
  • Elizabeth Hopper-Borge
  • Suneet Shukla
  • Kang Chen
  • Nagaraju Anreddy
  • Amal Kaddoumi
  • Alaa H Abuznait
  • Wen Deng
  • Priyank Kumar
  • Vijaya L Korlipara
  • Chung Pu Wu
  • Jeferson W K K Lee
  • Hsiang Chun Wu
  • Smitaben Parmar
  • Xiao Cong Huang
  • Sandeep Jain
  • Qiu Sheng Si
  • Yi jun Wang
  • De Shen Wang
  • Yun Kai Zhang
  • Wen Cai Ye
  • Hai Fan Chen
  • James M Gallo
  • Yang Lu Chen
  • Eduardo E Chufan
  • Ralph Stephani
  • Ying jie Li
  • Dong Mei Zhang
  • Kelvin Zheng
  • Saraubh G Vispute
  • Li Qiu Liao
  • Huiqin Guo
  • Shinobu Ohnuma
  • Xingxiang Peng
  • Atish S Patel
  • Qi Si Lu
  • Mohammad A Khanfar
  • Yibo Sun
  • Yehong Kuang
  • Angel Chen
  • Yu Lei
  • Curtis S Goldblatt
  • Yining Shao
  • Jiangyong Ouyang
  • Si Rong Wang
  • Yang Min Chen
  • Feiyang Zang
  • Carol E Cass
  • Amit Tiwari

Detail Information

Publications32

  1. doi request reprint Masitinib Antagonizes ATP-Binding Cassette Subfamily C Member 10-Mediated Paclitaxel Resistance: A Preclinical Study
    Rishil J Kathawala
    Corresponding Authors Zhe Sheng Chen, Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439
    Mol Cancer Ther 13:714-23. 2014
    ..In conclusion, the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10. Mol Cancer Ther; 13(3); 714-23. ©2014 AACR. ..
  2. pmc Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells
    Xing Xiang Peng
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:110-8. 2012
    ..These data suggest that the overexpression of P-gp may play a crucial role in acquired resistance to imatinib in CML K562-imatinib cells...
  3. pmc Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
    Zhe Sheng Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    FEBS J 278:3226-45. 2011
    ..The mutations in MRP2/ABCC2 leading to conjugated hyperbilirubinemia (Dubin-Johnson syndrome) and in MRP6/ABCC6 leading to the connective tissue disorder Pseudoxanthoma elasticum are also discussed...
  4. ncbi request reprint Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Cancer Res 67:11012-20. 2007
    ..These findings may be useful for cancer combinational therapy with erlotinib in the clinic...
  5. pmc OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
    Ye Hong Kuang
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 84:766-74. 2012
    ..Thus VKJP1 and VKJP3 represent a new class of drugs for reducing MDR in ABCG2 over-expressing tumors...
  6. pmc Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Lett 328:307-17. 2013
    ..The beneficial actions of nilotinib warrant consideration as viable combinations in the clinic with agents that suffer from MDR-mediated insensitivity...
  7. pmc Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10)
    Tong Shen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, United States of America
    PLoS ONE 4:e7520. 2009
    ..In this study, we examined the effects of BCR-Abl tyrosine kinase inhibitors imatinib, nilotinib and dasatinib on the activity and expression of MRP7 in HEK293 cells transfected with MRP7, designated HEK-MRP7-2...
  8. doi request reprint PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
    Atish Patel
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Chemother Pharmacol 72:189-99. 2013
    ..In this study, we determine whether PD173074, a specific fibroblast growth factor receptor (FGFR) inhibitor, could reverse ABC transporter-mediated multidrug resistance...
  9. ncbi request reprint Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Cancer Sci 98:1373-80. 2007
    ....
  10. pmc PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter
    Jun Jiang Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, USA
    Cancer Sci 103:1531-7. 2012
    ..Our findings indicate a potentially novel use of PDE5 inhibitors as an adjuvant chemotherapeutic agent in clinical practice...
  11. pmc Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York 10016, USA
    Cancer Res 71:3029-41. 2011
    ..Our findings suggest a possible strategy to enhance the distribution and potentially the activity of anticancer drugs by jointly using a clinically approved drug with known side effects and drug-drug interactions...
  12. pmc The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
    Oncol Rep 21:483-9. 2009
    ..These results will be useful in the development of novel and more effective EGFR TKIs as well as the development of combinational chemotherapeutic strategies...
  13. pmc Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells
    Ioana Abraham
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Biochem Pharmacol 80:1497-506. 2010
    ..In conclusion, sipholane triterpenoids efficiently inhibit the function of P-gp through direct interactions and may represent potential reversal agents for the treatment of MDR...
  14. pmc Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance
    Ye Hong Kuang
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 79:154-61. 2010
    ....
  15. pmc Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
    Wen Deng
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, New York, NY 11439, USA
    Oncol Rep 29:2479-85. 2013
    ..Thus, we conclude that the FLT3 inhibitor tandutinib can reverse MRP7-mediated MDR through inhibition of the drug efflux function and may have potential to be used clinically in combination therapy for cancer patients...
  16. ncbi request reprint Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine
    Xing Xiang Peng
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, United States
    Leuk Res 32:799-809. 2008
    ..Taken together these results showed that up-regulation of MRP4 and down-regulation of influx transporters played a major role in 6-MP resistance of CEM-MP5 cells...
  17. pmc GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance
    Kamlesh Sodani
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 83:1613-22. 2012
    ..These findings may be useful in developing combination therapy for cancer treatment with EGFR TKIs...
  18. pmc The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter
    Pei Rong Ding
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, United States of America
    PLoS ONE 6:e19329. 2011
    ..Overall, our results suggest that vardenafil reverses ABCB1-mediated MDR by directly blocking the drug efflux function of ABCB1...
  19. doi request reprint BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review
    Xin An
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Leuk Res 34:1255-68. 2010
    ..Here, we present an overview about the current treatment of Ph+ CML patients with the TKIs and the obstacles to successful treatment with these drugs...
  20. pmc Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar
    Yue Li Sun
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 8:e55576. 2013
    ....
  21. doi request reprint Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
    Yue Li Sun
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professionals, St John s University, Queens, New York, USA
    Anticancer Drugs 23:865-73. 2012
    ..Our findings suggest a possible strategy to potentially enhance the activity of anticancer drugs using a clinically approved drug with known side effects and drug-drug interactions...
  22. pmc Roles of sildenafil in enhancing drug sensitivity in cancer
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, USA
    Cancer Res 71:3735-8. 2011
    ..Emerging evidence indicates that sildenafil and other phosphodiesterase type 5 inhibitors may enhance the sensitivity of certain types of cancer to standard chemotherapeutic drugs...
  23. pmc bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10)
    Jun Jiang Chen
    Guangdong Key Laboratory for Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, New York, United States of America
    PLoS ONE 8:e74573. 2013
    ..Our findings suggest that BBA has the potential to be used in combination with conventional chemotherapeutic agents to augment the response to chemotherapy. ..
  24. ncbi request reprint Revisiting the ABCs of multidrug resistance in cancer chemotherapy
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Curr Pharm Biotechnol 12:570-94. 2011
    ..This review briefly discusses the current knowledge regarding the clinical involvement of ABC transporters in MDR to antineoplastic drugs and highlights approaches undertaken so far to overcome ABC transporter-mediated MDR in cancer...
  25. doi request reprint Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
    Rishil J Kathawala
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY, USA
    Int J Oncol 44:1634-42. 2014
    ..Overall, our in vitro findings suggest that masitinib reverses MDR to various anti-neoplastic drugs in HEK293 and H460 cells overexpressing ABCG2 by inhibiting their transport activity as opposed to altering their levels of expression. ..
  26. pmc Role of ABC transporters in cancer chemotherapy
    Yue Li Sun
    Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
    Chin J Cancer 31:51-7. 2012
    ..Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR...
  27. pmc Multidrug resistance associated proteins in multidrug resistance
    Kamlesh Sodani
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:58-72. 2012
    ..This review focuses mainly on the physiological functions, cellular resistance characteristics, and probable in vivo role of MRP1 to MRP9...
  28. pmc Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Biochem Pharmacol 77:781-93. 2009
    ..Our findings provide valuable contributions to the development of safer and more effective EGFR TKIs for use as anticancer agents in the clinic...
  29. doi request reprint Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance
    Ying Zhou
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY, USA
    Biochem Pharmacol 77:993-1001. 2009
    ..E(2)17betaG transport was competitively inhibited by cepharanthine with a K(i) value of 4.86microM. These findings indicate that cepharanthine reverses MRP7-mediated resistance to paclitaxel in a competitive manner...
  30. pmc Current status on marine products with reversal effect on cancer multidrug resistance
    Ioana Abraham
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Mar Drugs 10:2312-21. 2012
    ..This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones...
  31. doi request reprint Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Biochem Pharmacol 78:153-61. 2009
    ..Also, these findings may be useful in clinical practice for cancer combination therapy with nilotinib...
  32. doi request reprint Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930
    Jay P Patel
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Bioorg Med Chem Lett 21:6495-9. 2011
    ..Nitropyridyl derivative 5 and o-nitrophenyl derivative 7 exhibited complete inhibition of the ABCG2 pump with IC(50) values of 13.67μM and 16.67μM, respectively...