Zhe Sheng Chen

Summary

Affiliation: St. John's University
Country: USA

Publications

  1. pmc Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
    Wen Deng
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, New York, NY 11439, USA
    Oncol Rep 29:2479-85. 2013
  2. pmc Multidrug resistance associated proteins in multidrug resistance
    Kamlesh Sodani
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:58-72. 2012
  3. pmc Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs
    Rishil J Kathawala
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 33:223-30. 2014
  4. pmc The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter
    Pei Rong Ding
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, United States of America
    PLoS ONE 6:e19329. 2011
  5. pmc Role of ABC transporters in cancer chemotherapy
    Yue Li Sun
    Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
    Chin J Cancer 31:51-7. 2012
  6. pmc Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study
    Rishil J Kathawala
    Corresponding Authors Zhe Sheng Chen, Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439
    Mol Cancer Ther 13:714-23. 2014
  7. pmc Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells
    Xing Xiang Peng
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:110-8. 2012
  8. pmc Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
    Zhe Sheng Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    FEBS J 278:3226-45. 2011
  9. ncbi request reprint Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Cancer Res 67:11012-20. 2007
  10. pmc OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
    Ye Hong Kuang
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 84:766-74. 2012

Collaborators

  • Tanaji T Talele
  • Li Wu Fu
  • Susan E Bates
  • Xiang Chen
  • Dong Hua Yang
  • Ioana Abraham
  • Hui Zhang
  • Rui Hua Xu
  • Wen Qi Jiang
  • Gary D Kruh
  • Li Zhang
  • Nagarajan Rajendra Prasad
  • Diaa T A Youssef
  • Tatsuhiko Furukawa
  • Vijaya L Damaraju
  • Shin ichi Akiyama
  • Amit K Tiwari
  • Kamlesh Sodani
  • Atish Patel
  • Rishil J Kathawala
  • Zhi Shi
  • Yue Li Sun
  • Suresh V Ambudkar
  • Satyakam Singh
  • Charles R Ashby
  • Jun Jiang Chen
  • Ye Hong Kuang
  • Xing Xiang Peng
  • Yi jun Wang
  • De Shen Wang
  • Tong Shen
  • Chun Ling Dai
  • Robert W Robey
  • Zhi jie Xiao
  • Suneet Shukla
  • Ying Zhou
  • In Wha Kim
  • Yun Kai Zhang
  • Nagaraju Anreddy
  • Priyank Kumar
  • Si dong Chen
  • Jay P Patel
  • Pei Rong Ding
  • Xin An
  • Elizabeth Hopper-Borge
  • Amal Kaddoumi
  • Eduardo E Chufan
  • Kang Chen
  • Alaa H Abuznait
  • Wen Deng
  • Jinhui Chen
  • Vijaya L Korlipara
  • Jeferson W K K Lee
  • Hsiang Chun Wu
  • Smitaben Parmar
  • Xiao Cong Huang
  • Qiu Sheng Si
  • Bhargav A Patel
  • Hong May Sim
  • Yang Lu Chen
  • Ralph Stephani
  • David P Brown
  • Hai Fan Chen
  • James M Gallo
  • Wen Cai Ye
  • Dong Mei Zhang
  • Ying jie Li
  • Chung Pu Wu
  • Saraubh G Vispute
  • Kelvin Zheng
  • Li Qiu Liao
  • Atish S Patel
  • Qi Si Lu
  • Shinobu Ohnuma
  • Xingxiang Peng
  • Yibo Sun
  • Si Rong Wang
  • Curtis S Goldblatt
  • Yining Shao
  • Angel Chen
  • Yu Lei
  • Yang Min Chen
  • Feiyang Zang
  • Jiangyong Ouyang
  • Amit Tiwari
  • Carol E Cass
  • Khalid El Sayed
  • Sandeep Jain

Detail Information

Publications40

  1. pmc Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
    Wen Deng
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, New York, NY 11439, USA
    Oncol Rep 29:2479-85. 2013
    ..Thus, we conclude that the FLT3 inhibitor tandutinib can reverse MRP7-mediated MDR through inhibition of the drug efflux function and may have potential to be used clinically in combination therapy for cancer patients...
  2. pmc Multidrug resistance associated proteins in multidrug resistance
    Kamlesh Sodani
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:58-72. 2012
    ..This review focuses mainly on the physiological functions, cellular resistance characteristics, and probable in vivo role of MRP1 to MRP9...
  3. pmc Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs
    Rishil J Kathawala
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 33:223-30. 2014
    ....
  4. pmc The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter
    Pei Rong Ding
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, United States of America
    PLoS ONE 6:e19329. 2011
    ..Overall, our results suggest that vardenafil reverses ABCB1-mediated MDR by directly blocking the drug efflux function of ABCB1...
  5. pmc Role of ABC transporters in cancer chemotherapy
    Yue Li Sun
    Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
    Chin J Cancer 31:51-7. 2012
    ..Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR...
  6. pmc Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study
    Rishil J Kathawala
    Corresponding Authors Zhe Sheng Chen, Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439
    Mol Cancer Ther 13:714-23. 2014
    ..In conclusion, the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10...
  7. pmc Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells
    Xing Xiang Peng
    Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
    Chin J Cancer 31:110-8. 2012
    ..These data suggest that the overexpression of P-gp may play a crucial role in acquired resistance to imatinib in CML K562-imatinib cells...
  8. pmc Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
    Zhe Sheng Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    FEBS J 278:3226-45. 2011
    ..The mutations in MRP2/ABCC2 leading to conjugated hyperbilirubinemia (Dubin-Johnson syndrome) and in MRP6/ABCC6 leading to the connective tissue disorder Pseudoxanthoma elasticum are also discussed...
  9. ncbi request reprint Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Cancer Res 67:11012-20. 2007
    ..These findings may be useful for cancer combinational therapy with erlotinib in the clinic...
  10. pmc OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
    Ye Hong Kuang
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 84:766-74. 2012
    ..Thus VKJP1 and VKJP3 represent a new class of drugs for reducing MDR in ABCG2 over-expressing tumors...
  11. pmc Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10)
    Tong Shen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, United States of America
    PLoS ONE 4:e7520. 2009
    ..In this study, we examined the effects of BCR-Abl tyrosine kinase inhibitors imatinib, nilotinib and dasatinib on the activity and expression of MRP7 in HEK293 cells transfected with MRP7, designated HEK-MRP7-2...
  12. pmc Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York 10016, USA
    Cancer Res 71:3029-41. 2011
    ..Our findings suggest a possible strategy to enhance the distribution and potentially the activity of anticancer drugs by jointly using a clinically approved drug with known side effects and drug-drug interactions...
  13. pmc Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Lett 328:307-17. 2013
    ..The beneficial actions of nilotinib warrant consideration as viable combinations in the clinic with agents that suffer from MDR-mediated insensitivity...
  14. pmc The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
    Oncol Rep 21:483-9. 2009
    ..These results will be useful in the development of novel and more effective EGFR TKIs as well as the development of combinational chemotherapeutic strategies...
  15. pmc PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter
    Jun Jiang Chen
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, USA
    Cancer Sci 103:1531-7. 2012
    ..Our findings indicate a potentially novel use of PDE5 inhibitors as an adjuvant chemotherapeutic agent in clinical practice...
  16. pmc Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells
    Ioana Abraham
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Biochem Pharmacol 80:1497-506. 2010
    ..In conclusion, sipholane triterpenoids efficiently inhibit the function of P-gp through direct interactions and may represent potential reversal agents for the treatment of MDR...
  17. pmc Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance
    Ye Hong Kuang
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 79:154-61. 2010
    ....
  18. doi request reprint PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
    Atish Patel
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Chemother Pharmacol 72:189-99. 2013
    ..In this study, we determine whether PD173074, a specific fibroblast growth factor receptor (FGFR) inhibitor, could reverse ABC transporter-mediated multidrug resistance...
  19. ncbi request reprint Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Cancer Sci 98:1373-80. 2007
    ....
  20. pmc Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo
    Kamlesh Sodani
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 89:52-61. 2014
    ..These results, provided that they can be translated to humans, suggesting that telatinib, in combination with specific ABCG2 substrate drugs may be useful in treating tumors that overexpress ABCG2...
  21. pmc bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10)
    Jun Jiang Chen
    Guangdong Key Laboratory for Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, New York, United States of America
    PLoS ONE 8:e74573. 2013
    ..Our findings suggest that BBA has the potential to be used in combination with conventional chemotherapeutic agents to augment the response to chemotherapy. ..
  22. pmc GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance
    Kamlesh Sodani
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Biochem Pharmacol 83:1613-22. 2012
    ..These findings may be useful in developing combination therapy for cancer treatment with EGFR TKIs...
  23. doi request reprint BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review
    Xin An
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Leuk Res 34:1255-68. 2010
    ..Here, we present an overview about the current treatment of Ph+ CML patients with the TKIs and the obstacles to successful treatment with these drugs...
  24. ncbi request reprint Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine
    Xing Xiang Peng
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, United States
    Leuk Res 32:799-809. 2008
    ..Taken together these results showed that up-regulation of MRP4 and down-regulation of influx transporters played a major role in 6-MP resistance of CEM-MP5 cells...
  25. ncbi request reprint Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2
    De Shen Wang
    Department of Medical Oncology, Sun Yat sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, China Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, New York, USA these authors contributed equally to this work
    Oncotarget 5:4529-42. 2014
    ..Our findings suggested different possible strategies of overcoming the resistance of topotecan and pemetrexed in the NSCLC patients. ..
  26. ncbi request reprint Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance
    Hui Zhang
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA Sun Yat Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
    Int J Biochem Cell Biol 51:111-9. 2014
    ..Overall, our study suggests that linsitinib attenuates ABCG2- and ABCC10-mediated MDR by directly inhibiting their function as opposed to altering ABCG2 or ABCC10 protein expression. ..
  27. ncbi request reprint AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
    Hui Zhang
    Sun Yat sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Cancer Lett 350:61-8. 2014
    ..Moreover, AST1306 stimulated the ATPase activity of ABCG2. Homology modeling predicted the binding conformation of AST1306 to be within the transmembrane region of ABCG2. In conclusion, AST1306 could notably reverse ABCG2-mediated MDR. ..
  28. pmc ARRY-334543 Reverses Multidrug Resistance by Antagonizing the Activity of ATP-Binding Cassette Subfamily G Member 2
    De Shen Wang
    Department of Medical Oncology, Sun Yat sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong, China Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, New York, USA
    J Cell Biochem 115:1381-91. 2014
    ..We conclude that ARRY-334543 significantly reverses drug resistance mediated by ABCG2. J. Cell. Biochem. 115: 1381-1391, 2014. © 2014 Wiley Periodicals, Inc. ..
  29. pmc Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar
    Yue Li Sun
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 8:e55576. 2013
    ....
  30. doi request reprint Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
    Yue Li Sun
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professionals, St John s University, Queens, New York, USA
    Anticancer Drugs 23:865-73. 2012
    ..Our findings suggest a possible strategy to potentially enhance the activity of anticancer drugs using a clinically approved drug with known side effects and drug-drug interactions...
  31. pmc Roles of sildenafil in enhancing drug sensitivity in cancer
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, USA
    Cancer Res 71:3735-8. 2011
    ..Emerging evidence indicates that sildenafil and other phosphodiesterase type 5 inhibitors may enhance the sensitivity of certain types of cancer to standard chemotherapeutic drugs...
  32. doi request reprint Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Biochem Pharmacol 78:153-61. 2009
    ..Also, these findings may be useful in clinical practice for cancer combination therapy with nilotinib...
  33. ncbi request reprint Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance
    Ying Zhou
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY, USA
    Biochem Pharmacol 77:993-1001. 2009
    ..E(2)17betaG transport was competitively inhibited by cepharanthine with a K(i) value of 4.86microM. These findings indicate that cepharanthine reverses MRP7-mediated resistance to paclitaxel in a competitive manner...
  34. pmc Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Biochem Pharmacol 77:781-93. 2009
    ..Our findings provide valuable contributions to the development of safer and more effective EGFR TKIs for use as anticancer agents in the clinic...
  35. pmc Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
    Rishil J Kathawala
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY, USA
    Int J Oncol 44:1634-42. 2014
    ..Overall, our in vitro findings suggest that masitinib reverses MDR to various anti-neoplastic drugs in HEK293 and H460 cells overexpressing ABCG2 by inhibiting their transport activity as opposed to altering their levels of expression...
  36. ncbi request reprint Revisiting the ABCs of multidrug resistance in cancer chemotherapy
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Curr Pharm Biotechnol 12:570-94. 2011
    ..This review briefly discusses the current knowledge regarding the clinical involvement of ABC transporters in MDR to antineoplastic drugs and highlights approaches undertaken so far to overcome ABC transporter-mediated MDR in cancer...
  37. pmc Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid
    Satyakam Singh
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, 8000 Utopia Parkway, Queens, New York 11439, United States
    J Med Chem 57:4058-72. 2014
    ..Biochemical and docking studies showed site-1 to be the preferable binding site for 28 within the drug-binding pocket of human P-gp. ..
  38. pmc Current status on marine products with reversal effect on cancer multidrug resistance
    Ioana Abraham
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
    Mar Drugs 10:2312-21. 2012
    ..This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones...
  39. doi request reprint Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930
    Jay P Patel
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
    Bioorg Med Chem Lett 21:6495-9. 2011
    ..Nitropyridyl derivative 5 and o-nitrophenyl derivative 7 exhibited complete inhibition of the ABCG2 pump with IC(50) values of 13.67μM and 16.67μM, respectively...
  40. doi request reprint New phenstatin-fatty acid conjugates: synthesis and evaluation
    Jinhui Chen
    Department of Chemistry, St John s University, Jamaica, NY 11439, USA
    Bioorg Med Chem Lett 23:5119-22. 2013
    ....