Research Topics
Species | Zhe Sheng ChenSummaryAffiliation: St. John's University Country: USA Publications
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Detail Information
Publications
Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cellsXing Xiang Peng
Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
Chin J Cancer 31:110-8. 2012..These data suggest that the overexpression of P-gp may play a crucial role in acquired resistance to imatinib in CML K562-imatinib cells...
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseasesZhe Sheng Chen
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
FEBS J 278:3226-45. 2011..The mutations in MRP2/ABCC2 leading to conjugated hyperbilirubinemia (Dubin-Johnson syndrome) and in MRP6/ABCC6 leading to the connective tissue disorder Pseudoxanthoma elasticum are also discussed...
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceZhi Shi
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
Cancer Res 67:11012-20. 2007..These findings may be useful for cancer combinational therapy with erlotinib in the clinic...- OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistanceYe Hong Kuang
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
Biochem Pharmacol 84:766-74. 2012..Thus VKJP1 and VKJP3 represent a new class of drugs for reducing MDR in ABCG2 over-expressing tumors... - Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cellsZhi Shi
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
Cancer Sci 98:1373-80. 2007.... - Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10)Tong Shen
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, United States of America
PLoS ONE 4:e7520. 2009..These findings suggest that imatinib or nilotinib, in combination with other antineoplastic drugs, may be useful in the treatment of certain resistant cancers... - Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistanceZhi Shi
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York 10016, USA
Cancer Res 71:3029-41. 2011..Our findings suggest a possible strategy to enhance the distribution and potentially the activity of anticancer drugs by jointly using a clinically approved drug with known side effects and drug-drug interactions... - The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistanceZhi Shi
Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
Oncol Rep 21:483-9. 2009..These results will be useful in the development of novel and more effective EGFR TKIs as well as the development of combinational chemotherapeutic strategies... - Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft modelsAmit K Tiwari
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
Cancer Lett 328:307-17. 2013..The beneficial actions of nilotinib warrant consideration as viable combinations in the clinic with agents that suffer from MDR-mediated insensitivity... - Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistanceYe Hong Kuang
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
Biochem Pharmacol 79:154-61. 2010.... - Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cellsIoana Abraham
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
Biochem Pharmacol 80:1497-506. 2010..In conclusion, sipholane triterpenoids efficiently inhibit the function of P-gp through direct interactions and may represent potential reversal agents for the treatment of MDR... - GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistanceKamlesh Sodani
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
Biochem Pharmacol 83:1613-22. 2012..These findings may be useful in developing combination therapy for cancer treatment with EGFR TKIs... - Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurineXing Xiang Peng
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, United States
Leuk Res 32:799-809. 2008..Taken together these results showed that up-regulation of MRP4 and down-regulation of influx transporters played a major role in 6-MP resistance of CEM-MP5 cells... - The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporterPei Rong Ding
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, United States of America
PLoS ONE 6:e19329. 2011..Overall, our results suggest that vardenafil reverses ABCB1-mediated MDR by directly blocking the drug efflux function of ABCB1... - Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidarYue Li Sun
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People s Republic of China
PLoS ONE 8:e55576. 2013.... - Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistanceYue Li Sun
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professionals, St John s University, Queens, New York, USA
Anticancer Drugs 23:865-73. 2012..Our findings suggest a possible strategy to potentially enhance the activity of anticancer drugs using a clinically approved drug with known side effects and drug-drug interactions... - PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporterJun Jiang Chen
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York, USA
Cancer Sci 103:1531-7. 2012..Our findings indicate a potentially novel use of PDE5 inhibitors as an adjuvant chemotherapeutic agent in clinical practice... - Roles of sildenafil in enhancing drug sensitivity in cancerZhi Shi
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, New York, USA
Cancer Res 71:3735-8. 2011..Emerging evidence indicates that sildenafil and other phosphodiesterase type 5 inhibitors may enhance the sensitivity of certain types of cancer to standard chemotherapeutic drugs... - BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a reviewXin An
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Leuk Res 34:1255-68. 2010..Here, we present an overview about the current treatment of Ph+ CML patients with the TKIs and the obstacles to successful treatment with these drugs... - Revisiting the ABCs of multidrug resistance in cancer chemotherapyAmit K Tiwari
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
Curr Pharm Biotechnol 12:570-94. 2011..This review briefly discusses the current knowledge regarding the clinical involvement of ABC transporters in MDR to antineoplastic drugs and highlights approaches undertaken so far to overcome ABC transporter-mediated MDR in cancer... - Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478Zhi Shi
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
Biochem Pharmacol 77:781-93. 2009..Our findings provide valuable contributions to the development of safer and more effective EGFR TKIs for use as anticancer agents in the clinic... - Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistanceYing Zhou
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY, USA
Biochem Pharmacol 77:993-1001. 2009..E(2)17betaG transport was competitively inhibited by cepharanthine with a K(i) value of 4.86microM. These findings indicate that cepharanthine reverses MRP7-mediated resistance to paclitaxel in a competitive manner... - Role of ABC transporters in cancer chemotherapyYue Li Sun
Department of Pharmaceutical Sciences, St John s University, Jamaica, NY 11439, USA
Chin J Cancer 31:51-7. 2012..Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR... - Multidrug resistance associated proteins in multidrug resistanceKamlesh Sodani
Department of Pharmaceutical Sciences, St John s University, Queens, NY 11439, USA
Chin J Cancer 31:58-72. 2012..This review focuses mainly on the physiological functions, cellular resistance characteristics, and probable in vivo role of MRP1 to MRP9... - Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930Jay P Patel
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Queens, NY 11439, USA
Bioorg Med Chem Lett 21:6495-9. 2011..Nitropyridyl derivative 5 and o-nitrophenyl derivative 7 exhibited complete inhibition of the ABCG2 pump with IC(50) values of 13.67μM and 16.67μM, respectively... - Current status on marine products with reversal effect on cancer multidrug resistanceIoana Abraham
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John s University, Queens, NY 11439, USA
Mar Drugs 10:2312-21. 2012..This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones... - Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transportersAmit K Tiwari
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Biochem Pharmacol 78:153-61. 2009..Also, these findings may be useful in clinical practice for cancer combination therapy with nilotinib...