Affiliation: St. Jude Children's Research Hospital
- A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantationXiaohua Chen
Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, MaiJ Stop 321, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
Exp Hematol 35:831-41. 2007..In this study, we designed the first TCRbeeta-based oligonucleotide microarray and investigated its specificity, clonality discrimination, sensitivity of detection, and feasibility for monitoring T-cell population diversity in HSCT...
- Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patientsXiaohua Chen
Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis TN 38105 2794, USA
Blood 105:886-93. 2005..Therefore, pretransplantation measurement of sjTREC may provide an important tool for predicting thymus-dependent T-cell reconstitution after transplantation...
- Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignanciesXiaohua Chen
Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
Br J Haematol 135:524-32. 2006..Rapid T-cell reconstitution, retention of NK-cells in the graft and induction of low grade GvHD may also enhance the potential anti-cancer immune effect...
- Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiationMario Otto
Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, 332N Lauderdale Street, Memphis, Tennessee 38105 2794, USA
Stem Cells 25:537-42. 2007..Use of different or multiple epitopes, targeting of alternate stem cell markers, or use of cell-depletion strategies might prevent this loss...
- Biology and plasticity of CD133+ hematopoietic stem cellsRupert Handgretinger
Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Ann N Y Acad Sci 996:141-51. 2003..CD133(+) stem cells might be useful for research and for clinical application...
- Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25- counterpartsKimberly A Kasow
Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 172:6123-8. 2004..However, reduced levels of TCR on regulatory T cells suggest different requirements for activation and may contribute to how the immune system regulates whether a particular response is suppressed or augmented...
- Molecular monitoring of immune reconstitution after haploidentical stem cell transplantationXiaohua Chen
Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 332N Lauderdale St, Memphis TN 38105 2794, USA
Curr Stem Cell Res Ther 3:75-8. 2008..We also propose future directions for clinical research incorporating these novel concepts...
- Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cellsLeonard D Shultz
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Immunol 174:6477-89. 2005..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment...
- Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantationRupert Handgretinger
Children s University Hospital, University of Tuebingen, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
Ann N Y Acad Sci 1106:279-89. 2007..For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation...
- Beyond the FACSRaymond Barfield
Stem Cells 25:2972. 2007