Xiaohua Chen

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi request reprint A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation
    Xiaohua Chen
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, MaiJ Stop 321, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Exp Hematol 35:831-41. 2007
  2. ncbi request reprint Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients
    Xiaohua Chen
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis TN 38105 2794, USA
    Blood 105:886-93. 2005
  3. ncbi request reprint Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies
    Xiaohua Chen
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 135:524-32. 2006
  4. ncbi request reprint Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation
    Mario Otto
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, 332N Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Stem Cells 25:537-42. 2007
  5. ncbi request reprint Biology and plasticity of CD133+ hematopoietic stem cells
    Rupert Handgretinger
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Ann N Y Acad Sci 996:141-51. 2003
  6. ncbi request reprint Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25- counterparts
    Kimberly A Kasow
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 172:6123-8. 2004
  7. ncbi request reprint Molecular monitoring of immune reconstitution after haploidentical stem cell transplantation
    Xiaohua Chen
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 332N Lauderdale St, Memphis TN 38105 2794, USA
    Curr Stem Cell Res Ther 3:75-8. 2008
  8. ncbi request reprint Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 174:6477-89. 2005
  9. ncbi request reprint Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation
    Rupert Handgretinger
    Children s University Hospital, University of Tuebingen, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Ann N Y Acad Sci 1106:279-89. 2007
  10. ncbi request reprint Beyond the FACS
    Raymond Barfield
    Stem Cells 25:2972. 2007

Detail Information

Publications10

  1. ncbi request reprint A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation
    Xiaohua Chen
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, MaiJ Stop 321, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Exp Hematol 35:831-41. 2007
    ..In this study, we designed the first TCRbeeta-based oligonucleotide microarray and investigated its specificity, clonality discrimination, sensitivity of detection, and feasibility for monitoring T-cell population diversity in HSCT...
  2. ncbi request reprint Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients
    Xiaohua Chen
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis TN 38105 2794, USA
    Blood 105:886-93. 2005
    ..Therefore, pretransplantation measurement of sjTREC may provide an important tool for predicting thymus-dependent T-cell reconstitution after transplantation...
  3. ncbi request reprint Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies
    Xiaohua Chen
    Division of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Haematol 135:524-32. 2006
    ..Rapid T-cell reconstitution, retention of NK-cells in the graft and induction of low grade GvHD may also enhance the potential anti-cancer immune effect...
  4. ncbi request reprint Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation
    Mario Otto
    Division of Stem Cell Transplantation, Department of Hematology Oncology, St Jude Children s Research Hospital, 332N Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Stem Cells 25:537-42. 2007
    ..Use of different or multiple epitopes, targeting of alternate stem cell markers, or use of cell-depletion strategies might prevent this loss...
  5. ncbi request reprint Biology and plasticity of CD133+ hematopoietic stem cells
    Rupert Handgretinger
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Ann N Y Acad Sci 996:141-51. 2003
    ..CD133(+) stem cells might be useful for research and for clinical application...
  6. ncbi request reprint Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25- counterparts
    Kimberly A Kasow
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 172:6123-8. 2004
    ..However, reduced levels of TCR on regulatory T cells suggest different requirements for activation and may contribute to how the immune system regulates whether a particular response is suppressed or augmented...
  7. ncbi request reprint Molecular monitoring of immune reconstitution after haploidentical stem cell transplantation
    Xiaohua Chen
    Division of Bone Marrow Transplantation and Cellular Therapy, Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 332N Lauderdale St, Memphis TN 38105 2794, USA
    Curr Stem Cell Res Ther 3:75-8. 2008
    ..We also propose future directions for clinical research incorporating these novel concepts...
  8. ncbi request reprint Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 174:6477-89. 2005
    ..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment...
  9. ncbi request reprint Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation
    Rupert Handgretinger
    Children s University Hospital, University of Tuebingen, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Ann N Y Acad Sci 1106:279-89. 2007
    ..For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation...
  10. ncbi request reprint Beyond the FACS
    Raymond Barfield
    Stem Cells 25:2972. 2007