John Butenhoff

Summary

Affiliation: St. Paul
Country: USA

Publications

  1. ncbi request reprint Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys
    Andrew M Seacat
    3M Medical Department, Saint Paul, Minnesota 55133, USA
    Toxicol Sci 68:249-64. 2002
  2. ncbi request reprint Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals
    David J Ehresman
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144 1000, USA
    Environ Res 103:176-84. 2007
  3. doi request reprint Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats
    John L Butenhoff
    Medical Department, 3M Company, Saint Paul, MN 55144, USA
    Toxicology 293:1-15. 2012
  4. doi request reprint Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats
    John L Butenhoff
    3M Company, Medical Department, 3M Center 220 06 W 08, Saint Paul, MN 55144, USA
    Toxicology 298:1-13. 2012
  5. doi request reprint Toxicological evaluation of ammonium perfluorobutyrate in rats: twenty-eight-day and ninety-day oral gavage studies
    John L Butenhoff
    Medical Department, 3M Company, 3M Center 220 06 W 08, St Paul, MN, USA
    Reprod Toxicol 33:513-30. 2012
  6. doi request reprint Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions
    John L Butenhoff
    Medical Department, 3M Company, St Paul, MN 55455, USA
    Toxicol Lett 210:360-5. 2012
  7. doi request reprint Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: developmental neurotoxicity
    John L Butenhoff
    Medical Department, 3M Company, 3M Center 220 6W 08, Saint Paul, MN 55144, USA
    Reprod Toxicol 27:319-30. 2009
  8. ncbi request reprint Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys
    J L Butenhoff
    3M, St Paul, Minnesota 55144, USA
    Toxicol Sci 82:394-406. 2004
  9. ncbi request reprint Characterization of risk for general population exposure to perfluorooctanoate
    John L Butenhoff
    Medical Department, 3M Company, Building 220 2E 02, St Paul, MN 55144, USA
    Regul Toxicol Pharmacol 39:363-80. 2004
  10. doi request reprint Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats
    John L Butenhoff
    3M Company, Medical Department, 3M Center 220 6W 08, St Paul, MN 55144, USA
    Reprod Toxicol 27:331-41. 2009

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys
    Andrew M Seacat
    3M Medical Department, Saint Paul, Minnesota 55133, USA
    Toxicol Sci 68:249-64. 2002
    ..8 +/- 10.8 ppm for females. Comparison of serum PFOS concentrations associated with no adverse effect in this study to those reported in human blood samples (0.028 +/- 0.014 ppm) indicated an adequate margin of safety...
  2. ncbi request reprint Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals
    David J Ehresman
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144 1000, USA
    Environ Res 103:176-84. 2007
    ..The difference between plasma and serum and whole blood corresponded to volume displacement by red blood cells, suggesting that the fluorochemicals are not found intracellularly or attached to the red blood cells...
  3. doi request reprint Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats
    John L Butenhoff
    Medical Department, 3M Company, Saint Paul, MN 55144, USA
    Toxicology 293:1-15. 2012
    ..Recent mechanistic studies suggest a PPARĪ±/CAR/PXR-mediated mode of action for the liver tumors observed in the present two-year study...
  4. doi request reprint Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats
    John L Butenhoff
    3M Company, Medical Department, 3M Center 220 06 W 08, Saint Paul, MN 55144, USA
    Toxicology 298:1-13. 2012
    ..All other tumor types were those seen spontaneously in rats of this stock and age and were not associated with feeding of APFO...
  5. doi request reprint Toxicological evaluation of ammonium perfluorobutyrate in rats: twenty-eight-day and ninety-day oral gavage studies
    John L Butenhoff
    Medical Department, 3M Company, 3M Center 220 06 W 08, St Paul, MN, USA
    Reprod Toxicol 33:513-30. 2012
    ..No observable adverse effect levels (NOAELs) were 6 and >150mg/kg-d for male and female rats in the 28-day study and 6 and >30mg/kg-d in the 90-dat study, respectively...
  6. doi request reprint Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions
    John L Butenhoff
    Medical Department, 3M Company, St Paul, MN 55455, USA
    Toxicol Lett 210:360-5. 2012
    ..These data do not support a strong role for plasma lipoprotein fractions in explaining the inconsistent dose-response associations reported in cross-sectional epidemiological studies...
  7. doi request reprint Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: developmental neurotoxicity
    John L Butenhoff
    Medical Department, 3M Company, 3M Center 220 6W 08, Saint Paul, MN 55144, USA
    Reprod Toxicol 27:319-30. 2009
    ..0mg/kg-d. Mean serum concentrations of PFOS reported in a companion article for the 0.3mg/kg-d group maternal rats are several hundred times higher than those reported for females in the United States general population...
  8. ncbi request reprint Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys
    J L Butenhoff
    3M, St Paul, Minnesota 55144, USA
    Toxicol Sci 82:394-406. 2004
    ..Based on the result of both the oral and iv studies, the elimination half-life is approximately 14-42 days, and urine is the primary route of excretion...
  9. ncbi request reprint Characterization of risk for general population exposure to perfluorooctanoate
    John L Butenhoff
    Medical Department, 3M Company, Building 220 2E 02, St Paul, MN 55144, USA
    Regul Toxicol Pharmacol 39:363-80. 2004
    ..These MOE values represent substantial protection of children, adults, and the elderly...
  10. doi request reprint Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats
    John L Butenhoff
    3M Company, Medical Department, 3M Center 220 6W 08, St Paul, MN 55144, USA
    Reprod Toxicol 27:331-41. 2009
    ..Serum and liver concentrations of PFHxS are reported for parents, fetuses, and pups. PFHxS was not a reproductive or developmental toxicant under study conditions...
  11. ncbi request reprint Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months
    John Butenhoff
    3M, St Paul, Minnesota 55144 University of Verona, Verona 37134, Italy University of Dundee, Dundee DD1 95Y, Scotland Ineos Chlor, Runcorn, Cheshire WA7 4JE, United Kingdom
    Toxicol Sci 69:244-57. 2002
    ..In particular, effects that have been associated with the development of pancreatic and testicular toxicity in rats were not observed in this study...
  12. doi request reprint Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:387-99. 2009
    ..1-fold over control in GD 20 female fetuses from 1.0mg/kg-d-treated dams, yet the highest individual count was similar to that of controls (116 versus 113 in controls)...
  13. ncbi request reprint Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, United States
    Toxicology 243:330-9. 2008
    ..We undertook this study to investigate the causes for the PFOS-induced reduction of serum total thyroxine (TT4) in rats...
  14. ncbi request reprint Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
    Andrew M Seacat
    3M Medical Department, Corporate Toxicology, 3M Center 220 2E 02, Saint Paul, MN 55133, USA
    Toxicology 183:117-31. 2003
    ....
  15. doi request reprint Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Toxicol Sci 104:40-53. 2008
    ..These findings demonstrate that PFBA is eliminated efficiently from serum with a low potential for accumulation from repeated exposure...
  16. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
    ..The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals...
  17. ncbi request reprint Negative bias from analog methods used in the analysis of free thyroxine in rat serum containing perfluorooctanesulfonate (PFOS)
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Toxicology 234:21-33. 2007
    ..A reference method such as ED-RIA should be used for determination of serum FT4 in the presence of PFOS...
  18. ncbi request reprint Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, American Red Cross, North Central Region, St Paul, Minnesota, USA
    Environ Sci Technol 42:4989-95. 2008
    ..Direct and indirect exposure sources of PFOA could include historic and ongoing electrochemical cell fluorination (ECF) of PFOA, telomer production of PFOA, fluorotelomer-based precursors, and other fluoropoly-mer production...
  19. doi request reprint A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144 1000, USA
    Toxicology 256:65-74. 2009
    ..Thus, compared to PFOS and PFHxS, PFBS has a much lower potential for accumulation in human serum after repeated occupational, non-occupational (e.g., consumer), or environmental exposures...
  20. doi request reprint A two-generation oral gavage reproduction study with potassium perfluorobutanesulfonate (K+PFBS) in Sprague Dawley rats
    Paul H Lieder
    3M Company, St Paul, MN, USA
    Toxicology 259:33-45. 2009
    ..Essentially no effects were observed in the F1 females. F2 pups had normal body weights. The reproductive NOAEL was >1000mg/kg/day in both generations...
  21. doi request reprint Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
    ..Important issues are addressed regarding the methods and data analysis that may limit inferences from this particular study...
  22. doi request reprint Toxicological evaluation of potassium perfluorobutanesulfonate in a 90-day oral gavage study with Sprague-Dawley rats
    Paul H Lieder
    3M Company, St Paul, MN, USA
    Toxicology 255:45-52. 2009
    ..The NOAEL for the female rat in this study was 600 mg/kg-day (highest dose of study). The NOAEL for the male rat was 60 mg/kg-day based on hematological effects...
  23. ncbi request reprint Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors
    Geary W Olsen
    3M Company, Medical Department, St Paul, MN 55144, USA
    Chemosphere 68:105-11. 2007
    ..0001). The decrease was consistent across donors' age and sex. To confirm these preliminary findings, additional sub-sets of year 2000 samples will be analyzed, and a much larger biomonitoring study of other locations is planned...
  24. ncbi request reprint Interactions of fluorochemicals with rat liver fatty acid-binding protein
    Deanna J Luebker
    3M Medical Department, Corporate Toxicology, 3M Center Building 220 2E 02, Saint Paul, MN 55144, USA
    Toxicology 176:175-85. 2002
    ..Furthermore, this work provides evidence to support the hypothesis that displacement of endogenous ligands from L-FABP may contribute to toxicity in rodents fed these fluorochemicals...
  25. ncbi request reprint The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat
    John L Butenhoff
    3M Medical Department, Corporate Toxicology, 3M Center 220 2E 02, Saint Paul, MN 55133, USA
    Toxicology 196:95-116. 2004
    ....
  26. ncbi request reprint 13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats
    Roger G Perkins
    3M Medical Department, Corporate Toxicology, St Paul, MN 55144, USA
    Drug Chem Toxicol 27:361-78. 2004
    ..1, 41, 70, and 138 microg/mL in the 1, 10, 30 and 100 ppm dose groups. The study no effect level was 1 ppm (0.06 microg/mg) with doses of 10 ppm (0.64 microg/mg) and higher producing adaptive and reversible liver changes...
  27. pmc Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144, USA
    Environ Health Perspect 113:539-45. 2005
    ..Comparison with other regional data collected in 2001 did not suggest a continued increase in concentrations since 1989...
  28. ncbi request reprint Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters
    Deanna J Luebker
    3M Medical Department, Corporate Toxicology and Regulatory Services, 3M Center Building 220 06 E 03, St Paul, MN 55144, USA
    Toxicology 215:149-69. 2005
    ..Significant transfer of PFOS from dam to fetus in utero was confirmed, and results suggest that dam and corresponding fetal body burdens, as indicated by serum and liver PFOS levels, correlate with neonatal survival...
  29. ncbi request reprint Two-generation reproduction and cross-foster studies of perfluorooctanesulfonate (PFOS) in rats
    Deanna J Luebker
    3M Medical Department, Corporate Toxicology and Regulatory Services, 3M Center Building 220 06 E 03, St Paul, MN 55144, USA
    Toxicology 215:126-48. 2005
    ..Results of this study indicated that in utero exposure to PFOS causally contributed to post-natal pup mortality, and that pre-natal and post-natal exposure to PFOS was additive with respect to the toxic effects observed in pups...
  30. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
    ....
  31. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:382-92. 2003
    ..These results indicate that in utero exposure to PFOS severely compromised postnatal survival of neonatal rats and mice, and caused delays in growth and development that were accompanied by hypothyroxinemia in the surviving rat pups...
  32. ncbi request reprint Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives
    Melvin E Andersen
    CIIT Centers for Health Research, Research Triangle Park, NC 27709 2137, United States
    Toxicology 227:156-64. 2006
    ..PFOS has longer half-life and had respective values of 13.6 mg/(h kg), 0.023 mg/L, and 0.025. PFOS appeared to have a higher transport capacity and lower affinity than PFOA. Human kinetics indicates even higher resorption efficiency...
  33. ncbi request reprint trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals
    Jonathan M Shipley
    Division of Cell and Molecular Biology, Department of Biology, Boston University, 5 Cummington Street, Boston, Massachusetts 02215, USA
    Toxicol Sci 80:151-60. 2004
    ....
  34. ncbi request reprint Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450
    Lin Xu
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14624, USA
    Chem Res Toxicol 17:767-75. 2004
    ..These results show that the major pathway for the biotransformation of N-EtFOSE is N-dealkylation to give FOSA. The biotransformation of FOSA to PFOS explains the observation that PFOS is found in animals given N-EtFOSE...
  35. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations
    Julie R Thibodeaux
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:369-81. 2003
    ..Our results demonstrate both maternal and developmental toxicity of PFOS in the rat and mouse...
  36. ncbi request reprint The toxicology of perfluorooctanoate
    Gerald L Kennedy
    DuPont, Newark, Delaware, USA
    Crit Rev Toxicol 34:351-84. 2004
    ..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects...
  37. ncbi request reprint Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats
    Paul M Hinderliter
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
    Toxicology 211:139-48. 2005
    ..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure...
  38. ncbi request reprint Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action
    Melvin E Andersen
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:3-14. 2008
    ..This report summarizes the discourse that occurred during the symposium...
  39. doi request reprint Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression
    James A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, USA
    Toxicology 251:8-20. 2008
    ....
  40. doi request reprint Effects of perfluorobutyrate exposure during pregnancy in the mouse
    Kaberi P Das
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:173-81. 2008
    ..These data suggest that exposure to PFBA during pregnancy in the mouse did not produce developmental toxicity comparable to that observed with PFOA, in part, due to rapid elimination of the chemical...
  41. ncbi request reprint Perfluorinated compounds in human milk from Massachusetts, U.S.A
    Lin Tao
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Environ Sci Technol 42:3096-101. 2008
    ..We found that the daily ingestion rates of PFOS and PFOA did not exceed the tolerable daily intake recommended by the U.K. Food Standards Agency. This is the first study to measure the occurrence of PFCs in human milk from the U.S.A...
  42. pmc An interlaboratory study of perfluorinated alkyl compound levels in human plasma
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, MD A3 05, Research Triangle Park, NC 27709, USA
    Environ Res 107:152-9. 2008
    ..Considering the degree of between-subject variation in levels among people in background-exposed populations, the results indicate that biomarker-based epidemiologic studies of associations with health could have reasonable precision...
  43. ncbi request reprint The developmental toxicity of perfluoroalkyl acids and their derivatives
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 198:231-41. 2004
    ..Based on current understanding of the developmental effects of PFOS and PFOA in rodents, several avenues of research are suggested that would further support the risk assessment of these perfluorinated organic chemicals...
  44. ncbi request reprint N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases
    Lin Xu
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Drug Metab Dispos 34:1406-10. 2006
    ..These data show that rat liver UGT1.1, UGT2B1, and UGT2B12 catalyze the N-glucuronidation of FOSA, albeit at low rates, and that hUGT2B4 and hUGT2B7 catalyze the N-glucuronidation of FOSA...