Alberto Broniscer

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. pmc Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 19:3050-8. 2013
  2. ncbi request reprint Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer 106:1364-71. 2006
  3. pmc Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
  4. pmc Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
  5. doi request reprint Young age may predict a better outcome for children with diffuse pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 113:566-72. 2008
  6. ncbi request reprint Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Clin Cancer Res 13:6712-8. 2007
  7. pmc Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Cancer 116:4632-7. 2010
  8. ncbi request reprint Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 13:1511-5. 2007
  9. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
  10. ncbi request reprint Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 100:2246-52. 2004

Detail Information

Publications55

  1. pmc Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 19:3050-8. 2013
    ....
  2. ncbi request reprint Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer 106:1364-71. 2006
    ..In the current study, the authors assessed the characteristics and estimated the cumulative incidence of IH among children with BSG...
  3. pmc Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    St Jude Children s Research Hospital, Memphis, TN, USA
    J Clin Oncol 28:4762-8. 2010
    ....
  4. pmc Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
    ....
  5. doi request reprint Young age may predict a better outcome for children with diffuse pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 113:566-72. 2008
    ..Because diffuse pontine glioma (DPG) is rare among young children, the outcome of affected patients is unknown...
  6. ncbi request reprint Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Clin Cancer Res 13:6712-8. 2007
    ..To estimate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of escalating doses of temozolomide combined with O(6)-benzylguanine in patients < or =21 years with recurrent brain tumors...
  7. pmc Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Cancer 116:4632-7. 2010
    ..A prospective, multicenter study was conducted to assess the feasibility of tissue collection at autopsy and its suitability for molecular analyses in children with diffuse intrinsic pontine glioma...
  8. ncbi request reprint Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 13:1511-5. 2007
    ..To report cerebrospinal fluid (CSF) penetration of erlotinib and its metabolite OSI-420...
  9. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  10. ncbi request reprint Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children's Research Hospital experience
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 100:2246-52. 2004
    ..Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. The goal of the current study was to investigate and characterize these rare SNs...
  11. ncbi request reprint Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist
    Alberto Broniscer
    Division of Neuro Oncology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Oncologist 9:197-206. 2004
    ..Because the outcome for patients with either type of tumor is poor when standard multimodality therapy is used, these children are ideal candidates for innovative treatment approaches...
  12. ncbi request reprint Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 76:313-9. 2006
    ..Although the heterogeneity of prognostic factors in our patients made assessment of treatment outcome more difficult, the addition of 6 cycles of temozolomide after radiotherapy did not seem to alter the poor outcome of these patients...
  13. ncbi request reprint Past, present, and future strategies in the treatment of high-grade glioma in children
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Invest 24:77-81. 2006
    ..Despite the use of multimodality therapy, less than 20 percent of these children are long-term survivors. This review provides an overview of relevant past, current and future treatment strategies for high-grade glioma in children...
  14. ncbi request reprint Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98)
    Alberto Broniscer
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 103:133-9. 2005
    ..The role of chemotherapy in the treatment of children with newly diagnosed diffuse brainstem glioma is uncertain. In the current study, the authors tested the efficacy of temozolomide treatment after radiotherapy (RT) in this setting...
  15. pmc Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma
    Shawna L Palmer
    Department of Behavioral Medicine, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Neuro Oncol 12:1311-7. 2010
    ..This study highlights the need for careful follow-up with neuropsychological evaluation and for obtaining critical support for patients and their families...
  16. ncbi request reprint Survival and late mortality in long-term survivors of pediatric CNS tumors
    E Brannon Morris
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:1532-8. 2007
    ..To describe the pattern of survival and late mortality among contemporary long-term survivors of pediatric CNS tumor...
  17. pmc Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma
    Maryam Fouladi
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    J Clin Oncol 26:3749-55. 2008
    ....
  18. pmc White matter integrity is associated with cognitive processing in patients treated for a posterior fossa brain tumor
    Shawna L Palmer
    Department of Psychology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuro Oncol 14:1185-93. 2012
    ..Neuroprotective strategies are needed to preserve critical functions...
  19. pmc Sequencing of local therapy affects the pattern of treatment failure and survival in children with atypical teratoid rhabdoid tumors of the central nervous system
    Atmaram S Pai Panandiker
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 82:1756-63. 2012
    ..To assess the pattern of treatment failure associated with current therapeutic paradigms for childhood atypical teratoid rhabdoid tumors (AT/RT)...
  20. doi request reprint Resection of infantile brain tumors after neoadjuvant chemotherapy: the St. Jude experience
    Mark Van Poppel
    Division of Pediatric Neurosurgery, University of Tennessee College of Medicine, Memphis, Tennessee, USA
    J Neurosurg Pediatr 8:251-6. 2011
    ....
  21. doi request reprint Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial
    Stephen J Laughton
    Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:1112-8. 2008
    ....
  22. ncbi request reprint High-grade astrocytoma in very young children
    Robert P Sanders
    Division of Neuro Oncology, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 49:888-93. 2007
    ..High-grade astrocytomas are rare in young children, but have been reported to have a better prognosis than similar tumors in older patients...
  23. ncbi request reprint Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  24. pmc The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
    Gang Wu
    1 Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2
    Nat Genet 46:444-50. 2014
    ..This comprehensive analysis provides insights into the unique and shared pathways driving pediatric HGG within and outside the brainstem. ..
  25. pmc Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma
    Sadhana Jackson
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Neurooncol 114:339-44. 2013
    ..These patients remained at high risk for tumor progression even after long follow-ups. Four of our long-term survivors had clinical and radiologic characteristics at diagnosis associated with improved outcome...
  26. ncbi request reprint Concordance between the chang and the International Society of Pediatric Oncology (SIOP) ototoxicity grading scales in patients treated with cisplatin for medulloblastoma
    Johnnie K Bass
    Rehabilitation Services, St Jude Children s Research Hospital, Memphis, Tennessee School of Communication Sciences and Disorders, University of Memphis, Memphis, Tennessee
    Pediatr Blood Cancer 61:601-5. 2014
    ..Differences between the two scales were identified and the implications these differences may have in the clinical setting were discussed...
  27. pmc Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 29:3999-4006. 2011
    ..We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG...
  28. pmc Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 19:305-16. 2011
    ..Gene expression profiling revealed striking similarities to subclasses of human diffuse astrocytoma. Astrocytomas were found within and outside of proliferative niches in the adult brain...
  29. ncbi request reprint Phase I study of everolimus in pediatric patients with refractory solid tumors
    Maryam Fouladi
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Clin Oncol 25:4806-12. 2007
    ....
  30. pmc M1 Medulloblastoma: high risk at any age
    Robert P Sanders
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    J Neurooncol 90:351-5. 2008
    ..The prognosis for children with M1 medulloblastoma (positive CSF cytology) has not been well-defined...
  31. doi request reprint Magnetic resonance imaging is the preferred method to assess treatment-related skeletal changes in children with brain tumors
    Sue C Kaste
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, MSN 220, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 60:1552-6. 2013
    ..To evaluate the growing skeleton for potential altered skeletalgenesis associated with antiangiogenesis therapy...
  32. pmc Brain tumor therapy-induced changes in normal-appearing brainstem measured with longitudinal diffusion tensor imaging
    Chiaho Hua
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN, USA
    Int J Radiat Oncol Biol Phys 82:2047-54. 2012
    ..To characterize therapy-induced changes in normal-appearing brainstems of childhood brain tumor patients by serial diffusion tensor imaging (DTI)...
  33. pmc Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma
    James G Gurney
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis Tenneessee J G G, G T A Department of Rehabilitation Service, St Jude Children s Research Hospital, Memphis Tenneessee J K B Department of Biostatistics, St Jude Children s Research Hospital, Memphis Tenneessee A O T, J H Department of Oncology, St Jude Children s Research Hospital, Memphis Tenneessee C W, I Q, G T A, A B, A G Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis Tenneessee, A P P, T E M Department of Bone Marrow Transplantation, St Jude Children s Research Hospital, Memphis, Tenneessee A S Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis Tenneessee C F S Department of Pediatrics, Texas Children s Cancer Center, Houston, Texas M C Hospital for Sick Children, Toronto, Ontario, Canada E B Royal Children s Hospital Brisbane, Herston, Australia T H The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina S G The Royal Children s Hospital Melbourne, Victoria
    Neuro Oncol 16:848-55. 2014
    ..In addition, this study aimed to assess amifostine with serious hearing loss in patients with high-risk medulloblastoma treated with cisplatin...
  34. pmc Feasibility and efficacy of a computer-based intervention aimed at preventing reading decoding deficits among children undergoing active treatment for medulloblastoma: results of a randomized trial
    Shawna L Palmer
    Department of Psychology, St Jude Children s Research Hospital, Mail Stop 740, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Pediatr Psychol 39:450-8. 2014
    ..To investigate the feasibility of a computer-based reading intervention completed by patients diagnosed with a brain tumor...
  35. pmc Diagnostic utility and correlation of tumor markers in the serum and cerebrospinal fluid of children with intracranial germ cell tumors
    Ibrahim Qaddoumi
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Childs Nerv Syst 28:1017-24. 2012
    ....
  36. ncbi request reprint Effect of time from diagnosis to start of radiotherapy on children with diffuse intrinsic pontine glioma
    Atmaram S Pai Panandiker
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee
    Pediatr Blood Cancer 61:1180-3. 2014
    ..In this retrospective analysis, we studied the effect of time from diagnosis to start of RT on event-free survival (EFS) and overall survival (OS) in children with DIPG...
  37. ncbi request reprint Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH)...
  38. pmc Dysembryoplastic neuroepithelial tumors and cognitive outcome: cure at a price?
    Ibrahim Qaddoumi
    Division of Neuro Oncology, Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 116:5461-9. 2010
    ..Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection...
  39. pmc Determination of vandetanib in human plasma and cerebrospinal fluid by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS)
    Feng Bai
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 879:2561-6. 2011
    ..98, %CV ≤ 4.97, n=6). This method was successfully applied to the analysis of pharmacokinetic samples from children with brain tumors treated with oral vandetanib...
  40. pmc Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma
    Ulrike Löbel
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Mail Stop 220, Memphis, TN 38105, USA
    Neuroradiology 52:1167-77. 2010
    ....
  41. pmc Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature
    Shannon R Christiansen
    Department of Pharmaceutical Services, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pharmacotherapy 29:858-66. 2009
    ....
  42. ncbi request reprint "Occult" post-contrast signal enhancement in pediatric diffuse intrinsic pontine glioma is the MRI marker of angiogenesis?
    Ashley E Conway
    Department of Radiological Sciences, St Jude Children s Research Hospital, MS220, 262 Danny Thomas Place, Memphis, TN, 38105, USA
    Neuroradiology 56:405-12. 2014
    ..We hypothesized that this represents intravascular enhancement related to angiogenesis and hence that these tumors should have greater blood volume fractions than do non-enhancing tumors...
  43. pmc Characterization, treatment, and outcome of intracranial neoplasms in the first 120 days of life
    Ibrahim Qaddoumi
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    J Child Neurol 26:988-94. 2011
    ....
  44. pmc Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    Gang Wu
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 44:251-3. 2012
    ..3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration...
  45. doi request reprint Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosurg Pediatr 1:270-6. 2008
    ..The authors sought to determine whether DT imaging and white matter tractography could detect axonal degeneration in patients with brainstem tumors...
  46. pmc Bone marrow transplantation for severe aplastic anemia secondary to temozolomide
    E Brannon Morris
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Neurooncol 91:237-9. 2009
    ..We report the case of an adolescent patient with a high-grade glioma who, after >2 years of event-free survival, underwent successful bone marrow transplantation for treatment of temozolomide-induced severe aplastic anemia (SAA)...
  47. pmc Alexander disease: An important mimicker of focal brainstem glioma
    Katherine Van Poppel
    Division of Neurology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Pediatr Blood Cancer 53:1355-6. 2009
    ..AD is a neurodegenerative disease which must be included in the differential for tumor-like lesions within the posterior fossa...
  48. pmc Bereaved parents' intentions and suggestions about research autopsies in children with lethal brain tumors
    Justin Nathaniel Baker
    Division of Quality of Life and Palliative Care, Department of Pediatric Medicine, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr 163:581-6. 2013
    ..To determine bereaved parents' perceptions about participating in autopsy-related research and to elucidate their suggestions about how to improve the process...
  49. pmc Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007
    Ching Hon Pui
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 30:2005-12. 2012
    ..Treatment outcome for black patients with cancer has been significantly worse than for their white counterparts. We determined whether recent improved treatment had narrowed the gap in outcome between black and white pediatric patients...
  50. pmc Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 28:3061-8. 2010
    ..To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG)...
  51. pmc Pediatric low-grade gliomas and the need for new options for therapy: Why and how?
    Ibrahim Qaddoumi
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Biol Ther 8:4-10. 2009
    ..Such progress in pilocytic astrocytoma needs to be consolidated and expanded to other histologic varieties of pediatric low-grade gliomas...
  52. pmc Determination of crizotinib in human and mouse plasma by liquid chromatography electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS)
    Michael S Roberts
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 960:151-7. 2014
    ..The method was successfully applied to analyze crizotinib concentrations in plasma samples collected from children enrolled on a phase I pediatric study investigating the use of crizotinib for treatment of pediatric brain tumors...
  53. ncbi request reprint Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Cons
    Mark W Kieran
    Dana Farber Cancer Institute and Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 25:3137-43. 2007
    ..Primary objectives were to estimate the maximum-tolerated dose (MTD) and to describe the dose-limiting toxicities (DLTs) and pharmacokinetics of lonafarnib. Farnesylation inhibition of HDJ-2 in peripheral blood was also measured...
  54. pmc Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma
    Daphne A Haas-Kogan
    University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 10:341-7. 2008
    ..The MTD of tipifarnib with concurrent radiation is 125 mg/m(2)/dose b.i.d. One-year survival and progression-free survival estimates are 36.4% (SE 16.7%) and 9.4% (SE 6.3%), respectively...
  55. ncbi request reprint High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumors
    Alberto Broniscer
    Children s Cancer Group New York University Medical Center, New York, NY, USA
    Pediatr Blood Cancer 42:261-7. 2004
    ..XSWe tested the efficacy of high-dose chemotherapy (HDC) followed by autologous stem-cell rescue (ASCR) in this setting...