Suzanne Baker

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. ncbi Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN, 38105, USA
    Transgenic Res 17:919-28. 2008
  2. ncbi Redefining p53--entering the tumor suppressor era
    Suzanne J Baker
    Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA
    Cell Cycle 2:7-8. 2003
  3. ncbi PTEN and the PI3-kinase pathway in cancer
    Nader Chalhoub
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Annu Rev Pathol 4:127-50. 2009
  4. ncbi PTEN enters the nuclear age
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 128:25-8. 2007
  5. ncbi Tumour-suppressor function in the nervous system
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    Nat Rev Cancer 4:184-96. 2004
  6. ncbi Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Cancer 116:4632-7. 2010
  7. ncbi Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
  8. ncbi Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
  9. ncbi mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    Chang Hyuk Kwon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 100:12923-8. 2003
  10. ncbi PTEN function in normal and neoplastic growth
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Lett 241:184-96. 2006

Research Grants

  1. Normal and Neoplastic Growth Regulation in the Brain
    Suzanne Baker; Fiscal Year: 2007
  2. Pten regulation of growth and neoplasia in the brain
    Suzanne Baker; Fiscal Year: 2006
  3. Molecular Pathogenesis of Ewing Sarcoma
    Suzanne Baker; Fiscal Year: 2005
  4. Pten and P13K regulation of growth and neoplasia in the brain
    Suzanne J Baker; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN, 38105, USA
    Transgenic Res 17:919-28. 2008
    ..These mouse lines will provide important tools to dissect gene function in glial cells and in gliomagenesis...
  2. ncbi Redefining p53--entering the tumor suppressor era
    Suzanne J Baker
    Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA
    Cell Cycle 2:7-8. 2003
  3. ncbi PTEN and the PI3-kinase pathway in cancer
    Nader Chalhoub
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Annu Rev Pathol 4:127-50. 2009
    ..The significance and complexity of PI3K signaling make it an important but challenging therapeutic target for cancer...
  4. ncbi PTEN enters the nuclear age
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell 128:25-8. 2007
    ..2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability...
  5. ncbi Tumour-suppressor function in the nervous system
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    Nat Rev Cancer 4:184-96. 2004
  6. ncbi Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    Cancer 116:4632-7. 2010
    ..A prospective, multicenter study was conducted to assess the feasibility of tissue collection at autopsy and its suitability for molecular analyses in children with diffuse intrinsic pontine glioma...
  7. ncbi Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Mail Stop 260, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 15:701-7. 2009
    ....
  8. ncbi Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  9. ncbi mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    Chang Hyuk Kwon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 100:12923-8. 2003
    ..mTOR inhibitors may be useful therapeutic agents for diseases in brain resulting from PTEN deficiency such as Lhermitte-Duclos disease or glioblastoma multiforme...
  10. ncbi PTEN function in normal and neoplastic growth
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Lett 241:184-96. 2006
    ..Elucidation of the mechanisms regulating activation of unique downstream effectors that mediate distinct outcomes of PTEN loss will augment our understanding of tumorigenesis and ultimately lead to novel therapeutic options...
  11. ncbi Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 28:3061-8. 2010
    ..To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG)...
  12. ncbi Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains
    Nader Chalhoub
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 23:1619-24. 2009
    ..Our results show Pdk1-dependent and Pdk1-independent abnormalities in Pten-deficient brains, and demonstrate cell type specific differences in feedback regulation of the ubiquitous PI3K pathway...
  13. ncbi Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 29:3999-4006. 2011
    ..We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG...
  14. ncbi Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells
    Joby J Westmoreland
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 334:285-98. 2009
    ....
  15. ncbi Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Dev Dyn 235:2991-8. 2006
    ..This mouse line provides a powerful tool to dissect gene function at early and late stages in development of the cerebellum and inner ear...
  16. ncbi S6k1 is not required for Pten-deficient neuronal hypertrophy
    Nader Chalhoub
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Brain Res 1100:32-41. 2006
    ..Thus, we conclude that S6k1 is not required to cause hypertrophy of Pten-deficient neurons. This study reveals a cell type-dependent role for S6k1 in PI3K-dependent hypertrophy...
  17. ncbi Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
    Melissa M Fraser
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 64:7773-9. 2004
    ..This study shows cell-type dependent effects of Pten loss in the adult brain, including increased astrocyte proliferation that may render astroglial cells susceptible to neoplastic transformation or malignant progression...
  18. ncbi Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex
    Chuan He Yang
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis 38103, USA
    Exp Cell Res 298:197-206. 2004
    ....
  19. ncbi The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo
    Tomohiro Kawaguchi
    Brain Tumor Research Center, Department of Neurological Surgery, The University of California-San Francisco Comprehensive Cancer Center, CA 94115-0875, USA
    Cancer Res 66:11331-40. 2006
    ..These results show that tumstatin, previously considered to be only an endogenous inhibitor of angiogenesis, also directly inhibits the growth of tumors in a manner dependent on Akt/mTOR activation...

Research Grants14

  1. Normal and Neoplastic Growth Regulation in the Brain
    Suzanne Baker; Fiscal Year: 2007
    ..This includes characterization of the function of downstream effector genes in the cerebellum and the creation of new mutant mouse strains to investigate its contribution to growth, proliferation and tumorigenesis. ..
  2. Pten regulation of growth and neoplasia in the brain
    Suzanne Baker; Fiscal Year: 2006
    ..We will determine if the same signaling pathways that contribute to aberrant regulation of cell size in post-mitotic neurons are critical to Pten function in normal and neoplastic growth in astrocytes. ..
  3. Molecular Pathogenesis of Ewing Sarcoma
    Suzanne Baker; Fiscal Year: 2005
    ..Finally, we will establish a mouse model to evaluate the consequences of EWS/FLI expression on tumorigenesis and development in vivo. ..
  4. Pten and P13K regulation of growth and neoplasia in the brain
    Suzanne J Baker; Fiscal Year: 2010
    ..The proposed experiments will provide improved insights into the regulation of PI3K signaling in brain tumors that will be essential for informed design of therapeutic inhibition of this pathway in tumors with distinct mutations. ..