Gregory T Armstrong

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..In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival...

..Ongoing study of childhood cancer survivors is needed to establish long-term risks and to evaluate the impact of newer techniques such as conformal radiation therapy or proton-beam therapy...

..Survivors with a history of radiation exposure to temporal brain regions are at increased risk for impairment in memory and social functioning...

..We investigated changes in patterns of late mortality over time and cause-specific attribution of late-mortality among 5-year survivors...

..Ongoing study of childhood cancer survivors is needed to establish long-term risks and evaluate impact of newer techniques such as conformal RT or proton beam delivery that limit RT exposure and may reduce long-term effects...

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..To the authors' knowledge, data regarding the risk of altered timing of menarche after higher dose radiotherapy (RT), as used in the treatment of central nervous system (CNS) tumors, are limited...

..Appropriate and timely assessment of survivors at high risk of alterations in pubertal development will enable the identification of patients who would benefit from early medical intervention...

..Those surviving the first SN (SN1) remain at risk to develop multiple SNs. Because SNs are a common cause of late morbidity and mortality, characterization of rates of multiple SNs is needed...

..With greater knowledge of sex-specific risks, the potential application of sex-specific therapy designed to avoid poor long-term adverse outcomes may become a viable strategy...

..This study seeks an operational definition for optic nerve tortuosity...

..Survivors of childhood LGG experience substantial long-term adverse effects that continue to increase well beyond the 5-year survival time point...

..The aim of this study was to examine neurocognitive and brain imaging outcomes in adult survivors of childhood HL...

..Jude Children's Research Hospital (SJCRH) is establishing a lifetime cohort of survivors...

..Many Childhood Cancer Survivor Study (CCSS) participants are at increased risk for obesity. The etiology of their obesity is likely multifactorial but not well understood...

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..Analysis of biological samples in large cohort studies may provide insight into the mechanism of, and risk factors for, disease onset and progression...

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..The objective of this study was to ascertain the prevalence of and risk factors for fractures among individuals participating in the Childhood Cancer Survivor Study (CCSS)...

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..8, 95% CI = 1.6 to 9.3) and platinum-based chemotherapy (RR = 3.5, 95% CI = 1.0 to 11.2). To our knowledge, this is the first report of an association between cisplatin and subsequent renal carcinoma among survivors of childhood cancer...

..Restricted environmental access was associated with reduced HRQOL and diminished social functioning. Interventions directed at improving physical mobility may have significant impact on survivor quality of life...

..9-6.0). Median survival from diagnosis of subsequent leukemia was 2 years. This is the first description of a statistically significant increased risk of subsequent leukemia ≥ 15 years from primary diagnosis of childhood cancer...

..Because there is a limited literature on focal brainstem gliomas in pediatric patients, the objective of this paper was to report the management and outcome of these tumors...

..Neuroprotective strategies are needed to preserve critical functions...

..The prognosis for children with M1 medulloblastoma (positive CSF cytology) has not been well-defined...

..The proportion of pediatric and adolescent cancer patients surviving 5 years has increased during the past four decades. This growing population of survivors remains at risk for disease- and treatment-associated late mortality...