Gary Swan

Summary

Affiliation: SRI International
Country: USA

Publications

  1. ncbi Impaired olfaction predicts cognitive decline in nondemented older adults
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, Calif, 94025, USA
    Neuroepidemiology 21:58-67. 2002
  2. ncbi Genetic and environmental sources of variation in heart rate response to infused nicotine in twins
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Cancer Epidemiol Biomarkers Prev 16:1057-64. 2007
  3. pmc Genetics of nicotine dependence and pharmacotherapy
    Christina N Lessov-Schlaggar
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Biochem Pharmacol 75:178-95. 2008
  4. ncbi Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
    Huijun Z Ring
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    Pharmacogenet Genomics 17:1007-15. 2007
  5. doi Reliability of adult retrospective recall of lifetime tobacco use
    Janet Brigham
    SRI International, Menlo Park, CA 94043, USA
    Nicotine Tob Res 10:287-99. 2008
  6. pmc Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes
    G E Swan
    SRI International, Menlo Park, CA 94025, USA
    Pharmacogenomics J 12:349-58. 2012
  7. pmc Clinical trial participant characteristics and saliva and DNA metrics
    Denise M Nishita
    Center for Health Sciences, SRI International, Menlo Park, CA, 94025, USA
    BMC Med Res Methodol 9:71. 2009
  8. ncbi Evidence for genetic mediation of executive control: a study of aging male twins
    Gary E Swan
    Center for Health Sciences, SRI International formerly Stanford Research Institute, Menlo Park, California 94025, USA
    J Gerontol B Psychol Sci Soc Sci 57:P133-43. 2002
  9. pmc Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Cancer Epidemiol Biomarkers Prev 12:994-1005. 2003
  10. ncbi Effectiveness of bupropion sustained release for smoking cessation in a health care setting: a randomized trial
    Gary E Swan
    Center for Health Sciences, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Arch Intern Med 163:2337-44. 2003

Detail Information

Publications75

  1. ncbi Impaired olfaction predicts cognitive decline in nondemented older adults
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, Calif, 94025, USA
    Neuroepidemiology 21:58-67. 2002
    ..The predictive utility of impaired smell identification in older adults appears to be specific to a decline in components of verbal memory...
  2. ncbi Genetic and environmental sources of variation in heart rate response to infused nicotine in twins
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Cancer Epidemiol Biomarkers Prev 16:1057-64. 2007
    ..The contribution from genetic sources to heart rate response characteristics should be investigated further as a potential endophenotype for use in genetic studies of nicotine dependence...
  3. pmc Genetics of nicotine dependence and pharmacotherapy
    Christina N Lessov-Schlaggar
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Biochem Pharmacol 75:178-95. 2008
    ....
  4. ncbi Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
    Huijun Z Ring
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    Pharmacogenet Genomics 17:1007-15. 2007
    ..We investigated the influence of genetic variation in another potential nicotine-metabolizing enzyme, CYP2B6, and its interaction with CYP2A6, on the metabolism of nicotine...
  5. doi Reliability of adult retrospective recall of lifetime tobacco use
    Janet Brigham
    SRI International, Menlo Park, CA 94043, USA
    Nicotine Tob Res 10:287-99. 2008
    ..Few differences in the reliability of recall were apparent between sexes and between age groups. These results indicate that recall of important tobacco use information can form a reliable basis for research...
  6. pmc Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes
    G E Swan
    SRI International, Menlo Park, CA 94025, USA
    Pharmacogenomics J 12:349-58. 2012
    ..As nausea is the most common reason for discontinuance of varenicline, further pharmacogenetic investigations are warranted...
  7. pmc Clinical trial participant characteristics and saliva and DNA metrics
    Denise M Nishita
    Center for Health Sciences, SRI International, Menlo Park, CA, 94025, USA
    BMC Med Res Methodol 9:71. 2009
    ..This article describes an assessment of saliva biospecimen samples collected through the mail, trial participant demographic and behavioral characteristics, and their association with saliva and DNA quantity and quality...
  8. ncbi Evidence for genetic mediation of executive control: a study of aging male twins
    Gary E Swan
    Center for Health Sciences, SRI International formerly Stanford Research Institute, Menlo Park, California 94025, USA
    J Gerontol B Psychol Sci Soc Sci 57:P133-43. 2002
    ....
  9. pmc Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Cancer Epidemiol Biomarkers Prev 12:994-1005. 2003
    ..This investigation is unique among ongoing studies of the genetics of tobacco dependence in the extent to which equal importance has been assigned to both phenotypic and genotypic measurements...
  10. ncbi Effectiveness of bupropion sustained release for smoking cessation in a health care setting: a randomized trial
    Gary E Swan
    Center for Health Sciences, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Arch Intern Med 163:2337-44. 2003
    ..The efficacy of bupropion hydrochloride sustained release (SR) (Zyban) for smoking cessation has been evaluated in clinical trials that included frequent in-person behavioral counseling, but not in actual practice settings...
  11. ncbi Bupropion SR and counseling for smoking cessation in actual practice: predictors of outcome
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Nicotine Tob Res 5:911-21. 2003
    ..The results are discussed in terms of their implications for the need for more effective treatments in general, and the role of individual differences in the likelihood of returning to smoking following treatment for quitting...
  12. ncbi The effects of tobacco smoke and nicotine on cognition and the brain
    Gary E Swan
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neuropsychol Rev 17:259-73. 2007
    ....
  13. ncbi Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Health Psychol 26:361-8. 2007
    ..To determine the relationship between joint variation in 2 dopaminergic genes and the likelihood of nonsmoking following treatment with bupropion sustained release (SR)...
  14. ncbi Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR
    G E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Pharmacogenomics J 5:21-9. 2005
    ..Significant associations or trends were not observed in men. In women, individual variability in responsiveness to bupropion-based treatment may be partially due to differences in genetic variants influencing dopamine receptor function...
  15. ncbi Pharmacogenetics of nicotine metabolism in twins: methods and procedures
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Twin Res 7:435-48. 2004
    ....
  16. ncbi Apolipoprotein E epsilon4 and change in cognitive functioning in community-dwelling older adults
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    J Geriatr Psychiatry Neurol 18:196-201. 2005
    ..A significant gender x APOE epsilon4 interaction was seen for change in performance on short delay cued recall. These results suggest that APOE epsilon4 is associated with cognitive decline differently in older adult men and women...
  17. ncbi Predictors of 12-month outcome in smokers who received bupropion sustained-release for smoking cessation
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California, USA
    CNS Drugs 22:239-56. 2008
    ..To examine heterogeneity in outcome at 12 months following 8 weeks of treatment for smoking cessation with bupropion sustained-release (SR) 150 or 300 mg/day combined with behavioural counselling...
  18. pmc Genome-wide linkage of cotinine pharmacokinetics suggests candidate regions on chromosomes 9 and 11
    Yungang He
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Am J Med Genet B Neuropsychiatr Genet 150:554-9. 2009
    ..96 (P = 0.0013) and 1.94 (P = 0.0014). The confidence level of the linkage between the three genome regions and cotinine pharmacokinetics is statistically significant with a genome-wide empirical probability of P = 0.029...
  19. pmc Behavioral counseling and varenicline treatment for smoking cessation
    Gary E Swan
    SRI International, Menlo Park, California 94025, USA
    Am J Prev Med 38:482-90. 2010
    ..Smoking remains the primary preventable cause of death and illness in the U.S. Effective, convenient treatment programs are needed to reduce smoking prevalence...
  20. ncbi Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Pharmacogenet Genomics 15:115-25. 2005
    ..These results suggest the involvement of additional genetic factors (e.g. uncharacterized or novel CYP2A6 alleles as well as other genes in the metabolic pathway) that remain to be identified...
  21. pmc Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Pharmacogenet Genomics 19:388-98. 2009
    ..This analysis sought to conduct a combined genetic epidemiologic and pharmacogenetic investigation of the 3HC/COT ratio in plasma and urine...
  22. ncbi Heterogeneity in 12-month outcome among female and male smokers
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Addiction 99:237-50. 2004
    ..To examine heterogeneity in outcome following treatment for smoking cessation with combined bupropion SR and behavioral counseling in women and men...
  23. doi Tobacco addiction and pharmacogenetics of nicotine metabolism
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    J Neurogenet 23:262-71. 2009
    ....
  24. ncbi Parental smoking cessation and children's daily smoking: public health implications? commentary on Bricker et al
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    Addiction 98:596-7; discussion 598-9. 2003
  25. pmc Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample
    Jill Hardin
    SRI International, Menlo Park, CA 94025, USA
    Cancer Epidemiol Biomarkers Prev 18:3399-406. 2009
    ..A previous autosome-wide screen identified a nonparametric linkage (NPL) log-likelihood ratio (LOD) score of 2.7 on chromosome 6q26 for the sum of nine withdrawal symptoms...
  26. ncbi Support for previously identified alcoholism susceptibility Loci in a cohort selected for smoking behavior
    Kirk C Wilhelmsen
    Department of Neurology, Gallo Institute, Center for Health Sciences, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 29:2108-15. 2005
    ..In this paper we use, for the first time, linkage analysis to search for alcoholism-related phenotypes in a family sample selected for smoking behavior...
  27. doi A systems biology network model for genetic association studies of nicotine addiction and treatment
    Paul D Thomas
    Evolutionary Systems Biology, Artificial Intelligence Center, SRI International, Menlo Park, CA 94025, USA
    Pharmacogenet Genomics 19:538-51. 2009
    ..We suggest that known or hypothesized disease risk factors, and causal mechanisms, can be represented using an ontology, a computational specification of a set of concepts and the relations between them...
  28. ncbi Longitudinal genetic analysis of executive function in elderly men
    Christina N Lessov-Schlaggar
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neurobiol Aging 28:1759-68. 2007
    ..These results suggest that common genetic factors underlie longitudinal EF task performance. Genetic influences on EF decline, however, appear to be evident at longer time intervals between assessments...
  29. pmc Dopamine genes and nicotine dependence in treatment-seeking and community smokers
    Andrew W Bergen
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Neuropsychopharmacology 34:2252-64. 2009
    ..A community cohort of N=175 multiplex ever-smoking pedigrees (N=423 ever smokers) provided nominal evidence for association with the FTND at these top ranked SNPs, uncorrected for multiple comparisons...
  30. pmc Validity of recall of tobacco use in two prospective cohorts
    Janet Brigham
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Am J Epidemiol 172:828-35. 2010
    ..These findings support the utility of collecting recalled self-report information for reconstructing salient lifetime health behaviors and underscore the need for careful interpretation...
  31. pmc Association of tobacco dependence and quit attempt duration with Rasch-modeled withdrawal sensitivity using retrospective measures
    Harold S Javitz
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Addiction 104:1027-35. 2009
    ..To examine whether Rasch modeling would yield a unidimensional withdrawal sensitivity measure correlating with factors associated with successful smoking cessation...
  32. ncbi Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry
    Christina N Lessov-Schlaggar
    SRI International, Center for Health Sciences, Menlo Park, CA, USA
    Int J Epidemiol 35:1278-85. 2006
    ..In 2000, the Chinese National Twin Registry was established to provide a genetically informative resource for investigation of health behaviour including tobacco and alcohol use...
  33. ncbi The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations
    Ian M Colrain
    Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
    Nicotine Tob Res 6:913-25. 2004
    ....
  34. ncbi Heritability of plasma sex hormones and hormone binding globulin in adult male twins
    Huijun Z Ring
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    J Clin Endocrinol Metab 90:3653-8. 2005
    ..Assessment of the relative contribution of genetic and nongenetic influences on hormone concentrations may help in the search for genes underlying variation and covariation in complex traits affected by plasma sex hormone concentrations...
  35. ncbi Cost-effectiveness of different combinations of bupropion SR dose and behavioral treatment for smoking cessation: a societal perspective
    Harold S Javitz
    Center for Health Sciences, SRI International, Menlo Park, Calif 94025, USA
    Am J Manag Care 10:217-26. 2004
    ....
  36. ncbi Return on investment of different combinations of bupropion SR dose and behavioral treatment for smoking cessation in a health care setting: an employer's perspective
    Harold S Javitz
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Value Health 7:535-43. 2004
    ....
  37. ncbi Genetic and environmental influences in sleep-disordered breathing in older male twins
    Dorit Carmelli
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Sleep 27:917-22. 2004
    ..To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins...
  38. ncbi Bupropion SR and smoking cessation in actual practice: methods for recruitment, screening, and exclusion for a field trial in a managed-care setting
    Lisa M Jack
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Prev Med 36:585-93. 2003
    ..This article describes the methods for recruitment, screening for exclusions, and resulting sample in a field trial of bupropion SR undertaken in a managed-care setting...
  39. ncbi Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins
    Dorit Carmelli
    Center for Health Sciences, SRI International formerly Stanford Research Institute, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Biol Psychol 61:139-55. 2002
    ..These data may shed light on the genetic liability for brain diseases that affect the elderly...
  40. ncbi Financial burden of tobacco use: an employer's perspective
    Harold S Javitz
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Clin Occup Environ Med 5:9-29, vii. 2006
    ....
  41. ncbi Genetics and drug use as a complex phenotype
    Christina N Lessov
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Subst Use Misuse 39:1515-69. 2004
    ..In addition, this work demands adherence to the highest standards of confidentiality and ethical use of genetic information to best inform future prevention efforts...
  42. ncbi Gene-environment interaction in nicotine addiction: the need for a large-scale, collaborative effort
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California, USA
    Subst Use Misuse 39:2083-5. 2004
  43. pmc Test-retest reliability of web-based retrospective self-report of tobacco exposure and risk
    Janet Brigham
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    J Med Internet Res 11:e35. 2009
    ..Establishing the reliability of retrospective measures is a necessary step in determining the utility of that methodology and in studying behaviors in the context of risk and protective factors...
  44. pmc A genome-wide screen for nicotine dependence susceptibility loci
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California, USA
    Am J Med Genet B Neuropsychiatr Genet 141:354-60. 2006
    ..Several of the corresponding support intervals were near putative loci reported previously (on chromosomes 6, 7, and 8) while others appear to be novel (on chromosomes 5, 16, and 19)...
  45. doi Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, CA, USA
    Twin Res Hum Genet 13:412-25. 2010
    ..Methods and first results including heritability estimates for heat and cold pain sensitivity should be of interest to investigators considering similar studies...
  46. pmc Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Bioinformatics 24:1805-11. 2008
    ..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance...
  47. doi Adolescent smoking trajectories and nicotine dependence
    Christina N Lessov-Schlaggar
    Washington University, St Louis, MO 63110, USA
    Nicotine Tob Res 10:341-51. 2008
    ....
  48. ncbi Measures of abstinence in clinical trials: issues and recommendations
    John R Hughes
    Department of Psychiatry, Psychology and Family Practice University of Vermont, Burlington 05401 1419, USA
    Nicotine Tob Res 5:13-25. 2003
    ..Trials that use short-term follow-ups (< or = 3 months) to demonstrate possible efficacy should report a prolonged abstinence measure of > or = 4 weeks. We again recommend a 2-week grace period; however, that period can vary...
  49. pmc Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation
    David V Conti
    Department of Preventive Medicine, Keck School of Medicine, Zilkha Neurogenetics Institute, University of Southern California, 1501 San Pablo Street, ZNI 445, Los Angeles, CA 90089, USA
    Hum Mol Genet 17:2834-48. 2008
    ..0002) and an impact on withdrawal symptoms at target quit date (TQD) (P = 0.0009). Overall, while our results indicate strong evidence for CHRNB2 in ability to quit smoking, these results require replication in an independent sample...
  50. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  51. ncbi Agreement between proband and parental self-report of smoking behavior and nicotine dependence
    Judith L Marks
    Nicotine Research Laboratory, University of Michigan, Ann Arbor, MI 48108, USA
    Nicotine Tob Res 5:527-33. 2003
    ..Our findings should aid investigators in defining the limits of proband reports of parental smoking behavior and identify opportunities for the development of better approaches for the assessment of familial nicotine dependence...
  52. ncbi Depressive symptoms and metabolic risk in adult male twins enrolled in the National Heart, Lung, and Blood Institute twin study
    Jeanne M McCaffery
    Centers for Behavioral and Preventive Medicine, Brown Medical School and The Miriam Hospital, Providence, Rhode Island 02903, USA
    Psychosom Med 65:490-7. 2003
    ..To determine the extent to which depressive symptoms are associated with metabolic risk factors and whether genetic or environmental factors account for this association...
  53. ncbi Non-replication of genetic association studies: is DAT all, folks?
    Caryn Lerman
    Nicotine Tob Res 4:247-9. 2002
  54. ncbi Changes in Mini-Mental State Exam in community-dwelling older persons over 6 years: relationship to health and neuropsychological measures
    Paul J Eslinger
    Department of Medicine Division of Neurology, Penn State University College of Medicine, Hershey, PA, USA
    Neuroepidemiology 22:23-30. 2003
    ..Results suggest that a decline of three or more points on the MMSE in community-dwelling, older persons without acute illness may signify important changes in health and cognition...
  55. ncbi A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Addiction 98:23-31. 2003
    ....
  56. ncbi Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective
    Edmond D Shenassa
    Brown Medical School, Centers for Behavioral and Preventive Medicine, Providence, RI 02903, USA
    Nicotine Tob Res 5:S55-69. 2003
    ..Research gaps that exist between scientific disciplines are highlighted, and some directions for future research are suggested...
  57. ncbi A study of depressive symptoms and smoking behavior in adult male twins from the NHLBI twin study
    Jeanne M McCaffery
    Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island 02903, USA
    Nicotine Tob Res 5:77-83. 2003
    ..Taken together with the previous literature, these results suggest that the etiology of covariation among depressive symptoms and smoking behavior may vary by measurement and severity of depressive symptomology...
  58. ncbi Smoking cessation treatment: pharmacogenetic assessment
    Marcus R Munafo
    University of Bristol, Department of Experimental Psychology Bristol, UK
    Curr Opin Mol Ther 7:202-8. 2005
    ..In particular, future studies that need to be conducted before such research is translated into clinical practice and potential limitations and barriers to this translation are described...
  59. ncbi Validity of retrospective assessments of nicotine dependence: a preliminary report
    Karen Suchanek Hudmon
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, 4th Floor, New Haven, CT 06520, USA
    Addict Behav 30:613-7. 2005
    ..62 for the FTQ (p<0.005) and 0.72 for the FTND (p<0.05). These preliminary results suggest that retrospectively assessed FTQ/FTND scale scores have acceptable reliability...
  60. ncbi Tailoring nicotine replacement therapy: rationale and potential approaches
    Jennifer B McClure
    Group Health Cooperative, Center for Health Studies, Seattle, Washington 98101, USA
    CNS Drugs 20:281-91. 2006
    ..We also review emerging evidence that genetic profiling may one day be a useful consideration for tailoring NRT treatment...
  61. ncbi Female sex and oral contraceptive use accelerate nicotine metabolism
    Neal L Benowitz
    Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, University of California, San Francisco, San Francisco 94143 1220, USA
    Clin Pharmacol Ther 79:480-8. 2006
    ..This study tested the hypothesis that women metabolize nicotine more rapidly than men and that, among women, oral contraceptive users metabolize nicotine more rapidly than nonusers of oral contraceptives...
  62. ncbi Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics
    Nael Al Koudsi
    Centre for Addiction and Mental Health, and Department of Pharmacology, University of Toronto, Toronto, ON, Canada
    Eur J Clin Pharmacol 62:481-4. 2006
    ..The impact of CYP2A6*21 (K476R) on in vivo nicotine metabolism and disposition was investigated...
  63. ncbi Cigarette smoking and nicotine dependence
    Susan M Zbikowski
    Center for Health Promotion, Inc, 12401 East Marginal Way South, Tukwila, WA 98168, USA
    Med Clin North Am 88:1453-65, x. 2004
    ..This article presents a brief overview of nicotine dependence with particular emphasis placed on understanding what nicotine dependence is, why it occurs, how it is measured, and how it can be managed through effective treatments...
  64. ncbi CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
    Neal L Benowitz
    Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco 94143 1220, USA
    Clin Pharmacol Ther 80:457-67. 2006
    ..Our objective was to determine the relationship between variant CYP2A6 genotypes and the disposition and metabolism of nicotine administered intravenously...
  65. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  66. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  67. ncbi Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007
    ..As risk assessment for cancer risk is moving toward a multigenic pathway-based approach, future genotype-phenotype correlation studies should also investigate the combined effects of multiple genetic variants...
  68. ncbi Relationship of endogenous sex hormones to coronary heart disease: a twin study
    Katharine H Mikulec
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Endocrinol Metab 89:1240-5. 2004
    ..3). We observed no relationship between endogenous sex hormone concentrations and prevalent or incident CHD in this sample of male twins...
  69. ncbi Genetic research on complex behaviors: an examination of attempts to identify genes for smoking
    Ovide F Pomerleau
    Nicotine Research Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
    Nicotine Tob Res 9:883-901. 2007
    ..These proceedings are excerpts based on the presentations at the conference...
  70. ncbi Setting priorities for genomic research
    Wade Berrettini
    Science 304:1445-7; author reply 1445-7. 2004
  71. ncbi Genetic research and smoking behavior
    Laura Jean Bierut
    JAMA 297:809; author reply 810. 2007
  72. ncbi Habitual napping and performance on the Trail Making Test
    Donald L Bliwise
    J Sleep Res 14:209-10. 2005
  73. ncbi Mutagen sensitivity has high heritability: evidence from a twin study
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5993-6. 2006
    ..This study provides the strongest and most direct evidence that mutagen sensitivity is highly heritable, thereby validating the use of mutagen sensitivity as a cancer susceptibility factor...
  74. ncbi A multidimensional model for characterizing tobacco dependence
    Karen Suchanek Hudmon
    School of Pharmacy, University of California San Francisco, San Francisco CA 94118, USA
    Nicotine Tob Res 5:655-64. 2003
    ..34 - .68 and .64 - .81, respectively. Results of these analyses support the hypothesis that tobacco dependence is multidimensional...
  75. ncbi The need for dissemination of evidence-based results from research on nicotine and tobacco
    Gary E Swan
    Nicotine Tob Res 5:7-8. 2003

Research Grants30

  1. TREATMENT OF NICOTINE DEPENDENCE IN AN HMO SETTING
    Gary Swan; Fiscal Year: 2000
    ..This study will be conducted in collaboration with the nation's largest health maintenance organization, Kaiser Permanente Medical Care Plan (KPMCP) of Northern California. ..
  2. PHARMACOKINETICS OF NICOTINE IN TWINS
    Gary Swan; Fiscal Year: 2002
    ..Ultimately, this knowledge may lead to more informed and more finely targeted treatment of individuals who are either susceptible to nicotine addiction or are already addicted to this substance. ..
  3. TREATMENT OF NICOTINE DEPENDENCE IN AN HMO SETTING
    Gary Swan; Fiscal Year: 2002
    ..Thus, more efficient use of existing resources will result in greater reach of cessation efforts to smoking patients. ..
  4. Biometric and Measured Genetic Research on Smoking
    Gary Swan; Fiscal Year: 2006
    ..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..
  5. Treatment of Nicotine Dependence in Health Care Setting
    Gary Swan; Fiscal Year: 2007
    ....
  6. Impact of Smoking Cessation on Sleep
    Gary Swan; Fiscal Year: 2007
    ..The results of this project will be particularly important for the development of targeted treatment approaches designed to ameliorate sleep disruption as part of an overall smoking cessation strategy. ..
  7. Biometric and Measured Genetic Research on Smoking
    Gary Swan; Fiscal Year: 2007
    ..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..
  8. CVD RISK FACTORS AND BRAIN MORPHOLOGY IN NHLBI TWINS
    Gary Swan; Fiscal Year: 2001
    ....
  9. Treatment of Nicotine Dependence in Health Care Setting
    Gary Swan; Fiscal Year: 2009
    ....