A Pfefferbaum

Summary

Affiliation: SRI International
Country: USA

Publications

  1. ncbi In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging
    A Pfefferbaum
    Neuropsychiatry Program, Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 41:276-84. 1999
  2. ncbi Pattern of motor and cognitive deficits in detoxified alcoholic men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5717, USA
    Alcohol Clin Exp Res 24:611-21. 2000
  3. ncbi Remote memory for public figures in Alzheimer's disease: relationships to regional cortical and limbic brain volumes
    R Fama
    Neuropsychiatry Program, SRI International, Menlo Park, California, USA
    J Int Neuropsychol Soc 7:384-90. 2001
  4. ncbi Striatal and forebrain nuclei volumes: contribution to motor function and working memory deficits in alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Biol Psychiatry 57:768-76. 2005
  5. ncbi Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025
    Biol Psychiatry 59:364-72. 2006
  6. ncbi Combining atlas-based parcellation of regional brain data acquired across scanners at 1.5 T and 3.0 T field strengths
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuroimage 60:940-51. 2012
  7. ncbi Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuropsychopharmacology 30:1392-9. 2005
  8. ncbi In vivo structural imaging of the rat brain with a 3-T clinical human scanner
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94205, USA
    J Magn Reson Imaging 20:779-85. 2004
  9. ncbi Alcoholism and AIDS: magnetic resonance imaging approaches for detecting interactive neuropathology
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    Alcohol Clin Exp Res 26:1031-46. 2002
  10. ncbi Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 49:953-61. 2003

Research Grants

  1. Neuroimaging in Animal Models of Alcoholism
    Adolf Pfefferbaum; Fiscal Year: 2007
  2. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
  3. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
  4. TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGING
    Adolf Pfefferbaum; Fiscal Year: 2007
  5. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
  6. IN VIVO DIFFUSION AND SPECTROSCOPIC BRAIN IMAGING IN ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
  7. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
  8. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2007
  9. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
  10. IN VIVO DIFFUSION & SPECTROSCOPIC BRAIN IMAGING IN ALCOH
    Adolf Pfefferbaum; Fiscal Year: 2004

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging
    A Pfefferbaum
    Neuropsychiatry Program, Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 41:276-84. 1999
    ..Independent determination of metabolite values rather than use of ratios is essential for characterizing age-related changes in brain MRS metabolites...
  2. ncbi Pattern of motor and cognitive deficits in detoxified alcoholic men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5717, USA
    Alcohol Clin Exp Res 24:611-21. 2000
    ....
  3. ncbi Remote memory for public figures in Alzheimer's disease: relationships to regional cortical and limbic brain volumes
    R Fama
    Neuropsychiatry Program, SRI International, Menlo Park, California, USA
    J Int Neuropsychol Soc 7:384-90. 2001
    ....
  4. ncbi Striatal and forebrain nuclei volumes: contribution to motor function and working memory deficits in alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Biol Psychiatry 57:768-76. 2005
    ..Basal forebrain structures hold cholinergic mechanisms influencing memory formation, vulnerable to chronic alcoholism; however, alcoholism's effect on volumes of these structures has seldom been considered with in vivo measurement...
  5. ncbi Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025
    Biol Psychiatry 59:364-72. 2006
    ..The full extent of the white matter involvement in uncomplicated alcoholism, however, is unknown, yet knowledge of the distribution of white matter degradation might provide clues to mechanisms underlying the pathology...
  6. ncbi Combining atlas-based parcellation of regional brain data acquired across scanners at 1.5 T and 3.0 T field strengths
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuroimage 60:940-51. 2012
    ..5 T and 3.0 T field strengths with the application of an appropriate correction procedure...
  7. ncbi Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuropsychopharmacology 30:1392-9. 2005
    ..Further, the use of absolute measures revealed deficits in NAA and Cr that would have gone undetected if these metabolites were expressed as a ratio...
  8. ncbi In vivo structural imaging of the rat brain with a 3-T clinical human scanner
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94205, USA
    J Magn Reson Imaging 20:779-85. 2004
    ..To examine the feasibility of using product acquisition software on a 3-T human MRI system to acquire high-resolution structural brain images in the rat...
  9. ncbi Alcoholism and AIDS: magnetic resonance imaging approaches for detecting interactive neuropathology
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    Alcohol Clin Exp Res 26:1031-46. 2002
    ..We conclude with a consideration of the methodological issues such studies must address...
  10. ncbi Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 49:953-61. 2003
    ..25 in healthy adults may reflect partial voluming rather than actual changes in white matter coherence...
  11. ncbi Replicability of diffusion tensor imaging measurements of fractional anisotropy and trace in brain
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    J Magn Reson Imaging 18:427-33. 2003
    ..To evaluate within-scanner and between-scanner reliability of fractional anisotropy (FA) and trace (sum of the diagonal elements of the diffusion tensor) as measured by diffusion tensor imaging (DTI)...
  12. ncbi Morphological changes in aging brain structures are differentially affected by time-linked environmental influences despite strong genetic stability
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Center for Health Sciences BN 115, 333 Ravenswood Street, Menlo Park, CA 94025, USA
    Neurobiol Aging 25:175-83. 2004
    ..Genetic stability was present even in old age when brain and other morphological changes can be rapid and highly variable across individuals, inconsistent with an hypothesis that random DNA damage is the cause of aging...
  13. ncbi Alcoholism damages the brain, but does moderate alcohol use?
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Lancet Neurol 3:143-4. 2004
  14. ncbi Postmortem MR imaging of formalin-fixed human brain
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuroimage 21:1585-95. 2004
    ..Examples of high-resolution images and results from attempts at diffusion imaging are presented...
  15. ncbi Brain volumes, RBC status, and hepatic function in alcoholics after 1 and 4 weeks of sobriety: predictors of outcome
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Am J Psychiatry 161:1190-6. 2004
    ....
  16. ncbi Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neurobiol Aging 27:994-1009. 2006
    ..Thus, despite abstinence from alcohol, the interaction of age and recent alcoholism history exerted a compounded untoward effect on callosal macrostructure and microstructure...
  17. ncbi Disruption of brain white matter microstructure by excessive intracellular and extracellular fluid in alcoholism: evidence from diffusion tensor imaging
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Stanford University School of Medicine, CA, USA
    Neuropsychopharmacology 30:423-32. 2005
    ....
  18. ncbi Corpus callosum, pons, and cortical white matter in alcoholic women
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Alcohol Clin Exp Res 26:400-6. 2002
    ..To measure the effect of alcohol abuse on white matter brain macrostructure in women with alcoholism and to determine whether observed abnormalities interact with age...
  19. ncbi In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism
    A Pfefferbaum
    Neuropsychiatry Program, SRI International, Menlo Park, California 94025, USA
    Alcohol Clin Exp Res 24:1214-21. 2000
    ....
  20. ncbi Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging
    A Pfefferbaum
    Neuropsychiatry Program, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 44:259-68. 2000
    ..FA declined significantly with age in all regions except the splenium, whereas intervoxel coherence positively correlated with age in the genu. Magn Reson Med 44:259-268, 2000...
  21. ncbi Brain structure in men remains highly heritable in the seventh and eighth decades of life
    A Pfefferbaum
    Center for Health Sciences, SRI International, 333 Ravenswood Street, Menlo Park, CA 94025, USA
    Neurobiol Aging 21:63-74. 2000
    ....
  22. ncbi Brain gray and white matter transverse relaxation time in schizophrenia
    A Pfefferbaum
    Neuropsychiatry Program, SRI International, Menlo Park, CA 94025, USA
    Psychiatry Res 91:93-100. 1999
    ..Taken together, these results suggest that the process producing prolonged T2 does not fully account for the abnormally low anisotropy observed selectively in white matter in this group of schizophrenic patients...
  23. ncbi In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease
    A Pfefferbaum
    Neuropsychiatry Program, SRI International, Menlo Park, Calif 94025, USA
    Arch Gen Psychiatry 56:185-92. 1999
    ..Alzheimer disease (AD) and normal aging result in cortical gray matter volume deficits. The extent to which the remaining cortex is functionally compromised can be estimated in vivo with magnetic resonance spectroscopic imaging...
  24. ncbi A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval
    A Pfefferbaum
    Neuropsychiatry Program, Center for Health Sciences, SRI International, Menlo Park, Calif 94025, USA
    Arch Gen Psychiatry 55:905-12. 1998
    ..We report on structural brain changes during a 5-year period in healthy control and alcoholic men...
  25. ncbi Sex differences in the effects of alcohol on brain structure
    A Pfefferbaum
    Neuropsychiatry Program, SRI International, Menlo Park, CA 95025, USA
    Am J Psychiatry 158:188-97. 2001
    ..This study investigated whether alcoholic women manifest deficits in cortical gray and white matter volumes and ventricular enlargement similar to those seen in alcoholic men...
  26. ncbi Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences 5717, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305 5717, USA
    Arch Gen Psychiatry 57:894-902. 2000
    ..Complicating such investigations is the high incidence of alcoholism comorbidity in patients with schizophrenia that itself can contribute to cerebellar abnormalities...
  27. ncbi Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms
    V Menon
    Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305-5719, USA
    Neuroimage 13:433-46. 2001
    ..Our findings suggest an association between thinking disturbance symptoms, particularly unusual thought content, and disrupted WM processing in schizophrenia...
  28. ncbi Corpus callosal microstructural integrity influences interhemispheric processing: a diffusion tensor imaging study
    T Schulte
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Cereb Cortex 15:1384-92. 2005
    ..The results provide in vivo evidence for disruption of corpus callosum microstructure in normal aging and alcoholism that has functional ramifications for efficiency in interhemispheric processing...
  29. ncbi Equivalent disruption of regional white matter microstructure in ageing healthy men and women
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5723, USA
    Neuroreport 12:99-104. 2001
    ..Degree of regional white matter coherence correlated with gait, balance, and interhemispheric transfer test scores...
  30. ncbi Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: relationships to changes in brain structure
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5717, USA
    Neuropsychology 14:178-88. 2000
    ..Thus, alcoholic men who maintain abstinence can show substantial functional improvement that is related to improvement in brain structure condition...
  31. ncbi Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis
    L Marsh
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA, USA
    Psychiatry Res 108:1-15. 2001
    ..Structural brain abnormalities in E+PSY are not restricted to the left temporal lobe. The confluence of cortical gray matter deficits in E+PSY and SCZ suggests salience to chronic psychosis...
  32. ncbi Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: relation to ataxia
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5717, USA
    Neuropsychology 14:341-52. 2000
    ..Regional distribution but not severity of cerebellar volume deficits is similar in alcoholic individuals whether or not complicated by KS and relates to ataxia...
  33. ncbi Progressive brain volume changes and the clinical course of schizophrenia in men: a longitudinal magnetic resonance imaging study
    D H Mathalon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Arch Gen Psychiatry 58:148-57. 2001
    ..We sought to determine whether the brain dysmorphology previously observed cross-sectionally in people with schizophrenia progresses over time and whether such progression is related to the severity of the illness course...
  34. ncbi Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 67:846-54. 2010
    ..The current in vivo magnetic resonance (MR) imaging and spectroscopy study was conducted to test the hypothesis that binge EtOH exposure would injure but not cause the death of neurons as previously ascertained postmortem...
  35. ncbi Callosal involvement in a lateralized stroop task in alcoholic and healthy subjects
    T Schulte
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Neuropsychology 20:727-36. 2006
    ..The authors speculate that alcoholism-associated callosal thinning disrupts this processing route...
  36. ncbi Genetic regulation of regional microstructure of the corpus callosum in late life
    A Pfefferbaum
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    Neuroreport 12:1677-81. 2001
    ....
  37. ncbi Differential rates of regional brain change in callosal and ventricular size: a 4-year longitudinal MRI study of elderly men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cereb Cortex 12:438-45. 2002
    ....
  38. ncbi Heritability of hippocampal size in elderly twin men: equivalent influence from genes and environment
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Hippocampus 11:754-62. 2001
    ..Considering the potential of environmental modification of this structure suggested by lower heritability, the hippocampus appears well-suited to support the dynamic processes of encoding and consolidation of new, declarataive memories...
  39. ncbi Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study
    John E Desmond
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroimage 19:1510-20. 2003
    ....
  40. ncbi Parallel interhemispheric processing in aging and alcoholism: relation to corpus callosum size
    T Schulte
    Department of Psychiatry and Behavioral Sciences (MC 5723, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305-5723, USA
    Neuropsychologia 42:257-71. 2004
    ..These results suggest that chronic alcohol abuse together with advancing age exert subtle disruption on parallel interhemispheric processing reliant on callosal connections...
  41. ncbi Working and episodic memory in HIV infection, alcoholism, and their comorbidity: baseline and 1-year follow-up examinations
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California 94305 5723, USA
    Alcohol Clin Exp Res 33:1815-24. 2009
    ....
  42. ncbi Reorganization of frontal systems used by alcoholics for spatial working memory: an fMRI study
    A Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California 94025, USA
    Neuroimage 14:7-20. 2001
    ....
  43. ncbi Functional magnetic resonance imaging evidence for disrupted basal ganglia function in schizophrenia
    V Menon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Am J Psychiatry 158:646-9. 2001
    ..This study was an examination of basal ganglia dysfunction in schizophrenia using functional magnetic resonance imaging (fMRI)...
  44. ncbi In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics
    E V Sullivan
    Stanford University School of Medicine, Palo Alto, California, USA
    Alcohol Clin Exp Res 23:1629-36. 1999
    ....
  45. ncbi A profile of cortical gray matter volume deficits characteristic of schizophrenia
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5717, USA
    Cereb Cortex 8:117-24. 1998
    ..The overlapping patterns of cortical gray matter deficits in the two groups provide evidence for generality of this pattern of regional brain volume abnormalities in schizophrenia...
  46. ncbi Dual tasking and working memory in alcoholism: relation to frontocerebellar circuitry
    Sandra Chanraud
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 35:1868-78. 2010
    ....
  47. ncbi Frontostriatal fiber bundle compromise in HIV infection without dementia
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, San Jose, California, USA
    AIDS 23:1977-85. 2009
    ....
  48. ncbi Motor sequencing deficits in schizophrenia: a comparison with Parkinson's disease
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Neuropsychology 15:342-50. 2001
    ....
  49. ncbi Left temporal deficit of P300 in patients with schizophrenia: effects of task
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Int J Psychophysiol 38:71-9. 2000
    ..Failure to find P300 asymmetry is not related to the presence or absence of a button pressing task, or the hand used for button pressing. Rather, P300 asymmetry may be related to structural neuroanatomical asymmetries...
  50. ncbi In vivo 2D J-resolved magnetic resonance spectroscopy of rat brain with a 3-T clinical human scanner
    E Adalsteinsson
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroimage 22:381-6. 2004
    ..These results indicate that reliable, small animal brain MR spectroscopy can be performed on a human clinical 3-T scanner...
  51. ncbi Longitudinal study of callosal microstructure in the normal adult aging brain using quantitative DTI fiber tracking
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Dev Neuropsychol 35:233-56. 2010
    ....
  52. ncbi Improvement in memory and static balance with abstinence in alcoholic men and women: selective relations with change in brain structure
    Margaret J Rosenbloom
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Psychiatry Res 155:91-102. 2007
    ..Both memory and ataxia can improve with sustained sobriety, and brain-behavior associations suggest selective brain structural substrates for the changes observed...
  53. ncbi Diffusion tensor imaging with quantitative fibre tracking in HIV infection and alcoholism comorbidity: synergistic white matter damage
    Adolf Pfefferbaum
    Neuroscience Program, SRI International Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Brain 130:48-64. 2007
    ....
  54. ncbi Callosal microstructural abnormalities in Alzheimer's disease and alcoholism: same phenotype, different mechanisms
    Anne Lise Pitel
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Psychiatry Res 184:49-56. 2010
    ..Conversely, in alcoholism, disruption of callosal microstructural integrity was related to shrinkage of the corpus callosum itself...
  55. ncbi Neuroradiological characterization of normal adult ageing
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Br J Radiol 80:S99-108. 2007
    ....
  56. ncbi Sex differences in corpus callosum size: relationship to age and intracranial size
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neurobiol Aging 22:603-11. 2001
    ..Sexual dimorphism in the corpus callosum is not a simple artifact of sex differences in brain size and may reflect differences in connectivity necessitated by differences in brain size...
  57. ncbi Magnetic resonance relaxometry reveals central pontine abnormalities in clinically asymptomatic alcoholic men
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 25:1206-12. 2001
    ....
  58. ncbi Recovery of short-term memory and psychomotor speed but not postural stability with long-term sobriety in alcoholic women
    Margaret J Rosenbloom
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuropsychology 18:589-97. 2004
    ..By Year 4, 13 of 14 returners had maintained sobriety for more than 30 months; as a group, these women had returned to normal levels on tests of memory and psychomotor speed but remained impaired in standing balance...
  59. ncbi Differential effect of HIV infection and alcoholism on conflict processing, attentional allocation, and perceptual load: evidence from a Stroop Match-to-Sample task
    Tilman Schulte
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Biol Psychiatry 57:67-75. 2005
    ..Although HIV alone did not demonstrate detectable impairment in performance, HIV conferred liability on attentional processes when combined with alcohol abuse...
  60. ncbi In vivo glutamate decline associated with kainic acid-induced status epilepticus
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305, USA
    Brain Res 1300:65-78. 2009
    ..Taken together, these results support the conclusion that seizure activity following KA infusion causes loss of glutamatergic neurons...
  61. ncbi Physiological and focal cerebellar substrates of abnormal postural sway and tremor in alcoholic women
    Edith V Sullivan
    Departments of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Biol Psychiatry 67:44-51. 2010
    ....
  62. ncbi fMRI evidence for individual differences in premotor modulation of extrastriatal visual-perceptual processing of redundant targets
    T Schulte
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuroimage 30:973-82. 2006
    ....
  63. ncbi Callosal degradation in HIV-1 infection predicts hierarchical perception: a DTI study
    Eva M Müller-Oehring
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Neuropsychologia 48:1133-43. 2010
    ..We conclude that component processes of visuospatial perception are compromised in HIV-1 infection attributable, at least in part, to degraded callosal microstructural integrity relevant for local-global feature integration...
  64. ncbi Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cereb Cortex 16:1030-9. 2006
    ....
  65. ncbi Component cognitive and motor processes of the digit symbol test: differential deficits in alcoholism, HIV infection, and their comorbidity
    Stephanie A Sassoon
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 31:1315-24. 2007
    ....
  66. ncbi Local-global interference is modulated by age, sex and anterior corpus callosum size
    Eva M Müller-Oehring
    Department of Psychiatry and Behavioral Sciences MC 5723, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Brain Res 1142:189-205. 2007
    ....
  67. ncbi Regional striatal volume abnormalities in schizophrenia: effects of comorbidity for alcoholism, recency of alcoholic drinking, and antipsychotic medication type
    Anjali Deshmukh
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Schizophr Res 79:189-200. 2005
    ..Further, these cross-sectional data provide indirect support for at least partial recovery of nucleus accumbens volume with sobriety in alcoholics, regardless of schizophrenia comorbidity...
  68. ncbi Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, USA
    Neuroimage 26:891-9. 2005
    ..The selective decline of anterior anisotropy with advancing age provides evidence for the potential of a microstructural white matter mechanism for the commonly observed decline in frontally-based functions...
  69. ncbi Contribution of alcoholism to brain dysmorphology in HIV infection: effects on the ventricles and corpus callosum
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, CA 94025, USA
    Neuroimage 33:239-51. 2006
    ....
  70. ncbi Double dissociation between action-driven and perception-driven conflict resolution invoking anterior versus posterior brain systems
    Tilman Schulte
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Neuroimage 48:381-90. 2009
    ..These findings show a double dissociation of anterior and posterior cortical systems engaging in different types of control for perceptually-driven and action-driven conflict resolution...
  71. ncbi Perceptual learning in detoxified alcoholic men: contributions from explicit memory, executive function, and age
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 28:1657-65. 2004
    ..e., frontal executive systems) to perform the same task at normal levels. Use of more demanding cognitive systems by the alcoholics may be less efficient and more costly to processing capacity than those invoked by controls...
  72. ncbi Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women
    Edith V Sullivan
    Department of Psychiatry, Stanford University School of Medicine, California 94305 5723, USA
    Alcohol Clin Exp Res 26:705-13. 2002
    ..Whether evidence for such dysfunction lingers in patients with uncomplicated alcoholism, which is known to affect cerebellar structural integrity, is controversial...
  73. ncbi Failures of automatic and strategic processing in schizophrenia: comparisons of event-related brain potential and startle blink modification
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Schizophr Res 37:149-63. 1999
    ..These results suggest that different neural circuits are involved in blink and cortical reflections of startle modification in schizophrenics and controls, with both automatic and strategic processes being impaired in schizophrenia...
  74. ncbi Information fusion in biomedical image analysis: combination of data vs. combination of interpretations
    T Rohlfing
    Neuroscience Program, SRI International, Menlo Park, CA 94025, USA
    Inf Process Med Imaging 19:150-61. 2005
    ....
  75. ncbi Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy
    Natalie M Zahr
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA
    Cereb Cortex 18:2241-50. 2008
    ..The selective relations between performance and striatal Glu provide initial and novel, human in vivo support for age-related modification of Glu levels as contributing to cognitive decline in normal aging...
  76. ncbi Divergence-based framework for diffusion tensor clustering, interpolation, and regularization
    Torsten Rohlfing
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Inf Process Med Imaging 20:507-18. 2007
    ..e., smooth) noisy tensor data. For boundary-preserving regularization, we also propose a non-linear two-stage smoothing algorithm that can be considered remotely similar to a median filter...
  77. ncbi Volume reconstruction by inverse interpolation: application to interleaved MR motion correction
    Torsten Rohlfing
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Med Image Comput Comput Assist Interv 11:798-806. 2008
    ..We demonstrate the usefulness of our method by applying it to retrospective motion correction in interleaved MR images...
  78. ncbi Regression models of atlas appearance
    Torsten Rohlfing
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Inf Process Med Imaging 21:151-62. 2009
    ..We conclude that regression appearance models are a promising new technique for image analysis, with one potential application being the representation of a continuum of mutually consistent, age-specific atlases of the human brain...
  79. ncbi In vivo fiber tracking in the rat brain on a clinical 3T MRI system using a high strength insert gradient coil
    Dirk Mayer
    Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Neuroimage 35:1077-85. 2007
    ..An additional benefit of scanning at lower field strength, such as 3 T, is the reduction of artifacts due to main field inhomogeneity relative to higher field animal systems...
  80. ncbi Ventricular expansion in wild-type Wistar rats after alcohol exposure by vapor chamber
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 32:1459-67. 2008
    ....
  81. ncbi Degradation of association and projection white matter systems in alcoholism detected with quantitative fiber tracking
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Biol Psychiatry 65:680-90. 2009
    ..Excessive alcohol use can cause macrostructural tissue shrinkage with regional preference for frontal systems. The extent and locus of alcoholism's effect on white matter microstructure is less known...
  82. ncbi Global-local interference is related to callosal compromise in alcoholism: a behavior-DTI association study
    Eva M Müller-Oehring
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 33:477-89. 2009
    ....
  83. ncbi Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Magnetic resonance spectroscopy
    Thomas E Nordahl
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA
    Psychiatry Res 116:43-52. 2002
    ..The neuronal compromise that these changes reflect may contribute to the attentional deficits and dampened reward system in MD...
  84. ncbi The SRI24 multichannel atlas of normal adult human brain structure
    Torsten Rohlfing
    SRI International, Neuroscience Program, Menlo Park, California 94025 3493, USA
    Hum Brain Mapp 31:798-819. 2010
    ..5T data. Furthermore, the SRI24 atlas is as suitable for label propagation as the comparison atlases and detailed enough to allow delineation of anatomical structures for this purpose directly in the atlas...
  85. ncbi A profile of neuropsychological deficits in alcoholic women
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5723, USA
    Neuropsychology 16:74-83. 2002
    ..The alcohol-related deficits in working memory, visuospatial, and balance implicate disruption of prefrontal, superior parietal, and cerebellar brain systems...
  86. ncbi Subject-matched templates for spatial normalization
    Torsten Rohlfing
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Med Image Comput Comput Assist Interv 12:224-31. 2009
    ..We demonstrate that such an approach is technically feasible and significantly improves spatial normalization accuracy over using a single template...
  87. ncbi White matter fiber degradation attenuates hemispheric asymmetry when integrating visuomotor information
    Tilman Schulte
    Neuroscience Program, SRI International, Menlo Park, California 94025 3493, USA
    J Neurosci 30:12168-78. 2010
    ....
  88. ncbi Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects
    Ian M Colrain
    SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Psychopharmacology (Berl) 213:669-79. 2011
    ..Degradation of white matter tracts related to age or alcoholism should negatively affect the oscillatory activity within the network...
  89. ncbi Alcoholism, HIV infection, and their comorbidity: factors affecting self-rated health-related quality of life
    Margaret J Rosenbloom
    Neuroscience Program, Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    J Stud Alcohol Drugs 68:115-25. 2007
    ..We sought to determine whether comorbidity for both disorders further reduced HRQOL and what factors exacerbated or mitigated their effect...
  90. ncbi Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Neuropsychopharmacology 32:1159-77. 2007
    ....
  91. ncbi Effects of age and sex on volumes of the thalamus, pons, and cortex
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Neurobiol Aging 25:185-92. 2004
    ..Both pontine and cortical white matter volumes remained stable across the age span in both men and women...
  92. ncbi Deformation-based brain morphometry to track the course of alcoholism: differences between intra-subject and inter-subject analysis
    Torsten Rohlfing
    Neuroscience Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 3943, USA
    Psychiatry Res 146:157-70. 2006
    ..This discrepancy in results underscores the importance of distinguishing between volume differences and volume changes in morphometric analyses...
  93. ncbi Diffusion tensor imaging and aging
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Neurosci Biobehav Rev 30:749-61. 2006
    ..These hypotheses are not mutually exclusive but establish a basis for posing testable questions about brain systems recruited when those used in youth are altered by aging...
  94. ncbi N1 and P300 abnormalities in patients with schizophrenia, epilepsy, and epilepsy with schizophrenialike features
    J M Ford
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94304, USA
    Biol Psychiatry 49:848-60. 2001
    ..N1 amplitude reduction appears to be specific to schizophrenia, suggesting its sensitivity to the distinct etiology of schizophrenia...
  95. ncbi Disruption of frontocerebellar circuitry and function in alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Alcohol Clin Exp Res 27:301-9. 2003
    ..Martin and Mitchell H. Parks; and Functional reorganization of the brain in alcoholism: neuroimaging evidence, by John E. Desmond, S.H. Annabel Chen, Michelle R. Pryor, Eve De Rosa, Adolf Pfefferbaum, and Edith V. Sullivan...
  96. ncbi In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage
    Natalie M Zahr
    Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Neuropsychopharmacology 34:1427-42. 2009
    ..Thus, we provide novel in vivo evidence for alcohol exposure as causing changes in brain chemistry in the absence of protracted withdrawal, pronounced thiamine deficiency, or severe liver damage...
  97. ncbi Neurocircuitry in alcoholism: a substrate of disruption and repair
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Psychopharmacology (Berl) 180:583-94. 2005
    ....
  98. ncbi Volumetric cerebral perfusion imaging in healthy adults: regional distribution, laterality, and repeatability of pulsed continuous arterial spin labeling (PCASL)
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Psychiatry Res 182:266-73. 2010
    ..High CBF in the posterior cingulate and posterior and central precuneus cortices in this task-free acquisition suggests high activity in these principal nodes of the "default mode network."..
  99. ncbi Effects of alcohol dependence comorbidity and antipsychotic medication on volumes of the thalamus and pons in schizophrenia
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Am J Psychiatry 160:1110-6. 2003
    ..The authors sought to determine whether patients with both schizophrenia and alcohol dependence would manifest exaggerated volume deficits in either structure...
  100. ncbi Upper and lower limb motor impairments in alcoholism, HIV infection, and their comorbidity
    Rosemary Fama
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 31:1038-44. 2007
    ....
  101. ncbi Diffusion tensor imaging in normal aging and neuropsychiatric disorders
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Eur J Radiol 45:244-55. 2003
    ..Investigations comparing diagnoses hold promise for contribution to differential diagnosis. Correlations with cognitive and motor performance provide evidence for functional ramifications of these diffusion measures...

Research Grants25

  1. Neuroimaging in Animal Models of Alcoholism
    Adolf Pfefferbaum; Fiscal Year: 2007
    ..Aim 4: As a resource, provide MR imaging expertise to other INIA-West and INIA-East investigators for in vivo studies of animal models of alcoholism. ..
  2. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
    ..Specific Aim 4: Translation from rats to humans: Identify neuroradiological signs of nutritional deficiency compounding alcoholism-related dysmorphology in human alcoholics. ..
  3. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
    ..Specific Aim 4: Translation from rats to humans: Identify neuroradiological signs of nutritional deficiency compounding alcoholism-related dysmorphology in human alcoholics. ..
  4. TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGING
    Adolf Pfefferbaum; Fiscal Year: 2007
    ....
  5. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..Specific Aim 4: Translation from rats to humans: Identify neuroradiological signs of nutritional deficiency compounding alcoholism-related dysmorphology in human alcoholics. ..
  6. IN VIVO DIFFUSION AND SPECTROSCOPIC BRAIN IMAGING IN ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..abstract_text> ..
  7. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..Specific Aim 4: Translation from rats to humans: Identify neuroradiological signs of nutritional deficiency compounding alcoholism-related dysmorphology in human alcoholics. ..
  8. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2007
    ..Specific Aim 4: Translation from rats to humans: Identify neuroradiological signs of nutritional deficiency compounding alcoholism-related dysmorphology in human alcoholics. ..
  9. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  10. IN VIVO DIFFUSION & SPECTROSCOPIC BRAIN IMAGING IN ALCOH
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..We will develop high-resolution DTI and MRSI acquisition procedures in order to sample multiple diffusion and spectroscopic voxels within WMHIs. ..