S Morairty

Summary

Affiliation: SRI International
Country: USA

Publications

  1. ncbi request reprint Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion
    S Morairty
    SRI International, Menlo Park, CA, USA
    Neuroscience 123:451-7. 2004
  2. pmc Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone
    Stephen R Morairty
    Center for Neuroscience and Metabolic Disease Research, SRI International, Menlo Park, California, USA
    PLoS ONE 7:e39131. 2012
  3. pmc Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats
    Stephen R Morairty
    Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Sleep 31:34-44. 2008
  4. pmc The wake-promoting effects of hypocretin-1 are attenuated in old rats
    Stephen R Morairty
    Biosciences Division, SRI International, CA 94025, USA
    Neurobiol Aging 32:1514-27. 2011
  5. ncbi request reprint Age-related changes in histamine receptor mRNA levels in the mouse brain
    Akira Terao
    Molecular Neurobiology Laboratory, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neurosci Lett 355:81-4. 2004
  6. pmc GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus
    Xinmin Xie
    Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    J Physiol 574:399-414. 2006

Detail Information

Publications6

  1. ncbi request reprint Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion
    S Morairty
    SRI International, Menlo Park, CA, USA
    Neuroscience 123:451-7. 2004
    ..AD application increased the firing rate in two of four cells tested. These data are consistent with the hypothesis that one mechanism which AD may promote sleep is by blocking inhibitory inputs on VLPO sleep-active neurons...
  2. pmc Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone
    Stephen R Morairty
    Center for Neuroscience and Metabolic Disease Research, SRI International, Menlo Park, California, USA
    PLoS ONE 7:e39131. 2012
    ..In contrast to GABA receptor agonists which induce sleep by generalized inhibition, HCRTR antagonists seem to facilitate sleep by reducing waking "drive"...
  3. pmc Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats
    Stephen R Morairty
    Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Sleep 31:34-44. 2008
    ..Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT6 antagonist RO4368554 (RO) and the 5-HT2A receptor antagonist MDL100907 (MDL) relative to zolpidem...
  4. pmc The wake-promoting effects of hypocretin-1 are attenuated in old rats
    Stephen R Morairty
    Biosciences Division, SRI International, CA 94025, USA
    Neurobiol Aging 32:1514-27. 2011
    ..ICV infusions of hypocretin-2 (10 and 30 μg) produced fewer effects in both young and old rats. These data demonstrate that activation of a major sleep/wake regulatory pathway is attenuated in old rats...
  5. ncbi request reprint Age-related changes in histamine receptor mRNA levels in the mouse brain
    Akira Terao
    Molecular Neurobiology Laboratory, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neurosci Lett 355:81-4. 2004
    ....
  6. pmc GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus
    Xinmin Xie
    Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    J Physiol 574:399-414. 2006
    ....