Carol E Green

Summary

Affiliation: SRI International
Country: USA

Publications

  1. pmc Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent
    Carol E Green
    Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Cancer Chemother Pharmacol 67:995-1006. 2011
  2. ncbi request reprint Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1
    Anna M Furimsky
    Toxicology and Metabolism, Biosciences Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Drug Metab Dispos 36:129-36. 2008
  3. doi request reprint The stereoselective sulfate conjugation of 4'-methoxyfenoterol stereoisomers by sulfotransferase enzymes
    Lalitha V Iyer
    Biosciences Division, SRI International, Menlo Park, California, USA
    Chirality 24:796-803. 2012
  4. ncbi request reprint Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome
    Jon C Mirsalis
    Toxicology Laboratory, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 3493, USA
    Cancer Chemother Pharmacol 51:193-201. 2003
  5. ncbi request reprint Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9
    Lalitha V Iyer
    Biopharmaceutical Division, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    Toxicol Sci 73:36-43. 2003
  6. ncbi request reprint Absorption, tissue distribution and elimination of 4-[(3)h]-epigallocatechin gallate in beagle dogs
    Robert R Swezey
    Department of Drug Metabolism and Pharmacokinetics, SRI International, Menlo Park, California 94025, USA
    Int J Toxicol 22:187-93. 2003
  7. pmc A systematic screen of FDA-approved drugs for inhibitors of biological threat agents
    Peter B Madrid
    Center for Infectious Disease and Biodefense Research, SRI International, Menlo Park, California, USA
    PLoS ONE 8:e60579. 2013
  8. pmc Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity
    Toufan Parman
    Biosciences Division, SRI International, Menlo Park, California 94025 3493, USA
    Toxicol Sci 124:487-501. 2011
  9. pmc Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models
    Sunetra Ray
    SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    J Med Chem 53:3685-95. 2010
  10. pmc Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis
    Sidharth Chopra
    Center for Infectious Disease and Biodefense Research, Bioscience Division, SRI International, Menlo Park, CA 94025 3493, USA
    J Med Chem 55:6047-60. 2012

Collaborators

Detail Information

Publications15

  1. pmc Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent
    Carol E Green
    Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Cancer Chemother Pharmacol 67:995-1006. 2011
    ..The objective of these studies was to better understand the source of low oral exposure and to develop a formulation that could be used in preclinical development studies...
  2. ncbi request reprint Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1
    Anna M Furimsky
    Toxicology and Metabolism, Biosciences Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Drug Metab Dispos 36:129-36. 2008
    ..These findings also imply that resveratrol may inhibit the metabolism of other estrogen analogs or therapeutic agents such as ethinylestradiol or dietary components that are also substrates for SULT1E1...
  3. doi request reprint The stereoselective sulfate conjugation of 4'-methoxyfenoterol stereoisomers by sulfotransferase enzymes
    Lalitha V Iyer
    Biosciences Division, SRI International, Menlo Park, California, USA
    Chirality 24:796-803. 2012
    ..In conclusion, the results suggest that a formulation developed from a mixture of (R,R')-MF and (S,R')-MF may increase the oral bioavailability of (R,R')-MF...
  4. ncbi request reprint Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome
    Jon C Mirsalis
    Toxicology Laboratory, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 3493, USA
    Cancer Chemother Pharmacol 51:193-201. 2003
    ....
  5. ncbi request reprint Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9
    Lalitha V Iyer
    Biopharmaceutical Division, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    Toxicol Sci 73:36-43. 2003
    ..Our results also have toxicogenetic significance, as UGT2B7 is polymorphic and could potentially result in genetic differences in glucuronidation of 1'-HE and, hence, toxicity of estragole...
  6. ncbi request reprint Absorption, tissue distribution and elimination of 4-[(3)h]-epigallocatechin gallate in beagle dogs
    Robert R Swezey
    Department of Drug Metabolism and Pharmacokinetics, SRI International, Menlo Park, California 94025, USA
    Int J Toxicol 22:187-93. 2003
    ..These results are generally in accord with previous studies in rodents and indicate that, after oral administration, EGCG (as parent compound and metabolites) is widely distributed to tissues where it can exert a chemopreventive effect...
  7. pmc A systematic screen of FDA-approved drugs for inhibitors of biological threat agents
    Peter B Madrid
    Center for Infectious Disease and Biodefense Research, SRI International, Menlo Park, California, USA
    PLoS ONE 8:e60579. 2013
    ..Therefore, approved drugs could rapidly be made available for a new indication in an emergency...
  8. pmc Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity
    Toufan Parman
    Biosciences Division, SRI International, Menlo Park, California 94025 3493, USA
    Toxicol Sci 124:487-501. 2011
    ....
  9. pmc Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models
    Sunetra Ray
    SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA
    J Med Chem 53:3685-95. 2010
    ..When tested in mice, these compounds were found to have biological half-lives and plasma exposure values similar to or higher than those of CQ; they are therefore desirable candidates to pursue in future clinical trials...
  10. pmc Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis
    Sidharth Chopra
    Center for Infectious Disease and Biodefense Research, Bioscience Division, SRI International, Menlo Park, CA 94025 3493, USA
    J Med Chem 55:6047-60. 2012
    ..These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs...
  11. ncbi request reprint Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques
    Sandhya Ramanathan-Girish
    SRI International, Menlo Park, California 94025, USA
    Int J Toxicol 23:179-89. 2004
    ....
  12. doi request reprint Evaluating the toxicity of novel Zn-DTPA tablet formulation in dogs and rats
    Gita N Shankar
    SRI International, Biosciences Division, Menlo Park, CA, USA
    Drug Dev Res 75:37-46. 2014
    ..For rats, the NOAEL was estimated to be greater than 1000 mg/kg/day when administered by oral gavage of the crushed Zn-DTPA tablets as suspension once daily (qd) to male and female Sprague Dawley rats...
  13. pmc (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
    Rajib K Paul
    From the Laboratory of Clinical Investigation R K P, N S S, M K, R M, M S, I W W and Translational Gerontology Branch M B, National Institute on Aging, National Institutes of Health, Baltimore, Maryland SRI Biosciences, SRI International, Menlo Park, California C E G, K O and Department of Anesthesiology, Cooper Medical School of Rowan University, Camden, New Jersey M C T, I W W
    Anesthesiology 121:149-59. 2014
    ....
  14. ncbi request reprint Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms
    Shirley S Brill
    Toxicology and Metabolism, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    J Pharm Pharmacol 58:469-79. 2006
    ..2 +/- 2.1 microM) and 7-HFC (Ki = 0.6 +/- 0.2 microM). Hence, resveratrol has the potential to inhibit the glucuronidation of concomitantly administered therapeutic drugs or dietary components that are substrates of UGT1A1 and UGT1A9...
  15. ncbi request reprint Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent
    Paul Catz
    Toxicology and Metabolism Laboratory, SRI International, 333 Ravenswood Ave Menlo Park, CA 94025, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 829:123-35. 2005
    ....