Rupa S Doppalapudi

Summary

Affiliation: SRI International
Country: USA

Publications

  1. ncbi Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen
    Rupa S Doppalapudi
    SRI International, Biosciences Division, Menlo Park, CA 94025, USA
    Mutat Res 746:78-88. 2012
  2. ncbi Evaluation of chemopreventive agents for genotoxic activity
    Rupa S Doppalapudi
    SRI International, Biosciences Division, Menlo Park, CA 94025, USA
    Mutat Res 629:148-60. 2007
  3. ncbi Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: towards a safe and effective human dosing regimen
    Deborah I Bunin
    Biosciences Division, SRI International, Menlo Park, California 94025M, USA
    Radiat Res 179:171-82. 2013
  4. ncbi Low-calcemic, efficacious, 1alpha,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry
    Gary H Posner
    Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Steroids 69:757-62. 2004

Collaborators

Detail Information

Publications4

  1. ncbi Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen
    Rupa S Doppalapudi
    SRI International, Biosciences Division, Menlo Park, CA 94025, USA
    Mutat Res 746:78-88. 2012
    ..None of the compounds were genotoxic, in the presence or absence of S9, in the GADD45α-GFP Human GreenScreen assay and none induced MN in mouse bone marrow erythrocytes...
  2. ncbi Evaluation of chemopreventive agents for genotoxic activity
    Rupa S Doppalapudi
    SRI International, Biosciences Division, Menlo Park, CA 94025, USA
    Mutat Res 629:148-60. 2007
    ..The results with geraniol remain inconclusive. I3C, BBIC and BTP were not tested in the chromosomal aberration assay. None of the 11 agents induced micronuclei in mouse bone marrow erythrocytes...
  3. ncbi Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: towards a safe and effective human dosing regimen
    Deborah I Bunin
    Biosciences Division, SRI International, Menlo Park, California 94025M, USA
    Radiat Res 179:171-82. 2013
    ..These results are necessary components of the regulatory approval process and will help determine the optimal human dosing regimens for the treatment of internal radionuclide contamination...
  4. ncbi Low-calcemic, efficacious, 1alpha,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry
    Gary H Posner
    Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Steroids 69:757-62. 2004
    ..This analog is shown to be approximately 80-100 times less calciuric than the natural hormone 1alpha,25-dihydoxyvitamin D3. This analog is shown also to be non-genotoxic in three different standard assays...