IAN COLRAIN

Summary

Affiliation: SRI International
Country: USA

Publications

  1. ncbi request reprint The K-complex: a 7-decade history
    Ian M Colrain
    Human Sleep Research Program, SRI international and Department of Psychology, The University of Melbourne, Melbourne, Australia
    Sleep 28:255-73. 2005
  2. pmc Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence
    Ian M Colrain
    Human Sleep Research Program, Center for Health Sciences, SRI International Menlo Park, CA, USA
    Front Neurol 3:13. 2012
  3. pmc A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea
    Ian M Colrain
    SRI International, Menlo Park, CA 94025, USA
    Sleep Med 14:830-7. 2013
  4. pmc Electrophysiological evidence of enhanced performance monitoring in recently abstinent alcoholic men
    Mayra L Padilla
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Psychopharmacology (Berl) 213:81-91. 2011
  5. pmc Impact of alcoholism on sleep architecture and EEG power spectra in men and women
    Ian M Colrain
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Sleep 32:1341-52. 2009
  6. pmc The impact of alcoholism on sleep evoked Delta frequency responses
    Ian M Colrain
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Biol Psychiatry 66:177-84. 2009
  7. pmc A pilot evaluation of a nasal expiratory resistance device for the treatment of obstructive sleep apnea
    Ian M Colrain
    Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
    J Clin Sleep Med 4:426-33. 2008
  8. pmc Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan
    Ian M Colrain
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Neurobiol Aging 31:874-83. 2010
  9. ncbi request reprint The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations
    Ian M Colrain
    Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
    Nicotine Tob Res 6:913-25. 2004
  10. pmc The use of evoked potentials in sleep research
    Ian M Colrain
    Human Sleep Research Program, Stanford Research Institute, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Sleep Med Rev 11:277-93. 2007

Research Grants

  1. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2003
  2. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2004
  3. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2005
  4. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2006
  5. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2007
  6. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2006
  7. Alcohol, Sleep and Brain Development
    IAN COLRAIN; Fiscal Year: 2007

Collaborators

Detail Information

Publications41

  1. ncbi request reprint The K-complex: a 7-decade history
    Ian M Colrain
    Human Sleep Research Program, SRI international and Department of Psychology, The University of Melbourne, Melbourne, Australia
    Sleep 28:255-73. 2005
    ....
  2. pmc Partial recovery of alcohol dependence-related deficits in sleep evoked potentials following 12 months of abstinence
    Ian M Colrain
    Human Sleep Research Program, Center for Health Sciences, SRI International Menlo Park, CA, USA
    Front Neurol 3:13. 2012
    ..The data indicate that the sleep evoked response may provide a sensitive marker of brain recovery with abstinence from alcohol...
  3. pmc A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea
    Ian M Colrain
    SRI International, Menlo Park, CA 94025, USA
    Sleep Med 14:830-7. 2013
    ....
  4. pmc Electrophysiological evidence of enhanced performance monitoring in recently abstinent alcoholic men
    Mayra L Padilla
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Psychopharmacology (Berl) 213:81-91. 2011
    ..Chronic alcoholism is associated with mild to moderate cognitive impairment. Under certain conditions, impairment can be ameliorated by invoking compensatory processes...
  5. pmc Impact of alcoholism on sleep architecture and EEG power spectra in men and women
    Ian M Colrain
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Sleep 32:1341-52. 2009
    ..To determine the impact of alcoholism on sleep architecture and sleep EEG power spectra in men and women with uncomplicated alcoholism...
  6. pmc The impact of alcoholism on sleep evoked Delta frequency responses
    Ian M Colrain
    Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Biol Psychiatry 66:177-84. 2009
    ..Given the known neurodegenerative consequences of alcohol abuse it was hypothesized that alcoholism would be associated with further KC amplitude and incidence reductions...
  7. pmc A pilot evaluation of a nasal expiratory resistance device for the treatment of obstructive sleep apnea
    Ian M Colrain
    Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
    J Clin Sleep Med 4:426-33. 2008
    ..The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary snorers...
  8. pmc Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespan
    Ian M Colrain
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Neurobiol Aging 31:874-83. 2010
    ..Smaller, yet still significant reductions were seen in the ability to elicit K-complexes. The data highlight the utility of evoked K-complexes as a sensitive marker of brain aging in men and women...
  9. ncbi request reprint The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendations
    Ian M Colrain
    Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
    Nicotine Tob Res 6:913-25. 2004
    ....
  10. pmc The use of evoked potentials in sleep research
    Ian M Colrain
    Human Sleep Research Program, Stanford Research Institute, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Sleep Med Rev 11:277-93. 2007
    ....
  11. pmc Independent contributions of cortical gray matter, aging, sex and alcoholism to K-complex amplitude evoked during sleep
    Ian M Colrain
    Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
    Sleep 34:787-95. 2011
    ..The study was designed to determine whether these declines are related to the extent of cortical or subcortical shrinkage...
  12. pmc Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects
    Ian M Colrain
    SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Psychopharmacology (Berl) 213:669-79. 2011
    ..Degradation of white matter tracts related to age or alcoholism should negatively affect the oscillatory activity within the network...
  13. doi request reprint Changes in sleep as a function of adolescent development
    Ian M Colrain
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
    Neuropsychol Rev 21:5-21. 2011
    ....
  14. doi request reprint Sleep and the brain
    Ian M Colrain
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neuropsychol Rev 21:1-4. 2011
    ....
  15. pmc Developmental changes in the sleep electroencephalogram of adolescent boys and girls
    Fiona C Baker
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
    J Sleep Res 21:59-67. 2012
    ..Declines in sleep EEG spectral power occur across adolescence in both boys and girls, particularly in the occipital derivation, and are not state-specific, occurring in both NREM and REM sleep...
  16. ncbi request reprint The effects of alcoholism on auditory evoked potentials during sleep
    Christian L Nicholas
    Department of Psychology, University of Melbourne, Melbourne, Australia
    J Sleep Res 11:247-53. 2002
    ..The finding also suggests that the evoked K-complex may be a relatively simple measure of the effect of alcoholism on EEG during sleep...
  17. ncbi request reprint The effects of hormone replacement therapy on sleep-disordered breathing in postmenopausal women: a pilot study
    Rachel Manber
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA
    Sleep 26:163-8. 2003
    ..To evaluate the impact of estrogen and estrogen plus progesterone hormone-replacement therapy (HRT) on mild-to-moderate sleep-disordered breathing (SDB) in postmenopausal women...
  18. pmc Sleep quality and the sleep electroencephalogram in women with severe premenstrual syndrome
    Fiona C Baker
    Human Sleep Research Program, SRI International, Menlo Park, CA 94043, USA
    Sleep 30:1283-91. 2007
    ..We investigated sleep quality and sleep composition using conventional and quantitative electroencephalographic analyses in women with severe PMS, as compared with that of controls...
  19. doi request reprint Personality disorders in women with severe premenstrual syndrome
    Stephanie A Sassoon
    Neuroscience Program, SRI International, 333 Ravenswood Ave, BN 165, Menlo Park, CA 94025, USA
    Arch Womens Ment Health 14:257-64. 2011
    ..The comorbidity of a personality disorder and severe PMS places an additive burden on general life functioning and may have implications for psychiatric treatment or medication given to those with severe premenstrual symptoms...
  20. pmc Daytime sleepiness, psychomotor performance, waking EEG spectra and evoked potentials in women with severe premenstrual syndrome
    Fiona C Baker
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
    J Sleep Res 19:214-27. 2010
    ..However, the ability to maintain wakefulness under soporific conditions, spectral properties of waking EEG and cognitive processing do not vary in synchrony with premenstrual symptoms...
  21. pmc Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome
    Fiona C Baker
    Human Sleep Research Program, SRI International, CA, USA
    J Psychosom Res 65:13-22. 2008
    ..There is some evidence that altered autonomic function may be an important component of PMS, but few studies have used heart rate variability (HRV) as a sensitive marker of autonomic activity in severe PMS, and findings are conflicting...
  22. ncbi request reprint Evoked K-complex generation: the impact of sleep spindles and age
    Kate Crowley
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Clin Neurophysiol 115:471-6. 2004
    ..The present study sought to test this hypothesis in young and elderly subjects...
  23. ncbi request reprint A review of the evidence for P2 being an independent component process: age, sleep and modality
    Kate E Crowley
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Clin Neurophysiol 115:732-44. 2004
    ....
  24. ncbi request reprint Genetic and environmental influences in sleep-disordered breathing in older male twins
    Dorit Carmelli
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Sleep 27:917-22. 2004
    ..To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins...
  25. ncbi request reprint P3-specific amplitude reductions to respiratory and auditory stimuli in subjects with asthma
    Kate E Webster
    Musculoskeletal Research Centre, La Trobe University, Melbourne, Australia
    Am J Respir Crit Care Med 166:47-52. 2002
    ..Other components were similar between the groups. These results suggest an intrinsic reduction in P3 amplitude for patients with asthma, which may relate to differences in processing perceptual information...
  26. ncbi request reprint Differentiating pathologic delta from healthy physiologic delta in patients with Alzheimer disease
    Kate Crowley
    Compumedics Limited, Melbourne, Australia
    Sleep 28:865-70. 2005
    ....
  27. ncbi request reprint Evidence of a sleep-specific blunted cortical response to inspiratory occlusions in mild obstructive sleep apnea syndrome
    John Gora
    Department of Psychology, University of Melbourne, Australia
    Am J Respir Crit Care Med 166:1225-34. 2002
    ..This appears not to be related to compromised mechanoreceptor function, as the RREP was normal in the patients when they were awake...
  28. ncbi request reprint Increased production of evoked and spontaneous K-complexes following a night of fragmented sleep
    Christian L Nicholas
    School of Behavioural Science, The University of Melbourne
    Sleep 25:882-7. 2002
    ..To determine whether K-complex production is better interpreted as being an arousal response or reflective of a sleep protective micro-state...
  29. ncbi request reprint The effects of normal aging on sleep spindle and K-complex production
    Kate Crowley
    Department of Psychology, University of Melbourne, Australia
    Clin Neurophysiol 113:1615-22. 2002
    ..Whether or not these changes are an inevitable consequence of the aging process can be addressed by studying healthy older adults who provide an example of the effects of age independently from those of disease...
  30. ncbi request reprint Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS
    Lamia Afifi
    Department of Neurology, Cairo University, Cairo, Egypt
    Respir Physiol Neurobiol 136:221-34. 2003
    ..The absence of significant group differences in the responses to auditory stimuli highlight that the sleep-related differences seen in OSAS patients are specific to the processing of inspiratory effort related stimuli...
  31. ncbi request reprint Novel measures of daytime central nervous system function following sleep disruption
    Ian M Colrain
    Sleep 26:650-1. 2003
  32. ncbi request reprint An examination of evoked K-complex amplitude and frequency of occurrence in the elderly
    Kate Crowley
    Department of Psychology, University of Melbourne, Australia
    J Sleep Res 11:129-40. 2002
    ..The enhanced P2 component and the long-lasting positive deflection in the EEG in the elderly indicate the existence of age differences other than smaller EEG amplitude...
  33. pmc Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome
    Jingtao Huang
    The Sleep Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 178:757-64. 2008
    ..The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown...
  34. ncbi request reprint The impact of slow wave sleep proximity on evoked K-complex generation
    Christian L Nicholas
    Department of Psychology, University of Melbourne, Vic, Australia
    Neurosci Lett 404:127-31. 2006
    ..They also indicate that stage 2 may consist of a continuum of microstates between SWS and REM sleep that are indicative of different brain stem, diecephalic and cortical patterns of activation...
  35. pmc Effect of sleep stage on breathing in children with central hypoventilation
    Jingtao Huang
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol (1985) 105:44-53. 2008
    ..The hypoventilation in CHS is more severe during NREM than REM sleep. We speculate that this may be due to increased excitatory inputs to the respiratory system during REM sleep...
  36. pmc Cortical processing of respiratory afferent stimuli during sleep in children with the obstructive sleep apnea syndrome
    Jingtao Huang
    The Sleep Center Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 31:403-10. 2008
    ..We hypothesized that children with OSAS have blunted RREP responses compared to normal children during sleep...
  37. ncbi request reprint P300 and the daytime consequences of disturbed nocturnal sleep: easy to measure but difficult to interpret
    Ian M Colrain
    Sleep 28:790-2. 2005
  38. ncbi request reprint The effect of stimulus probability on P3 in the respiratory-related evoked potential
    Kate E Webster
    La Trobe University Musculoskeletal Research Centre, La Trobe University, Victoria, Australia
    Psychophysiology 39:9-15. 2002
    ..These data suggest that models developed to describe the effect of stimulus probability on the amplitude of visual and auditory P3 components are applicable to the respiratory somatosensory modality...
  39. ncbi request reprint Event-related potential measures of the inhibition of information processing: II. The sleep onset period
    Kenneth B Campbell
    School of Psychology, University of Ottawa, Ottawa, Canada K1N 6N5
    Int J Psychophysiol 46:197-214. 2002
    ..It is unique to the sleep onset and sleep periods, becoming very large during stage 1-theta or when the subject no longer shows signs of awareness of the external stimulus...
  40. ncbi request reprint Evoked potential components unique to non-REM sleep: relationship to evoked K-complexes and vertex sharp waves
    Celyne H Bastien
    Centre d étude des troubles du sommeil et Ecole de Psychologie, Universite Laval, Cite Universitaire, Ste Foy, Quebec, Canada GIK 7P4
    Int J Psychophysiol 46:257-74. 2002
    ....
  41. ncbi request reprint P300 from inspiratory occlusion reflects orienting but not startle
    Kate E Webster
    Musculoskeletal Research Centre, La Trobe University, La Trobe, Victoria, Australia
    Biol Psychol 66:21-33. 2004
    ..These data indicate that the previously studied centro-parietal P300 is not related to a startle reflex. However, when occlusions are first presented, a scalp topography similar to that previously noted for novel stimuli is observed...

Research Grants8

  1. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2003
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  2. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2004
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  3. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2005
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  4. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2006
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  5. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2007
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  6. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2006
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  7. Alcohol, Sleep and Brain Development
    IAN COLRAIN; Fiscal Year: 2007
    ..Aim 4. By comparing drinking with non-drinking children in the older cohort, determine the effect sizes of the measured influence of alcohol exposure on our various measures of brain development in mid-adolescence. ..