Research Topics
| IAN COLRAINSummaryAffiliation: SRI International Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
The K-complex: a 7-decade historyIan M Colrain
Human Sleep Research Program, SRI international and Department of Psychology, The University of Melbourne, Melbourne, Australia
Sleep 28:255-73. 2005....
Electrophysiological evidence of enhanced performance monitoring in recently abstinent alcoholic menMayra L Padilla
Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
Psychopharmacology (Berl) 213:81-91. 2011..Chronic alcoholism is associated with mild to moderate cognitive impairment. Under certain conditions, impairment can be ameliorated by invoking compensatory processes...- The use of evoked potentials in sleep researchIan M Colrain
Human Sleep Research Program, Stanford Research Institute, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
Sleep Med Rev 11:277-93. 2007.... 
Sleep evoked delta frequency responses show a linear decline in amplitude across the adult lifespanIan M Colrain
Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
Neurobiol Aging 31:874-83. 2010..Smaller, yet still significant reductions were seen in the ability to elicit K-complexes. The data highlight the utility of evoked K-complexes as a sensitive marker of brain aging in men and women...- A pilot evaluation of a nasal expiratory resistance device for the treatment of obstructive sleep apneaIan M Colrain
Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
J Clin Sleep Med 4:426-33. 2008..The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary snorers... - The impact of alcoholism on sleep evoked Delta frequency responsesIan M Colrain
Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
Biol Psychiatry 66:177-84. 2009..Given the known neurodegenerative consequences of alcohol abuse it was hypothesized that alcoholism would be associated with further KC amplitude and incidence reductions... - Impact of alcoholism on sleep architecture and EEG power spectra in men and womenIan M Colrain
Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
Sleep 32:1341-52. 2009..To determine the impact of alcoholism on sleep architecture and sleep EEG power spectra in men and women with uncomplicated alcoholism... - Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effectsIan M Colrain
SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
Psychopharmacology (Berl) 213:669-79. 2011..Degradation of white matter tracts related to age or alcoholism should negatively affect the oscillatory activity within the network... - Changes in sleep as a function of adolescent developmentIan M Colrain
Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
Neuropsychol Rev 21:5-21. 2011.... - Sleep and the brainIan M Colrain
Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
Neuropsychol Rev 21:1-4. 2011.... - Independent contributions of cortical gray matter, aging, sex and alcoholism to K-complex amplitude evoked during sleepIan M Colrain
Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
Sleep 34:787-95. 2011..The study was designed to determine whether these declines are related to the extent of cortical or subcortical shrinkage... - The impact of smoking cessation on objective and subjective markers of sleep: review, synthesis, and recommendationsIan M Colrain
Human Sleep Research Program, SRI International, Menlo Park, CA 94025, USA
Nicotine Tob Res 6:913-25. 2004.... - Developmental changes in the sleep electroencephalogram of adolescent boys and girlsFiona C Baker
Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
J Sleep Res 21:59-67. 2012..Declines in sleep EEG spectral power occur across adolescence in both boys and girls, particularly in the occipital derivation, and are not state-specific, occurring in both NREM and REM sleep... - The effects of hormone replacement therapy on sleep-disordered breathing in postmenopausal women: a pilot studyRachel Manber
Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA
Sleep 26:163-8. 2003..To evaluate the impact of estrogen and estrogen plus progesterone hormone-replacement therapy (HRT) on mild-to-moderate sleep-disordered breathing (SDB) in postmenopausal women... - The effects of alcoholism on auditory evoked potentials during sleepChristian L Nicholas
Department of Psychology, University of Melbourne, Melbourne, Australia
J Sleep Res 11:247-53. 2002..The finding also suggests that the evoked K-complex may be a relatively simple measure of the effect of alcoholism on EEG during sleep... - P3-specific amplitude reductions to respiratory and auditory stimuli in subjects with asthmaKate E Webster
Musculoskeletal Research Centre, La Trobe University, Melbourne, Australia
Am J Respir Crit Care Med 166:47-52. 2002..Other components were similar between the groups. These results suggest an intrinsic reduction in P3 amplitude for patients with asthma, which may relate to differences in processing perceptual information... - Personality disorders in women with severe premenstrual syndromeStephanie A Sassoon
Neuroscience Program, SRI International, 333 Ravenswood Ave, BN 165, Menlo Park, CA 94025, USA
Arch Womens Ment Health 14:257-64. 2011..The comorbidity of a personality disorder and severe PMS places an additive burden on general life functioning and may have implications for psychiatric treatment or medication given to those with severe premenstrual symptoms... - Daytime sleepiness, psychomotor performance, waking EEG spectra and evoked potentials in women with severe premenstrual syndromeFiona C Baker
Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
J Sleep Res 19:214-27. 2010..However, the ability to maintain wakefulness under soporific conditions, spectral properties of waking EEG and cognitive processing do not vary in synchrony with premenstrual symptoms... - A review of the evidence for P2 being an independent component process: age, sleep and modalityKate E Crowley
Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
Clin Neurophysiol 115:732-44. 2004.... - Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndromeFiona C Baker
Human Sleep Research Program, SRI International, CA, USA
J Psychosom Res 65:13-22. 2008..There is some evidence that altered autonomic function may be an important component of PMS, but few studies have used heart rate variability (HRV) as a sensitive marker of autonomic activity in severe PMS, and findings are conflicting... - Sleep quality and the sleep electroencephalogram in women with severe premenstrual syndromeFiona C Baker
Human Sleep Research Program, SRI International, Menlo Park, CA 94043, USA
Sleep 30:1283-91. 2007..We investigated sleep quality and sleep composition using conventional and quantitative electroencephalographic analyses in women with severe PMS, as compared with that of controls... - Genetic and environmental influences in sleep-disordered breathing in older male twinsDorit Carmelli
Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
Sleep 27:917-22. 2004..To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins... - Evoked K-complex generation: the impact of sleep spindles and ageKate Crowley
Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
Clin Neurophysiol 115:471-6. 2004..The present study sought to test this hypothesis in young and elderly subjects... - Differentiating pathologic delta from healthy physiologic delta in patients with Alzheimer diseaseKate Crowley
Compumedics Limited, Melbourne, Australia
Sleep 28:865-70. 2005.... - Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSASLamia Afifi
Department of Neurology, Cairo University, Cairo, Egypt
Respir Physiol Neurobiol 136:221-34. 2003..The absence of significant group differences in the responses to auditory stimuli highlight that the sleep-related differences seen in OSAS patients are specific to the processing of inspiratory effort related stimuli... - The effects of normal aging on sleep spindle and K-complex productionKate Crowley
Department of Psychology, University of Melbourne, Australia
Clin Neurophysiol 113:1615-22. 2002..CONCLUSIONS: The age-related decrease in sleep spindle and K-complex density is consistent with previous reports and may be interpreted as an age-related alteration of thalamocortical regulatory mechanisms... - Evidence of a sleep-specific blunted cortical response to inspiratory occlusions in mild obstructive sleep apnea syndromeJohn Gora
Department of Psychology, University of Melbourne, Australia
Am J Respir Crit Care Med 166:1225-34. 2002..This appears not to be related to compromised mechanoreceptor function, as the RREP was normal in the patients when they were awake... - An examination of evoked K-complex amplitude and frequency of occurrence in the elderlyKate Crowley
Department of Psychology, University of Melbourne, Australia
J Sleep Res 11:129-40. 2002..The enhanced P2 component and the long-lasting positive deflection in the EEG in the elderly indicate the existence of age differences other than smaller EEG amplitude... - Increased production of evoked and spontaneous K-complexes following a night of fragmented sleepChristian L Nicholas
School of Behavioural Science, The University of Melbourne
Sleep 25:882-7. 2002..CONCLUSIONS: The increase in K-complex frequency together with the decrease seen in stimulus-related alpha activity supports the view that they reflect a sleep maintenance, rather than an arousal, response... - Cortical processing of respiratory afferent stimuli during sleep in children with the obstructive sleep apnea syndromeJingtao Huang
The Sleep Center Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
Sleep 31:403-10. 2008..We hypothesized that children with OSAS have blunted RREP responses compared to normal children during sleep... - Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndromeJingtao Huang
The Sleep Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Am J Respir Crit Care Med 178:757-64. 2008..The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown... - Novel measures of daytime central nervous system function following sleep disruptionIan M Colrain
Sleep 26:650-1. 2003 - Effect of sleep stage on breathing in children with central hypoventilationJingtao Huang
Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Appl Physiol 105:44-53. 2008..The hypoventilation in CHS is more severe during NREM than REM sleep. We speculate that this may be due to increased excitatory inputs to the respiratory system during REM sleep... - The impact of slow wave sleep proximity on evoked K-complex generationChristian L Nicholas
Department of Psychology, University of Melbourne, Vic, Australia
Neurosci Lett 404:127-31. 2006..They also indicate that stage 2 may consist of a continuum of microstates between SWS and REM sleep that are indicative of different brain stem, diecephalic and cortical patterns of activation... - P300 from inspiratory occlusion reflects orienting but not startleKate E Webster
Musculoskeletal Research Centre, La Trobe University, La Trobe, Victoria, Australia
Biol Psychol 66:21-33. 2004..These data indicate that the previously studied centro-parietal P300 is not related to a startle reflex. However, when occlusions are first presented, a scalp topography similar to that previously noted for novel stimuli is observed... - The effect of stimulus probability on P3 in the respiratory-related evoked potentialKate E Webster
La Trobe University Musculoskeletal Research Centre, La Trobe University, Victoria, Australia
Psychophysiology 39:9-15. 2002..These data suggest that models developed to describe the effect of stimulus probability on the amplitude of visual and auditory P3 components are applicable to the respiratory somatosensory modality... - Evoked potential components unique to non-REM sleep: relationship to evoked K-complexes and vertex sharp wavesCelyne H Bastien
Centre d étude des troubles du sommeil et Ecole de Psychologie, Universite Laval, Cite Universitaire, Ste Foy, Quebec, Canada GIK 7P4
Int J Psychophysiol 46:257-74. 2002.... - Event-related potential measures of the inhibition of information processing: II. The sleep onset periodKenneth B Campbell
School of Psychology, University of Ottawa, Ottawa, Canada K1N 6N5
Int J Psychophysiol 46:197-214. 2002..It is unique to the sleep onset and sleep periods, becoming very large during stage 1-theta or when the subject no longer shows signs of awareness of the external stimulus... - P300 and the daytime consequences of disturbed nocturnal sleep: easy to measure but difficult to interpretIan M Colrain
Sleep 28:790-2. 2005
Research Grants
- Alcoholism, Sleep and the BrainIAN COLRAIN; Fiscal Year: 2007..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
- Alcohol, Sleep and Brain DevelopmentIAN COLRAIN; Fiscal Year: 2007..Aim 4. By comparing drinking with non-drinking children in the older cohort, determine the effect sizes of the measured influence of alcohol exposure on our various measures of brain development in mid-adolescence. ..