P Y Chang

Summary

Affiliation: SRI International
Country: USA

Publications

  1. ncbi request reprint p53 deficiency alters the yield and spectrum of radiation-induced lacZ mutants in the brain of transgenic mice
    P Y Chang
    PN147, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Mutagenesis 16:7-15. 2001
  2. ncbi request reprint Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E
    Polly Y Chang
    Biopharmaceutical Development Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Environ Mol Mutagen 41:43-54. 2003
  3. doi request reprint Biological impact of low dose-rate simulated solar particle event radiation in vivo
    P Y Chang
    SRI International, PN175, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Radiat Environ Biophys 49:379-88. 2010
  4. ncbi request reprint Impact of p53 status on heavy-ion radiation-induced micronuclei in circulating erythrocytes
    P Y Chang
    PN147, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Mutat Res 466:87-96. 2000
  5. ncbi request reprint HZE particle radiation induces tissue-specific and p53-dependent mutagenesis in transgenic animals
    P Y Chang
    SRI International, Menlo Park, CA 94025, USA
    Phys Med 17:189-91. 2001
  6. ncbi request reprint Proton-induced genetic damage in lacZ transgenic mice
    Polly Y Chang
    SRI International, Menlo Park, California 94025, USA
    Radiat Res 164:481-6. 2005
  7. ncbi request reprint Evaluation of the impact of shielding materials in radiation protection in transgenic animals
    P Y Chang
    SRI International, PN175, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Radiat Environ Biophys 46:113-8. 2007
  8. ncbi request reprint Late effects from hadron therapy
    Eleanor A Blakely
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94620, USA
    Radiother Oncol 73:S134-40. 2004

Collaborators

Detail Information

Publications8

  1. ncbi request reprint p53 deficiency alters the yield and spectrum of radiation-induced lacZ mutants in the brain of transgenic mice
    P Y Chang
    PN147, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Mutagenesis 16:7-15. 2001
    ..These observations are unique in that mutations in brain tissue after particle radiation exposure have never before been reported owing to technical limitations in most other mutation assays...
  2. ncbi request reprint Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E
    Polly Y Chang
    Biopharmaceutical Development Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Environ Mol Mutagen 41:43-54. 2003
    ..In addition, these studies highlight the importance of using both in vitro and in vivo systems in genetic toxicity screening of pharmaceuticals before they are administered to humans...
  3. doi request reprint Biological impact of low dose-rate simulated solar particle event radiation in vivo
    P Y Chang
    SRI International, PN175, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Radiat Environ Biophys 49:379-88. 2010
    ....
  4. ncbi request reprint Impact of p53 status on heavy-ion radiation-induced micronuclei in circulating erythrocytes
    P Y Chang
    PN147, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Mutat Res 466:87-96. 2000
    ..These results suggest that the lack of p53 gene function may play a role in the iron particle radiation-induced genomic instability in stem cell populations in the hematopoietic system...
  5. ncbi request reprint HZE particle radiation induces tissue-specific and p53-dependent mutagenesis in transgenic animals
    P Y Chang
    SRI International, Menlo Park, CA 94025, USA
    Phys Med 17:189-91. 2001
    ..Our results indicate that the accumulation of transgene MF after radiation exposure is dependant on the tissue examined as well as the p53 genetic background of the animals...
  6. ncbi request reprint Proton-induced genetic damage in lacZ transgenic mice
    Polly Y Chang
    SRI International, Menlo Park, California 94025, USA
    Radiat Res 164:481-6. 2005
    ..These in vivo results highlight the importance of considering tissue specificity, dose and temporal dependence when assessing radiation effects...
  7. ncbi request reprint Evaluation of the impact of shielding materials in radiation protection in transgenic animals
    P Y Chang
    SRI International, PN175, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Radiat Environ Biophys 46:113-8. 2007
    ....
  8. ncbi request reprint Late effects from hadron therapy
    Eleanor A Blakely
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94620, USA
    Radiother Oncol 73:S134-40. 2004
    ..Low-dose tissue effects at tumor margins need further study, and there is need for more acute molecular studies underlying late effects of hadron therapy...