Wenjie Wu

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. pmc Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:27. 2007
  2. pmc Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:150. 2007
  3. ncbi SmTR2/4, a Schistosoma mansoni homologue of TR2/TR4 orphan nuclear receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Int J Parasitol 36:1113-22. 2006
  4. ncbi Identification and characterization of a novel fushi tarazu factor 1 (FTZ-F1) nuclear receptor in Schistosoma mansoni
    Changxue Lu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Research, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:25-36. 2006
  5. ncbi Identification and characterization of a nuclear receptor subfamily I member in the Platyhelminth Schistosoma mansoni (SmNR1)
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY, USA
    FEBS J 274:390-405. 2007
  6. ncbi Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni
    Joelle M Carlo
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    FEBS J 274:4075-93. 2007
  7. ncbi Isolation and characterization of Schistosoma mansoni constitutive androstane receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 148:31-43. 2006
  8. ncbi Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: sixteen new members and a novel subfamily
    Wenjie Wu
    Department of Microbiology and Immunology, and Center for Microbial Pathogenesis, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    Gene 366:303-15. 2006
  9. pmc Nuclear hormone receptors in parasitic helminths
    Wenjie Wu
    Department of Biochemistry, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    Mol Cell Endocrinol 334:56-66. 2011
  10. doi Schistosoma mansoni: SmE78, a nuclear receptor orthologue of Drosophila ecdysone-induced protein 78
    Wenjie Wu
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0594, USA
    Exp Parasitol 119:313-8. 2008

Collaborators

Detail Information

Publications12

  1. pmc Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:27. 2007
    ..NRs typically have a single DBD with a LBD...
  2. pmc Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:150. 2007
    ..Thyroid hormone receptors (TRs) function as molecular switches in response to thyroid hormone to regulate gene transcription. TRs were previously believed to be present only in chordates...
  3. ncbi SmTR2/4, a Schistosoma mansoni homologue of TR2/TR4 orphan nuclear receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Int J Parasitol 36:1113-22. 2006
    ..A yeast-based transactivation assay demonstrated that the A/B domain, F domain and N-terminal part of the hinge region in SmTR2/4, when tethered to a GAL4 DNA binding domain, exhibited an autonomous transcription activation function...
  4. ncbi Identification and characterization of a novel fushi tarazu factor 1 (FTZ-F1) nuclear receptor in Schistosoma mansoni
    Changxue Lu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Research, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:25-36. 2006
    ..Our results suggest that SmFTZ-F1alpha plays a role in regulating schistosome development and sexual differentiation similar to other FTZ-F1 family members...
  5. ncbi Identification and characterization of a nuclear receptor subfamily I member in the Platyhelminth Schistosoma mansoni (SmNR1)
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY, USA
    FEBS J 274:390-405. 2007
    ..Transient transfection in mammalian COS-7 cells showed that SmNR1/SmRXR1 could enhance the transcriptional activation of a DR2-dependent reporter gene. Our results demonstrate that SmNR1 is a partner of SmRXR1...
  6. ncbi Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni
    Joelle M Carlo
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    FEBS J 274:4075-93. 2007
    ..In all, these data suggest the involvement of SmSmad1B in critical biological processes such as schistosome reproductive development...
  7. ncbi Isolation and characterization of Schistosoma mansoni constitutive androstane receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 148:31-43. 2006
    ..The AGTGCA half site is essential for binding of SmCAR to the p14 gene upstream region. Therefore, AGTGCA probably serves as a high affinity binding half site for ESCKA containing nuclear receptors...
  8. ncbi Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: sixteen new members and a novel subfamily
    Wenjie Wu
    Department of Microbiology and Immunology, and Center for Microbial Pathogenesis, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    Gene 366:303-15. 2006
    ..mansoni nuclear receptors evolved from a second gene duplication. As the second gene duplication of NRs was thought to be specific to vertebrates, our data challenge the current theory of NR evolution...
  9. pmc Nuclear hormone receptors in parasitic helminths
    Wenjie Wu
    Department of Biochemistry, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    Mol Cell Endocrinol 334:56-66. 2011
    ..NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss...
  10. doi Schistosoma mansoni: SmE78, a nuclear receptor orthologue of Drosophila ecdysone-induced protein 78
    Wenjie Wu
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0594, USA
    Exp Parasitol 119:313-8. 2008
    ..The result is consistent with the previous studies that Ecdysterone was effective in stimulating host location activities in miracidia. The data suggest that SmE78 may be involved in transduction of an ecdysone signal in S. mansoni...
  11. pmc Schistosoma mansoni: identification of SmNR4A, a member of nuclear receptor subfamily 4
    Wenjie Wu
    Departments of Biochemistry and Pathology, University of Texas Health Sciences Center, San Antonio, TX 78229 3800, USA
    Exp Parasitol 120:208-13. 2008
    ..The results demonstrated that SmNR4A expression was regulated throughout development. It was highly expressed in daughter sporocysts and 35-day worms, but barely expressed in cercariae and 1-h and 3-day schistosomules...
  12. ncbi Evidence for a dispersed Hox gene cluster in the platyhelminth parasite Schistosoma mansoni
    Raymond J Pierce
    INSERM U 547, Institut Pasteur de Lille, France
    Mol Biol Evol 22:2491-503. 2005
    ..The schistosome Hox cluster is therefore not duplicated, but is both dispersed and disintegrated in the genome...