Research Topics
Genomes and GenesSpecies | Venkata Saroja VorugantiSummaryAffiliation: Southwest Foundation for Biomedical Research Country: USA Publications
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Detail Information
Publications
Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.)Paul B Higgins
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Cardiovasc Diabetol 9:71. 2010....
Characterization of ghrelin in pedigreed baboons: evidence for heritability and pleiotropyV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Obesity (Silver Spring) 16:804-10. 2008..Ghrelin is an orexigenic hormone that is produced primarily in the stomach, and stimulates food intake via its receptors situated in the hypothalamus...
Genetics of variation in HOMA-IR and cardiovascular risk factors in Mexican-AmericansV Saroja Voruganti
Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
J Mol Med (Berl) 86:303-11. 2008..Significant genetic correlations between HOMA-IR and phenotypes related to CVD risk factors suggest that a common set of gene(s) influence the regulation of these phenotypes...
Genetic influence on variation in serum uric acid in American Indians: the strong heart family studyV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Hum Genet 126:667-76. 2009..These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations...
Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan EskimosV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Am J Clin Nutr 91:1574-83. 2010..Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease...
Genome-wide scan for serum ghrelin detects linkage on chromosome 1p36 in Hispanic children: results from the Viva La Familia studyV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
Pediatr Res 62:445-50. 2007..9), and C-peptide (LOD=2.0). Several family-based studies have reported linkages for obesity-related phenotypes in the region of 1p36. These results indicate the importance of this region in relation to adiposity in children from the VFS...
Short-term weight loss in overweight/obese low-income women improves plasma zinc and metabolic syndrome risk factorsVenkata Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
J Trace Elem Med Biol 24:271-6. 2010..28, p<0.05). The circulating levels of zinc, as well as the metabolic syndrome components, showed significant improvements in overweight/obese low-income women after weight loss...
Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican AmericansV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78227, USA
J Clin Endocrinol Metab 94:632-8. 2009..However, the role of uric acid as an independent risk factor for CVD is not yet clear...
Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family StudyPhillip E Melton
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
Hum Mol Genet 19:3662-71. 2010..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study...
Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic childrenShelley A Cole
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Am J Clin Nutr 91:191-9. 2010..Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain...
Genome scan for determinants of serum uric acid variabilitySubrata D Nath
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Am Soc Nephrol 18:3156-63. 2007..Given the relationship between uric acid level and these conditions, future studies should investigate potential candidate susceptibility genes found in this region...
Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican AmericansFarook Thameem
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA
Kidney Blood Press Res 32:200-4. 2009....
Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican AmericansFarook Thameem
Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Hum Genet 124:557-9. 2008..The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease...
Common set of genes regulates low-density lipoprotein size and obesity-related factors in Alaskan Eskimos: results from the GOCADAN studyV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227 5301, USA
Am J Hum Biol 18:525-31. 2006..36), waist (rhoG = -0.42,), and subscapular and tricep skinfolds (rhoG = -0.44 and -0.43, respectively) (P < 0.005). These results show that a common set of genes is influencing LDL size and obesity-related factors in Alaskan Eskimos...
Heritability of measures of kidney disease among Zuni Indians: the Zuni Kidney ProjectJean W Maccluer
Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Am J Kidney Dis 56:289-302. 2010....
Genome-wide scan of plasma cholecystokinin in baboons shows linkage to human chromosome 17V Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
Obesity (Silver Spring) 15:2043-50. 2007..Cholecystokinin (CCK) is known to inhibit food intake and is an important signal for controlling meal volume, indicating a possible role in weight regulation. Our objective was to investigate genetic influences on plasma CCK in baboons...
A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart StudySue Rutherford
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Am J Hum Genet 81:744-55. 2007..Further investigation of this region is necessary for the identification of the genetic variation responsible for QTLs influencing the rate of change in BP...
The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican AmericansSubrata D Nath
Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
Mol Cell Biochem 331:201-5. 2009....
Polyunsaturated fatty acids effect on serum triglycerides concentration in the presence of metabolic syndrome components. The Alaska-Siberia ProjectJuan C Lopez-Alvarenga
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
Metabolism 59:86-92. 2010..The Westernized dietary habits among Eskimos are likely to change their metabolic profile and increase comorbidities related to metabolic disease...
Physiological and molecular determinants of insulin action in the baboonAlberto O Chavez
Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Diabetes 57:899-908. 2008..To quantitate insulin sensitivity in lean and obese nondiabetic baboons and examine the underlying cellular/molecular mechanisms responsible for impaired insulin action to characterize a baboon model of insulin resistance...
A quantitative trait locus on chromosome 13q affects fasting glucose levels in Hispanic childrenGuowen Cai
United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, Texas 77030, USA
J Clin Endocrinol Metab 92:4893-6. 2007..The objective of this study was to localize quantitative trait loci influencing fasting serum glucose levels in Hispanic children participating in the Viva La Familia Study...
Low-income, overweight and obese mothers as agents of change to improve food choices, fat habits, and physical activity in their 1-to-3-year-old childrenDeborah M Klohe Lehman
Division of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, USA
J Am Coll Nutr 26:196-208. 2007..To examine the effects of a weight loss program for mothers on the diet and activity of mothers and their 1-3 year old children...
Impaired zinc and copper status in children with burn injuries: need to reassess nutritional requirementsV Saroja Voruganti
Division of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
Burns 31:711-6. 2005..We demonstrate that burn injury in children results in low plasma levels of Zn and Cu that are inadequately compensated during hospitalization...
