Research Topics
| Henry C McGillSummaryAffiliation: Southwest Foundation for Biomedical Research Country: USA Publications
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Detail Information
Publications
Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA studyC Alex McMahan
Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Cardiovasc Pathol 16:151-8. 2007....
Are pediatricians responsible for prevention of adult cardiovascular disease?Henry C McGill
University of Texas Health Science Center at San Antonio, USA
Nat Clin Pract Cardiovasc Med 6:10-1. 2009..Ultimately, however, effective prevention of adult disease requires a massive cultural change...
Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) studyHenry C McGill
University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
Circulation 117:1216-27. 2008
Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosisC Alex McMahan
Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Pediatrics 118:1447-55. 2006..In this study we investigated the relation of these risk scores to the early atherosclerotic lesions...
Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipidsRampratap S Kushwaha
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
J Nutr Biochem 16:714-21. 2005..These results suggest that differences in ACAT1 expression may affect plasma cholesterol concentration and partly affect diet-induced hyperlipidemia...
Risk scores predict atherosclerotic lesions in young peopleC Alex McMahan
Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Arch Intern Med 165:883-90. 2005..Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons...
Association of Pathobiologic Determinants of Atherosclerosis in Youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study)C Alex McMahan
Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Am J Cardiol 100:1124-9. 2007..997 for a 1-point decrease). In conclusion, the change in risk score over time (decrease or increase) during adolescence and young adulthood, as well as the risk score early in life, are important predictors of atherosclerosis...
Coronary heart disease risk factors and atherosclerosis in young peopleC Alex McMahan
Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Clin Lipidol 2:118-26. 2008..Risk-factor control beginning in the late teenage years will retard development of the earliest stage of atherosclerosis and its progression, and will reduce or delay occurrence of CHD...
Expression levels of genes for ATP-binding cassette transporters and sterol 27-hydroxylase in liver and intestine of baboons with high and low cholesterolemic responses to dietary lipidsRampratap S Kushwaha
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
J Med Primatol 34:122-9. 2005....
Obesity accelerates the progression of coronary atherosclerosis in young menHenry C McGill
University of Texas Health Science Center at San Antonio, USA
Circulation 105:2712-8. 2002..Results regarding the association of obesity with atherosclerosis are conflicting, particularly when analyses account for other risk factors...
A major gene influences variation in large HDL particles and their response to diet in baboonsDavid L Rainwater
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
Atherosclerosis 163:241-8. 2002..Our results suggest this major gene in baboons plays a pivotal role in HDL metabolism, but is unlikely to code for any of the proteins previously implicated in studies of human HDL(1)...
Genetic determination of HDL variation and response to diet in baboonsDavid L Rainwater
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245-0549, USA
Atherosclerosis 161:335-43. 2002..Therefore, dietary fat and cholesterol alter HDL levels and characteristics, but the dietary responses are not strongly mediated by additive genetic effects...
PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youthC Alex McMahan
The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Atherosclerosis 190:370-7. 2007..These results support the proposal that early control of risk factors is likely to prevent or delay the onset of CHD...
Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA studySamuel S Gidding
Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
Arch Intern Med 166:2341-7. 2006....
Elevated serum C-reactive protein levels and advanced atherosclerosis in youthArthur W Zieske
Louisiana State University Health Sciences Center, New Orleans 70112-1393, USA
Arterioscler Thromb Vasc Biol 25:1237-43. 2005..The associations of CRP with lesions were independent of the traditional CHD risk factors. CONCLUSIONS: Serum CRP level is independently associated with advanced atherosclerosis in young persons...
Starting earlier to prevent heart diseaseHenry C McGill
JAMA 290:2320-2. 2003
Smoking is associated with advanced coronary atherosclerosis in youthArthur W Zieske
Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USA
Atherosclerosis 180:87-92. 2005..The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque...
ACE insert/delete polymorphism and atherosclerosisW Douglas Scheer
Louisiana State University Health Sciences Center, Department of Pathology, 1901 Perdido Street, New Orleans, LA 70112, USA
Atherosclerosis 178:241-7. 2005..In addition, the results suggest that ACE genotype does not contribute to the formation of atherosclerotic lesions that have the characteristics of vulnerable plaques in the left anterior descending coronary artery of young adults...
