H C McGill

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. ncbi request reprint Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth
    H C McGill
    Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
    Arterioscler Thromb Vasc Biol 17:95-106. 1997
  2. ncbi request reprint Obesity accelerates the progression of coronary atherosclerosis in young men
    Henry C McGill
    University of Texas Health Science Center at San Antonio, USA
    Circulation 105:2712-8. 2002
  3. ncbi request reprint Origin of atherosclerosis in childhood and adolescence
    H C McGill
    University of Texas Health Science Center at San Antonio, Texas, USA
    Am J Clin Nutr 72:1307S-1315S. 2000
  4. ncbi request reprint Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
    H C McGill
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Arterioscler Thromb Vasc Biol 20:1998-2004. 2000
  5. ncbi request reprint Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youth
    H C McGill
    Department of Pathology, The University of Texas Health Science Center at San Antonio, USA
    Circulation 102:374-9. 2000
  6. ncbi request reprint Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth
    H C McGill
    University of Texas Health Science Center at San Antonio, the Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 20:836-45. 2000
  7. ncbi request reprint Relation of a postmortem renal index of hypertension to atherosclerosis and coronary artery size in young men and women. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
    H C McGill
    University of Texas Health Science Center at San Antonio, USA
    Arterioscler Thromb Vasc Biol 18:1108-18. 1998
  8. ncbi request reprint Nutrition in early life and cardiovascular disease
    H C McGill
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Curr Opin Lipidol 9:23-7. 1998
  9. ncbi request reprint Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profile
    H C McGill
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Circulation 103:1546-50. 2001
  10. ncbi request reprint Atherosclerosis in youth
    H C McGill
    University of Texas Health Science Center at San Antonio, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Minerva Pediatr 54:437-47. 2002

Detail Information

Publications26

  1. ncbi request reprint Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth
    H C McGill
    Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
    Arterioscler Thromb Vasc Biol 17:95-106. 1997
    ..Primary prevention of atherosclerosis by controlling these adult coronary heart disease risk factors is applicable to young men and women and to young blacks and whites...
  2. ncbi request reprint Obesity accelerates the progression of coronary atherosclerosis in young men
    Henry C McGill
    University of Texas Health Science Center at San Antonio, USA
    Circulation 105:2712-8. 2002
    ..Results regarding the association of obesity with atherosclerosis are conflicting, particularly when analyses account for other risk factors...
  3. ncbi request reprint Origin of atherosclerosis in childhood and adolescence
    H C McGill
    University of Texas Health Science Center at San Antonio, Texas, USA
    Am J Clin Nutr 72:1307S-1315S. 2000
    ..These observations indicate that long-range prevention of atherosclerosis and its sequelae by control of the risk factors for adult coronary artery disease should begin in adolescence and young adulthood...
  4. ncbi request reprint Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
    H C McGill
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Arterioscler Thromb Vasc Biol 20:1998-2004. 2000
    ..Thus, long-range prevention of atherosclerosis should begin in childhood or adolescence...
  5. ncbi request reprint Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youth
    H C McGill
    Department of Pathology, The University of Texas Health Science Center at San Antonio, USA
    Circulation 102:374-9. 2000
    ..91 mmol/L (35 mg/dL) and smoking. AHA grade 4 or 5 lesions were associated with obesity (body mass index > or =30 kg/m(2)) and hypertension (mean arterial pressure > or =110 mm Hg)...
  6. ncbi request reprint Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth
    H C McGill
    University of Texas Health Science Center at San Antonio, the Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 20:836-45. 2000
    ..These risk factor effects on vulnerable sites emphasize the need for risk factor control during adolescence and young adulthood to prevent or delay the progression of atherosclerosis...
  7. ncbi request reprint Relation of a postmortem renal index of hypertension to atherosclerosis and coronary artery size in young men and women. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
    H C McGill
    University of Texas Health Science Center at San Antonio, USA
    Arterioscler Thromb Vasc Biol 18:1108-18. 1998
    ..Hypertension augments atherosclerosis in both men and women primarily by accelerating the conversion of fatty streaks to raised lesions beginning in the third decade of life, and the effect of hypertension increases with age...
  8. ncbi request reprint Nutrition in early life and cardiovascular disease
    H C McGill
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Curr Opin Lipidol 9:23-7. 1998
    ..Although modifying dietary intakes of children and adolescents appears difficult, changes sufficient to lower plasma cholesterol levels would retard the progression of atherosclerosis and would be safe...
  9. ncbi request reprint Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profile
    H C McGill
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Circulation 103:1546-50. 2001
    ....
  10. ncbi request reprint Atherosclerosis in youth
    H C McGill
    University of Texas Health Science Center at San Antonio, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Minerva Pediatr 54:437-47. 2002
    ..Treatment of end stage disease has improved, and risk factor modification has succeeded in reducing risk among adults. However, the age at which to begin risk factor control for long-range primary prevention is controversial...
  11. ncbi request reprint Diet, plasma lipoproteins and experimental atherosclerosis in baboons (Papio sp.)
    R S Kushwaha
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Reprod Update 4:420-9. 1998
    ..The inhibitor peptide is a gene product and the presence of this peptide produces an antiatherogenic high HDL1 phenotype...
  12. ncbi request reprint Two major loci control variation in beta-lipoprotein cholesterol and response to dietary fat and cholesterol in baboons
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
    Arterioscler Thromb Vasc Biol 18:1061-8. 1998
    ..Detection of these major loci with large effects on the LDLC response to dietary cholesterol in a nonhuman primate offers hope of detecting and ultimately identifying similar loci that determine LDLC variation in human populations...
  13. ncbi request reprint Genetic determination of HDL variation and response to diet in baboons
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 161:335-43. 2002
    ..Therefore, dietary fat and cholesterol alter HDL levels and characteristics, but the dietary responses are not strongly mediated by additive genetic effects...
  14. ncbi request reprint PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youth
    C Alex McMahan
    The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Atherosclerosis 190:370-7. 2007
    ..These results support the proposal that early control of risk factors is likely to prevent or delay the onset of CHD...
  15. ncbi request reprint Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipids
    Rampratap S Kushwaha
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Nutr Biochem 16:714-21. 2005
    ..These results suggest that differences in ACAT1 expression may affect plasma cholesterol concentration and partly affect diet-induced hyperlipidemia...
  16. ncbi request reprint Expression levels of genes for ATP-binding cassette transporters and sterol 27-hydroxylase in liver and intestine of baboons with high and low cholesterolemic responses to dietary lipids
    Rampratap S Kushwaha
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    J Med Primatol 34:122-9. 2005
    ....
  17. doi request reprint Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study
    Henry C McGill
    University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
    Circulation 117:1216-27. 2008
  18. ncbi request reprint A major gene influences variation in large HDL particles and their response to diet in baboons
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 163:241-8. 2002
    ..Our results suggest this major gene in baboons plays a pivotal role in HDL metabolism, but is unlikely to code for any of the proteins previously implicated in studies of human HDL(1)...
  19. ncbi request reprint Smoking is associated with advanced coronary atherosclerosis in youth
    Arthur W Zieske
    Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Atherosclerosis 180:87-92. 2005
    ..The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque...
  20. ncbi request reprint Elevated serum C-reactive protein levels and advanced atherosclerosis in youth
    Arthur W Zieske
    Louisiana State University Health Sciences Center, New Orleans 70112 1393, USA
    Arterioscler Thromb Vasc Biol 25:1237-43. 2005
    ..To determine the associations among serum C-reactive protein (CRP) concentration, age, sex, risk factors for coronary heart disease (CHD), and atherosclerosis in young people...
  21. ncbi request reprint ACE insert/delete polymorphism and atherosclerosis
    W Douglas Scheer
    Louisiana State University Health Sciences Center, Department of Pathology, 1901 Perdido Street, New Orleans, LA 70112, USA
    Atherosclerosis 178:241-7. 2005
    ..In addition, the results suggest that ACE genotype does not contribute to the formation of atherosclerotic lesions that have the characteristics of vulnerable plaques in the left anterior descending coronary artery of young adults...
  22. ncbi request reprint Starting earlier to prevent heart disease
    Henry C McGill
    JAMA 290:2320-2. 2003
  23. ncbi request reprint Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis
    C Alex McMahan
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Pediatrics 118:1447-55. 2006
    ..In this study we investigated the relation of these risk scores to the early atherosclerotic lesions...
  24. ncbi request reprint Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA study
    Samuel S Gidding
    Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Arch Intern Med 166:2341-7. 2006
    ....
  25. ncbi request reprint Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Cardiovasc Pathol 16:151-8. 2007
    ....
  26. ncbi request reprint Risk scores predict atherosclerotic lesions in young people
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Arch Intern Med 165:883-90. 2005
    ..Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons...