Research Topics
| H C McGillSummaryAffiliation: Southwest Foundation for Biomedical Research Country: USA Publications
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Detail Information
Publications
Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in YouthH C McGill
Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
Arterioscler Thromb Vasc Biol 17:95-106. 1997..Primary prevention of atherosclerosis by controlling these adult coronary heart disease risk factors is applicable to young men and women and to young blacks and whites...- Obesity accelerates the progression of coronary atherosclerosis in young menHenry C McGill
University of Texas Health Science Center at San Antonio, USA
Circulation 105:2712-8. 2002..Results regarding the association of obesity with atherosclerosis are conflicting, particularly when analyses account for other risk factors... - Origin of atherosclerosis in childhood and adolescenceH C McGill
University of Texas Health Science Center at San Antonio, Texas, USA
Am J Clin Nutr 72:1307S-1315S. 2000..These observations indicate that long-range prevention of atherosclerosis and its sequelae by control of the risk factors for adult coronary artery disease should begin in adolescence and young adulthood... - Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research GroupH C McGill
University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Arterioscler Thromb Vasc Biol 20:1998-2004. 2000..Thus, long-range prevention of atherosclerosis should begin in childhood or adolescence... - Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youthH C McGill
Department of Pathology, The University of Texas Health Science Center at San Antonio, USA
Circulation 102:374-9. 2000..Early atherosclerosis is influenced by the risk factors for clinical CHD. Long-range prevention of CHD must begin in adolescence or young adulthood... - Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in YouthH C McGill
University of Texas Health Science Center at San Antonio, the Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Arterioscler Thromb Vasc Biol 20:836-45. 2000..These risk factor effects on vulnerable sites emphasize the need for risk factor control during adolescence and young adulthood to prevent or delay the progression of atherosclerosis... - Relation of a postmortem renal index of hypertension to atherosclerosis and coronary artery size in young men and women. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research GroupH C McGill
University of Texas Health Science Center at San Antonio, USA
Arterioscler Thromb Vasc Biol 18:1108-18. 1998..Hypertension augments atherosclerosis in both men and women primarily by accelerating the conversion of fatty streaks to raised lesions beginning in the third decade of life, and the effect of hypertension increases with age... - Nutrition in early life and cardiovascular diseaseH C McGill
Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Curr Opin Lipidol 9:23-7. 1998..Although modifying dietary intakes of children and adolescents appears difficult, changes sufficient to lower plasma cholesterol levels would retard the progression of atherosclerosis and would be safe... - Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profileH C McGill
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Circulation 103:1546-50. 2001.... - Atherosclerosis in youthH C McGill
University of Texas Health Science Center at San Antonio, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Minerva Pediatr 54:437-47. 2002..CONCLUSIONS: These results suggest that long-range prevention of CHD should begin in adolescence or at least in young adulthood with control of the major established risk factors for adult CHD... - Diet, plasma lipoproteins and experimental atherosclerosis in baboons (Papio sp.)R S Kushwaha
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Hum Reprod Update 4:420-9. 1998..The inhibitor peptide is a gene product and the presence of this peptide produces an antiatherogenic high HDL1 phenotype... - Two major loci control variation in beta-lipoprotein cholesterol and response to dietary fat and cholesterol in baboonsD L Rainwater
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
Arterioscler Thromb Vasc Biol 18:1061-8. 1998..Detection of these major loci with large effects on the LDLC response to dietary cholesterol in a nonhuman primate offers hope of detecting and ultimately identifying similar loci that determine LDLC variation in human populations... - Genetic determination of HDL variation and response to diet in baboonsDavid L Rainwater
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245-0549, USA
Atherosclerosis 161:335-43. 2002..Therefore, dietary fat and cholesterol alter HDL levels and characteristics, but the dietary responses are not strongly mediated by additive genetic effects... - PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youthC Alex McMahan
The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Atherosclerosis 190:370-7. 2007..These results support the proposal that early control of risk factors is likely to prevent or delay the onset of CHD... - Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipidsRampratap S Kushwaha
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
J Nutr Biochem 16:714-21. 2005..These results suggest that differences in ACAT1 expression may affect plasma cholesterol concentration and partly affect diet-induced hyperlipidemia... - Expression levels of genes for ATP-binding cassette transporters and sterol 27-hydroxylase in liver and intestine of baboons with high and low cholesterolemic responses to dietary lipidsRampratap S Kushwaha
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
J Med Primatol 34:122-9. 2005.... - Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) studyHenry C McGill
University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
Circulation 117:1216-27. 2008 - A major gene influences variation in large HDL particles and their response to diet in baboonsDavid L Rainwater
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
Atherosclerosis 163:241-8. 2002..Our results suggest this major gene in baboons plays a pivotal role in HDL metabolism, but is unlikely to code for any of the proteins previously implicated in studies of human HDL(1)... - Smoking is associated with advanced coronary atherosclerosis in youthArthur W Zieske
Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USA
Atherosclerosis 180:87-92. 2005..The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque... - Elevated serum C-reactive protein levels and advanced atherosclerosis in youthArthur W Zieske
Louisiana State University Health Sciences Center, New Orleans 70112-1393, USA
Arterioscler Thromb Vasc Biol 25:1237-43. 2005..The associations of CRP with lesions were independent of the traditional CHD risk factors. CONCLUSIONS: Serum CRP level is independently associated with advanced atherosclerosis in young persons... - ACE insert/delete polymorphism and atherosclerosisW Douglas Scheer
Louisiana State University Health Sciences Center, Department of Pathology, 1901 Perdido Street, New Orleans, LA 70112, USA
Atherosclerosis 178:241-7. 2005..In addition, the results suggest that ACE genotype does not contribute to the formation of atherosclerotic lesions that have the characteristics of vulnerable plaques in the left anterior descending coronary artery of young adults... - Starting earlier to prevent heart diseaseHenry C McGill
JAMA 290:2320-2. 2003 - Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosisC Alex McMahan
Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Pediatrics 118:1447-55. 2006..In this study we investigated the relation of these risk scores to the early atherosclerotic lesions... - Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA studySamuel S Gidding
Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
Arch Intern Med 166:2341-7. 2006.... - Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA studyC Alex McMahan
Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Cardiovasc Pathol 16:151-8. 2007.... - Risk scores predict atherosclerotic lesions in young peopleC Alex McMahan
Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Arch Intern Med 165:883-90. 2005..Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons...