L J Martin

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. ncbi request reprint A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20
    L J Martin
    Departments of Genetics, Physiology and Medicine, Southwest Foundation for Biomedical Research San Antonio, Texas 78245 0549, USA
    Physiol Genomics 5:75-80. 2001
  2. ncbi request reprint Lifespan in captive baboons is heritable
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 123:1461-7. 2002
  3. ncbi request reprint Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Obes Res 10:14-21. 2002
  4. ncbi request reprint Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
  5. ncbi request reprint A quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Hum Biol 73:787-800. 2001
  6. ncbi request reprint Distribution of lod scores in oligogenic linkage analysis
    J T Williams
    Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S805-10. 2001
  7. ncbi request reprint The utility of Bayesian model averaging for detecting known oligogenic effects
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S789-93. 2001
  8. ncbi request reprint The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    J Clin Endocrinol Metab 86:4321-5. 2001
  9. ncbi request reprint Searching for genes underlying normal variation in human adiposity
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 79:57-70. 2001
  10. ncbi request reprint Genetic control of coordinated changes in HDL and LDL size phenotypes
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Arterioscler Thromb Vasc Biol 21:1829-33. 2001

Detail Information

Publications35

  1. ncbi request reprint A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20
    L J Martin
    Departments of Genetics, Physiology and Medicine, Southwest Foundation for Biomedical Research San Antonio, Texas 78245 0549, USA
    Physiol Genomics 5:75-80. 2001
    ..This is the first evidence of a quantitative trait locus with a significant effect on estrogen...
  2. ncbi request reprint Lifespan in captive baboons is heritable
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 123:1461-7. 2002
    ..This research demonstrates that lifespan is under partial genetic control. Given these findings, we believe that the baboon has potential as a model of human aging...
  3. ncbi request reprint Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Obes Res 10:14-21. 2002
    ..As we have shown for other measures of adiposity, such sexual dimorphism can arise from a special case of genotype by environment interaction, that of genotype by sex interaction...
  4. ncbi request reprint Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
    ..04). Given these results, we hypothesize that a quantitative trait locus in this vicinity of chromosome 8 may have a differential effect on the expression of leptin in smokers versus non-smokers...
  5. ncbi request reprint A quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Hum Biol 73:787-800. 2001
    ..This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio...
  6. ncbi request reprint Distribution of lod scores in oligogenic linkage analysis
    J T Williams
    Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S805-10. 2001
    ..We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic...
  7. ncbi request reprint The utility of Bayesian model averaging for detecting known oligogenic effects
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S789-93. 2001
    ..The results were consistent with the underlying genetic model: two major QTLs were identified on chromosomes 19 and 2, with heritabilities of 17% and 20%, respectively, located near the position of major genes 1 and 2...
  8. ncbi request reprint The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    J Clin Endocrinol Metab 86:4321-5. 2001
    ....
  9. ncbi request reprint Searching for genes underlying normal variation in human adiposity
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 79:57-70. 2001
    ..of obesity and its related phenotypes, which must be considered in designing analyses to identify the genes involved as well as reviewing what these approaches have provided in the search for genes influencing adiposity in humans..
  10. ncbi request reprint Genetic control of coordinated changes in HDL and LDL size phenotypes
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Arterioscler Thromb Vasc Biol 21:1829-33. 2001
    ..Thus, our study demonstrates that the phenotypic correlation of HDL and LDL sizes results in part from the pleiotropic actions of a set of genes, some of which also influence TG levels and some of which do not...
  11. ncbi request reprint Genetics of leptin expression in baboons
    S A Cole
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Int J Obes Relat Metab Disord 27:778-83. 2003
    ..We have investigated leptin (LEP) gene express-ion, to determine whether it is heritable, and whether the difference in LEP expression between males and females has a genetic component...
  12. ncbi request reprint Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Biol Psychiatry 55:739-44. 2004
    ..Further genetic analysis can help explain phenotypic correlations among monoamine levels and might eventually help identify genes involved in response to therapy or risk of psychopathology...
  13. ncbi request reprint Linkage analysis for complex diseases using variance component analysis: SOLAR
    Ulrich Broeckel
    Department of Medicine, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, USA
    Methods Mol Med 128:91-100. 2006
    ..In this chapter, we present as an introduction the statistical background of variance component analysis as implemented in the genetic analysis package SOLAR...
  14. ncbi request reprint Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  15. ncbi request reprint A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone
    Lisa J Martin
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Obes Res 10:602-7. 2002
    ..Because interactions such as genotype x sex can confound the detection of quantitative trait loci (QTLs), we wanted to determine if there are QTLs associated with the expression of leptin adjusted for testosterone...
  16. ncbi request reprint The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity
    Lisa J Martin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Endocrinol Metab 90:4255-9. 2005
    ..Because adiponectin is secreted by adipocytes, it may also act locally to counteract insulin resistance and dyslipidemia worsened by inflammation...
  17. ncbi request reprint Adolescent sex differences in adiponectin are conditional on pubertal development and adiposity
    Jessica G Woo
    Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Obes Res 13:2095-101. 2005
    ..In this study, we hypothesized that sex differences in adiponectin would develop during puberty and would be influenced by level of adiposity...
  18. pmc Quality assessment of buccal versus blood genomic DNA using the Affymetrix 500 K GeneChip
    Jessica G Woo
    University of Cincinnati College of Medicine, 321 Albert Sabin Way, Cincinnati, OH 45267, USA
    BMC Genet 8:79. 2007
    ..We sought to describe the genomic DNA yield and concordance between stored buccal brushes and blood samples from the same individuals in the context of Affymetrix 500 K Human GeneChip genotyping...
  19. ncbi request reprint Adiponectin is present in human milk and is associated with maternal factors
    Lisa J Martin
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Am J Clin Nutr 83:1106-11. 2006
    ..If present in milk, adiponectin would be a promising candidate for influencing infant development, given its metabolic functions...
  20. ncbi request reprint Intervention with a low-fat, high-carbohydrate diet does not influence the timing of menopause
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Canada
    Am J Clin Nutr 84:920-8. 2006
    ..Later age at menopause is associated with a greater risk of breast cancer. Dietary factors may at least partially influence breast cancer risk through an effect on the age at menopause...
  21. ncbi request reprint Mammographic density: a hormonally responsive risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Br Menopause Soc 12:186-93. 2006
    ..A better understanding of the factors that influence the response of breast tissue to these hormonal exposures may lead to an improved understanding of the aetiology of mammographic density and of breast cancer...
  22. ncbi request reprint Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans
    Nancy A Crimmins
    Department of Pediatrics, MLC 7012, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Obesity (Silver Spring) 15:1903-7. 2007
    ..Our findings suggest not only that ADIPOR1 variants influence insulin resistance in the presence of adiposity, but also that these variants and haplotypes are protective in African Americans...
  23. ncbi request reprint Stability of adolescent body mass index during three years of follow-up
    Nancy A Crimmins
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 151:383-7. 2007
    ..A 4-year longitudinal study was conducted to determine the prevalence of overweight, detect shifts in body mass index (BMI) distribution, and determine which adolescents were at risk for pathologic weight gain...
  24. ncbi request reprint Hypoplastic left heart syndrome is heritable
    Robert B Hinton
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Coll Cardiol 50:1590-5. 2007
    ..This study sought to determine the size of the genetic effect (heritability) in families identified by a hypoplastic left heart syndrome (HLHS) proband...
  25. ncbi request reprint Bicuspid aortic valve is heritable
    Linda Cripe
    Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital, Ohio 45229, USA
    J Am Coll Cardiol 44:138-43. 2004
    ..Our objective was to statistically test whether the segregation pattern of BAV is consistent with genetic inheritance and to obtain an estimate of the size of the genetic effect (heritability)...
  26. ncbi request reprint A comprehensive linkage analysis for myocardial infarction and its related risk factors
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Genet 30:210-4. 2002
    ..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...
  27. ncbi request reprint A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 2800 Winslow, Room 2110, Mail Code 5041, Cincinnati, OH 45229, USA
    Diabetes 51:3568-72. 2002
    ..Within the 1-LOD unit support interval, there are two strong candidates: PCSK1 and CAST. Furthermore, we have obtained a replication (LOD = 1.6) for a QTL for type 2 diabetes on chromosome 11 detected by Hanson and colleagues (1998)...
  28. ncbi request reprint Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption rates in the splotch mouse
    Lisa J Martin
    Department of Environmental Health Sciences, Interdepartmental Program in Molecular Toxicology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Birth Defects Res A Clin Mol Teratol 67:231-9. 2003
    ....
  29. ncbi request reprint Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13
    Lynn R Goldin
    Genetic Epidemiology Branch, DCEG, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Genet Epidemiol 25:S78-89. 2003
    ..Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses...
  30. ncbi request reprint The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  31. pmc Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
    ..We next applied factor analysis to summarize the relationship between these phenotypes...
  32. pmc HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill 27514 USA
    BMC Genet 4:S98. 2003
    ....
  33. ncbi request reprint Major quantitative trait locus for resting heart rate maps to a region on chromosome 4
    Lisa J Martin
    Department of Pediatrics, Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Mail Code 5041, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Hypertension 43:1146-51. 2004
    ..This signal is in the same region as a quantitative trait locus (QTL) for long QT syndrome 4 and a QTL for heart rate in rats. Within the 1-LOD unit support interval, there are 2 strong candidates: ankyrin-B and myozenin 2...
  34. ncbi request reprint Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  35. ncbi request reprint The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Biol 79:191-200. 2007
    ....