Roger S Holmes

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. pmc Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    BMC Evol Biol 8:54. 2008
  2. pmc Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 139:291-304. 2011
  3. pmc Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Mamm Genome 21:427-41. 2010
  4. pmc Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo)
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 5:217-26. 2010
  5. pmc Mammalian carboxylesterase 3: comparative genomics and proteomics
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 138:695-708. 2010
  6. pmc Horse carboxylesterases: evidence for six CES1 and four families of CES genes on chromosome 3
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:54-65. 2009
  7. pmc Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism
    Roger S Holmes
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, USA
    Comp Biochem Physiol Part D Genomics Proteomics 6:224-34. 2011
  8. pmc Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    J Med Primatol 38:27-38. 2009
  9. pmc A new class of mammalian carboxylesterase CES6
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:209-17. 2009
  10. pmc Mammalian carboxylesterase 5: comparative biochemistry and genomics
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 3:195-204. 2008

Detail Information

Publications12

  1. pmc Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    BMC Evol Biol 8:54. 2008
    ..We also discuss the likely sequence of gene duplication events generating multiple CES genes during vertebrate evolution...
  2. pmc Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 139:291-304. 2011
    ..It is apparent that the triglyceride lipase ancestral gene for the vertebrate LIPG gene predated the appearance of fish during vertebrate evolution >500 million years ago...
  3. pmc Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Mamm Genome 21:427-41. 2010
    ..It also serves as a model for naming CES genes from other mammalian species...
  4. pmc Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo)
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 5:217-26. 2010
    ....
  5. pmc Mammalian carboxylesterase 3: comparative genomics and proteomics
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Genetica 138:695-708. 2010
    ..Phylogenetic analyses demonstrated the relationships and potential evolutionary origins of the mammalian CES3 family of genes which were related to but distinct from other mammalian CES gene families...
  6. pmc Horse carboxylesterases: evidence for six CES1 and four families of CES genes on chromosome 3
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:54-65. 2009
    ..Several CES1 gene duplication events have apparently occurred following the appearance of the 'dawn' horse approximately 55 million years ago...
  7. pmc Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism
    Roger S Holmes
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, USA
    Comp Biochem Physiol Part D Genomics Proteomics 6:224-34. 2011
    ..Comparative divergence rates for these vertebrate sequences indicated that LPL is evolving more slowly (2-3 times) than for LIPC and LIPG genes and proteins...
  8. pmc Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    J Med Primatol 38:27-38. 2009
    ....
  9. pmc A new class of mammalian carboxylesterase CES6
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:209-17. 2009
    ..CES6 may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid...
  10. pmc Mammalian carboxylesterase 5: comparative biochemistry and genomics
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 3:195-204. 2008
    ..Roles for CES5 may include regulating urinary levels of male cat pheromones; catalysing lipid transfer reactions within mammalian male reproductive fluids; and protecting neural tissue from drugs and xenobiotics...
  11. pmc Bovine Carboxylesterases: Evidence for Two CES1 and Five Families of CES Genes on Chromosome 18
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Comp Biochem Physiol Part D Genomics Proteomics 4:11-20. 2009
    ..In addition, a subsequent CES1 gene duplication event is proposed during mammalian evolution prior to the appearance of the Bovidae common ancestor ~ 20 MY ago...
  12. pmc Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport
    Roger S Holmes
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    Cholesterol 2011:781643. 2011
    ..Phylogenetic analyses demonstrated the relationships and potential evolutionary origins of the vertebrate CEL family of genes which were related to a nematode carboxylesterase (CES) gene and five mammalian CES gene families...