Harald H H Goring

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. pmc Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genet 126:667-76. 2009
  2. pmc Large upward bias in estimation of locus-specific effects from genomewide scans
    H H Göring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 69:1357-69. 2001
  3. pmc On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S72. 2003
  4. pmc Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Clin Nutr 91:1574-83. 2010
  5. ncbi request reprint Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:389-93. 2007
  6. pmc Genotype×age interaction in human transcriptional ageing
    Jack W Kent
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Mech Ageing Dev 133:581-90. 2012
  7. pmc A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13
    V Saroja Voruganti
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
    Obesity (Silver Spring) 19:1840-6. 2011
  8. pmc Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Hum Mol Genet 19:3662-71. 2010
  9. ncbi request reprint Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Nat Genet 39:1208-16. 2007
  10. pmc Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells
    Hemant Kulkarni
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA
    Cancer Chemother Pharmacol 71:1095-100. 2013

Detail Information

Publications33

  1. pmc Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genet 126:667-76. 2009
    ..These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations...
  2. pmc Large upward bias in estimation of locus-specific effects from genomewide scans
    H H Göring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 69:1357-69. 2001
    ..It is hoped that, by keeping this bias in mind, we will more realistically interpret and extrapolate from the results of genomewide scans...
  3. pmc On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S72. 2003
    ..It should be kept in mind, however, that an increase in computational accuracy is expected to go hand in hand with a decrease in robustness to various sources of errors...
  4. pmc Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Clin Nutr 91:1574-83. 2010
    ..Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease...
  5. ncbi request reprint Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:389-93. 2007
    ..02, RR 1.64). These data provide evidence that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations...
  6. pmc Genotype×age interaction in human transcriptional ageing
    Jack W Kent
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Mech Ageing Dev 133:581-90. 2012
    ..Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort...
  7. pmc A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13
    V Saroja Voruganti
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
    Obesity (Silver Spring) 19:1840-6. 2011
    ....
  8. pmc Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Hum Mol Genet 19:3662-71. 2010
    ..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study...
  9. ncbi request reprint Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Nat Genet 39:1208-16. 2007
    ....
  10. pmc Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells
    Hemant Kulkarni
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA
    Cancer Chemother Pharmacol 71:1095-100. 2013
    ..Yeast studies indicate that the tyrosine kinase inhibitor imatinib may interact with the v-ATPase genes and alter the course of cancer progression. Data from humans in this regard are lacking...
  11. ncbi request reprint Type I error rates in association versus joint linkage/association tests in related individuals
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Genet Epidemiol 31:173-7. 2007
    ..These results support the idea that an appropriate association analysis must test both the random effect of shared marker alleles (linkage) and the mean effects of the marker genotypes (association)...
  12. ncbi request reprint Genome-wide scan for serum ghrelin detects linkage on chromosome 1p36 in Hispanic children: results from the Viva La Familia study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Pediatr Res 62:445-50. 2007
    ..9), and C-peptide (LOD=2.0). Several family-based studies have reported linkages for obesity-related phenotypes in the region of 1p36. These results indicate the importance of this region in relation to adiposity in children from the VFS...
  13. ncbi request reprint Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 54:2655-62. 2005
    ..87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations...
  14. ncbi request reprint A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American family
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes Metab Res Rev 22:331-6. 2006
    ..The aim of this study was to investigate the association of this mutation in the SAFDGS with risk for diabetes...
  15. pmc A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study
    Sue Rutherford
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 81:744-55. 2007
    ..Further investigation of this region is necessary for the identification of the genetic variation responsible for QTLs influencing the rate of change in BP...
  16. doi request reprint Genetic architecture of carotid artery intima-media thickness in Mexican Americans
    Phillip E Melton
    Deptartment of Genetics, Texas Biomedical Research Institute, San Antonio, USA
    Circ Cardiovasc Genet 6:211-21. 2013
    ..We do not detect any shared GWAS signals between common and internal carotid arterial segments, but the moderate genetic correlation implies both common and unique genetic components...
  17. doi request reprint A kernel of truth: statistical advances in polygenic variance component models for complex human pedigrees
    John Blangero
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA Electronic address
    Adv Genet 81:1-31. 2013
    ..These procedures are being added to our general statistical genetic computer package, SOLAR...
  18. pmc Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging
    Vincent P Diego
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 133:11-9. 2012
    ..1, 1q41, 2q34, 3q23, and 7p15.3. We are currently examining potential associations with single nucleotide polymorphisms within the 1-LOD intervals of our linkage signals...
  19. ncbi request reprint Quantitative trait nucleotide analysis using Bayesian model selection
    John Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 620 NW Loop 410, San Antonio, TX 78245 0549, USA
    Hum Biol 77:541-59. 2005
    ..We also include instructions on how to use our computer program, SOLAR, for association analysis and BQTN analysis...
  20. ncbi request reprint Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study
    Vincent P Diego
    Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 55:1874-8. 2006
    ..42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas...
  21. pmc Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 195:367-73. 2007
    ..0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait...
  22. pmc Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene
    Matthew P Johnson
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 7:e33666. 2012
    ....
  23. ncbi request reprint A novel obesity locus on chromosome 4q: the Strong Heart Family Study
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio TX 78245 0549, USA
    Obesity (Silver Spring) 15:1741-8. 2007
    ....
  24. ncbi request reprint Genetic determinants of mitochondrial content
    Joanne E Curran
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Hum Mol Genet 16:1504-14. 2007
    ....
  25. pmc Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines
    Hemant Kulkarni
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA
    BMC Med Genomics 5:37. 2012
    ..Given that drug cytotoxicity represents a major problem during treatment, it is essential to understand the biological pathways affected to better predict poor drug response and prioritize a treatment regime...
  26. pmc Novel associations of nonstructural Loci with paraoxonase activity
    Ellen E Quillen
    Department of Genetics, Texas Biomedical Research Institute, P O Box 760549, San Antonio, TX 78245 0549, USA
    J Lipids 2012:189681. 2012
    ..6% with the arylester, and 3.0% with paraoxon. In light of the potential importance of PON1 in preventing cardiovascular disease/events, these novel loci merit further investigation...
  27. pmc Utilizing extended pedigree information for discovery and confirmation of copy number variable regions among Mexican Americans
    August Blackburn
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA
    Eur J Hum Genet 21:404-9. 2013
    ..These results provide insight to the structural variation present in Mexican Americans and show the strength of multigenerational pedigrees to elucidate structural variation in the human genome...
  28. pmc Integrating genomic analysis with the genetic basis of gene expression: preliminary evidence of the identification of causal genes for cardiovascular and metabolic traits related to nutrition in Mexicans
    Raul A Bastarrachea
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
    Adv Nutr 3:596S-604S. 2012
    ..Such data will be crucial for the formal integration of positional and transcriptomic information characterized as genetical genomics...
  29. pmc A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1)
    Rohina Rubicz
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
    PLoS Genet 9:e1003147. 2013
    ..The significance of this work is that a major locus related to EBV infection has been identified, which may ultimately reveal the underlying mechanisms by which the immune system regulates infection with this pathogen...
  30. pmc Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos
    V Saroja Voruganti
    Department of Genetics, Texas Biomedical Research Institute San Antonio, TX, USA
    Front Genet 3:86. 2012
    ..These findings strongly suggest a functional role for FADS1, FADS2, and CPT1A SNPs in the variation in eD5D activity...
  31. ncbi request reprint A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies
    Rector Arya
    Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
    Hum Mol Genet 15:1569-79. 2006
    ..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans...
  32. ncbi request reprint Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Stroke 33:2775-80. 2002
    ..In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control...
  33. ncbi request reprint A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229, USA
    Diabetes 54:1214-21. 2005
    ..The variance attributed to this SNP accounted for approximately 25% of the logarithm of odds. These results suggest that this variant within the MGEA5 gene may increase diabetes risk in Mexican Americans...