Research Topics
Genomes and Genes | Harald H H GoringSummaryAffiliation: Southwest Foundation for Biomedical Research Country: USA Publications
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Publications
Genetic influence on variation in serum uric acid in American Indians: the strong heart family studyV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Hum Genet 126:667-76. 2009..These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations...- Large upward bias in estimation of locus-specific effects from genomewide scansH H Göring
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Am J Hum Genet 69:1357-69. 2001..It is hoped that, by keeping this bias in mind, we will more realistically interpret and extrapolate from the results of genomewide scans... - On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysisHarald H H Goring
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
BMC Genet 4:S72. 2003..It should be kept in mind, however, that an increase in computational accuracy is expected to go hand in hand with a decrease in robustness to various sources of errors... 
Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican AmericansDonna M Lehman
Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Diabetes 56:389-93. 2007..02, RR 1.64). These data provide evidence that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations...- Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan EskimosV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Am J Clin Nutr 91:1574-83. 2010..Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease... - Genotype×age interaction in human transcriptional ageingJack W Kent
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
Mech Ageing Dev 133:581-90. 2012..Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort... - A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13V Saroja Voruganti
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
Obesity (Silver Spring) 19:1840-6. 2011.... - Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family StudyPhillip E Melton
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
Hum Mol Genet 19:3662-71. 2010..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study... - Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytesHarald H H Goring
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
Nat Genet 39:1208-16. 2007.... - A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American familyDonna M Lehman
Department of Medicine Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Diabetes Metab Res Rev 22:331-6. 2006..The aim of this study was to investigate the association of this mutation in the SAFDGS with risk for diabetes... - Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder StudyKelly J Hunt
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Diabetes 54:2655-62. 2005..87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations... - Type I error rates in association versus joint linkage/association tests in related individualsJack W Kent
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Genet Epidemiol 31:173-7. 2007..These results support the idea that an appropriate association analysis must test both the random effect of shared marker alleles (linkage) and the mean effects of the marker genotypes (association)... - Genome-wide scan for serum ghrelin detects linkage on chromosome 1p36 in Hispanic children: results from the Viva La Familia studyV Saroja Voruganti
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
Pediatr Res 62:445-50. 2007..9), and C-peptide (LOD=2.0). Several family-based studies have reported linkages for obesity-related phenotypes in the region of 1p36. These results indicate the importance of this region in relation to adiposity in children from the VFS... - A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart StudySue Rutherford
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Am J Hum Genet 81:744-55. 2007..Further investigation of this region is necessary for the identification of the genetic variation responsible for QTLs influencing the rate of change in BP... - Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cellsHemant Kulkarni
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA
Cancer Chemother Pharmacol 71:1095-100. 2013..Yeast studies indicate that the tyrosine kinase inhibitor imatinib may interact with the v-ATPase genes and alter the course of cancer progression. Data from humans in this regard are lacking... - Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to agingVincent P Diego
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
Mech Ageing Dev 133:11-9. 2012..1, 1q41, 2q34, 3q23, and 7p15.3. We are currently examining potential associations with single nucleotide polymorphisms within the 1-LOD intervals of our linkage signals... - Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican AmericansJack W Kent
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
Atherosclerosis 195:367-73. 2007..0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait... - Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family StudyVincent P Diego
Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245 0549, USA
Diabetes 55:1874-8. 2006..42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas... - Quantitative trait nucleotide analysis using Bayesian model selectionJohn Blangero
Department of Genetics, Southwest Foundation for Biomedical Research, 620 NW Loop 410, San Antonio, TX 78245-0549, USA
Hum Biol 77:541-59. 2005..We also include instructions on how to use our computer program, SOLAR, for association analysis and BQTN analysis... - Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B geneMatthew P Johnson
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
PLoS ONE 7:e33666. 2012.... - A novel obesity locus on chromosome 4q: the Strong Heart Family StudyLaura Almasy
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio TX 78245 0549, USA
Obesity (Silver Spring) 15:1741-8. 2007.... - Genetic determinants of mitochondrial contentJoanne E Curran
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
Hum Mol Genet 16:1504-14. 2007.... - Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell linesHemant Kulkarni
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA
BMC Med Genomics 5:37. 2012..Given that drug cytotoxicity represents a major problem during treatment, it is essential to understand the biological pathways affected to better predict poor drug response and prioritize a treatment regime... - Novel associations of nonstructural Loci with paraoxonase activityEllen E Quillen
Department of Genetics, Texas Biomedical Research Institute, P O Box 760549, San Antonio, TX 78245 0549, USA
J Lipids 2012:189681. 2012..6% with the arylester, and 3.0% with paraoxon. In light of the potential importance of PON1 in preventing cardiovascular disease/events, these novel loci merit further investigation... 
A kernel of truth: statistical advances in polygenic variance component models for complex human pedigreesJohn Blangero
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
Adv Genet 81:1-31. 2013..These procedures are being added to our general statistical genetic computer package, SOLAR...- Integrating genomic analysis with the genetic basis of gene expression: preliminary evidence of the identification of causal genes for cardiovascular and metabolic traits related to nutrition in MexicansRaul A Bastarrachea
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
Adv Nutr 3:596S-604S. 2012..Such data will be crucial for the formal integration of positional and transcriptomic information characterized as genetical genomics... - A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1)Rohina Rubicz
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
PLoS Genet 9:e1003147. 2013..The significance of this work is that a major locus related to EBV infection has been identified, which may ultimately reveal the underlying mechanisms by which the immune system regulates infection with this pathogen... - Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan EskimosV Saroja Voruganti
Department of Genetics, Texas Biomedical Research Institute San Antonio, TX, USA
Front Genet 3:86. 2012..These findings strongly suggest a functional role for FADS1, FADS2, and CPT1A SNPs in the variation in eD5D activity... - A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studiesRector Arya
Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
Hum Mol Genet 15:1569-79. 2006..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans... - Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart StudyKelly J Hunt
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
Stroke 33:2775-80. 2002..In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control... - A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican AmericansDonna M Lehman
Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229, USA
Diabetes 54:1214-21. 2005..The variance attributed to this SNP accounted for approximately 25% of the logarithm of odds. These results suggest that this variant within the MGEA5 gene may increase diabetes risk in Mexican Americans...