Anthony G Comuzzie

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. ncbi The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Biol 79:191-200. 2007
  2. doi Cutting the fat: the genetic dissection of body weight
    Anthony G Comuzzie
    Chronic Disease and Genomics, Southwest National Primate Research Center, San Antonio, Texas, USA
    Prog Mol Biol Transl Sci 94:197-212. 2010
  3. pmc Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.)
    Paul B Higgins
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Cardiovasc Diabetol 9:71. 2010
  4. ncbi Effects of a major gene for apolipoprotein A-I concentration are thyroid hormone dependent in Mexican Americans
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Arterioscler Thromb Vasc Biol 16:1177-83. 1996
  5. ncbi Principal component for metabolic syndrome risk maps to chromosome 4p in Mexican Americans: the San Antonio Family Heart Study
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Hum Biol 76:651-65. 2004
  6. pmc Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
  7. pmc HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill 27514 USA
    BMC Genet 4:S98. 2003
  8. ncbi The baboon as a nonhuman primate model for the study of the genetics of obesity
    Anthony G Comuzzie
    Department of Genetics, Southwest Regional Primate Research Center, San Antonio, Texas 78245 0549, USA
    Obes Res 11:75-80. 2003
  9. ncbi Searching for genes underlying normal variation in human adiposity
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 79:57-70. 2001
  10. ncbi Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans
    A G Comuzzie
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Int J Obes Relat Metab Disord 24:1065-8. 2000

Detail Information

Publications128 found, 100 shown here

  1. ncbi The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Biol 79:191-200. 2007
    ....
  2. doi Cutting the fat: the genetic dissection of body weight
    Anthony G Comuzzie
    Chronic Disease and Genomics, Southwest National Primate Research Center, San Antonio, Texas, USA
    Prog Mol Biol Transl Sci 94:197-212. 2010
    ..These consortia may have the power to elucidate how genetic and environmental factors act and interact to produce variation in obesity-related phenotypes...
  3. pmc Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.)
    Paul B Higgins
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Cardiovasc Diabetol 9:71. 2010
    ....
  4. ncbi Effects of a major gene for apolipoprotein A-I concentration are thyroid hormone dependent in Mexican Americans
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Arterioscler Thromb Vasc Biol 16:1177-83. 1996
    ..These findings suggest that thyroid hormone has an important role in the genetic control of lipoprotein metabolism...
  5. ncbi Principal component for metabolic syndrome risk maps to chromosome 4p in Mexican Americans: the San Antonio Family Heart Study
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Hum Biol 76:651-65. 2004
    ..20) and on chromosome 6 near marker D6S 1031 (LOD = 2.08), respectively. In summary, our findings suggest that the factor structures for the risk of metabolic syndrome are influenced by multiple distinct genes across the genome...
  6. pmc Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
    ..We next applied factor analysis to summarize the relationship between these phenotypes...
  7. pmc HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill 27514 USA
    BMC Genet 4:S98. 2003
    ....
  8. ncbi The baboon as a nonhuman primate model for the study of the genetics of obesity
    Anthony G Comuzzie
    Department of Genetics, Southwest Regional Primate Research Center, San Antonio, Texas 78245 0549, USA
    Obes Res 11:75-80. 2003
    ..Therefore, we are currently developing the baboon as a nonhuman primate model for the study of the genetics of obesity...
  9. ncbi Searching for genes underlying normal variation in human adiposity
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 79:57-70. 2001
    ..of obesity and its related phenotypes, which must be considered in designing analyses to identify the genes involved as well as reviewing what these approaches have provided in the search for genes influencing adiposity in humans..
  10. ncbi Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans
    A G Comuzzie
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Int J Obes Relat Metab Disord 24:1065-8. 2000
    ..To investigate whether the region of chromosome 11 (11q13) containing the genes UCP2 and UCP3 could be excluded for linkage with a variety of obesity-related phenotypes in humans...
  11. ncbi The search for human obesity genes
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Science 280:1374-7. 1998
    ..This article discusses the strategies currently being used to search for human obesity genes and recent promising results from these efforts...
  12. ncbi Shared and unique genetic effects among seven HDL phenotypes
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
    Arterioscler Thromb Vasc Biol 17:859-64. 1997
    ..We conclude that the genetic variation in these HDL phenotypes is a result of the action of common as well as unique genes...
  13. ncbi Genetic and environmental correlations among hormone levels and measures of body fat accumulation and topography
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228, USA
    J Clin Endocrinol Metab 81:597-600. 1996
    ..However, we also show that it is possible for significant genetic and environmental correlations to interact in such a way as to produce a phenotypic correlation that itself would not be considered significant...
  14. ncbi A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Nat Genet 15:273-6. 1997
    ..Our results show strong evidence of linkage of this region of chromosome 2 with serum leptin levels and indicate that this region could contain an important human obesity gene...
  15. ncbi Triiodothyronine exerts a major pleiotropic effect on reverse cholesterol transport phenotypes
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78228 0147, USA
    Arterioscler Thromb Vasc Biol 16:289-93. 1996
    ..Thus, genes that influence T3 have a significant effect on HDL-C, apo AI, apo AII, and LpAI and also on the correlations among these phenotypes...
  16. pmc Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population
    Anthony G Comuzzie
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
    PLoS ONE 7:e51954. 2012
    ..7E-08) and in CHRNA3 for sleeping energy expenditure (p = 6.0E-08). Unprecedented phenotyping and high-density SNP genotyping enabled localization of novel genetic loci associated with the pathophysiology of childhood obesity...
  17. pmc Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children
    Shelley A Cole
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Clin Nutr 91:191-9. 2010
    ..Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain...
  18. pmc Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Genet 124:557-9. 2008
    ..The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease...
  19. pmc Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Clin Nutr 91:1574-83. 2010
    ..Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease...
  20. pmc Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78227, USA
    J Clin Endocrinol Metab 94:632-8. 2009
    ..However, the role of uric acid as an independent risk factor for CVD is not yet clear...
  21. pmc Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA
    Kidney Blood Press Res 32:200-4. 2009
    ....
  22. ncbi Genome-wide scan for serum ghrelin detects linkage on chromosome 1p36 in Hispanic children: results from the Viva La Familia study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Pediatr Res 62:445-50. 2007
    ..9), and C-peptide (LOD=2.0). Several family-based studies have reported linkages for obesity-related phenotypes in the region of 1p36. These results indicate the importance of this region in relation to adiposity in children from the VFS...
  23. ncbi Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 53:2691-5. 2004
    ..Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se...
  24. pmc A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN Study) on chromosome 19q12-13
    V Saroja Voruganti
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
    Obesity (Silver Spring) 19:1840-6. 2011
    ....
  25. ncbi Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Nat Genet 39:1208-16. 2007
    ....
  26. pmc The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans
    Subrata D Nath
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Mol Cell Biochem 331:201-5. 2009
    ....
  27. ncbi Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
    ..04). Given these results, we hypothesize that a quantitative trait locus in this vicinity of chromosome 8 may have a differential effect on the expression of leptin in smokers versus non-smokers...
  28. doi Genetics of variation in HOMA-IR and cardiovascular risk factors in Mexican-Americans
    V Saroja Voruganti
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 86:303-11. 2008
    ..Significant genetic correlations between HOMA-IR and phenotypes related to CVD risk factors suggest that a common set of gene(s) influence the regulation of these phenotypes...
  29. pmc Plasma lipidomic profile signature of hypertension in Mexican American families: specific role of diacylglycerols
    Hemant Kulkarni
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Hypertension 62:621-6. 2013
    ..Our results demonstrate the value of plasma lipidomic profiling in the context of hypertension and identify disturbance of diacylglycerol metabolism as an independent biomarker of hypertension. ..
  30. pmc A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks
    James N Mubiru
    Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA
    J Med Primatol 40:335-41. 2011
    ..The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition...
  31. pmc Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Hum Mol Genet 19:3662-71. 2010
    ..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study...
  32. ncbi Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  33. pmc Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons
    Alberto O Chavez
    Department of Medicine, Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cardiovasc Diabetol 8:22. 2009
    ..e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available...
  34. pmc Genetic architecture of carotid artery intima-media thickness in Mexican Americans
    Phillip E Melton
    Deptartment of Genetics, Texas Biomedical Research Institute, San Antonio, USA
    Circ Cardiovasc Genet 6:211-21. 2013
    ..We do not detect any shared GWAS signals between common and internal carotid arterial segments, but the moderate genetic correlation implies both common and unique genetic components...
  35. pmc Genetic variation in PARL influences mitochondrial content
    Joanne E Curran
    Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Hum Genet 127:183-90. 2010
    ..These results suggest that genetic variation within PARL influences mitochondrial abundance and integrity...
  36. pmc Genotype×age interaction in human transcriptional ageing
    Jack W Kent
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Mech Ageing Dev 133:581-90. 2012
    ..Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort...
  37. pmc Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates
    Subhash Kamath
    Department of Medicine Division of Diabetes The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 6:e27617. 2011
    ..The mechanisms of NAFLD are not fully understood, but insulin resistance has been proposed as a key determinant...
  38. ncbi Pleiotropic effects of genes for insulin resistance on adiposity in baboons
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Obes Res 12:1766-72. 2004
    ..Previous research has suggested a genetic contribution to the development of insulin resistance and obesity. We hypothesized that the same genes influencing insulin resistance might also contribute to the variation in adiposity...
  39. pmc A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS
    Nedal H Arar
    Department of Medicine Nephrology, University of Texas Health Science Center, South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX 78229 4404, USA
    Nephrol Dial Transplant 23:3184-91. 2008
    ..Therefore, the purpose of this study is to identify susceptible chromosomal regions for CKD phenotypes in Mexican American families enrolled in the San Antonio Family Heart Study (SAFHS)...
  40. pmc Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genet 126:667-76. 2009
    ..These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations...
  41. pmc Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 195:367-73. 2007
    ..0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait...
  42. doi Characterization of ghrelin in pedigreed baboons: evidence for heritability and pleiotropy
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obesity (Silver Spring) 16:804-10. 2008
    ..Ghrelin is an orexigenic hormone that is produced primarily in the stomach, and stimulates food intake via its receptors situated in the hypothalamus...
  43. pmc Integrating genomic analysis with the genetic basis of gene expression: preliminary evidence of the identification of causal genes for cardiovascular and metabolic traits related to nutrition in Mexicans
    Raul A Bastarrachea
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
    Adv Nutr 3:596S-604S. 2012
    ..Such data will be crucial for the formal integration of positional and transcriptomic information characterized as genetical genomics...
  44. pmc Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging
    Vincent P Diego
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 133:11-9. 2012
    ..1, 1q41, 2q34, 3q23, and 7p15.3. We are currently examining potential associations with single nucleotide polymorphisms within the 1-LOD intervals of our linkage signals...
  45. ncbi Genome scan for determinants of serum uric acid variability
    Subrata D Nath
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Am Soc Nephrol 18:3156-63. 2007
    ..Given the relationship between uric acid level and these conditions, future studies should investigate potential candidate susceptibility genes found in this region...
  46. pmc A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study
    Sue Rutherford
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 81:744-55. 2007
    ..Further investigation of this region is necessary for the identification of the genetic variation responsible for QTLs influencing the rate of change in BP...
  47. doi Physiological and molecular determinants of insulin action in the baboon
    Alberto O Chavez
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Diabetes 57:899-908. 2008
    ..To quantitate insulin sensitivity in lean and obese nondiabetic baboons and examine the underlying cellular/molecular mechanisms responsible for impaired insulin action to characterize a baboon model of insulin resistance...
  48. pmc Heritability of measures of kidney disease among Zuni Indians: the Zuni Kidney Project
    Jean W Maccluer
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Kidney Dis 56:289-302. 2010
    ....
  49. ncbi A quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Hum Biol 73:787-800. 2001
    ..This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio...
  50. pmc Waist circumference independently associates with the risk of insulin resistance and type 2 diabetes in mexican american families
    Manju Mamtani
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 8:e59153. 2013
    ..Our objective was to determine whether WC is a better T2D predictor than BMI in family-based settings...
  51. pmc Genetic epidemiology of cardiometabolic risk factors and their clustering patterns in Mexican American children and adolescents: the SAFARI Study
    Sharon P Fowler
    University of Texas Health Science Center at San Antonio UTHSCSA, San Antonio, TX, USA
    Hum Genet 132:1059-71. 2013
    ..These findings highlight the complex genetic architecture of MS/MSCs in MA children, and underscore the need for early screening and intervention to prevent chronic sequelae in this vulnerable pediatric population. ..
  52. ncbi Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Clin Nutr 80:1410-4. 2004
    ..Obesity is generally accompanied by increased food intake...
  53. pmc Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children
    V Saroja Voruganti
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    Cytokine 60:634-8. 2012
    ..In summary, the association of the DARC Asp42Gly variant with MCP-1 levels replicates previous GWA results substantiating a potential role for DARC in the regulation of pro-inflammatory cytokines...
  54. ncbi Genome-wide scans reveal quantitative trait Loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227 5301, USA
    Diabetes 53:1369-74. 2004
    ....
  55. ncbi Common set of genes regulates low-density lipoprotein size and obesity-related factors in Alaskan Eskimos: results from the GOCADAN study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227 5301, USA
    Am J Hum Biol 18:525-31. 2006
    ..36), waist (rhoG = -0.42,), and subscapular and tricep skinfolds (rhoG = -0.44 and -0.43, respectively) (P < 0.005). These results show that a common set of genes is influencing LDL size and obesity-related factors in Alaskan Eskimos...
  56. pmc Polyunsaturated fatty acids effect on serum triglycerides concentration in the presence of metabolic syndrome components. The Alaska-Siberia Project
    Juan C Lopez-Alvarenga
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Metabolism 59:86-92. 2010
    ..The Westernized dietary habits among Eskimos are likely to change their metabolic profile and increase comorbidities related to metabolic disease...
  57. ncbi Heritability and genetic correlations of metabolic disease-related phenotypes in Mexico: preliminary report from the GEMM Family Study
    Raul A Bastarrachea
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 79:121-9. 2007
    ..These preliminary data represent the first heritability estimates for many of these phenotypes in the Republic of Mexico and indicate that this study design offers excellent power for future gene discovery relative to metabolic disease...
  58. pmc Genotype x adiposity interaction linkage analyses reveal a locus on chromosome 1 for lipoprotein-associated phospholipase A2, a marker of inflammation and oxidative stress
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245 0549, USA
    Am J Hum Genet 80:168-77. 2007
    ..Additionally, we conclude that GxE interaction analyses can improve our ability to identify and localize quantitative-trait loci...
  59. ncbi Genome-wide scan of plasma cholecystokinin in baboons shows linkage to human chromosome 17
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Obesity (Silver Spring) 15:2043-50. 2007
    ..Cholecystokinin (CCK) is known to inhibit food intake and is an important signal for controlling meal volume, indicating a possible role in weight regulation. Our objective was to investigate genetic influences on plasma CCK in baboons...
  60. ncbi Quantitative genetic analysis of glucose transporter 4 mRNA levels in baboon adipose
    M Elizabeth Tejero
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227 5301, USA
    Obes Res 12:1652-7. 2004
    ..The objective was to conduct quantitative genetic analyses using GLUT4 mRNA levels in omental adipose tissue of baboons as a novel phenotype...
  61. ncbi The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  62. pmc Significant genotype by diet (G × D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus)
    Venkata S Voruganti
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    Am J Primatol 75:491-9. 2013
    ..and suggest that mimicking the typical human nutritional environment can reveal genetic influences that might not be observed in animals consuming standard, plant-based diets...
  63. pmc Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans
    Melanie A Carless
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 8:e73950. 2013
    ..In addition, we found a significant influence of age and sex on DNA methylation, and report on trend-level, novel associations between DNA methylation and measures of obesity...
  64. pmc Renal histopathology of a baboon model with type 2 diabetes
    Hernan Rincon-Choles
    Audie L Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas, USA
    Toxicol Pathol 40:1020-30. 2012
    ..One diabetic animal had a Kimmestiel-Wilson nodule. We conclude that the baboon represents a useful primate model of diabetes and nephropathy that resembles the nephropathy associated with type 2 diabetes in humans...
  65. ncbi Genetic and environmental influences on thyroid hormone variation in Mexican Americans
    Paul B Samollow
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    J Clin Endocrinol Metab 89:3276-84. 2004
    ....
  66. pmc Pleiotropic effects on subclasses of HDL, adiposity, and glucose metabolism in adult Alaskan Eskimos
    M Elizabeth Tejero
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Am J Hum Biol 22:444-8. 2010
    ..These observations confirm the presence of possible pleiotropic effects on HDL, adiposity, and cardiovascular risk factors and provide novel insight on the relationship between HDL subclasses, adiposity, and glucose regulation...
  67. pmc Variability in associations of phosphatidylcholine molecular species with metabolic syndrome in Mexican-American families
    Hemant Kulkarni
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA
    Lipids 48:497-503. 2013
    ..Our results demonstrate the value of lipid species-specific information provided by the upcoming array of lipidomic studies and open potential avenues for prevention and control of metabolic syndrome in high prevalence settings...
  68. doi Prevalence and heritability of clusters for diagnostic components of metabolic syndrome: the Oman family study
    Juan C Lopez-Alvarenga
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Metab Syndr Relat Disord 6:129-35. 2008
    ....
  69. ncbi [Transciptome among Mexicans: a large scale methodology to analyze the genetics expression profile of simultaneous samples in muscle, adipose tissue and lymphocytes obtained from the same individual]
    Raul A Bastarrachea
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Gac Med Mex 144:473-9. 2008
    ....
  70. ncbi Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Obes Res 10:14-21. 2002
    ..As we have shown for other measures of adiposity, such sexual dimorphism can arise from a special case of genotype by environment interaction, that of genotype by sex interaction...
  71. pmc The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species
    Natalia E Schlabritz-Loutsevitch
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Reprod Sci 16:308-19. 2009
    ..Maternal obesity represents a risk factor for pregnancy-related complications. Glucocorticoids are known to promote obesity in adults...
  72. ncbi Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Biol Psychiatry 55:739-44. 2004
    ..Further genetic analysis can help explain phenotypic correlations among monoamine levels and might eventually help identify genes involved in response to therapy or risk of psychopathology...
  73. ncbi The emerging pattern of the genetic contribution to human obesity
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Best Pract Res Clin Endocrinol Metab 16:611-21. 2002
    ....
  74. ncbi [Macrophages, inflammation, adipose tissue, obesity and insulin resistance]
    Raul A Bastarrachea
    Department of Genetics, Auxology and Metabolism Working Group, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Gac Med Mex 143:505-12. 2007
    ..Our study focuses on the molecular and genetic mechanisms that recruit and retain macrophages in adipose tissue...
  75. ncbi Distribution of lod scores in oligogenic linkage analysis
    J T Williams
    Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S805-10. 2001
    ..We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic...
  76. ncbi Linkage analysis of circulating levels of adiponectin in Hispanic children
    M E Tejero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Int J Obes (Lond) 31:535-42. 2007
    ..The aim of this study was to find quantitative trait loci (QTLs) that affect circulating levels of adiponectin in Hispanic children participating in the VIVA LA FAMILIA Study by use of a systematic genome scan...
  77. doi [Molecular targets for new drug discovery to treat type 2 diabetes and obesity]
    Raul A Bastarrachea
    Department of Genetics, Auxology and Metabolism Working Group, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Rev Med Chil 136:107-17. 2008
    ..Several compounds have already been validated through genetic engineering in animal models or the preliminary use of therapeutic compounds in humans...
  78. doi Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon
    M E Tejero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Heredity (Edinb) 101:60-6. 2008
    ..The parallel findings of a cis-eQTL for RETN mRNA in baboon omental tissue and human lymphocytes lends support to the strategy of using lymphocyte gene expression levels as a surrogate for gene expression levels in other tissues...
  79. ncbi The utility of Bayesian model averaging for detecting known oligogenic effects
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S789-93. 2001
    ..The results were consistent with the underlying genetic model: two major QTLs were identified on chromosomes 19 and 2, with heritabilities of 17% and 20%, respectively, located near the position of major genes 1 and 2...
  80. ncbi [Genomics of body weight regulation: unraveling the molecular mechanisms predisposing to obesity]
    Raul A Bastarrachea
    Department of Genetics, Auxology and Metabolism Working Group, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Med Clin (Barc) 123:104-17. 2004
    ..Approaches based on Mendelian and quantitative genetics may well converge, and ultimately lead to more rational and selective therapies...
  81. ncbi Lifespan in captive baboons is heritable
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 123:1461-7. 2002
    ..This research demonstrates that lifespan is under partial genetic control. Given these findings, we believe that the baboon has potential as a model of human aging...
  82. pmc Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons
    Rodolfo Guardado-Mendoza
    Department of Medicine Diabetes Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:13992-7. 2009
    ..519, P < 0.0001), and different FPG levels were sensitive and specific to predict IA severity. Finally, a predictive model for islet amyloid severity was generated with age and FPG as required variables...
  83. ncbi [Patients with type III obesity given sibutramine 15 mg/day lose weight in amounts proportional to those in types I and II, but waist circumferences does not decrease proportionally]
    Juan Carlos Lopez-Alvarenga
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Gac Med Mex 143:109-14. 2007
    ..We assessed the association between obesity type with body mass index, waist circumference and tolerance to a daily dose of 15 mg of sibutramine...
  84. ncbi Genetics of leptin expression in baboons
    S A Cole
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Int J Obes Relat Metab Disord 27:778-83. 2003
    ..We have investigated leptin (LEP) gene express-ion, to determine whether it is heritable, and whether the difference in LEP expression between males and females has a genetic component...
  85. ncbi A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20
    L J Martin
    Departments of Genetics, Physiology and Medicine, Southwest Foundation for Biomedical Research San Antonio, Texas 78245 0549, USA
    Physiol Genomics 5:75-80. 2001
    ..This is the first evidence of a quantitative trait locus with a significant effect on estrogen...
  86. pmc Feto-placental adaptations to maternal obesity in the baboon
    D Farley
    Center of Pregnancy related and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Placenta 30:752-60. 2009
    ..In summary, these data demonstrate that in obese baboons in the absence of increased fetal weight, placental and fetal phenotype are consistent with those described for large-for-gestational age human fetuses...
  87. ncbi Genetic control of coordinated changes in HDL and LDL size phenotypes
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Arterioscler Thromb Vasc Biol 21:1829-33. 2001
    ..Thus, our study demonstrates that the phenotypic correlation of HDL and LDL sizes results in part from the pleiotropic actions of a set of genes, some of which also influence TG levels and some of which do not...
  88. ncbi The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    J Clin Endocrinol Metab 86:4321-5. 2001
    ....
  89. pmc A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans
    B D Mitchell
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    J Clin Invest 101:584-7. 1998
    ..The paired sibling design probably enhanced our ability to detect the effects of this variant by allowing us to account for variation attributable to another obesity susceptibility locus and to background genes...
  90. pmc Amplification of simian retroviral sequences from human recipients of baboon liver transplants
    J S Allan
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228, USA
    AIDS Res Hum Retroviruses 14:821-4. 1998
    ..The persistence of SFV and BaEV in human recipients throughout the posttransplant period underscores the potential infectious risks associated with xenotransplantation...
  91. ncbi Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study
    B D Mitchell
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78245 0549, USA
    Circulation 94:2159-70. 1996
    ....
  92. ncbi A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor
    B D Mitchell
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Diabetes 48:1863-7. 1999
    ..It is also possible that a gene closely linked to ADRB3 may influence susceptibility to obesity...
  93. ncbi The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans
    S A Cole
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Int J Obes Relat Metab Disord 24:522-4. 2000
    ..022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans...
  94. ncbi Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures
    B D Mitchell
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Tex 78228 0147, USA
    Arterioscler Thromb Vasc Biol 16:281-8. 1996
    ....
  95. ncbi Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans
    B D Mitchell
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Diabetes 49:513-6. 2000
    ..Possible candidate genes in this region include GBE1 and ACOX2, which encode enzymes involved in glycogen and fatty acid metabolism, respectively...
  96. ncbi Pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of HDL subfractions in two dietary environments
    M C Mahaney
    Southwest Foundation for Biomedical Research, Department of Genetics, San Antonio, TX, USA
    Arterioscler Thromb Vasc Biol 19:1134-41. 1999
    ..However, the expression of genes influencing HDL1-C and HDL2-C is altered by the HCSF diet, disrupting the pleiotropy observed between the 3 subfractions on the Chow diet...
  97. ncbi Serum leptin levels are independently correlated with two measures of HDL
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Atherosclerosis 132:237-43. 1997
    ..A better understanding of the genes responsible for this relationship may provide a molecular explanation for the aggregation of atherogenic phenotypes, such as diabetes, obesity, and dyslipoproteinemia...
  98. ncbi [Study of the genetic component of cardiovascular risk phenotypes in a Mexican population]
    Raul A Bastarrachea
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, Estados Unidos
    Med Clin (Barc) 129:11-3. 2007
    ..The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD risk factor phenotypes are estimated using a variance component approach...
  99. ncbi Genetic variation in selenoprotein S influences inflammatory response
    Joanne E Curran
    Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Nat Genet 37:1234-41. 2005
    ..0049) and IL-1beta (P = 0.0101). These results provide a direct mechanistic link between SEPS1 and the production of inflammatory cytokines and suggest that SEPS1 has a role in mediating inflammation...
  100. ncbi Quantitative trait locus on chromosome 12q14.1 influences variation in plasma plasminogen levels in the San Antonio Family Heart Study
    A Santamaria
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227, USA
    Hum Biol 79:515-23. 2007
    ..Because plasminogen has important effects in many human health problems, such as cancer and atherosclerosis, the role of this putative QTL in the regulation of plasminogen variability needs to be studied further...
  101. ncbi A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies
    Rector Arya
    Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
    Hum Mol Genet 15:1569-79. 2006
    ..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans...