John Blangero

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. ncbi Linkage disequilibrium across two different single-nucleotide polymorphism genome scans
    Juan Manuel Peralta
    Centro de Investigacion en Biologia Celular y Molecular, Ciudad de la Investigación, Universidad de Costa Rica, San Jose, Costa Rica
    BMC Genet 6:S86. 2005
  2. ncbi Smoothing of the bivariate LOD score for non-normal quantitative traits
    Alfonso Buil
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 6:S111. 2005
  3. ncbi Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
  4. ncbi On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S72. 2003
  5. ncbi Longitudinal familial analysis of blood pressure involving parametric (co)variance functions
    Julia M P Soler
    Department of Statistics, University of Sao Paulo, Sao Paulo SP, Brazil
    BMC Genet 4:S87. 2003
  6. ncbi A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245 0549, USA
    BMC Genet 6:S117. 2005
  7. ncbi Novel family-based approaches to genetic risk in thrombosis
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    J Thromb Haemost 1:1391-7. 2003
  8. ncbi Effects of a major gene for apolipoprotein A-I concentration are thyroid hormone dependent in Mexican Americans
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Arterioscler Thromb Vasc Biol 16:1177-83. 1996
  9. ncbi Robust LOD scores for variance component-based linkage analysis
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 19:S8-14. 2000
  10. ncbi Localization and identification of human quantitative trait loci: king harvest has surely come
    John Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, Texas 78227 5301, USA
    Curr Opin Genet Dev 14:233-40. 2004

Detail Information

Publications105 found, 100 shown here

  1. ncbi Linkage disequilibrium across two different single-nucleotide polymorphism genome scans
    Juan Manuel Peralta
    Centro de Investigacion en Biologia Celular y Molecular, Ciudad de la Investigación, Universidad de Costa Rica, San Jose, Costa Rica
    BMC Genet 6:S86. 2005
    ..Caution should probably be taken when using high density SNP maps when many non-genotyped founders are present in the study pedigrees...
  2. ncbi Smoothing of the bivariate LOD score for non-normal quantitative traits
    Alfonso Buil
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 6:S111. 2005
    ..We perform a novel correction that achieves acceptable levels of type I error...
  3. ncbi Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
    ..We next applied factor analysis to summarize the relationship between these phenotypes...
  4. ncbi On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S72. 2003
    ..It should be kept in mind, however, that an increase in computational accuracy is expected to go hand in hand with a decrease in robustness to various sources of errors...
  5. ncbi Longitudinal familial analysis of blood pressure involving parametric (co)variance functions
    Julia M P Soler
    Department of Statistics, University of Sao Paulo, Sao Paulo SP, Brazil
    BMC Genet 4:S87. 2003
    ..Due to the availability of multiple measures on the same individual, we permitted environmental correlations that may change across time...
  6. ncbi A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245 0549, USA
    BMC Genet 6:S117. 2005
    ..Based on a comparison of the number of LOD scores achieving statistical significance, our results suggest that the microsatellite- and Illumina SNP-based genotypes have similar utility for detecting genomic regions of interest...
  7. ncbi Novel family-based approaches to genetic risk in thrombosis
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    J Thromb Haemost 1:1391-7. 2003
    ..Unfortunately, family-based designs are still relatively rare in thrombosis/hemostasis studies. In this review, we detail the reasons why the field would benefit from a more vigorous pursuit of modern family-based genetic studies...
  8. ncbi Effects of a major gene for apolipoprotein A-I concentration are thyroid hormone dependent in Mexican Americans
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Arterioscler Thromb Vasc Biol 16:1177-83. 1996
    ..These findings suggest that thyroid hormone has an important role in the genetic control of lipoprotein metabolism...
  9. ncbi Robust LOD scores for variance component-based linkage analysis
    J Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 19:S8-14. 2000
    ....
  10. ncbi Localization and identification of human quantitative trait loci: king harvest has surely come
    John Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, Texas 78227 5301, USA
    Curr Opin Genet Dev 14:233-40. 2004
    ....
  11. ncbi Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes 58:279-84. 2009
    ..The goal of our study was to perform a genome-wide linkage scan to identify genetic regions that influence variation in plasma triglyceride levels in families that are enriched with individuals with type 2 diabetes...
  12. ncbi Association of genetic variation in ENPP1 with obesity-related phenotypes
    Christopher P Jenkinson
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Obesity (Silver Spring) 16:1708-13. 2008
    ..However, these results indicate that ENPP1 is a genetic determinant of these traits in this population, and are consistent with multiple positive association findings in independent studies in diverse human populations...
  13. ncbi Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Genet 124:557-9. 2008
    ..The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease...
  14. ncbi Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA
    Kidney Blood Press Res 32:200-4. 2009
    ....
  15. ncbi Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus
    Farook Thameem
    Division of Nephrology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Metabolism 58:1496-502. 2009
    ..In conclusion, the variants examined at GREM1 are not significant contributors to variation in ACR in Mexican Americans, although they appear to minimally influence risk factors related to ACR...
  16. ncbi The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans
    Subrata D Nath
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Mol Cell Biochem 331:201-5. 2009
    ....
  17. ncbi Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children
    Shelley A Cole
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Clin Nutr 91:191-9. 2010
    ..Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain...
  18. ncbi Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Nat Genet 39:1208-16. 2007
    ....
  19. ncbi Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78227, USA
    J Clin Endocrinol Metab 94:632-8. 2009
    ..However, the role of uric acid as an independent risk factor for CVD is not yet clear...
  20. ncbi Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
    ..Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits...
  21. ncbi Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q
    Donna M Lehman
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Biol 77:231-46. 2005
    ..23, 103-109 cM; a maximum bivariate LOD of 4.51 was found for the trait pair HDLC and LSPI (the LODeq score is 3.94)]. We observed evidence of pleiotropic effects in this region on obesity and insulin-related trait pairs...
  22. ncbi Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 53:2691-5. 2004
    ..Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se...
  23. ncbi Genome-wide linkage screen for systolic blood pressure in the Veterans Administration Genetic Epidemiology Study (VAGES) of Mexican-Americans and confirmation of a major susceptibility locus on chromosome 6q14.1
    Sobha Puppala
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Hum Hered 71:1-10. 2011
    ....
  24. ncbi Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
    ..04). Given these results, we hypothesize that a quantitative trait locus in this vicinity of chromosome 8 may have a differential effect on the expression of leptin in smokers versus non-smokers...
  25. ncbi Autosomal genome-wide linkage analysis to identify loci for gallbladder wall thickness in Mexican Americans
    Narahari Samudrala
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 80:11-28. 2008
    ....
  26. ncbi Two quantitative trait loci influence whipworm (Trichuris trichiura) infection in a Nepalese population
    Sarah Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    J Infect Dis 197:1198-203. 2008
    ..In a follow-up study of significant heritability for whipworm infection, we conducted the first genome scan for quantitative trait loci (QTL) influencing the heritability of susceptibility to this important parasitic disease...
  27. ncbi The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations
    Matthew P Johnson
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Hum Genet 126:655-66. 2009
    ..We herein report a novel preeclampsia risk locus, ERAP2, in a region of known genetic linkage to this pregnancy-specific disorder...
  28. ncbi P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:513-7. 2007
    ....
  29. ncbi Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:389-93. 2007
    ..02, RR 1.64). These data provide evidence that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations...
  30. ncbi Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 195:367-73. 2007
    ..0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait...
  31. ncbi Genotype×age interaction in human transcriptional ageing
    Jack W Kent
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Mech Ageing Dev 133:581-90. 2012
    ..Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort...
  32. ncbi A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS
    Nedal H Arar
    Department of Medicine Nephrology, University of Texas Health Science Center, South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX 78229 4404, USA
    Nephrol Dial Transplant 23:3184-91. 2008
    ..Therefore, the purpose of this study is to identify susceptible chromosomal regions for CKD phenotypes in Mexican American families enrolled in the San Antonio Family Heart Study (SAFHS)...
  33. ncbi Genetics of variation in HOMA-IR and cardiovascular risk factors in Mexican-Americans
    V Saroja Voruganti
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 86:303-11. 2008
    ..Significant genetic correlations between HOMA-IR and phenotypes related to CVD risk factors suggest that a common set of gene(s) influence the regulation of these phenotypes...
  34. ncbi Genome scan for determinants of serum uric acid variability
    Subrata D Nath
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Am Soc Nephrol 18:3156-63. 2007
    ..Given the relationship between uric acid level and these conditions, future studies should investigate potential candidate susceptibility genes found in this region...
  35. ncbi Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses
    Peter Kochunov
    Dip ABMP, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 41:2137-42. 2010
    ..Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements...
  36. ncbi Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study
    Vincent P Diego
    Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 55:1874-8. 2006
    ..42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas...
  37. ncbi The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling
    Farook Thameem
    Division of Nephrology, The University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 61:2385-93. 2012
    ..Taken together, the data provide the first evidence that genetic variation in IRS1 may influence variation in GFR probably through impaired insulin receptor signaling...
  38. ncbi Systems genetics of the nuclear factor-κB signal transduction network. I. Detection of several quantitative trait loci potentially relevant to aging
    Vincent P Diego
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 133:11-9. 2012
    ..1, 1q41, 2q34, 3q23, and 7p15.3. We are currently examining potential associations with single nucleotide polymorphisms within the 1-LOD intervals of our linkage signals...
  39. ncbi Sex-specific QTL effects on variation in paraoxonase 1 (PON1) activity in Mexican Americans
    Deidre A Winnier
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Genet Epidemiol 31:66-74. 2007
    ..This study represents the first formal statistical genetic test for G x S interactions on normal quantitative variation in PON1 activity in humans...
  40. ncbi Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides
    Sarah Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    J Infect Dis 197:66-71. 2008
    ..031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13...
  41. ncbi A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans
    Sobha Puppala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 78:377-92. 2006
    ..In conclusion, we found significant evidence of major genetic determinants of symptomatic GBD on chromosome 1p in Mexican Americans...
  42. ncbi Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Hum Biol 77:17-25. 2005
    ....
  43. ncbi Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Diab Vasc Dis Res 5:109-13. 2008
    ..In conclusion, of the genetic polymorphisms examined at the eNOS locus, only 27bp-VNTR appears to be a minor contributor to the variation in T2DM-related traits in Mexican Americans...
  44. ncbi Pleiotropic effects of genes for insulin resistance on adiposity in baboons
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227-5301, USA
    Obes Res 12:1766-72. 2004
    ..Further genetic research in a larger sample size is needed to identify the common genes that constitute the genetic basis for the development of insulin resistance and obesity...
  45. ncbi Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX, USA
    BMC Med Genomics 3:29. 2010
    ..This investigation offers insights into system-wide pathological processes induced in response to cigarette smoke exposure by determining its influences at the gene expression level...
  46. ncbi Quantitative trait nucleotide analysis using Bayesian model selection
    John Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 620 NW Loop 410, San Antonio, TX 78245-0549, USA
    Hum Biol 77:541-59. 2005
    ..We also include instructions on how to use our computer program, SOLAR, for association analysis and BQTN analysis...
  47. ncbi Genetic variation in PARL influences mitochondrial content
    Joanne E Curran
    Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Hum Genet 127:183-90. 2010
    ..These results suggest that genetic variation within PARL influences mitochondrial abundance and integrity...
  48. ncbi Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans
    Dawn K Coletta
    Division of Diabetes MC 7886, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Obesity (Silver Spring) 15:809-15. 2007
    ..98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in our Mexican American population...
  49. ncbi Host genetics and population structure effects on parasitic disease
    Sarah Williams-Blangero
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Philos Trans R Soc Lond B Biol Sci 367:887-94. 2012
    ..No significant influences of population structure on measures associated with progression of cardiac disease in individuals who were seropositive for T. cruzi infection were found...
  50. ncbi Genetic determinants of mitochondrial content
    Joanne E Curran
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Hum Mol Genet 16:1504-14. 2007
    ....
  51. ncbi Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Hum Mol Genet 19:3662-71. 2010
    ..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study...
  52. ncbi Type I error rates in association versus joint linkage/association tests in related individuals
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Genet Epidemiol 31:173-7. 2007
    ..These results support the idea that an appropriate association analysis must test both the random effect of shared marker alleles (linkage) and the mean effects of the marker genotypes (association)...
  53. ncbi A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study
    Sue Rutherford
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 81:744-55. 2007
    ..Further investigation of this region is necessary for the identification of the genetic variation responsible for QTLs influencing the rate of change in BP...
  54. ncbi The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  55. ncbi Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 54:2655-62. 2005
    ..87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations...
  56. ncbi Genome-wide scans reveal quantitative trait Loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227 5301, USA
    Diabetes 53:1369-74. 2004
    ....
  57. ncbi Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  58. ncbi A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American family
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes Metab Res Rev 22:331-6. 2006
    ..The aim of this study was to investigate the association of this mutation in the SAFDGS with risk for diabetes...
  59. ncbi Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans
    Vidya S Farook
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
    Obesity (Silver Spring) 20:2083-92. 2012
    ..7). In conclusion, our linkage and subsequent association studies implicate a region on chromosome 7q21 to influence MS in Mexican Americans...
  60. ncbi Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene
    Matthew P Johnson
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 7:e33666. 2012
    ....
  61. ncbi Genotype x adiposity interaction linkage analyses reveal a locus on chromosome 1 for lipoprotein-associated phospholipase A2, a marker of inflammation and oxidative stress
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245 0549, USA
    Am J Hum Genet 80:168-77. 2007
    ..Additionally, we conclude that GxE interaction analyses can improve our ability to identify and localize quantitative-trait loci...
  62. ncbi A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 176:379-86. 2004
    ..These data provide evidence for a novel gene, influencing beta-lipoprotein phenotypes, whose effect(s) is detected only when several lipoprotein traits are considered together...
  63. ncbi Principal component for metabolic syndrome risk maps to chromosome 4p in Mexican Americans: the San Antonio Family Heart Study
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227-5301, USA
    Hum Biol 76:651-65. 2004
    ..20) and on chromosome 6 near marker D6S 1031 (LOD = 2.08), respectively. In summary, our findings suggest that the factor structures for the risk of metabolic syndrome are influenced by multiple distinct genes across the genome...
  64. ncbi A linkage analysis of cigarette and alcohol consumption in an unselected Mexican American population
    Kevin Viel
    Southwest Foundation for Biomedical Research, Department of Genetics, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 147:983-6. 2008
    ..16, P = 0.34). The results from the bivariate linkage analysis found a maximum LOD score of 3.82 (genome-wide P = 0.0054) at 151 cM on chromosome 10, at the location of the overlapping peaks from the univariate analyses...
  65. ncbi Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Hum Genet 74:272-82. 2004
    ..In conclusion, we identified a major genetic locus influencing BMI on chromosome 4p in Mexican Americans...
  66. ncbi Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 40:3685-90. 2009
    ....
  67. ncbi The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification
    Lorena M Havill
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    BMC Genet 6:S91. 2005
    ..We also demonstrate by simulation the increase in power obtained with the QTLD test, relative to the QTDT, when a true association exists between a marker and a QTL...
  68. ncbi Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S34. 2003
    ..Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study...
  69. ncbi Factors of insulin resistance syndrome--related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic mexican-americans
    Rector Arya
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA
    Diabetes 51:841-7. 2002
    ..2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans...
  70. ncbi Multiple QTLs influence variation in paraoxonase 1 activity in Mexican Americans
    Deidre A Winnier
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245-0549, USA
    Hum Biol 78:341-52. 2006
    ..We have provided evidence that other genes, in addition to the well-known ones on chromosome 7, play a role in influencing normal variation in PON1 activity...
  71. ncbi Genetic influences on plasma cytokine variation in a parasitized population
    Sarah Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA
    Hum Biol 76:515-25. 2004
    ..400-0.577) in these derived measures of relative type 2/type 1 response is due to genetic factors...
  72. ncbi The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Biol 79:191-200. 2007
    ....
  73. ncbi Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Nat Genet 30:102-5. 2002
    ..A replication study in an independent set of Mexican American families confirmed the existence of a QTL on chromosome 9p...
  74. ncbi X chromosome effects and their interactions with mitochondrial effects
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    BMC Genet 6:S157. 2005
    ..Results for ntth1 suggest that methods that do not also allow for male-female heterogeneity in environmental variance may be overly conservative in detection of X-chromosomal effects...
  75. ncbi Genetic association of preeclampsia to the inflammatory response gene SEPS1
    Eric K Moses
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Obstet Gynecol 198:336.e1-5. 2008
    ..The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia...
  76. ncbi A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229, USA
    Diabetes 54:1214-21. 2005
    ..The variance attributed to this SNP accounted for approximately 25% of the logarithm of odds. These results suggest that this variant within the MGEA5 gene may increase diabetes risk in Mexican Americans...
  77. ncbi Genes on chromosomes 1 and 13 have significant effects on Ascaris infection
    Sarah Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245, USA
    Proc Natl Acad Sci U S A 99:5533-8. 2002
    ..This is the first evidence that individual quantitative trait loci influence variation in Ascaris burden in humans...
  78. ncbi Genetic component to susceptibility to Trichuris trichiura: evidence from two Asian populations
    Sarah Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:254-64. 2002
    ..These concordant results from two separate populations provide strong evidence of the important role of genetics in determining differential susceptibility to whipworm infection...
  79. ncbi Heritability of brain volume, surface area and shape: an MRI study in an extended pedigree of baboons
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Hum Brain Mapp 28:576-83. 2007
    ....
  80. ncbi Genetic and environmental influences on thyroid hormone variation in Mexican Americans
    Paul B Samollow
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    J Clin Endocrinol Metab 89:3276-84. 2004
    ....
  81. ncbi The baboon as a nonhuman primate model for the study of the genetics of obesity
    Anthony G Comuzzie
    Department of Genetics, Southwest Regional Primate Research Center, San Antonio, Texas 78245 0549, USA
    Obes Res 11:75-80. 2003
    ..Therefore, we are currently developing the baboon as a nonhuman primate model for the study of the genetics of obesity...
  82. ncbi Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22
    Guowen Cai
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Clin Nutr 80:1410-4. 2004
    ..Obesity is generally accompanied by increased food intake...
  83. ncbi Estimating the additive genetic effect of the X chromosome
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 29:377-88. 2005
    ..We present simulation studies to estimate the power and computational efficiency of our proposed method...
  84. ncbi A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 23:508-11. 2003
    ..As part of the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project, we conducted a genome-wide linkage screen to localize genes influencing variation in free PS (fPS) plasma levels...
  85. ncbi Genetic epidemiology of Trypanosoma cruzi infection and Chagas' disease
    Sarah Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227, USA
    Front Biosci 8:e337-45. 2003
    ....
  86. ncbi Genetic variation in selenoprotein S influences inflammatory response
    Joanne E Curran
    Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Nat Genet 37:1234-41. 2005
    ..0049) and IL-1beta (P = 0.0101). These results provide a direct mechanistic link between SEPS1 and the production of inflammatory cytokines and suggest that SEPS1 has a role in mediating inflammation...
  87. ncbi Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Stroke 33:2775-80. 2002
    ..In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control...
  88. ncbi A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility
    Jose Manuel Soria
    Unitat d Hemostasia i Trombosi, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Blood 101:163-7. 2003
    ..Importantly, there are no known thrombosis-related candidate genes in this region, implying that this QTL represents a completely novel thrombosis risk factor...
  89. ncbi Genetic polymorphisms in the renin-angiotensin system (RAS) genes and their association analysis with type 2 diabetes and related traits in Mexican Americans
    Farook Thameem
    Diabetes Res Clin Pract 79:e14-6. 2008
  90. ncbi The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus
    Jose Manuel Soria
    Unitat d Hemostasia i Trombosi, Departament d Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Hum Biol 77:561-75. 2005
    ..These variants include both rare coding variants and more common, potentially regulatory polymorphisms in intronic and promoter regions...
  91. ncbi Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Hypertension 43:780-4. 2004
    ..4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI...
  92. ncbi Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  93. ncbi Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  94. ncbi Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Psychiatry 164:813-9. 2007
    ..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort...
  95. ncbi Genetic determinants of obesity-related lipid traits
    Gabriele E Sonnenberg
    Division of Endocrinology, Metabolism and Clinical Nutrition, Department of Medicine and Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 45:610-5. 2004
    ..These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity...
  96. ncbi Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis
    Juan Carlos Souto
    Haematologica 88:1436-8. 2003
  97. ncbi Genome-wide scans for microalbuminuria in Mexican Americans: the San Antonio Family Heart Study
    Nedal Arar
    Department of Medicine Nephrology, University of Texas Health Science Center at San Antonio, South Texas Veterans Health Care System, 78229 4404, USA
    Genet Med 9:80-7. 2007
    ..03 to 0.299 mg/mg, is a major risk factor for cardiovascular disease. Several genetic epidemiological studies have established that microalbuminuria clusters in families, suggesting a genetic predisposition...
  98. ncbi Phenotypical characterisation of the isolated norfolk island population focusing on epidemiological indicators of cardiovascular disease
    Claire Bellis
    Genomics Research Centre, School of Medical Science, Griffith University, Gold Coast, Gold Coast Mail Centre Queensland, Australia
    Hum Hered 60:211-9. 2005
    ..2. CONCLUSIONS: The Norfolk Island population is a potentially useful genetic isolate for gene mapping studies aimed at identifying CVD risk factor quantitative trait loci (QTL)...
  99. ncbi A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project
    Juan Carlos Souto
    Unitat de Trombosi i Hemostasia, Departament d Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Hum Genet 76:925-33. 2005
    ..These data could be relevant in determining the relationships between Hcy level, cardiovascular disease, osteoporosis, and Alzheimer disease...
  100. ncbi Genetic and environmental influences on infant weight and weight change: the Fels Longitudinal Study
    Ellen W Demerath
    Lifespan Health Research Center, Wright State University School of Medicine, Dayton, Ohio 45420 4014, USA
    Am J Hum Biol 19:692-702. 2007
    ..Understanding genetic influences on growth rate in a well-nourished, nutritionally stable population may help us interpret the causes and consequences of centile crossing in nutritionally compromised contexts...
  101. ncbi Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes
    Jeremy B Jowett
    International Diabetes Institute, 336 Glenferrie Rd, Malvern VIC, Australia
    Diabetes 53:2467-72. 2004
    ..018). Multivariate analysis of these correlated phenotypes also yielded a highly significant association (P = 0.0004), suggesting that BEACON may influence phenotypic variation in metabolic syndrome-related traits...