Tim Anderson

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. pmc Adaptive copy number evolution in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX, USA
    PLoS Genet 4:e1000243. 2008
  2. pmc An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations
    John C Tan
    The Eck Institute for Global Health, University of Notre Dame, 100 Galvin Life Sciences, Notre Dame, IN 46556, USA
    Genome Biol 12:R35. 2011
  3. pmc Genomic linkage map of the human blood fluke Schistosoma mansoni
    Charles D Criscione
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Genome Biol 10:R71. 2009
  4. pmc Gene copy number and malaria biology
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Trends Parasitol 25:336-43. 2009
  5. pmc How can we identify parasite genes that underlie antimalarial drug resistance?
    Tim Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Pharmacogenomics 12:59-85. 2011
  6. pmc Inferred relatedness and heritability in malaria parasites
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Proc Biol Sci 277:2531-40. 2010
  7. pmc High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
    J Infect Dis 201:1326-30. 2010
  8. pmc Genetic changes during laboratory propagation: copy number At the reticulocyte-binding protein 1 locus of Plasmodium falciparum
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX, USA
    Mol Biochem Parasitol 172:145-8. 2010
  9. ncbi Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 24:562-73. 2007
  10. ncbi Mapping drug resistance genes in Plasmodium falciparum by genome-wide association
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX 78248, USA
    Curr Drug Targets Infect Disord 4:65-78. 2004

Collaborators

Detail Information

Publications17

  1. pmc Adaptive copy number evolution in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX, USA
    PLoS Genet 4:e1000243. 2008
    ..More generally, these data demonstrate how selection affects multiple enzymes in a single biochemical pathway, and suggest that investigation of structural variation may provide a fast-track to locating genes underlying adaptation...
  2. pmc An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations
    John C Tan
    The Eck Institute for Global Health, University of Notre Dame, 100 Galvin Life Sciences, Notre Dame, IN 46556, USA
    Genome Biol 12:R35. 2011
    ..The microarray and workflow presented can be used to identify CNVs and SNPs with 95% accuracy in a single hybridization, in field samples containing up to 92% human DNA contamination...
  3. pmc Genomic linkage map of the human blood fluke Schistosoma mansoni
    Charles D Criscione
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Genome Biol 10:R71. 2009
    ..mansoni's molecular, quantitative, and population genetics. Our goal was to construct a genetic linkage map for S. mansoni, and thus provide a new resource that will help stimulate research on this neglected pathogen...
  4. pmc Gene copy number and malaria biology
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Trends Parasitol 25:336-43. 2009
    ..In this review, we summarize the distribution of CNP, its evolutionary dynamics within populations, its functional importance and its mode of evolution...
  5. pmc How can we identify parasite genes that underlie antimalarial drug resistance?
    Tim Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Pharmacogenomics 12:59-85. 2011
    ..Our intention is both to review past progress and highlight promising approaches for future investigations...
  6. pmc Inferred relatedness and heritability in malaria parasites
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Proc Biol Sci 277:2531-40. 2010
    ....
  7. pmc High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
    J Infect Dis 201:1326-30. 2010
    ....
  8. pmc Genetic changes during laboratory propagation: copy number At the reticulocyte-binding protein 1 locus of Plasmodium falciparum
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX, USA
    Mol Biochem Parasitol 172:145-8. 2010
    ..We conclude that PfRh1 CNV is not an important determinant of gene expression, cell invasion or growth rate in natural parasite populations...
  9. ncbi Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 24:562-73. 2007
    ..This may be particularly likely when mutation rate is high, as appears to be the case for gene duplications, and in pathogen populations where effective population sizes are typically very large...
  10. ncbi Mapping drug resistance genes in Plasmodium falciparum by genome-wide association
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX 78248, USA
    Curr Drug Targets Infect Disord 4:65-78. 2004
    ..Finally, to demonstrate the utility of the approach I describe two proof-of-principle studies documenting patterns of genetic variability around known drug resistance genes...
  11. pmc Selection strength and hitchhiking around two anti-malarial resistance genes
    Denae Nash
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX 78245, USA
    Proc Biol Sci 272:1153-61. 2005
    ..However, the lower levels of LD surrounding resistance alleles in populations under weak selection may simplify identification of functional mutations...
  12. ncbi A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 20:1526-36. 2003
    ....
  13. ncbi Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan
    Tim J C Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Trop Med Int Health 8:1068-73. 2003
    ..To assess resistance to chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) in a Sudanese parasite population...
  14. ncbi The origins and spread of antimalarial drug resistance: lessons for policy makers
    Tim J C Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Acta Trop 94:269-80. 2005
    ..De novo mutation appears to be less important than migration for introducing resistance alleles into parasite populations. Attempts to manage drug resistance will be of limited effectiveness unless this is taken into account...
  15. ncbi Rapid genotyping of loci involved in antifolate drug resistance in Plasmodium falciparum by primer extension
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, PO Box 760549, San, Antonio, TX 78245, USA
    Int J Parasitol 32:852-8. 2002
    ..The method can be easily adapted to other P. falciparum genes and will greatly simplify scoring of point mutations in this and other parasitic organisms...
  16. ncbi Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 22:2362-74. 2005
    ..falciparum genome violates the central assumption that selected sites are rare, which complicates identification of outlier loci, and suggests that caution is needed when using this approach...

Research Grants17

  1. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2004
    ..Candidate genes will be identified using sequence data emerging from the malaria genome project. ..
  2. Copy Number Variation in Malaria Parasites
    Tim Anderson; Fiscal Year: 2009
    ..We propose to systematically describe DNA rearrangements in the malaria parasite genome, and evaluate the role that they play in this important pathogen. ..
  3. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2000
    ..Candidate genes will be identified using sequence data emerging from the malaria genome project. ..
  4. Copy Number Variation in Malaria Parasites
    Tim J Anderson; Fiscal Year: 2010
    ..We propose to systematically describe DNA rearrangements in the malaria parasite genome, and evaluate the role that they play in this important pathogen. ..
  5. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim J Anderson; Fiscal Year: 2010
    ..We aim to locate parasite genes underlying resistance. This will allow us to track the spread of resistance, to better understand how antimalarial drugs work, and to redesign drugs to restore their effectiveness. ..
  6. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2009
    ..We aim to locate parasite genes underlying resistance. This will allow us to track the spread of resistance, to better understand how antimalarial drugs work, and to redesign drugs to restore their effectiveness. ..
  7. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2007
    ..We aim to locate parasite genes underlying resistance. This will allow us to track the spread of resistance, to better understand how antimalarial drugs work, and to redesign drugs to restore their effectiveness. ..
  8. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2007
    ..We aim to locate parasite genes underlying resistance. This will allow us to track the spread of resistance, to better understand how antimalarial drugs work, and to redesign drugs to restore their effectiveness. ..
  9. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2006
    ..abstract_text> ..
  10. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2003
    ..Candidate genes will be identified using sequence data emerging from the malaria genome project. ..
  11. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2002
    ..Candidate genes will be identified using sequence data emerging from the malaria genome project. ..
  12. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2002
    ..Candidate genes will be identified using sequence data emerging from the malaria genome project. ..
  13. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim Anderson; Fiscal Year: 2001
    ..Candidate genes will be identified using sequence data emerging from the malaria genome project. ..
  14. MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUM
    Tim J Anderson; Fiscal Year: 2010
    ..We aim to locate parasite genes underlying resistance. This will allow us to track the spread of resistance, to better understand how antimalarial drugs work, and to redesign drugs to restore their effectiveness. ..