Research Topics
| T JC ANDERSONSummaryAffiliation: Southwest Foundation for Biomedical Research Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in southern VietnamMarcelo U Ferreira
Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900 São Paulo SP, Brazil
J Clin Microbiol 40:1854-7. 2002..Temporal structure and linkage disequilibrium were also examined in this data set...- Disentangling hybridization and host colonization in parasitic roundworms of humans and pigsCharles D Criscione
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245, USA
Proc Biol Sci 274:2669-77. 2007..These results indicate that there is contemporary cross-transmission between populations of human and pig Ascaris... - Microsatellite markers for the human nematode parasite Ascaris lumbricoides: development and assessment of utilityCharles D Criscione
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245, USA
J Parasitol 93:704-8. 2007..These markers have high genetic variability and provide the tools to address multiple questions concerning the epidemiology, fine-scale genetic structure, host specificity, and mating systems of this parasite... - Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoitesMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Infect Dis 195:927-33. 2007..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection... - Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasitesTim J C Anderson
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Mol Biol Evol 22:2362-74. 2005..falciparum genome violates the central assumption that selected sites are rare, which complicates identification of outlier loci, and suggests that caution is needed when using this approach... - Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparumT J Anderson
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
Mol Biol Evol 17:1467-82. 2000..These data reveal a range of population structures within a single pathogen species and suggest intimate links between patterns of epidemiology and genetic structure in this organism... - Complex mutations in a high proportion of microsatellite loci from the protozoan parasite Plasmodium falciparumT J Anderson
Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
Mol Ecol 9:1599-608. 2000.... - The dangers of using single locus markers in parasite epidemiology: Ascaris as a case studyT J Anderson
Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Trends Parasitol 17:183-8. 2001.... - Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?Timothy J C Anderson
Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245, USA
Antimicrob Agents Chemother 49:2180-8. 2005..However, the consistent association observed between a 3-bp indel in G7 and AS response merits further investigation... - Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, SudanTim J C Anderson
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
Trop Med Int Health 8:1068-73. 2003..To assess resistance to chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) in a Sudanese parasite population... - Mapping drug resistance genes in Plasmodium falciparum by genome-wide associationTim J C Anderson
Southwest Foundation for Biomedical Research, San Antonio, TX 78248, USA
Curr Drug Targets Infect Disord 4:65-78. 2004..Finally, to demonstrate the utility of the approach I describe two proof-of-principle studies documenting patterns of genetic variability around known drug resistance genes... - The origins and spread of antimalarial drug resistance: lessons for policy makersTim J C Anderson
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
Acta Trop 94:269-80. 2005..De novo mutation appears to be less important than migration for introducing resistance alleles into parasite populations. Attempts to manage drug resistance will be of limited effectiveness unless this is taken into account... - Selection strength and hitchhiking around two anti-malarial resistance genesDenae Nash
Southwest Foundation for Biomedical Research (SFBR, San Antonio, TX 78245, USA
Proc Biol Sci 272:1153-61. 2005..However, the lower levels of LD surrounding resistance alleles in populations under weak selection may simplify identification of functional mutations... - Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasitesShalini Nair
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Mol Biol Evol 24:562-73. 2007..This may be particularly likely when mutation rate is high, as appears to be the case for gene duplications, and in pathogen populations where effective population sizes are typically very large... - Adaptive copy number evolution in malaria parasitesShalini Nair
Southwest Foundation for Biomedical Research SFBR, San Antonio, TX, USA
PLoS Genet 4:e1000243. 2008..More generally, these data demonstrate how selection affects multiple enzymes in a single biochemical pathway, and suggest that investigation of structural variation may provide a fast-track to locating genes underlying adaptation... - A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasitesShalini Nair
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Mol Biol Evol 20:1526-36. 2003.... - High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western CambodiaTim J C Anderson
Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
J Infect Dis 201:1326-30. 2010.... - Rapid genotyping of loci involved in antifolate drug resistance in Plasmodium falciparum by primer extensionShalini Nair
Southwest Foundation for Biomedical Research SFBR, PO Box 760549, San, Antonio, TX 78245, USA
Int J Parasitol 32:852-8. 2002..The method can be easily adapted to other P. falciparum genes and will greatly simplify scoring of point mutations in this and other parasitic organisms... - Inferred relatedness and heritability in malaria parasitesTim J C Anderson
Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Proc Biol Sci 277:2531-40. 2010.... - Gene copy number and malaria biologyTim J C Anderson
Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
Trends Parasitol 25:336-43. 2009..In this review, we summarize the distribution of CNP, its evolutionary dynamics within populations, its functional importance and its mode of evolution... - Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and MyanmarMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
Antimicrob Agents Chemother 52:2657-9. 2008..02). Five coding mutations in pvmdr1, independent of gene amplification, were also found...
Research Grants
- A Linkage Map for Schistosoma mansoniTim Anderson; Fiscal Year: 2007..Development of a linkage map will pave the way for finding these genes. ..
- Copy Number Variation in Malaria ParasitesTim Anderson; Fiscal Year: 2007..We propose to systematically describe DNA rearrangements in the malaria parasite genome, and evaluate the role that they play in this important pathogen. ..