T JC ANDERSON

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. pmc Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in southern Vietnam
    Marcelo U Ferreira
    Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900 São Paulo SP, Brazil
    J Clin Microbiol 40:1854-7. 2002
  2. pmc Disentangling hybridization and host colonization in parasitic roundworms of humans and pigs
    Charles D Criscione
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245, USA
    Proc Biol Sci 274:2669-77. 2007
  3. ncbi request reprint Microsatellite markers for the human nematode parasite Ascaris lumbricoides: development and assessment of utility
    Charles D Criscione
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245, USA
    J Parasitol 93:704-8. 2007
  4. ncbi request reprint Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
  5. ncbi request reprint Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 22:2362-74. 2005
  6. ncbi request reprint Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    T J Anderson
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
    Mol Biol Evol 17:1467-82. 2000
  7. ncbi request reprint Complex mutations in a high proportion of microsatellite loci from the protozoan parasite Plasmodium falciparum
    T J Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Mol Ecol 9:1599-608. 2000
  8. ncbi request reprint The dangers of using single locus markers in parasite epidemiology: Ascaris as a case study
    T J Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Trends Parasitol 17:183-8. 2001
  9. pmc Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
    Timothy J C Anderson
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245, USA
    Antimicrob Agents Chemother 49:2180-8. 2005
  10. ncbi request reprint Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan
    Tim J C Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Trop Med Int Health 8:1068-73. 2003

Research Grants

  1. A Linkage Map for Schistosoma mansoni
    Tim Anderson; Fiscal Year: 2007
  2. Copy Number Variation in Malaria Parasites
    Tim Anderson; Fiscal Year: 2007

Detail Information

Publications21

  1. pmc Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in southern Vietnam
    Marcelo U Ferreira
    Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900 São Paulo SP, Brazil
    J Clin Microbiol 40:1854-7. 2002
    ..Temporal structure and linkage disequilibrium were also examined in this data set...
  2. pmc Disentangling hybridization and host colonization in parasitic roundworms of humans and pigs
    Charles D Criscione
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245, USA
    Proc Biol Sci 274:2669-77. 2007
    ..These results indicate that there is contemporary cross-transmission between populations of human and pig Ascaris...
  3. ncbi request reprint Microsatellite markers for the human nematode parasite Ascaris lumbricoides: development and assessment of utility
    Charles D Criscione
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245, USA
    J Parasitol 93:704-8. 2007
    ..These markers have high genetic variability and provide the tools to address multiple questions concerning the epidemiology, fine-scale genetic structure, host specificity, and mating systems of this parasite...
  4. ncbi request reprint Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  5. ncbi request reprint Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 22:2362-74. 2005
    ..falciparum genome violates the central assumption that selected sites are rare, which complicates identification of outlier loci, and suggests that caution is needed when using this approach...
  6. ncbi request reprint Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    T J Anderson
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
    Mol Biol Evol 17:1467-82. 2000
    ..These data reveal a range of population structures within a single pathogen species and suggest intimate links between patterns of epidemiology and genetic structure in this organism...
  7. ncbi request reprint Complex mutations in a high proportion of microsatellite loci from the protozoan parasite Plasmodium falciparum
    T J Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Mol Ecol 9:1599-608. 2000
    ....
  8. ncbi request reprint The dangers of using single locus markers in parasite epidemiology: Ascaris as a case study
    T J Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Trends Parasitol 17:183-8. 2001
    ....
  9. pmc Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
    Timothy J C Anderson
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245, USA
    Antimicrob Agents Chemother 49:2180-8. 2005
    ..However, the consistent association observed between a 3-bp indel in G7 and AS response merits further investigation...
  10. ncbi request reprint Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan
    Tim J C Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Trop Med Int Health 8:1068-73. 2003
    ..To assess resistance to chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) in a Sudanese parasite population...
  11. ncbi request reprint Mapping drug resistance genes in Plasmodium falciparum by genome-wide association
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX 78248, USA
    Curr Drug Targets Infect Disord 4:65-78. 2004
    ..Finally, to demonstrate the utility of the approach I describe two proof-of-principle studies documenting patterns of genetic variability around known drug resistance genes...
  12. ncbi request reprint The origins and spread of antimalarial drug resistance: lessons for policy makers
    Tim J C Anderson
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Acta Trop 94:269-80. 2005
    ..De novo mutation appears to be less important than migration for introducing resistance alleles into parasite populations. Attempts to manage drug resistance will be of limited effectiveness unless this is taken into account...
  13. pmc Selection strength and hitchhiking around two anti-malarial resistance genes
    Denae Nash
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX 78245, USA
    Proc Biol Sci 272:1153-61. 2005
    ..However, the lower levels of LD surrounding resistance alleles in populations under weak selection may simplify identification of functional mutations...
  14. ncbi request reprint Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 24:562-73. 2007
    ..This may be particularly likely when mutation rate is high, as appears to be the case for gene duplications, and in pathogen populations where effective population sizes are typically very large...
  15. pmc Adaptive copy number evolution in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, San Antonio, TX, USA
    PLoS Genet 4:e1000243. 2008
    ..More generally, these data demonstrate how selection affects multiple enzymes in a single biochemical pathway, and suggest that investigation of structural variation may provide a fast-track to locating genes underlying adaptation...
  16. ncbi request reprint A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 20:1526-36. 2003
    ....
  17. pmc High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
    J Infect Dis 201:1326-30. 2010
    ....
  18. ncbi request reprint Rapid genotyping of loci involved in antifolate drug resistance in Plasmodium falciparum by primer extension
    Shalini Nair
    Southwest Foundation for Biomedical Research SFBR, PO Box 760549, San, Antonio, TX 78245, USA
    Int J Parasitol 32:852-8. 2002
    ..The method can be easily adapted to other P. falciparum genes and will greatly simplify scoring of point mutations in this and other parasitic organisms...
  19. pmc Inferred relatedness and heritability in malaria parasites
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Proc Biol Sci 277:2531-40. 2010
    ....
  20. pmc Gene copy number and malaria biology
    Tim J C Anderson
    Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Trends Parasitol 25:336-43. 2009
    ..In this review, we summarize the distribution of CNP, its evolutionary dynamics within populations, its functional importance and its mode of evolution...
  21. pmc Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 52:2657-9. 2008
    ..02). Five coding mutations in pvmdr1, independent of gene amplification, were also found...

Research Grants3

  1. A Linkage Map for Schistosoma mansoni
    Tim Anderson; Fiscal Year: 2007
    ..Development of a linkage map will pave the way for finding these genes. ..
  2. Copy Number Variation in Malaria Parasites
    Tim Anderson; Fiscal Year: 2007
    ..We propose to systematically describe DNA rearrangements in the malaria parasite genome, and evaluate the role that they play in this important pathogen. ..