Laura A Almasy

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. ncbi A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 23:508-11. 2003
  2. pmc Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
  3. pmc Pedigree and genotype errors in the Framingham Heart Study
    Gerry Brush
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S41. 2003
  4. pmc Linkage disequilibrium across two different single-nucleotide polymorphism genome scans
    Juan Manuel Peralta
    Centro de Investigacion en Biologia Celular y Molecular, Ciudad de la Investigación, Universidad de Costa Rica, San Jose, Costa Rica
    BMC Genet 6:S86. 2005
  5. pmc Smoothing of the bivariate LOD score for non-normal quantitative traits
    Alfonso Buil
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 6:S111. 2005
  6. pmc Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S34. 2003
  7. pmc Mitochondrial genetic effects on latent class variables associated with susceptibility to alcoholism
    Loren R Lease
    Youngstown State University, Department of Sociology and Anthropology, One University Plaza, Youngstown, OH 44555, USA
    BMC Genet 6:S158. 2005
  8. pmc X chromosome effects and their interactions with mitochondrial effects
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    BMC Genet 6:S157. 2005
  9. pmc Effect of genotype x alcoholism interaction on linkage analysis of an alcoholism-related quantitative phenotype
    Rector Arya
    Division Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    BMC Genet 6:S120. 2005
  10. pmc A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245 0549, USA
    BMC Genet 6:S117. 2005

Detail Information

Publications67

  1. ncbi A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 23:508-11. 2003
    ..As part of the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project, we conducted a genome-wide linkage screen to localize genes influencing variation in free PS (fPS) plasma levels...
  2. pmc Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
    ..Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits...
  3. pmc Pedigree and genotype errors in the Framingham Heart Study
    Gerry Brush
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S41. 2003
    ..Genotyping errors were then detected with SIMWALK2. Five Mendelian errors were found following the pedigree corrections. Double-recombinant errors were more common, with 142 being detected at mistyping probabilities of 0.25 or greater...
  4. pmc Linkage disequilibrium across two different single-nucleotide polymorphism genome scans
    Juan Manuel Peralta
    Centro de Investigacion en Biologia Celular y Molecular, Ciudad de la Investigación, Universidad de Costa Rica, San Jose, Costa Rica
    BMC Genet 6:S86. 2005
    ..Caution should probably be taken when using high density SNP maps when many non-genotyped founders are present in the study pedigrees...
  5. pmc Smoothing of the bivariate LOD score for non-normal quantitative traits
    Alfonso Buil
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 6:S111. 2005
    ..We perform a novel correction that achieves acceptable levels of type I error...
  6. pmc Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S34. 2003
    ..Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study...
  7. pmc Mitochondrial genetic effects on latent class variables associated with susceptibility to alcoholism
    Loren R Lease
    Youngstown State University, Department of Sociology and Anthropology, One University Plaza, Youngstown, OH 44555, USA
    BMC Genet 6:S158. 2005
    ..We conclude that mitochondrial genes may contribute to variation in some latent class psychiatric/behavioral variables associated with alcoholism...
  8. pmc X chromosome effects and their interactions with mitochondrial effects
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    BMC Genet 6:S157. 2005
    ..Results for ntth1 suggest that methods that do not also allow for male-female heterogeneity in environmental variance may be overly conservative in detection of X-chromosomal effects...
  9. pmc Effect of genotype x alcoholism interaction on linkage analysis of an alcoholism-related quantitative phenotype
    Rector Arya
    Division Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    BMC Genet 6:S120. 2005
    ..These potential hints of differences in genetic effect may influence future analyses of variants under these linkage peaks...
  10. pmc A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245 0549, USA
    BMC Genet 6:S117. 2005
    ..Based on a comparison of the number of LOD scores achieving statistical significance, our results suggest that the microsatellite- and Illumina SNP-based genotypes have similar utility for detecting genomic regions of interest...
  11. pmc A comparison of discrete versus continuous environment in a variance components-based linkage analysis of the COGA data
    Kevin R Viel
    Department of Epidemiology, Emory University, Atlanta, Georgia, USA
    BMC Genet 6:S57. 2005
    ....
  12. ncbi A locus on chromosome 2 influences levels of tissue factor pathway inhibitor: results from the GAIT study
    L Almasy
    Southwest Foundation for Biomedical Research, San Antonio, Tex X 78245 0549, USA
    Arterioscler Thromb Vasc Biol 25:1489-92. 2005
    ..Although a genetic component to variation in TFPI levels is well-documented, no systematic genome-wide screens have been conducted to localize genes influencing levels of TFPI...
  13. ncbi The complex hunt for genes influencing complex disease
    L Almasy
    Department of Genetics, South West Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Thromb Haemost 2:866-7. 2004
  14. ncbi Exploring positional candidate genes: linkage conditional on measured genotype
    L Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Behav Genet 34:173-7. 2004
    ..We illustrate the properties of this method using simulated data from Genetic Analysis Workshops 10 and 12 and discuss example applications of this method to human quantitative trait data...
  15. ncbi Genetic Analysis Workshop 13: introduction to workshop summaries
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 25:S1-4. 2003
  16. pmc Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism
    L Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245 0549, USA
    Am J Hum Genet 64:1686-93. 1999
    ....
  17. ncbi Heritability of event-related brain potentials in families with a history of alcoholism
    L Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Am J Med Genet 88:383-90. 1999
    ....
  18. pmc Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism
    L Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245, USA
    Am J Hum Genet 68:128-135. 2001
    ..N4 amplitudes showed suggestive evidence of linkage in several chromosomal regions, and P3 amplitudes showed significant evidence of linkage to chromosome 5 and suggestive evidence of linkage to chromosome 4...
  19. pmc Multipoint quantitative-trait linkage analysis in general pedigrees
    L Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 62:1198-211. 1998
    ..The general pedigree variance component and IBD estimation methods have been implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package...
  20. pmc Software for quantitative trait analysis
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genomics 2:191-5. 2005
    ..Where possible, the paper provides URLs for acquiring these programs through the internet, details of the platforms for which the software is available and the types of analyses performed...
  21. ncbi Quantitative risk factors as indices of alcoholism susceptibility
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Ann Med 35:337-43. 2003
    ..Genetic studies of such quantitative risk factors in families of probands with alcohol dependence may help to disentangle the complex genetic architecture of this disorder...
  22. ncbi Factors of insulin resistance syndrome--related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic mexican-americans
    Rector Arya
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes 51:841-7. 2002
    ..2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans...
  23. ncbi Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Nat Genet 30:102-5. 2002
    ..A replication study in an independent set of Mexican American families confirmed the existence of a QTL on chromosome 9p...
  24. pmc Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genet 126:667-76. 2009
    ..These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations...
  25. ncbi A novel obesity locus on chromosome 4q: the Strong Heart Family Study
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio TX 78245 0549, USA
    Obesity (Silver Spring) 15:1741-8. 2007
    ....
  26. ncbi Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q
    Donna M Lehman
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Biol 77:231-46. 2005
    ..23, 103-109 cM; a maximum bivariate LOD of 4.51 was found for the trait pair HDLC and LSPI (the LODeq score is 3.94)]. We observed evidence of pleiotropic effects in this region on obesity and insulin-related trait pairs...
  27. doi A linkage analysis of cigarette and alcohol consumption in an unselected Mexican American population
    Kevin Viel
    Southwest Foundation for Biomedical Research, Department of Genetics, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 147:983-6. 2008
    ..16, P = 0.34). The results from the bivariate linkage analysis found a maximum LOD score of 3.82 (genome-wide P = 0.0054) at 151 cM on chromosome 10, at the location of the overlapping peaks from the univariate analyses...
  28. pmc Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Hum Genet 74:272-82. 2004
    ..In conclusion, we identified a major genetic locus influencing BMI on chromosome 4p in Mexican Americans...
  29. ncbi Consistency of genetic analyses in longitudinal data: observations from the GAW13 Framingham Heart Study data
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Genet Epidemiol 25:S29-35. 2003
    ..Finally, modeling of longitudinal processes provided evidence for genotype x age interactions that may partially explain variation in results of genetic analyses across time or age...
  30. ncbi Autosomal genome-wide linkage analysis to identify loci for gallbladder wall thickness in Mexican Americans
    Narahari Samudrala
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 80:11-28. 2008
    ....
  31. ncbi Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  32. doi A schizophrenia gene locus on chromosome 17q21 in a new set of families of Mexican and central american ancestry: evidence from the NIMH Genetics of schizophrenia in latino populations study
    Michael Escamilla
    Psychiatric Genetics Center, University of Texas Health Science Center at San Antonio, Suite 200, 454 Soledad St, San Antonio, TX 78205, USA
    Am J Psychiatry 166:442-9. 2009
    ..The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders...
  33. ncbi Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Nat Genet 39:1208-16. 2007
    ....
  34. pmc Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 40:3685-90. 2009
    ....
  35. pmc Genetic Analysis Workshop 16: introduction to workshop summaries
    Jean W Maccluer
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227 5301, USA
    Genet Epidemiol 33:S1-7. 2009
    ..The third data set included simulated phenotypes for participants in the FHS, using actual pedigree structures and genotypes. This volume includes a paper for each of the 17 discussion groups, summarizing their main findings...
  36. pmc Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Hum Mol Genet 19:3662-71. 2010
    ..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study...
  37. ncbi Linkage disequilibrium analyses in the Costa Rican population suggests discrete gene loci for schizophrenia at 8p23.1 and 8q13.3
    Consuelo Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, and Southwest Foundation for Biomedical Research, San Antonio, Texas 78229 3900, USA
    Psychiatr Genet 16:159-68. 2006
    ....
  38. ncbi Heritability and linkage analysis of hand, foot, and eye preference in Mexican Americans
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Laterality 11:508-24. 2006
    ..No obvious candidate genes occur in these regions. Our results indicate that genes are an important component of side preferences, and suggest chromosomal regions for further investigation...
  39. pmc Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 195:367-73. 2007
    ..0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait...
  40. pmc Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses
    Peter Kochunov
    Dip ABMP, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 41:2137-42. 2010
    ..Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements...
  41. ncbi Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study
    Vincent P Diego
    Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 55:1874-8. 2006
    ..42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas...
  42. ncbi Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 53:2691-5. 2004
    ..Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se...
  43. ncbi A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 176:379-86. 2004
    ..These data provide evidence for a novel gene, influencing beta-lipoprotein phenotypes, whose effect(s) is detected only when several lipoprotein traits are considered together...
  44. ncbi Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Obes Res 10:14-21. 2002
    ..As we have shown for other measures of adiposity, such sexual dimorphism can arise from a special case of genotype by environment interaction, that of genotype by sex interaction...
  45. ncbi Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Stroke 33:2775-80. 2002
    ..In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control...
  46. ncbi Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
    ..04). Given these results, we hypothesize that a quantitative trait locus in this vicinity of chromosome 8 may have a differential effect on the expression of leptin in smokers versus non-smokers...
  47. pmc A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans
    Sobha Puppala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 78:377-92. 2006
    ..In conclusion, we found significant evidence of major genetic determinants of symptomatic GBD on chromosome 1p in Mexican Americans...
  48. ncbi Quantitative trait nucleotide analysis using Bayesian model selection
    John Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 620 NW Loop 410, San Antonio, TX 78245 0549, USA
    Hum Biol 77:541-59. 2005
    ..We also include instructions on how to use our computer program, SOLAR, for association analysis and BQTN analysis...
  49. ncbi Evidence of genetic overlap of schizophrenia and bipolar disorder: linkage disequilibrium analysis of chromosome 18 in the Costa Rican population
    Consuelo Walss-Bass
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 139:54-60. 2005
    ....
  50. ncbi Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 77:17-25. 2005
    ....
  51. ncbi Heritability of hemostasis phenotypes and their correlation with type 2 diabetes status in Mexican Americans
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Hum Biol 77:1-15. 2005
    ..40) and tPS (-0.31). Our results suggest that genes are important contributors to the normal variation in hemostasis-related traits and that genes influencing hemostasis-related traits pleiotropically influence diabetes risk...
  52. ncbi The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  53. pmc A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78249 0549, USA
    Am J Psychiatry 165:1185-92. 2008
    ..The authors conducted a multiplex, multigenerational family study using a genome-wide screen for schizophrenia and related neurocognitive phenotypes...
  54. pmc Human QTL linkage mapping
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Genetica 136:333-40. 2009
    ..These SNP panels are being used to identify QTLs previously localized by linkage and linkage results are being used to place informative priors on genome-wide association studies...
  55. doi Contemporary model-free methods for linkage analysis
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Adv Genet 60:175-93. 2008
    ..These methods have been used to identify numerous genes influencing complex human phenotypes and remain viable approaches to gene localization in the twenty-first century...
  56. ncbi Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 54:2655-62. 2005
    ..87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations...
  57. pmc Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX, USA
    BMC Med Genomics 3:29. 2010
    ..This investigation offers insights into system-wide pathological processes induced in response to cigarette smoke exposure by determining its influences at the gene expression level...
  58. ncbi A novel missense mutation in the transmembrane domain of neuregulin 1 is associated with schizophrenia
    Consuelo Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA
    Biol Psychiatry 60:548-53. 2006
    ..The neuregulin 1 gene is among the few candidate genes to have been implicated in schizophrenia susceptibility in several populations. However, no causal mutations within this gene have been identified...
  59. ncbi Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q
    Ravindranath Duggirala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
    Genet Epidemiol 24:240-2. 2003
  60. ncbi A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies
    Rector Arya
    Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
    Hum Mol Genet 15:1569-79. 2006
    ..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans...
  61. ncbi Adjudicating neurocognitive endophenotypes for schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:242-9. 2007
    ..We present a practical model for adjudicating endophenotypes and determining which measures are best suited for use in linkage analyses...
  62. ncbi Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans
    Sobha Puppala
    Southwest Foundation for Biomedical Research, Department of Genetics, P O Box 760549, San Antonio, TX 78254, USA
    Diabetes 56:2818-28. 2007
    ..We also examined the effect of genotype by diabetes interaction (G x DM) on the detection of linkage to address whether genetic effects on GFR differ in diabetic and nondiabetic subjects...
  63. pmc Inhibitors of factor VIII in black patients with hemophilia
    Kevin R Viel
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    N Engl J Med 360:1618-27. 2009
    ..H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients...
  64. doi Heritability of age of onset of psychosis in schizophrenia
    Elizabeth Hare
    South Texas Psychiatric Genetics Research Center, UT Health Science Center, San Antonio, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 153:298-302. 2010
    ..33 (SE = 0.09; P = 0.00004). These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well...
  65. ncbi Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Mol Genet 17:963-70. 2008
    ..Thus, variations in NFKB1 appear to affect the risk for alcoholism, particularly contributing to an earlier onset of the disease...
  66. ncbi Assessment of sex-specific genetic and environmental effects on bone mineral density
    Lillian B Brown
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 21201, USA
    Genet Epidemiol 27:153-61. 2004
    ..Overall, these analyses do not provide evidence for sex-specific genetic effects, suggesting that many of the genes influencing variation in BMD should be detectable in both men and women...