Laura A Almasy

Summary

Affiliation: Southwest Foundation for Biomedical Research
Country: USA

Publications

  1. pmc Searching for master regulators of transcription in a human gene expression data set
    Alfonso Buil
    Unitat de Bioinformatica i Malalties Complexes, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, Barcelona, 08025 Spain
    BMC Proc 1:S81. 2007
  2. pmc Genome-wide discovery of maternal effect variants
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227, USA
    BMC Proc 3:S19. 2009
  3. pmc Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes
    Juan Manuel Peralta
    , Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, 2060, , Costa Rica
    BMC Proc 1:S158. 2007
  4. pmc Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, P, O, Box 760549, San Antonio, Texas 78245, USA
    BMC Proc 3:S92. 2009
  5. pmc Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX, USA
    BMC Med Genomics 3:29. 2010
  6. pmc Linkage study of fibrinogen levels: the Strong Heart Family Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 9:77. 2008
  7. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
  8. pmc A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78249 0549, USA
    Am J Psychiatry 165:1185-92. 2008
  9. ncbi request reprint A novel obesity locus on chromosome 4q: the Strong Heart Family Study
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio TX 78245 0549, USA
    Obesity (Silver Spring) 15:1741-8. 2007
  10. pmc Human QTL linkage mapping
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Genetica 136:333-40. 2009

Research Grants

  1. 3/3 - A Neurobehavioral Family Study of Schizophrenia
    Laura A Almasy; Fiscal Year: 2010
  2. Genetic Analysis of Common Diseases: An Evaluation
    Laura A Almasy; Fiscal Year: 2010
  3. Genetic Analysis of Idiopathic Thrombosis
    Laura A Almasy; Fiscal Year: 2010
  4. Genetic Analysis of Common Diseases: An Evaluation
    Laura Almasy; Fiscal Year: 2009
  5. Genetic Analysis of Idiopathic Thrombosis
    Laura Almasy; Fiscal Year: 2009
  6. Genetic Analysis of Idiopathic Thrombosis
    Laura Almasy; Fiscal Year: 2007
  7. A Neurobehavioral Family Study of Schizophrenia
    Laura Almasy; Fiscal Year: 2005
  8. Genetic Analysis of Idiopathic Thrombosis
    Laura Almasy; Fiscal Year: 2005
  9. 3/3 - A Neurobehavioral Family Study of Schizophrenia
    Laura A Almasy; Fiscal Year: 2010

Detail Information

Publications89

  1. pmc Searching for master regulators of transcription in a human gene expression data set
    Alfonso Buil
    Unitat de Bioinformatica i Malalties Complexes, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, Barcelona, 08025 Spain
    BMC Proc 1:S81. 2007
    ..These loci are candidates for master regulators of transcription (MRT). Finally, for each candidate MRT, we did a gene ontology (GO) analysis to test whether the genes linked to it were biologically related...
  2. pmc Genome-wide discovery of maternal effect variants
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227, USA
    BMC Proc 3:S19. 2009
    ..This work establishes a methodological framework for identifying genetic variants that may influence the contribution of the maternal environment to offspring phenotypes...
  3. pmc Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes
    Juan Manuel Peralta
    , Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, 2060, , Costa Rica
    BMC Proc 1:S158. 2007
    ..On average, that meant that the same quantitative trait loci (QTLs) were detected across methods, but the magnitude of the LOD score of each particular QTL and the false-positive ratio of QTL detection varied between the methods...
  4. pmc Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, P, O, Box 760549, San Antonio, Texas 78245, USA
    BMC Proc 3:S92. 2009
    ..We propose that formal combination of information from multiple gene-identification approaches may lead to the identification of novel loci that are missed when only one form of information is available...
  5. pmc Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX, USA
    BMC Med Genomics 3:29. 2010
    ..This investigation offers insights into system-wide pathological processes induced in response to cigarette smoke exposure by determining its influences at the gene expression level...
  6. pmc Linkage study of fibrinogen levels: the Strong Heart Family Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 9:77. 2008
    ..The Strong Heart Study has demonstrated an increased incidence of cardiovascular disease in the American Indian population, and therefore represents an important source for genetic-epidemiological investigations...
  7. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
    ..1.4)...
  8. pmc A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78249 0549, USA
    Am J Psychiatry 165:1185-92. 2008
    ..The authors conducted a multiplex, multigenerational family study using a genome-wide screen for schizophrenia and related neurocognitive phenotypes...
  9. ncbi request reprint A novel obesity locus on chromosome 4q: the Strong Heart Family Study
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio TX 78245 0549, USA
    Obesity (Silver Spring) 15:1741-8. 2007
    ....
  10. pmc Human QTL linkage mapping
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Genetica 136:333-40. 2009
    ..These SNP panels are being used to identify QTLs previously localized by linkage and linkage results are being used to place informative priors on genome-wide association studies...
  11. ncbi request reprint Fasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study
    Vincent P Diego
    Southwest Foundation for Biomedical Research, Department of Genetics, PO Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 55:1874-8. 2006
    ..42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas...
  12. ncbi request reprint Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Nat Genet 30:102-5. 2002
    ..A replication study in an independent set of Mexican American families confirmed the existence of a QTL on chromosome 9p...
  13. doi request reprint A schizophrenia gene locus on chromosome 17q21 in a new set of families of Mexican and central american ancestry: evidence from the NIMH Genetics of schizophrenia in latino populations study
    Michael Escamilla
    Psychiatric Genetics Center, University of Texas Health Science Center at San Antonio, Suite 200, 454 Soledad St, San Antonio, TX 78205, USA
    Am J Psychiatry 166:442-9. 2009
    ..The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders...
  14. pmc Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
    ..Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits...
  15. pmc A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans
    Sobha Puppala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 78:377-92. 2006
    ..In conclusion, we found significant evidence of major genetic determinants of symptomatic GBD on chromosome 1p in Mexican Americans...
  16. ncbi request reprint Linkage disequilibrium analyses in the Costa Rican population suggests discrete gene loci for schizophrenia at 8p23.1 and 8q13.3
    Consuelo Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, and Southwest Foundation for Biomedical Research, San Antonio, Texas 78229 3900, USA
    Psychiatr Genet 16:159-68. 2006
    ....
  17. ncbi request reprint Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
    ..04). Given these results, we hypothesize that a quantitative trait locus in this vicinity of chromosome 8 may have a differential effect on the expression of leptin in smokers versus non-smokers...
  18. pmc Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Hum Genet 74:272-82. 2004
    ..In conclusion, we identified a major genetic locus influencing BMI on chromosome 4p in Mexican Americans...
  19. ncbi request reprint Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
    Harald H H Goring
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Nat Genet 39:1208-16. 2007
    ....
  20. ncbi request reprint A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins
    David L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 176:379-86. 2004
    ..These data provide evidence for a novel gene, influencing beta-lipoprotein phenotypes, whose effect(s) is detected only when several lipoprotein traits are considered together...
  21. ncbi request reprint Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Diabetes 53:2691-5. 2004
    ..Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se...
  22. ncbi request reprint Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  23. ncbi request reprint Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans
    Sobha Puppala
    Southwest Foundation for Biomedical Research, Department of Genetics, P O Box 760549, San Antonio, TX 78254, USA
    Diabetes 56:2818-28. 2007
    ..We also examined the effect of genotype by diabetes interaction (G x DM) on the detection of linkage to address whether genetic effects on GFR differ in diabetic and nondiabetic subjects...
  24. pmc Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence
    Mark Zlojutro
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 156:44-58. 2011
    ....
  25. pmc Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Atherosclerosis 195:367-73. 2007
    ..0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait...
  26. pmc Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genet 126:667-76. 2009
    ..These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations...
  27. pmc Genetic Analysis Workshop 16: introduction to workshop summaries
    Jean W Maccluer
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227 5301, USA
    Genet Epidemiol 33:S1-7. 2009
    ..The third data set included simulated phenotypes for participants in the FHS, using actual pedigree structures and genotypes. This volume includes a paper for each of the 17 discussion groups, summarizing their main findings...
  28. pmc Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Hum Mol Genet 19:3662-71. 2010
    ..012) with HR. These findings in independent populations support that KIAA1797 genetic variation may be associated with HR but elucidation of a functional relationship requires additional study...
  29. doi request reprint A linkage analysis of cigarette and alcohol consumption in an unselected Mexican American population
    Kevin Viel
    Southwest Foundation for Biomedical Research, Department of Genetics, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 147:983-6. 2008
    ..16, P = 0.34). The results from the bivariate linkage analysis found a maximum LOD score of 3.82 (genome-wide P = 0.0054) at 151 cM on chromosome 10, at the location of the overlapping peaks from the univariate analyses...
  30. ncbi request reprint Factors of insulin resistance syndrome--related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic mexican-americans
    Rector Arya
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes 51:841-7. 2002
    ..2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans...
  31. pmc Genetic influences on serum bilirubin in American Indians: The Strong Heart Family Study
    Phillip E Melton
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Am J Hum Biol 23:118-25. 2011
    ..However, no study has investigated the UGT1A1 promoter in American Indians...
  32. ncbi request reprint Quantitative trait nucleotide analysis using Bayesian model selection
    John Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, 620 NW Loop 410, San Antonio, TX 78245 0549, USA
    Hum Biol 77:541-59. 2005
    ..We also include instructions on how to use our computer program, SOLAR, for association analysis and BQTN analysis...
  33. pmc Effect of genotype x alcoholism interaction on linkage analysis of an alcoholism-related quantitative phenotype
    Rector Arya
    Division Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    BMC Genet 6:S120. 2005
    ..These potential hints of differences in genetic effect may influence future analyses of variants under these linkage peaks...
  34. ncbi request reprint Evidence of genetic overlap of schizophrenia and bipolar disorder: linkage disequilibrium analysis of chromosome 18 in the Costa Rican population
    Consuelo Walss-Bass
    Psychiatric Genetics Research Center, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 139:54-60. 2005
    ....
  35. ncbi request reprint Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q
    Donna M Lehman
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Biol 77:231-46. 2005
    ..23, 103-109 cM; a maximum bivariate LOD of 4.51 was found for the trait pair HDLC and LSPI (the LODeq score is 3.94)]. We observed evidence of pleiotropic effects in this region on obesity and insulin-related trait pairs...
  36. ncbi request reprint Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 54:2655-62. 2005
    ..87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations...
  37. ncbi request reprint Consistency of genetic analyses in longitudinal data: observations from the GAW13 Framingham Heart Study data
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Genet Epidemiol 25:S29-35. 2003
    ..Finally, modeling of longitudinal processes provided evidence for genotype x age interactions that may partially explain variation in results of genetic analyses across time or age...
  38. ncbi request reprint The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  39. pmc Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 40:3685-90. 2009
    ....
  40. ncbi request reprint Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Stroke 33:2775-80. 2002
    ..In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control...
  41. pmc Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses
    Peter Kochunov
    Dip ABMP, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 41:2137-42. 2010
    ..Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements...
  42. ncbi request reprint Heritability and linkage analysis of hand, foot, and eye preference in Mexican Americans
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Laterality 11:508-24. 2006
    ..No obvious candidate genes occur in these regions. Our results indicate that genes are an important component of side preferences, and suggest chromosomal regions for further investigation...
  43. ncbi request reprint Adjudicating neurocognitive endophenotypes for schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:242-9. 2007
    ..We present a practical model for adjudicating endophenotypes and determining which measures are best suited for use in linkage analyses...
  44. ncbi request reprint Autosomal genome-wide linkage analysis to identify loci for gallbladder wall thickness in Mexican Americans
    Narahari Samudrala
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 80:11-28. 2008
    ....
  45. ncbi request reprint A novel missense mutation in the transmembrane domain of neuregulin 1 is associated with schizophrenia
    Consuelo Walss-Bass
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA
    Biol Psychiatry 60:548-53. 2006
    ..The neuregulin 1 gene is among the few candidate genes to have been implicated in schizophrenia susceptibility in several populations. However, no causal mutations within this gene have been identified...
  46. ncbi request reprint Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q
    Ravindranath Duggirala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
    Genet Epidemiol 24:240-2. 2003
  47. ncbi request reprint Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Obes Res 10:14-21. 2002
    ..As we have shown for other measures of adiposity, such sexual dimorphism can arise from a special case of genotype by environment interaction, that of genotype by sex interaction...
  48. pmc Pedigree and genotype errors in the Framingham Heart Study
    Gerry Brush
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S41. 2003
    ..Genotyping errors were then detected with SIMWALK2. Five Mendelian errors were found following the pedigree corrections. Double-recombinant errors were more common, with 142 being detected at mistyping probabilities of 0.25 or greater...
  49. pmc Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process
    Vincent P Diego
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 4:S34. 2003
    ..Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study...
  50. ncbi request reprint A quantitative trait locus influencing free plasma protein S levels on human chromosome 1q: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Arterioscler Thromb Vasc Biol 23:508-11. 2003
    ..As part of the Genetic Analysis of Idiopathic Thrombophilia (GAIT) project, we conducted a genome-wide linkage screen to localize genes influencing variation in free PS (fPS) plasma levels...
  51. ncbi request reprint Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 77:17-25. 2005
    ....
  52. ncbi request reprint Genetic Analysis Workshop 13: introduction to workshop summaries
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 25:S1-4. 2003
  53. doi request reprint Contemporary model-free methods for linkage analysis
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    Adv Genet 60:175-93. 2008
    ..These methods have been used to identify numerous genes influencing complex human phenotypes and remain viable approaches to gene localization in the twenty-first century...
  54. pmc Smoothing of the bivariate LOD score for non-normal quantitative traits
    Alfonso Buil
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    BMC Genet 6:S111. 2005
    ..We perform a novel correction that achieves acceptable levels of type I error...
  55. ncbi request reprint Quantitative risk factors as indices of alcoholism susceptibility
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Ann Med 35:337-43. 2003
    ..Genetic studies of such quantitative risk factors in families of probands with alcohol dependence may help to disentangle the complex genetic architecture of this disorder...
  56. ncbi request reprint Heritability of hemostasis phenotypes and their correlation with type 2 diabetes status in Mexican Americans
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Hum Biol 77:1-15. 2005
    ..40) and tPS (-0.31). Our results suggest that genes are important contributors to the normal variation in hemostasis-related traits and that genes influencing hemostasis-related traits pleiotropically influence diabetes risk...
  57. ncbi request reprint A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies
    Rector Arya
    Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
    Hum Mol Genet 15:1569-79. 2006
    ..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans...
  58. pmc A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78245 0549, USA
    BMC Genet 6:S117. 2005
    ..Based on a comparison of the number of LOD scores achieving statistical significance, our results suggest that the microsatellite- and Illumina SNP-based genotypes have similar utility for detecting genomic regions of interest...
  59. pmc Software for quantitative trait analysis
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Genomics 2:191-5. 2005
    ..Where possible, the paper provides URLs for acquiring these programs through the internet, details of the platforms for which the software is available and the types of analyses performed...
  60. doi request reprint Heritability of age of onset of psychosis in schizophrenia
    Elizabeth Hare
    South Texas Psychiatric Genetics Research Center, UT Health Science Center, San Antonio, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 153:298-302. 2010
    ..33 (SE = 0.09; P = 0.00004). These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well...
  61. pmc X chromosome effects and their interactions with mitochondrial effects
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA
    BMC Genet 6:S157. 2005
    ..Results for ntth1 suggest that methods that do not also allow for male-female heterogeneity in environmental variance may be overly conservative in detection of X-chromosomal effects...
  62. pmc Inhibitors of factor VIII in black patients with hemophilia
    Kevin R Viel
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    N Engl J Med 360:1618-27. 2009
    ..H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients...
  63. ncbi request reprint Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes
    Bernice Porjesz
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Biol Psychol 61:229-48. 2002
    ..The advent of genomics and proteomics and a fuller understanding of gene regulation, will open new horizons on the critical electrical events so essential for human brain function...
  64. ncbi request reprint A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility
    Jose Manuel Soria
    Unitat d Hemostasia i Trombosi, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Blood 101:163-7. 2003
    ..Importantly, there are no known thrombosis-related candidate genes in this region, implying that this QTL represents a completely novel thrombosis risk factor...
  65. ncbi request reprint Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans
    Candace M Kammerer
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 18:2245-52. 2003
    ..We obtained evidence for QTL on chromosome 4p, affecting forearm BMD overall, and on chromosomes 2p and 13q, affecting hip BMD in men...
  66. ncbi request reprint Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Hypertension 43:780-4. 2004
    ..4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI...
  67. ncbi request reprint Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism
    Danielle M Dick
    Washington University School of Medicine, St Louis, MO, USA
    Behav Genet 36:112-26. 2006
    ..Our results provide an illustration of the successful use of endophenotypes to identify genes involved in the predisposition to a complex psychiatric phenotype, a strategy originally proposed by Gottesman and Shields in 1972...
  68. ncbi request reprint Genomewide linkage analysis of soluble transferrin receptor plasma levels
    Angel F Remacha
    Hematology Department, Hospital de Sant Pau, Avda Padre Claret 167, Barcelona, 08025, Spain
    Ann Hematol 85:25-8. 2006
    ..Moreover, a second linkage signal was observed in 3q21.2; albeit the evidence for this second locus was lower. The next step will be to identify the gene(s) and its possible involvement in thrombosis and iron homeostasis...
  69. ncbi request reprint A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone
    Lisa J Martin
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Obes Res 10:602-7. 2002
    ..Because interactions such as genotype x sex can confound the detection of quantitative trait loci (QTLs), we wanted to determine if there are QTLs associated with the expression of leptin adjusted for testosterone...
  70. ncbi request reprint A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514 3628, USA
    Hypertension 48:266-70. 2006
    ..8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes...
  71. pmc A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project
    Juan Carlos Souto
    Unitat de Trombosi i Hemostasia, Departament d Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Hum Genet 76:925-33. 2005
    ..These data could be relevant in determining the relationships between Hcy level, cardiovascular disease, osteoporosis, and Alzheimer disease...
  72. ncbi request reprint Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Psychiatry 164:813-9. 2007
    ..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort...
  73. ncbi request reprint Linkage analysis of factors underlying insulin resistance: Strong Heart Family Study
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, Bank of America Center, 137 E Franklin Street, Suite 306, NC 27514, USA
    Obes Res 13:1877-84. 2005
    ..The corroboration of existing QTLs will bring us closer to the identification of the functional genes that predispose to IR...
  74. ncbi request reprint Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  75. ncbi request reprint Protein C levels are regulated by a quantitative trait locus on chromosome 16: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) Project
    Alfonso Buil
    Unitat d Hemostasia i Trombosi, Departament d Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 24:1321-5. 2004
    ..As part of the Genetic Analysis of Idiopathic Thrombophilia (GAIT) Project, we conducted a genome-wide linkage scan to localize genes that influence variation in PC plasma levels...
  76. ncbi request reprint Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence
    Xiaoling Xuei
    Department of Biochemistry and Molecular Biology, Indiana Unviersity School of Medicine, Indianapolis, IN 46202, USA
    Addict Biol 13:80-7. 2008
    ..04-0.05). Secondary analyses suggested that two adjacent SNPs in intron 1 of OPRL1 were marginally associated with opioid dependence (P = 0.05); none of the SNPs in PNOC were associated with opioid dependence...
  77. pmc Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
    Bernice Porjesz
    Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 99:3729-33. 2002
    ..Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing...
  78. ncbi request reprint The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus
    Jose Manuel Soria
    Unitat d Hemostasia i Trombosi, Departament d Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Hum Biol 77:561-75. 2005
    ..These variants include both rare coding variants and more common, potentially regulatory polymorphisms in intronic and promoter regions...
  79. ncbi request reprint Identification of a large deletion and three novel mutations in exon 13 of the factor V gene in a Spanish family with normal factor V coagulant and anticoagulant properties
    Jose Manuel Soria
    Unitat d Hemostasia i Trombosi, Hospital de la Santa Creu i Sant Pau, C Sant Antoni M Claret 167, 08025 Barcelona, Spain
    Hum Genet 111:59-65. 2002
    ..Further analyses of this naturally occurring mutation and the novel DNA variants should yield useful information for the understanding of the function of the B domain of FV...
  80. pmc A quantitative-trait locus in the human factor XII gene influences both plasma factor XII levels and susceptibility to thrombotic disease
    Jose Manuel Soria
    Unitat d Hemostasia i Trombosi, Departament d Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Hum Genet 70:567-74. 2002
    ....
  81. ncbi request reprint Genome-wide linkage analysis of von Willebrand factor plasma levels: results from the GAIT project
    Juan Carlos Souto
    Unitat d Hemostasia i Trombosi, Hospital de la Santa Creu i Sant Pau, Barcelona Spain
    Thromb Haemost 89:468-74. 2003
    ..It is possible that there are other potential regions on chromosomes 1, 2, 5, 6 and 22 that influence this thrombosis risk factor. However, the structural vWF gene itself has a very low influence (if any) on the plasma levels of vWF...
  82. ncbi request reprint Common genetic and environmental effects on lipid phenotypes: the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Hum Hered 59:34-40. 2005
    ..Our aim is to investigate pair-wise polygenic and environmental correlations among lipid-lipoprotein levels at baseline and in response to regular exercise in Whites and Blacks...
  83. ncbi request reprint Genetic determinants of variation in the plasma levels of the C4b-binding protein (C4BP) in Spanish families
    Jorge Esparza-Gordillo
    Departamento de Inmunologia, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Immunogenetics 54:862-6. 2003
    ..These observations might have important implications in the individual susceptibility to thrombotic disease...
  84. ncbi request reprint Genetic determinants of iron metabolism plasma phenotypes and their relationship with risk of thrombosis
    Juan Carlos Souto
    Haematologica 88:1436-8. 2003
  85. doi request reprint A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Biol Psychiatry 63:1047-53. 2008
    ..To follow up on this linkage region, we systematically screened single nucleotide polymorphisms (SNPs) across a 2 LOD support interval surrounding the alcohol dependence peak...
  86. ncbi request reprint Genetic and environmental factors influencing the human factor H plasma levels
    Jorge Esparza-Gordillo
    Departamento de Inmunologia, Laboratorio 143, Centro de Investigaciones Biologicas CSIC, C Ramiro de Maeztu N masculine 9, 28040, Madrid, Spain
    Immunogenetics 56:77-82. 2004
    ..Three genomic regions (1q32, 2p21-24 and 15q22-24) provided suggestive evidence of linkage (LOD scores 2.03, 2.15 and 2.00, respectively) with the plasma levels of factor H...
  87. ncbi request reprint Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Salt Lake City, UT 84108 3528, USA
    Chin Med J (Engl) 118:362-9. 2005
    ..We report here an investigation of the relationship between LDL-C and cholesterol 7alpha-hydroxylase (CYP7), as well as apoE and low-density lipoprotein receptor (LDLR), three pivotal genes in LDL metabolism...
  88. pmc Identification of a locus modulating serum C-reactive protein levels on chromosome 5p15
    Hillary A Keenan
    Research Division, Joslin Diabetes Center, Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Atherosclerosis 196:863-70. 2008
    ..To identify genes involved in this modulation, we performed a 10cM genome screen for linkage with plasma C-reactive protein in 38 extended families including 317 non-diabetic and 177 type 2 diabetic family members (2547 relative pairs)...
  89. ncbi request reprint A cholinergic receptor gene (CHRM2) affects event-related oscillations
    Kevin A Jones
    Department of Psychiatry, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
    Behav Genet 36:627-39. 2006
    ..These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders...

Research Grants19

  1. 3/3 - A Neurobehavioral Family Study of Schizophrenia
    Laura A Almasy; Fiscal Year: 2010
    ..The goal of the Multiplex Multigenerational Investigation of the schizophrenia consortium is to integrate neurobehavioral and neuroimaging methods in high-risk families that will yield the data needed for progress in the field. ..
  2. Genetic Analysis of Common Diseases: An Evaluation
    Laura A Almasy; Fiscal Year: 2010
    ..GAW data are extensively used in grant proposals and in teaching and dissertation research. ..
  3. Genetic Analysis of Idiopathic Thrombosis
    Laura A Almasy; Fiscal Year: 2010
    ..abstract_text> ..
  4. Genetic Analysis of Common Diseases: An Evaluation
    Laura Almasy; Fiscal Year: 2009
    ..GAW data are extensively used in grant proposals and in teaching and dissertation research. ..
  5. Genetic Analysis of Idiopathic Thrombosis
    Laura Almasy; Fiscal Year: 2009
    ..abstract_text> ..
  6. Genetic Analysis of Idiopathic Thrombosis
    Laura Almasy; Fiscal Year: 2007
    ....
  7. A Neurobehavioral Family Study of Schizophrenia
    Laura Almasy; Fiscal Year: 2005
    ..All collected data will become part of the NIMH-sponsored archival database for schizophrenia. ..
  8. Genetic Analysis of Idiopathic Thrombosis
    Laura Almasy; Fiscal Year: 2005
    ..abstract_text> ..
  9. 3/3 - A Neurobehavioral Family Study of Schizophrenia
    Laura A Almasy; Fiscal Year: 2010
    ..The goal of the Multiplex Multigenerational Investigation of the schizophrenia consortium is to integrate neurobehavioral and neuroimaging methods in high-risk families that will yield the data needed for progress in the field. ..