R G Struble

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, Charleston, Illinois 61920, USA
    Endocrinology 145:3065-73. 2004
  2. ncbi request reprint [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components
    Kun Xiong
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Brain Res 1157:81-91. 2007
  3. ncbi request reprint Apolipoprotein E may be a critical factor in hormone therapy neuroprotection
    Robert G Struble
    Center for Alzheimer s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P O Box 19643, Springfield, IL 62794 9643, USA
    Front Biosci 13:5387-405. 2008
  4. pmc Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulb
    Ikemefuna Nwosu
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, United States
    Neurosci Lett 441:282-5. 2008
  5. pmc Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?
    Robert G Struble
    Center for Alzheimer s Disease and Related Disorders, Southern Illinois University School of Medicine, Carbondale, IL 62794, USA
    J Alzheimers Dis 22:393-9. 2010
  6. ncbi request reprint Neocortical and hippocampal glial fibrillary acidic protein immunoreactivity shows region-specific variation during the mouse estrous cycle
    Robert G Struble
    Department of Neurology, Center for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Neuroendocrinology 83:325-35. 2006
  7. ncbi request reprint Estradiol regulation of astroglia and apolipoprotein E: an important role in neuronal regeneration
    Robert G Struble
    Department of Neurology and Center for Alzheimer Disease, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 42:54-63. 2007
  8. ncbi request reprint Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions
    R G Struble
    Center for Alzheimer Disease and Related Disorders, PO Box 19682, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Chem Senses 26:971-81. 2001
  9. ncbi request reprint Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol
    R G Struble
    Department of Neurology, Center for Alzheimer Disease and Related Disorders, PO Box 19628, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Neurol 183:638-44. 2003
  10. ncbi request reprint Apolipoprotein E immunoreactivity in human and mouse olfactory bulb
    R G Struble
    Center for Alzheimer s Disease and Related Disorders, Southern Illinois School of Medicine, Springfield 62794 9628, USA
    Neurosci Lett 267:137-40. 1999

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, Charleston, Illinois 61920, USA
    Endocrinology 145:3065-73. 2004
    ..The effects of ERT on chronic neurological diseases may vary with ApoE genotype. The clinical use of ERT may require ApoE genotyping for optimal efficacy...
  2. ncbi request reprint [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components
    Kun Xiong
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Brain Res 1157:81-91. 2007
    ..Together, [3H]-L-685,458 is an excellent radiotracer for mapping active gamma-secretase complex, and may serve as a useful tool for studying the enzyme in vivo and in vitro...
  3. ncbi request reprint Apolipoprotein E may be a critical factor in hormone therapy neuroprotection
    Robert G Struble
    Center for Alzheimer s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P O Box 19643, Springfield, IL 62794 9643, USA
    Front Biosci 13:5387-405. 2008
    ..Future studies of HT should evaluate the effects of apoE genotype and production estradiol on neuroprotection...
  4. pmc Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulb
    Ikemefuna Nwosu
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, United States
    Neurosci Lett 441:282-5. 2008
    ..The data indicate that apoE deficiency in KO mice is associated with a delayed recovery of the glomerular area and a slower recovery in Syn concentration in the OB...
  5. pmc Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?
    Robert G Struble
    Center for Alzheimer s Disease and Related Disorders, Southern Illinois University School of Medicine, Carbondale, IL 62794, USA
    J Alzheimers Dis 22:393-9. 2010
    ..This novel interpretation can tie the disparate risk factors for dementia to a unifying hypothesis and present a roadmap for interventions to decrease the prevalence of dementia in the elderly population...
  6. ncbi request reprint Neocortical and hippocampal glial fibrillary acidic protein immunoreactivity shows region-specific variation during the mouse estrous cycle
    Robert G Struble
    Department of Neurology, Center for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Neuroendocrinology 83:325-35. 2006
    ..Characterizing glial activation by ovarian hormones is important since astroglia are the source of numerous trophic factors and play an important, although often unrecognized, role in neuronal metabolism and function...
  7. ncbi request reprint Estradiol regulation of astroglia and apolipoprotein E: an important role in neuronal regeneration
    Robert G Struble
    Department of Neurology and Center for Alzheimer Disease, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 42:54-63. 2007
    ..Moreover, the role of glial-derived proteins in neuroprotection should not be ignored...
  8. ncbi request reprint Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions
    R G Struble
    Center for Alzheimer Disease and Related Disorders, PO Box 19682, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Chem Senses 26:971-81. 2001
    ..These data indicate substantial transynaptic degeneration in the olfactory bulb and a heretofore unrecognized gradient in olfactory nerve regeneration that can be used to systematically study recovery of a cortical structure...
  9. ncbi request reprint Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol
    R G Struble
    Department of Neurology, Center for Alzheimer Disease and Related Disorders, PO Box 19628, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Neurol 183:638-44. 2003
    ..In addition, exogenous E2 has regionally specific effects on apoE expression. Regional variability in apoE production appears to vary as a function of the estrogen receptor subtype...
  10. ncbi request reprint Apolipoprotein E immunoreactivity in human and mouse olfactory bulb
    R G Struble
    Center for Alzheimer s Disease and Related Disorders, Southern Illinois School of Medicine, Springfield 62794 9628, USA
    Neurosci Lett 267:137-40. 1999
    ..Experimental manipulation of the olfactory nerve may be a useful technique to determine the functions of apoE in a well-defined neural system...
  11. ncbi request reprint Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brain
    Xiangying Cheng
    Center for Alzheimer s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P O Box 19643, Springfield, IL 62794 9643, USA
    Neurosci Lett 417:50-4. 2007
    ..In contrast, E2 treatment decreased LDL-r protein expression in olfactory bulb. HT modification of both apoE and LRP could have wide-spread effects on cellular function given LRP's manifold signaling functions...
  12. ncbi request reprint Response of the olfactory bulb antioxidant system following diethyldithiocarbamate (DDTC) administration in rats
    R G Struble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield 62794, USA
    J Appl Toxicol 19:221-8. 1999
    ..These data suggest that increased ROS flux perturbs the olfactory bulb antioxidant defense system during olfactory nerve regeneration...
  13. ncbi request reprint Beta-amyloid precursor protein-like immunoreactivity is upregulated during olfactory nerve regeneration in adult rats
    R G Struble
    Center for Alzheimer s Disease, Southern Illinois University School of Medicine, Springfield 62794 1413, USA
    Brain Res 780:129-37. 1998
    ..Olfactory nerve regeneration appears to be a useful in vivo model system to understand the regulation of APP-like proteins...
  14. ncbi request reprint beta-Secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity
    Xiao Xin Yan
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    J Comp Neurol 501:52-69. 2007
    ..The results point to a biological role of BACE in synapse function and plasticity as well as a potential mechanism whereby reduced neuronal activity or metabolism could lead to amyloid overproduction in synaptic terminals...
  15. ncbi request reprint Time course of response to estradiol replacement in ovariectomized mice: brain apolipoprotein E and synaptophysin transiently increase and glial fibrillary acidic protein is suppressed
    Mary E McAsey
    Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield, IL 62794 9672, USA
    Exp Neurol 197:197-205. 2006
    ..These observations suggest that estradiol is able to suppress reactive gliosis. In addition, E2 replacement in OVX mice is associated with transiently higher levels of apoE and synaptophysin...
  16. ncbi request reprint Effect of Neuregen nutrient medium on survival of cortical neurons after aspiration lesion in rats
    Gregory J Brewer
    Department of Neurology, Medical Microbiology, and Immunology, Division of Neurosurgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
    J Neurosurg 98:1291-8. 2003
    ..The authors hypothesize that brain lesions irrigated and soaked in Neuregen nutrients will have better neuron survival rates in deafferented regions than lesions irrigated with saline...
  17. ncbi request reprint Cancer treatment and growth cone-associated protein in human olfactory bulb glomeruli
    R G Struble
    Center for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield 62794 1413, USA
    Arch Otolaryngol Head Neck Surg 124:867-70. 1998
    ..Disruption of regeneration should be evidenced by decreased presence of growing axons in the olfactory bulb...
  18. pmc Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
    Xue Mei Zhang
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Eur J Neurosci 30:2271-83. 2009
    ..Our findings appear to be in harmony with an early hypothesis that axonal pathogenesis plays a key or leading role in plaque formation...
  19. ncbi request reprint Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina
    Kun Xiong
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Exp Brain Res 181:435-46. 2007
    ..In addition, plaque constituents such as Fe(3+) and Abeta42f may participate in a self-enforcing cycle of amyloidogenesis via BACE upregulation...
  20. pmc Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex
    Xue Mei Zhang
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Eur J Neurosci 31:710-21. 2010
    ..The data also implicate an intrinsic association of amyloid accumulation and plaque formation with progressive axonal pathology...
  21. ncbi request reprint Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studies
    L F Hughes
    Center for Alzheimer Disease and Related Disorders, Department of Surgery, Division of Otolaryngology, Neurology, Southern Illinois University School of Medicine, PO Box 19643, Springfield, Illinois 62794 9643, USA
    Climacteric 5:140-50. 2002
    ..To determine whether hormone replacement therapy (HRT) preserved or improved olfactory sensitivity in healthy postmenopausal women...
  22. pmc Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markers
    Kun Xiong
    Department of Anatomy, Southern Illinois University School of Medicine, 1135 Lincoln Drive, Carbondale, IL 62901, USA
    Exp Neurol 211:271-82. 2008
    ..This population of cells might be involved in interneuron plasticity in the adult mammalian cerebral cortex...
  23. ncbi request reprint Delayed olfactory nerve regeneration in ApoE-deficient mice
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
    Brain Res 1041:87-94. 2005
    ..Together, these results show that olfactory nerve regeneration is significantly slower in KO mice as compared to WT mice, suggesting apoE facilitates olfactory nerve regeneration...
  24. pmc The distribution of apolipoprotein E in mouse olfactory epithelium
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
    Brain Res 1137:78-83. 2007
    ....
  25. ncbi request reprint Olfactory function in apoE knockout mice
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
    Behav Brain Res 150:1-7. 2004
    ..These data demonstrate that apoE deficiency in apoE KO mice leads to a deficit in olfactory function, suggesting an important role for apoE in the olfactory system...
  26. ncbi request reprint Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
    Brain Res 928:96-105. 2002
    ..These data suggest a potential mechanism whereby apoE4 may play a role in regenerative failure and accelerate the development of AD...