Research Topics
| R G StrubleSummaryAffiliation: Southern Illinois University School of Medicine Country: USA Publications
| Collaborators
|
Detail Information
Publications
Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neuronsBritto P Nathan
Department of Biological Sciences, Eastern Illinois University, Charleston, Illinois 61920, USA
Endocrinology 145:3065-73. 2004..The effects of ERT on chronic neurological diseases may vary with ApoE genotype. The clinical use of ERT may require ApoE genotyping for optimal efficacy...- [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 componentsKun Xiong
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
Brain Res 1157:81-91. 2007..Together, [3H]-L-685,458 is an excellent radiotracer for mapping active gamma-secretase complex, and may serve as a useful tool for studying the enzyme in vivo and in vitro... - Apolipoprotein E may be a critical factor in hormone therapy neuroprotectionRobert G Struble
Center for Alzheimer s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P O Box 19643, Springfield, IL 62794 9643, USA
Front Biosci 13:5387-405. 2008..Future studies of HT should evaluate the effects of apoE genotype and production estradiol on neuroprotection... 
Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulbIkemefuna Nwosu
Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, United States
Neurosci Lett 441:282-5. 2008..The data indicate that apoE deficiency in KO mice is associated with a delayed recovery of the glomerular area and a slower recovery in Syn concentration in the OB...- Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?Robert G Struble
Center for Alzheimer s Disease and Related Disorders, Southern Illinois University School of Medicine, Carbondale, IL 62794, USA
J Alzheimers Dis 22:393-9. 2010..This novel interpretation can tie the disparate risk factors for dementia to a unifying hypothesis and present a roadmap for interventions to decrease the prevalence of dementia in the elderly population... - Neocortical and hippocampal glial fibrillary acidic protein immunoreactivity shows region-specific variation during the mouse estrous cycleRobert G Struble
Department of Neurology, Center for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
Neuroendocrinology 83:325-35. 2006..Characterizing glial activation by ovarian hormones is important since astroglia are the source of numerous trophic factors and play an important, although often unrecognized, role in neuronal metabolism and function... - Estradiol regulation of astroglia and apolipoprotein E: an important role in neuronal regenerationRobert G Struble
Department of Neurology and Center for Alzheimer Disease, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Exp Gerontol 42:54-63. 2007..Moreover, the role of glial-derived proteins in neuroprotection should not be ignored... - Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesionsR G Struble
Center for Alzheimer Disease and Related Disorders, PO Box 19682, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Chem Senses 26:971-81. 2001..These data indicate substantial transynaptic degeneration in the olfactory bulb and a heretofore unrecognized gradient in olfactory nerve regeneration that can be used to systematically study recovery of a cortical structure... - Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiolR G Struble
Department of Neurology, Center for Alzheimer Disease and Related Disorders, PO Box 19628, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Exp Neurol 183:638-44. 2003..In addition, exogenous E2 has regionally specific effects on apoE expression. Regional variability in apoE production appears to vary as a function of the estrogen receptor subtype... - Apolipoprotein E immunoreactivity in human and mouse olfactory bulbR G Struble
Center for Alzheimer s Disease and Related Disorders, Southern Illinois School of Medicine, Springfield 62794 9628, USA
Neurosci Lett 267:137-40. 1999..Experimental manipulation of the olfactory nerve may be a useful technique to determine the functions of apoE in a well-defined neural system... - Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brainXiangying Cheng
Center for Alzheimer s Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, P O Box 19643, Springfield, IL 62794 9643, USA
Neurosci Lett 417:50-4. 2007..In contrast, E2 treatment decreased LDL-r protein expression in olfactory bulb. HT modification of both apoE and LRP could have wide-spread effects on cellular function given LRP's manifold signaling functions... - Response of the olfactory bulb antioxidant system following diethyldithiocarbamate (DDTC) administration in ratsR G Struble
Department of Neurology, Southern Illinois University School of Medicine, Springfield 62794, USA
J Appl Toxicol 19:221-8. 1999..These data suggest that increased ROS flux perturbs the olfactory bulb antioxidant defense system during olfactory nerve regeneration... - Beta-amyloid precursor protein-like immunoreactivity is upregulated during olfactory nerve regeneration in adult ratsR G Struble
Center for Alzheimer s Disease, Southern Illinois University School of Medicine, Springfield 62794 1413, USA
Brain Res 780:129-37. 1998..Olfactory nerve regeneration appears to be a useful in vivo model system to understand the regulation of APP-like proteins... - beta-Secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activityXiao Xin Yan
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
J Comp Neurol 501:52-69. 2007..The results point to a biological role of BACE in synapse function and plasticity as well as a potential mechanism whereby reduced neuronal activity or metabolism could lead to amyloid overproduction in synaptic terminals... - Time course of response to estradiol replacement in ovariectomized mice: brain apolipoprotein E and synaptophysin transiently increase and glial fibrillary acidic protein is suppressedMary E McAsey
Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield, IL 62794 9672, USA
Exp Neurol 197:197-205. 2006..These observations suggest that estradiol is able to suppress reactive gliosis. In addition, E2 replacement in OVX mice is associated with transiently higher levels of apoE and synaptophysin... - Effect of Neuregen nutrient medium on survival of cortical neurons after aspiration lesion in ratsGregory J Brewer
Department of Neurology, Medical Microbiology, and Immunology, Division of Neurosurgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
J Neurosurg 98:1291-8. 2003..The authors hypothesize that brain lesions irrigated and soaked in Neuregen nutrients will have better neuron survival rates in deafferented regions than lesions irrigated with saline... - Cancer treatment and growth cone-associated protein in human olfactory bulb glomeruliR G Struble
Center for Alzheimer Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield 62794 1413, USA
Arch Otolaryngol Head Neck Surg 124:867-70. 1998..Disruption of regeneration should be evidenced by decreased presence of growing axons in the olfactory bulb... - Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque developmentXue Mei Zhang
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
Eur J Neurosci 30:2271-83. 2009..Our findings appear to be in harmony with an early hypothesis that axonal pathogenesis plays a key or leading role in plaque formation... - Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retinaKun Xiong
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
Exp Brain Res 181:435-46. 2007..In addition, plaque constituents such as Fe(3+) and Abeta42f may participate in a self-enforcing cycle of amyloidogenesis via BACE upregulation... - Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortexXue Mei Zhang
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
Eur J Neurosci 31:710-21. 2010..The data also implicate an intrinsic association of amyloid accumulation and plaque formation with progressive axonal pathology... - Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studiesL F Hughes
Center for Alzheimer Disease and Related Disorders, Department of Surgery, Division of Otolaryngology, Neurology, Southern Illinois University School of Medicine, PO Box 19643, Springfield, Illinois 62794-9643, USA
Climacteric 5:140-50. 2002..CONCLUSION: Although prophylactic HRT has been suggested to be associated with improved olfactory function, we find that its use in healthy postmenopausal women does not enhance performance in a wide range of olfactory tasks... - Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markersKun Xiong
Department of Anatomy, Southern Illinois University School of Medicine, 1135 Lincoln Drive, Carbondale, IL 62901, USA
Exp Neurol 211:271-82. 2008..This population of cells might be involved in interneuron plasticity in the adult mammalian cerebral cortex... - Delayed olfactory nerve regeneration in ApoE-deficient miceBritto P Nathan
Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
Brain Res 1041:87-94. 2005..Together, these results show that olfactory nerve regeneration is significantly slower in KO mice as compared to WT mice, suggesting apoE facilitates olfactory nerve regeneration... - The distribution of apolipoprotein E in mouse olfactory epitheliumBritto P Nathan
Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
Brain Res 1137:78-83. 2007.... - Olfactory function in apoE knockout miceBritto P Nathan
Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
Behav Brain Res 150:1-7. 2004..These data demonstrate that apoE deficiency in apoE KO mice leads to a deficit in olfactory function, suggesting an important role for apoE in the olfactory system... - Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related proteinBritto P Nathan
Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
Brain Res 928:96-105. 2002..These data suggest a potential mechanism whereby apoE4 may play a role in regenerative failure and accelerate the development of AD...