Andrew F Shorr

Summary

Affiliation: Southern Iron Disorders Center
Country: USA

Publications

  1. doi request reprint Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME)
    Jeremy G Perkins
    Walter Reed Army Medical Center, Washington, DC 20307, USA
    Transfusion 51:242-52. 2011
  2. pmc Application of a population-based severity scoring system to individual patients results in frequent misclassification
    Frank V Booth
    Eli Lilly and Company, Indianapolis, IN, USA
    Crit Care 9:R522-9. 2005
  3. ncbi request reprint Epidemiology and economic impact of meticillin-resistant Staphylococcus aureus: review and analysis of the literature
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Pharmacoeconomics 25:751-68. 2007
  4. ncbi request reprint Epidemiology of staphylococcal resistance
    Andrew F Shorr
    Pulmonary and Critical Care Medicine and Pulmonary Clinic, Washington Hospital Center, Washington, DC 20010, USA
    Clin Infect Dis 45:S171-6. 2007
  5. ncbi request reprint Ventilator-associated pneumonia: insights from recent clinical trials
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 128:583S-591S. 2005
  6. doi request reprint Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit
    Andrew F Shorr
    Department of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington DC, USA
    Crit Care Med 37:1463-9. 2009
  7. doi request reprint Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia
    Andrew F Shorr
    Washington Hospital Center, DC 20010, USA
    Infect Control Hosp Epidemiol 30:759-63. 2009
  8. ncbi request reprint Linezolid versus vancomycin for Staphylococcus aureus bacteraemia: pooled analysis of randomized studies
    Andrew F Shorr
    Pulmonary, Critical Care and Respiratory Services, Washington Hospital Center, 110 Irving Street NW, Room 2A38 D, Washington, DC 20010, USA
    J Antimicrob Chemother 56:923-9. 2005
  9. doi request reprint Bacteremia in Staphylococcus aureus pneumonia: outcomes and epidemiology
    Matthew P Schreiber
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Crit Care 26:395-401. 2011
  10. doi request reprint Severe acute hypertension among inpatients admitted from the emergency department
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, DC 20010, USA
    J Hosp Med 7:203-10. 2012

Collaborators

Detail Information

Publications99

  1. doi request reprint Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME)
    Jeremy G Perkins
    Walter Reed Army Medical Center, Washington, DC 20307, USA
    Transfusion 51:242-52. 2011
    ..In massively transfused trauma patients, we compared outcomes of patients receiving FWB to those receiving aPLT...
  2. pmc Application of a population-based severity scoring system to individual patients results in frequent misclassification
    Frank V Booth
    Eli Lilly and Company, Indianapolis, IN, USA
    Crit Care 9:R522-9. 2005
    ..This study reports the AP2 scoring errors of researchers involved in a large sepsis trial and models the consequences of such an error rate for individual severe sepsis patients...
  3. ncbi request reprint Epidemiology and economic impact of meticillin-resistant Staphylococcus aureus: review and analysis of the literature
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Pharmacoeconomics 25:751-68. 2007
    ..Current opinion favours rational prescribing to maximise therapeutic benefit and minimise the risk of further antibacterial resistance...
  4. ncbi request reprint Epidemiology of staphylococcal resistance
    Andrew F Shorr
    Pulmonary and Critical Care Medicine and Pulmonary Clinic, Washington Hospital Center, Washington, DC 20010, USA
    Clin Infect Dis 45:S171-6. 2007
    ..Improvements in the preparation and dissemination of antibiograms, along with adequate public reporting of MRSA trends, are needed to address the challenge of choosing appropriate initial antibiotic treatment for MRSA infections...
  5. ncbi request reprint Ventilator-associated pneumonia: insights from recent clinical trials
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 128:583S-591S. 2005
    ..This review highlights selected areas of new clinical research on VAP treatment and prevention in order to place their significance in context...
  6. doi request reprint Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit
    Andrew F Shorr
    Department of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington DC, USA
    Crit Care Med 37:1463-9. 2009
    ..To review studies addressing mortality, length of stay (LOS), and cost of resistant Gram-negative bacterial infections in the intensive care unit (ICU)...
  7. doi request reprint Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia
    Andrew F Shorr
    Washington Hospital Center, DC 20010, USA
    Infect Control Hosp Epidemiol 30:759-63. 2009
    ..To conduct a cost-effectiveness analysis of the economic outcomes of ventilator-associated pneumonia (VAP) prevention associated with silver-coated endotracheal tubes versus uncoated endotracheal tubes...
  8. ncbi request reprint Linezolid versus vancomycin for Staphylococcus aureus bacteraemia: pooled analysis of randomized studies
    Andrew F Shorr
    Pulmonary, Critical Care and Respiratory Services, Washington Hospital Center, 110 Irving Street NW, Room 2A38 D, Washington, DC 20010, USA
    J Antimicrob Chemother 56:923-9. 2005
    ..To compare outcomes in patients with Staphylococcus aureus bacteraemia treated with linezolid with those of vancomycin-treated patients...
  9. doi request reprint Bacteremia in Staphylococcus aureus pneumonia: outcomes and epidemiology
    Matthew P Schreiber
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Crit Care 26:395-401. 2011
    ..Although bacteremia may complicate S aureus pneumonia, the epidemiology of and outcomes associated with bacteremia in this syndrome are poorly described...
  10. doi request reprint Severe acute hypertension among inpatients admitted from the emergency department
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, DC 20010, USA
    J Hosp Med 7:203-10. 2012
    ..Hospitalists often treat patients with severe acute hypertension (AH) presenting to the hospital. Little is known about the epidemiology of this syndrome...
  11. ncbi request reprint Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Clin Infect Dis 40:S123-9. 2005
    ..imipenem-cilastatin) was not predictive of outcomes, thus suggesting that the treatment regimens were equivalent. Both levofloxacin and imipenem-cilastatin regimens were well tolerated and had similar adverse event profiles...
  12. ncbi request reprint Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs?
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, USA
    Crit Care Med 35:1257-62. 2007
    ..To determine the financial impact of a sepsis protocol designed for use in the emergency department...
  13. ncbi request reprint Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 32:137-43. 2004
    ..To determine the incremental cost-effectiveness of linezolid compared with vancomycin for treatment of ventilator-associated pneumonia due to Staphylococcus aureus...
  14. ncbi request reprint Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:2588-95. 2006
    ..To gain a better understanding of the epidemiology, microbiology, and outcomes of early-onset, culture-positive, community-acquired, healthcare-associated, and hospital-acquired bloodstream infections...
  15. ncbi request reprint Comparison of cost, effectiveness, and safety of injectable anticoagulants used for thromboprophylaxis after orthopedic surgery
    Andrew F Shorr
    Pulmonary and Critical Care, Washington Hospital Center, Washington, DC 20010, USA
    Am J Health Syst Pharm 64:2349-55. 2007
    ..The cost, effectiveness, and safety of injectable anticoagulants used for thromboprophylaxis after orthopedic surgery were compared...
  16. ncbi request reprint Invasive approaches to the diagnosis of ventilator-associated pneumonia: a meta-analysis
    Andrew F Shorr
    Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 33:46-53. 2005
    ..g., bronchoscopy) remains unclear. We hypothesized that invasive testing would alter antibiotic management in patients with ventilator-associated pneumonia but would not necessarily alter mortality...
  17. ncbi request reprint Venous thromboembolism in critically ill patients. Observations from a randomized trial in sepsis
    Andrew F Shorr
    Pulmonary and Critical Care Department, Room 2A 38D, Washington Hospital Center, 110 Irving St, NW, Washington, DC 20010, USA
    Thromb Haemost 101:139-44. 2009
    ..Despite multiple guidelines, physicians do not uniformly prescribe VTE prophylaxis. Nonetheless, early VTE occurs even in persons given DAA. Most VTE in critically ill patients are clinically silent...
  18. doi request reprint Impact of vancomycin minimum inhibitory concentration on mortality among critically ill patients with methicillin-resistant Staphylococcus aureus bacteremia
    Christian J Woods
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC 20010, USA
    Infect Control Hosp Epidemiol 33:1246-9. 2012
    ..This MIC was found in 5.1% of patients and was associated with the probability of death (adjusted odds ratio, 13.9 [95% confidence interval, 1.1-171.2]) independent of other factors...
  19. doi request reprint Inappropriate therapy for methicillin-resistant Staphylococcus aureus: resource utilization and cost implications
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center and Georgetown University, Washington, DC, USA
    Crit Care Med 36:2335-40. 2008
    ..Initially inappropriate antibiotic therapy for methicillin-resistant S. aureus increases the risk for mortality. The impact of initially inappropriate antibiotic therapy on hospital length of stay and costs remains unknown...
  20. ncbi request reprint Transfusion practice and blood stream infections in critically ill patients
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 127:1722-8. 2005
    ..To examine the relationship between packed RBC (pRBC) transfusion and the development of ICU-acquired bloodstream infections (BSIs)..
  21. ncbi request reprint Levofloxacin 750-mg for 5 days for the treatment of hospitalized Fine Risk Class III/IV community-acquired pneumonia patients
    Andrew F Shorr
    Department of Medicine, Pulmonary and Critical Care Medicine, Room 2A 38D, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    Respir Med 100:2129-36. 2006
    ..This subgroup analysis attempted to compare the safety and efficacy of a short-course levofloxacin regimen with traditional levofloxacin dosing for PSI Class III/IV patients...
  22. ncbi request reprint Do clinical features allow for accurate prediction of fungal pathogenesis in bloodstream infections? Potential implications of the increasing prevalence of non-albicans candidemia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 35:1077-83. 2007
    ..To describe the evolving epidemiology of fungal bloodstream infections in critically ill and noncritically ill patients and to identify predictors of infection with non-albicans yeast species...
  23. doi request reprint Resistant pathogens in nonnosocomial pneumonia and respiratory failure: is it time to refine the definition of health-care-associated pneumonia?
    Matthew P Schreiber
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Chest 137:1283-8. 2010
    ..The concept of health-care-associated pneumonia (HCAP) exists to identify patients infected with highly resistant pathogens. It is unclear how precise this concept is and how well it performs as a screening tool for resistance...
  24. ncbi request reprint A multicenter, randomized, double-blind, retrospective comparison of 5- and 10-day regimens of levofloxacin in a subgroup of patients aged > or =65 years with community-acquired pneumonia
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Clin Ther 27:1251-9. 2005
    ....
  25. doi request reprint Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Section, Room 2A 38D, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    Arch Intern Med 168:2205-10. 2008
    ..The concept of health care-associated pneumonia (HCAP) attempts to capture this, but its predictive value is unclear...
  26. ncbi request reprint The distance-saturation product predicts mortality in idiopathic pulmonary fibrosis
    Christopher J Lettieri
    Pulmonary and Critical Care Medicine, Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Washington, DC 20307, USA
    Respir Med 100:1734-41. 2006
    ..We compared the performance of the DSP to the individual 6MWT parameters in predicting mortality...
  27. ncbi request reprint Impact of antibiotic guideline compliance on duration of mechanical ventilation in critically ill patients with community-acquired pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Section, Department of Medicine, Room 2A 38D, Washington Hospital Center, Washington, DC 20010, USA
    Chest 130:93-100. 2006
    ..Our goal was to assess the impact of following these guidelines, such as those from the Infectious Disease Society of America (IDSA), on the duration of mechanical ventilation (MV)...
  28. doi request reprint Burden of sodium abnormalities in patients hospitalized for heart failure
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Congest Heart Fail 17:1-7. 2011
    ..0001). Sodium abnormalities were common in patients hospitalized for CHF. Adverse outcomes resulted not only from severe hyponatremia, but also from mild hyponatremia and hypernatremia...
  29. ncbi request reprint Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:700-6. 2006
    ....
  30. doi request reprint Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Crit Care Med 39:46-51. 2011
    ..To describe the impact of initially inappropriate antibiotic therapy on hospital length of stay in Gram-negative severe sepsis and septic shock...
  31. pmc Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, District of Columbia, USA
    Crit Care 10:R97. 2006
    ....
  32. ncbi request reprint Low-molecular weight heparin for deep vein thrombosis prophylaxis in hospitalized medical patients: results from a cost-effectiveness analysis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
    Blood Coagul Fibrinolysis 18:309-16. 2007
    ..We conclude that, despite their higher cost, LMWHs for thromboprophylaxis in medical patients result in savings...
  33. doi request reprint Readmission following hospitalization for pneumonia: the impact of pneumonia type and its implication for hospitals
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    Clin Infect Dis 57:362-7. 2013
    ..Readmission rates following discharge after pneumonia are thought to represent the quality of care. Factors associated with readmission, however, remain poorly described. It is unclear if readmission rates vary based on pneumonia type...
  34. doi request reprint Predicting the need for mechanical ventilation in acute exacerbations of chronic obstructive pulmonary disease: comparing the CURB-65 and BAP-65 scores
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Washington Hospital Center, NW Washington, DC 20010, USA
    J Crit Care 27:564-70. 2012
    ..We sought to compare 2 risk scores, BAP-65 and CURB-65, at predicting a need for MV in AECOPDs...
  35. doi request reprint Validation of a novel risk score for severity of illness in acute exacerbations of COPD
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, 110 Irving St, NW, Washington, DC 20010, USA
    Chest 140:1177-83. 2011
    ..Clinicians lack a validated tool for risk stratification in acute exacerbations of COPD (AECOPD). We sought to validate the BAP-65 (elevated BUN, altered mental status, pulse > 109 beats/min, age > 65 years) score for this purpose...
  36. ncbi request reprint Transfusion practice and nosocomial infection: assessing the evidence
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC 20010, USA
    Curr Opin Crit Care 11:468-72. 2005
    ..To evaluate recent literature describing the potential relation between transfusion practice in the intensive care unit and the subsequent risk for nosocomial infection...
  37. pmc Candidemia on presentation to the hospital: development and validation of a risk score
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, DC 20010, USA
    Crit Care 13:R156. 2009
    ..Candidemia results in substantial morbidity and mortality, especially if initial antifungal therapy is delayed or is inappropriate; however, candidemia is difficult to diagnose because of its nonspecific presentation...
  38. ncbi request reprint Red blood cell transfusion and ventilator-associated pneumonia: A potential link?
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 32:666-74. 2004
    ..To determine the relationship between packed red blood cell transfusion practice and the development of ventilator-associated pneumonia (VAP)...
  39. pmc Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Irving Street, Washington, District of Columbia 20010, USA
    Crit Care 12:R45. 2008
    ..The goal of this study was to identify a dependable, sensitive measure with which to monitor disease progression and response in patients during DrotAA treatment...
  40. doi request reprint Postdischarge oral versus injectable anticoagulation following major orthopedic surgery
    Andrew F Shorr
    Pulmonary and Critical Care, Washington Hospital Center, Georgetown University, Washington, DC 34685, USA
    Ann Pharmacother 42:1222-8. 2008
    ..Multiple clinical studies have shown postdischarge anticoagulation to be beneficial following major orthopedic surgery (MOS); however, outpatient prophylaxis is not widely practiced...
  41. doi request reprint Prevention of venous thromboembolism in neurosurgery: a metaanalysis
    Jacob F Collen
    Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 134:237-49. 2008
    ..We conducted a systematic review asking, "Among patients undergoing neurosurgical procedures, how safe and effective is the prophylactic use of heparin and mechanical devices?"..
  42. doi request reprint Factors associated with acute lung injury in combat casualties receiving massive blood transfusions: a retrospective analysis
    Chee M Chan
    Pulmonary and Critical Care Department, Washington Hospital Center, Georgetown University Medical Center, Washington, DC 20010, USA
    J Crit Care 27:419.e7-14. 2012
    ..We sought to determine if use of warm fresh whole blood (WFWB), rather than blood component therapy, alters rates of acute lung injury (ALI) in patients with trauma...
  43. pmc Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)
    Andrew F Shorr
    Washington Hospital Center, 110 Irving Street NW, Washington DC 20010, USA
    Crit Care 14:R229. 2010
    ..The purpose of this study was to evaluate the dose and duration of drotrecogin alfa (activated) treatment using serial measurements of protein C compared to standard therapy in patients with severe sepsis...
  44. ncbi request reprint Sarcoidosis, race, and short-term outcomes following lung transplantation
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 125:990-6. 2004
    ..Patients with sarcoidosis, many of whom are African American, may require lung transplantation (LT). Little is known about survival following LT for sarcoidosis...
  45. doi request reprint Quality pneumonia care: distinguishing community-acquired from health care-associated pneumonia
    Andrew F Shorr
    Washington Hospital Center, Washington, DC 20010, USA
    Am J Health Syst Pharm 66:S8-14. 2009
    ..Differences in the definition, demographics, risk factors, etiology, and treatment for health care-associated pneumonia (HCAP) versus community-acquired pneumonia (CAP) are discussed...
  46. doi request reprint Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large U.S. database
    Andrew F Shorr
    Pulmonary Critical Care, Washington Hospital Center, Potomac, MD, USA
    Crit Care Med 37:2519-26; quiz 2535. 2009
    ..To characterize the epidemiology and burden of early-onset, nonnosocomial candidemia...
  47. ncbi request reprint Cost-minimization analysis of two algorithms for diagnosing acute pulmonary embolism
    Christopher W Humphreys
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Thromb Res 113:275-82. 2004
    ..We hypothesized that an algorithmic approach to diagnosis of pulmonary embolism based upon clinical risk stratification and D-dimer testing would be less costly than a standard approach...
  48. ncbi request reprint Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis
    Christopher J Lettieri
    Walter Reed Army Medical Center, Department of Pulmonary and Critical Care, 6900 Georgia Avenue NW, Washington, DC 20307, USA
    Chest 129:746-52. 2006
    ..We sought to characterize the prevalence of PAH and its impact on survival in patients with advanced IPF...
  49. doi request reprint Diagnostics and epidemiology in ventilator-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Room 2A 68D, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
    Ther Adv Respir Dis 5:121-30. 2011
    ..Second, select cohorts of patients are at high risk for VAP, and patient case-mix clearly influences the epidemiology of VAP. Third, rates of VAP appear higher outside the US, irrespective of the diagnostic paradigm utilized...
  50. ncbi request reprint Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis
    Andrew F Shorr
    Washington Hospital Center, Medstar, Potomac, MD, USA
    Crit Care Med 33:1928-35; quiz 1936. 2005
    ..To evaluate the impact of fluconazole prophylaxis on the incidence of fungal infections and on mortality among critically ill surgical patients...
  51. doi request reprint Assessment of ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia due to Streptococcus pneumoniae: insights from two randomized trials
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    Diagn Microbiol Infect Dis 75:298-303. 2013
    ..Our findings indicate that ceftaroline may result in improved outcomes of S. pneumoniae pneumonia. Formal clinical trials are warranted to confirm this hypothesis...
  52. doi request reprint Outcomes with micafungin in patients with candidaemia or invasive candidiasis due to Candida glabrata and Candida krusei
    Andrew F Shorr
    Pulmonary and Critical Care, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    J Antimicrob Chemother 66:375-80. 2011
    ..Infection with Candida glabrata and Candida krusei represents a major challenge. We sought to describe outcomes for patients with candidaemia/invasive candidiasis (C/IC) due to these pathogens who were treated with micafungin...
  53. pmc Clinical and economic outcomes for patients with health care-associated Staphylococcus aureus pneumonia
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    J Clin Microbiol 48:3258-62. 2010
    ..aureus HCAP have evidence of MRSA infection. S. aureus HCAP, irrespective of MRSA versus MSSA status, is associated with significant mortality and high health care costs, despite appropriate initial antibiotic therapy...
  54. ncbi request reprint Differences between low-molecular-weight and unfractionated heparin for venous thromboembolism prevention following ischemic stroke: a metaanalysis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Room 2A 39D, 110 Irving St, NW, Washington, DC 20010, USA
    Chest 133:149-55. 2008
    ..Venous thromboembolism (VTE) remains a major cause of morbidity following stroke. The optimal form of pharmacologic prophylaxis following stroke is unknown...
  55. ncbi request reprint Practical utility of clinical prediction rules for suspected acute pulmonary embolism in a large academic institution
    Lisa K Moores
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Building 2, WD 77, 6900 Georgia Avenue NW, Washington, DC 20307 5001, USA
    Thromb Res 113:1-6. 2004
    ..We sought to determine the utility of these algorithms in patients with suspected PE in a large, tertiary, academic medical center...
  56. ncbi request reprint Discordance between general and pulmonary pathologists in the diagnosis of interstitial lung disease
    Christopher J Lettieri
    Pulmonary and Critical Care Medicine, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Ave, NW Washington, DC 20307, USA
    Respir Med 99:1425-30. 2005
    ..However, the agreement between general and pulmonary pathologists in histopathologic diagnosis of ILD has not been established...
  57. doi request reprint Acute kidney injury and cardiovascular outcomes in acute severe hypertension
    Lynda A Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Circulation 121:2183-91. 2010
    ....
  58. ncbi request reprint Venous thromboembolism after orthopedic surgery: implications of the choice for prophylaxis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC 20010, USA
    Thromb Res 121:17-24. 2007
    ..We retrospectively analyzed a large hospital discharge database to assess the occurrence of clinically detected VTE as a function of the injectable antithrombotic agent used for VTE prophylaxis in orthopedic surgery...
  59. ncbi request reprint Outcomes for patients with sarcoidosis awaiting lung transplantation
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 122:233-8. 2002
    ....
  60. doi request reprint Ventilator-associated pneumonia: the clinical pulmonary infection score as a surrogate for diagnostics and outcome
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, DC, USA
    Clin Infect Dis 51:S131-5. 2010
    ..At present, the CPIS has a limited role both clinically and as a research tool...
  61. doi request reprint Guidelines and quality for community-acquired pneumonia: measures from the Joint Commission and the Centers for Medicare and Medicaid Services
    Andrew F Shorr
    Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Am J Health Syst Pharm 66:S2-7. 2009
    ..The rationales for and recent updates on quality measures for the treatment of community-acquired pneumonia (CAP) are reviewed...
  62. ncbi request reprint Update in ventilator-associated pneumonia
    William L Jackson
    Critical Care Medicine Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20010, USA
    Curr Opin Anaesthesiol 19:117-21. 2006
    ..This review examines the latest literature in this area, including promising approaches to infection prevention and recently developed guidelines to aid clinicians in limiting, identifying and treating ventilator-associated pneumonia...
  63. ncbi request reprint Quinolones for treatment of nosocomial pneumonia: a meta-analysis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Clin Infect Dis 40:S115-22. 2005
    ..12 (95% confidence interval, 0.80-1.55). Neither microbiological eradication rates nor mortality rates varied on the basis of antimicrobial selection...
  64. ncbi request reprint Anemia in chronic obstructive pulmonary disease: epidemiology and economic implications
    Andrew F Shorr
    Washington Hospital Center, Washington, DC 20010, USA
    Curr Med Res Opin 24:1123-30. 2008
    ..Because no data studies have been performed either in a single center or a subpopulation of COPD patients, anemia's influence on the outcomes is not fully understood...
  65. ncbi request reprint Minimizing costs for treating deep vein thrombosis: the role for fondaparinux
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, 110 Irving St, NW, Washington, DC 20010, USA
    J Thromb Thrombolysis 23:229-36. 2007
    ....
  66. ncbi request reprint Twice vs three times daily heparin dosing for thromboembolism prophylaxis in the general medical population: A metaanalysis
    Christopher S King
    Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Ave NW, Washington, DC 20307, USA
    Chest 131:507-16. 2007
    ..While twice-daily (BID) and three-times-daily (TID) dosing regimens have been studied, the two have never been directly compared. We performed a metaanalysis to assess whether TID is superior to BID dosing in the prevention of VTE...
  67. ncbi request reprint The pharmacoeconomics of deep vein thrombosis treatment
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, DC 20010, USA
    Am J Med 120:S35-41. 2007
    ..A recent cost-effective analysis demonstrated that fondaparinux use offers an attractive economic alternative to other agents for initial DVT therapy that could yield cost savings without compromising clinical outcomes or patient safety...
  68. ncbi request reprint Preventing pneumonia: the role for pneumococcal and influenza vaccines
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, NW, Washington, DC 20307, USA
    Clin Chest Med 26:123-34. 2005
    ..The pneumococcal and influenza vaccines are considered cost-effective options for pneumonia prevention...
  69. ncbi request reprint Depreotide scanning in sarcoidosis: a pilot study
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA
    Chest 126:1337-43. 2004
    ..To determine whether sarcoidosis results in uptake on (99m)Tc-labeled depreotide (DP) scintigraphy and to generate preliminary data to guide the development of future trials exploring this imaging modality in sarcoidosis patients...
  70. ncbi request reprint Acute eosinophilic pneumonia among US Military personnel deployed in or near Iraq
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    JAMA 292:2997-3005. 2004
    ..Acute eosinophilic pneumonia (AEP) is a rare disease of unknown etiology characterized by respiratory failure, radiographic infiltrates, and eosinophilic infiltration of the lung...
  71. ncbi request reprint An update on cost-effectiveness analysis in critical care
    Andrew F Shorr
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Curr Opin Crit Care 8:337-43. 2002
    ..With a framework for evaluating these studies, clinicians can better apply their findings to their own institutions...
  72. pmc Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care 10:R92. 2006
    ..The objective of this study was to determine whether early directional changes in protein C levels correlate with outcome...
  73. doi request reprint Correlates of clinical failure in ventilator-associated pneumonia: insights from a large, randomized trial
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    J Crit Care 23:64-73. 2008
    ..Our objective was to determine clinical variables measured at baseline and day 3 that may relate to failure of resolution of ventilator-associated pneumonia (VAP)...
  74. ncbi request reprint D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 121:1262-8. 2002
    ..To determine the relationship between d-dimer (DD) and both proinflammatory and anti-inflammatory cytokine levels, and to confirm the association between DD status and outcomes in critically ill patients...
  75. ncbi request reprint Predicting mortality in patients with sarcoidosis awaiting lung transplantation
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA
    Chest 124:922-8. 2003
    ..To identify factors associated with mortality in patients with sarcoidosis listed for lung transplantation, and to create a model for predicting intermediate-term mortality in these individuals...
  76. ncbi request reprint Outcomes and safety of surgical lung biopsy for interstitial lung disease
    Christopher J Lettieri
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 127:1600-5. 2005
    ..To determine the safety of surgical lung biopsy (SLB) in patients with interstitial lung disease (ILD), and specifically in those with idiopathic pulmonary fibrosis (IPF)...
  77. doi request reprint Health care-associated candidemia--a distinct entity?
    Joyti Gulia
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Hosp Med 5:298-301. 2010
    ..Although epidemiologic studies document the clear existence of health care-associated pneumonia, little is known about fungal pathogens and their role in HCAIs...
  78. ncbi request reprint New choices for central venous catheters: potential financial implications
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 124:275-84. 2003
    ..To determine the cost-effectiveness of the newer antiseptic and antibiotic-impregnated central venous catheters (CVCs) relative to uncoated CVCs and to each other...
  79. ncbi request reprint Pulmonary infiltrates in the non-HIV-infected immunocompromised patient: etiologies, diagnostic strategies, and outcomes
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 125:260-71. 2004
    ..With the results of invasive testing, these treatments are then narrowed. Frustratingly, outcomes for immunocompromised patients with infiltrates remain poor...
  80. ncbi request reprint Is the implementation of research findings in the critically ill hampered by the lack of universal definitions of illness?
    Shannon S Carson
    Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7020, USA
    Curr Opin Crit Care 9:308-15. 2003
    ..More specific identifiers of critical illnesses using specific biochemical or genetic markers are being explored. This approach may also be useful for staging disease...
  81. ncbi request reprint Effect of standardized orders and provider education on head-of-bed positioning in mechanically ventilated patients
    Donald L Helman
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 31:2285-90. 2003
    ....
  82. ncbi request reprint Transfusion practice in the ICU: when will we apply the evidence?
    Andrew F Shorr
    Chest 127:702-5. 2005
  83. pmc The protein C pathway: implications for the design of the RESPOND study
    Burkhard Vangerow
    Eli Lilly Critical Care Europe, Air Center, 1214 Vernier Geneva, Switzerland
    Crit Care 11:S4. 2007
    ....
  84. doi request reprint Not everything that can be counted counts
    Lee E Morrow
    Chest 133:336-7. 2008
  85. ncbi request reprint The quick and the dead: the importance of rapid evaluation of infiltrates in the immunocompromised patient
    Andrew F Shorr
    Chest 122:9-12. 2002
  86. doi request reprint Prolonged acute mechanical ventilation, hospital resource utilization, and mortality in the United States
    Marya D Zilberberg
    University of Massachusetts, School of Public Health and Health Sciences, Amherst, MA, USA
    Crit Care Med 36:724-30. 2008
    ..We compared the prevalence, characteristics, and outcomes of MV < 96 hrs (MV < 96) and prolonged acute MV (PAMV) of > or = 96 hrs' duration in a representative sample of U.S. hospital discharges...
  87. ncbi request reprint Mortality from time of listing for transplantation as an indicator of candidate outcomes
    Steven D Nathan
    Inova Transplant Center, Inova Fairfax Hospital, Falls Church, VA, USA
    Prog Transplant 14:29-32. 2004
    ..We propose that mortality from the time of listing is a more significant outcome measure for potential transplant candidates. We present our lung transplant program's outcomes using this measure...
  88. pmc Red blood cell transfusions and the risk of acute respiratory distress syndrome among the critically ill: a cohort study
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, P, O, Box 303, Goshen, MA 01032, USA
    Crit Care 11:R63. 2007
    ..Uncertainty remains regarding the strength of this relationship...
  89. ncbi request reprint Resistance in the intensive care unit: whose problem is it and how can intensivists help?
    Andrew F Shorr
    Crit Care Med 35:299-301. 2007
  90. doi request reprint There is no "cap" on the importance of community-acquired pneumonia in the ICU
    Andrew F Shorr
    Chest 133:590-2. 2008
  91. doi request reprint The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia
    Francois Lauzier
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 23:50-7. 2008
    ..The aim of the study was to assess the utility of pretest probability and modified clinical pulmonary infection score CPIS in the diagnosis of late-onset ventilator-associated pneumonia (VAP)...
  92. ncbi request reprint Making the wrong choice: Consequences for patients with infections due to methicillin-resistant Staphylococcus aureus
    Andrew F Shorr
    Crit Care Med 34:2239-41. 2006
  93. pmc Anemia, transfusions and hospital outcomes among critically ill patients on prolonged acute mechanical ventilation: a retrospective cohort study
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, North Pleasant Street, Amherst, Massachusetts 01003, USA
    Crit Care 12:R60. 2008
    ..We hypothesized that transfusions among patients receiving PAMV are common and associated with worsened clinical and economic outcomes...
  94. doi request reprint Health care-associated pneumonia: identification and initial management in the ED
    Fredrick M Abrahamian
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Emerg Med 26:1-11. 2008
    ..The aim of this article is to create awareness of the entity known as HCAP and to provide knowledge of its identification and initial management in the emergency department...
  95. ncbi request reprint Dollars and sense in the intensive care unit: the costs of ventilator-associated pneumonia
    Andrew F Shorr
    Crit Care Med 31:1582-3. 2003
  96. ncbi request reprint Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital, AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, Paris, France
    Crit Care Med 33:341-8. 2005
    ..To determine whether changes in coagulation biomarkers during the first day of severe sepsis correlate with progression from single to multiple organ failure and subsequent death...
  97. pmc Hyponatremia and hospital outcomes among patients with pneumonia: a retrospective cohort study
    Marya D Zilberberg
    Evi Med Research Group, LLC, Goshen, Massachusetts, USA
    BMC Pulm Med 8:16. 2008
    ..Hyponatremia, occurring in >1/4 of patients with CAP, is associated with greater disease severity and worsened outcomes...
  98. ncbi request reprint Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use
    Stanley A Nasraway
    Division of Surgical Critical Care, Department of Surgery, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Clin Infect Dis 37:1609-16. 2003
    ..Clinically significant thrombocytopenia was uncommon in our analysis, and linezolid was not associated with a greater risk of thrombocytopenia in seriously ill patients than was vancomycin...
  99. ncbi request reprint Interferon gamma-1b as therapy for idiopathic pulmonary fibrosis. An intrapatient analysis
    Steven D Nathan
    Inova Transplant Center, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Respiration 71:77-82. 2004
    ..We report our results using this medication in a cohort of patients with a wide range of severity of IPF...