A F Shorr

Summary

Affiliation: Southern Iron Disorders Center
Country: USA

Publications

  1. pmc Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis: support for the 2009 IDSA treatment guidelines for candidiasis
    Daniel H Kett
    The Miller School of Medicine at the University of Miami, Jackson Memorial Hospital, 1611 NW 12th Avenue, Miami, FL 33136, USA
    Crit Care 15:R253. 2011
  2. doi Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department
    Andrew F Shorr
    Department of Medicine, Pulmonary and Critical Care Medicine Division, Washington Hospital Center, Washington, District of Columbia 20010, USA
    Clin Infect Dis 54:193-8. 2012
  3. pmc Anemia, transfusions and hospital outcomes among critically ill patients on prolonged acute mechanical ventilation: a retrospective cohort study
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, North Pleasant Street, Amherst, Massachusetts 01003, USA
    Crit Care 12:R60. 2008
  4. pmc Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Arnold House, Amherst, MA 01003, USA
    Crit Care 13:R94. 2009
  5. pmc Red blood cell transfusions and the risk of acute respiratory distress syndrome among the critically ill: a cohort study
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, P, O, Box 303, Goshen, MA 01032, USA
    Crit Care 11:R63. 2007
  6. pmc Hyponatremia and hospital outcomes among patients with pneumonia: a retrospective cohort study
    Marya D Zilberberg
    Evi Med Research Group, LLC, Goshen, Massachusetts, USA
    BMC Pulm Med 8:16. 2008
  7. pmc Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
    BMC Pulm Med 10:45. 2010
  8. pmc Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study
    Marya D Zilberberg
    EviMed Research Group, LLC, PO Box 303, Goshen, MA 01032, USA
    BMC Infect Dis 10:150. 2010
  9. pmc Effect of a restrictive transfusion strategy on transfusion-attributable severe acute complications and costs in the US ICUs: a model simulation
    Marya D Zilberberg
    University of Massachusetts, 715 North Pleasant Street, Amherst, MA 01003, USA
    BMC Health Serv Res 7:138. 2007
  10. pmc Prolonged acute mechanical ventilation and hospital bed utilization in 2020 in the United States: implications for budgets, plant and personnel planning
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
    BMC Health Serv Res 8:242. 2008

Detail Information

Publications101 found, 100 shown here

  1. pmc Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis: support for the 2009 IDSA treatment guidelines for candidiasis
    Daniel H Kett
    The Miller School of Medicine at the University of Miami, Jackson Memorial Hospital, 1611 NW 12th Avenue, Miami, FL 33136, USA
    Crit Care 15:R253. 2011
    ..To validate these guidelines, clinical trial data were reviewed...
  2. doi Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department
    Andrew F Shorr
    Department of Medicine, Pulmonary and Critical Care Medicine Division, Washington Hospital Center, Washington, District of Columbia 20010, USA
    Clin Infect Dis 54:193-8. 2012
    ..We sought to validate a previously developed score for determining the risk for an RO and to compare it with the HCAP definition...
  3. pmc Anemia, transfusions and hospital outcomes among critically ill patients on prolonged acute mechanical ventilation: a retrospective cohort study
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, North Pleasant Street, Amherst, Massachusetts 01003, USA
    Crit Care 12:R60. 2008
    ..We hypothesized that transfusions among patients receiving PAMV are common and associated with worsened clinical and economic outcomes...
  4. pmc Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Arnold House, Amherst, MA 01003, USA
    Crit Care 13:R94. 2009
    ..400 mg daily fluconazole (FLU) for suspected intensive care unit-acquired candidemia (ICU-AC) among septic patients...
  5. pmc Red blood cell transfusions and the risk of acute respiratory distress syndrome among the critically ill: a cohort study
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, P, O, Box 303, Goshen, MA 01032, USA
    Crit Care 11:R63. 2007
    ..Uncertainty remains regarding the strength of this relationship...
  6. pmc Hyponatremia and hospital outcomes among patients with pneumonia: a retrospective cohort study
    Marya D Zilberberg
    Evi Med Research Group, LLC, Goshen, Massachusetts, USA
    BMC Pulm Med 8:16. 2008
    ..Hyponatremia, occurring in >1/4 of patients with CAP, is associated with greater disease severity and worsened outcomes...
  7. pmc Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
    BMC Pulm Med 10:45. 2010
    ..NPs in particular are likely to be caused by Pseudomonas aeruginosa (PA), ~20% of which in observational studies are resistant to imipenem. We sought to identify the burden of PA imipenem resistance in pneumonia...
  8. pmc Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study
    Marya D Zilberberg
    EviMed Research Group, LLC, PO Box 303, Goshen, MA 01032, USA
    BMC Infect Dis 10:150. 2010
    ..Inappropriate antifungal therapy (IAT) is known to increase a patient's risk for death. We hypothesized that in an ICU cohort it would also adversely affect resource utilization...
  9. pmc Effect of a restrictive transfusion strategy on transfusion-attributable severe acute complications and costs in the US ICUs: a model simulation
    Marya D Zilberberg
    University of Massachusetts, 715 North Pleasant Street, Amherst, MA 01003, USA
    BMC Health Serv Res 7:138. 2007
    ..We estimated the potential annual reduction in transfusion-attributable severe acute complications (TSACs) and costs across the US ICUs with the adoption of restrictive strategy...
  10. pmc Prolonged acute mechanical ventilation and hospital bed utilization in 2020 in the United States: implications for budgets, plant and personnel planning
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
    BMC Health Serv Res 8:242. 2008
    ..Their numbers are projected to double by year 2020. To aid in planning for this growth, we projected their annualized days and costs of hospital use and SNF discharges in year 2020 in the US...
  11. doi Inappropriate therapy for methicillin-resistant Staphylococcus aureus: resource utilization and cost implications
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center and Georgetown University, Washington, DC, USA
    Crit Care Med 36:2335-40. 2008
    ..Initially inappropriate antibiotic therapy for methicillin-resistant S. aureus increases the risk for mortality. The impact of initially inappropriate antibiotic therapy on hospital length of stay and costs remains unknown...
  12. ncbi Do clinical features allow for accurate prediction of fungal pathogenesis in bloodstream infections? Potential implications of the increasing prevalence of non-albicans candidemia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 35:1077-83. 2007
    ..To describe the evolving epidemiology of fungal bloodstream infections in critically ill and noncritically ill patients and to identify predictors of infection with non-albicans yeast species...
  13. ncbi A multicenter, randomized, double-blind, retrospective comparison of 5- and 10-day regimens of levofloxacin in a subgroup of patients aged > or =65 years with community-acquired pneumonia
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Clin Ther 27:1251-9. 2005
    ....
  14. ncbi Transfusion practice and nosocomial infection: assessing the evidence
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC 20010, USA
    Curr Opin Crit Care 11:468-72. 2005
    ..To evaluate recent literature describing the potential relation between transfusion practice in the intensive care unit and the subsequent risk for nosocomial infection...
  15. ncbi Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis
    Andrew F Shorr
    Washington Hospital Center, Medstar, Potomac, MD, USA
    Crit Care Med 33:1928-35; quiz 1936. 2005
    ..To evaluate the impact of fluconazole prophylaxis on the incidence of fungal infections and on mortality among critically ill surgical patients...
  16. ncbi Transfusion practice and blood stream infections in critically ill patients
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 127:1722-8. 2005
    ..To examine the relationship between packed RBC (pRBC) transfusion and the development of ICU-acquired bloodstream infections (BSIs)..
  17. ncbi Pulmonary hypertension in advanced sarcoidosis: epidemiology and clinical characteristics
    A F Shorr
    The Pulomonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Eur Respir J 25:783-8. 2005
    ..Since pulmonary hypertension is associated with poor outcomes and because simple clinical criteria fail to identify patients with sarcoidosis and pulmonary hypertension, more aggressive screening for this should be considered...
  18. ncbi Pulmonary hypertension in patients with pulmonary fibrosis awaiting lung transplant
    A F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington DC 20010, USA
    Eur Respir J 30:715-21. 2007
    ..Given the prevalence of pulmonary hypertension and its relationship with surrogate markers for quality of life (e.g. activities of daily living), future trials of therapies for this may be warranted...
  19. pmc Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Irving Street, Washington, District of Columbia 20010, USA
    Crit Care 12:R45. 2008
    ..The goal of this study was to identify a dependable, sensitive measure with which to monitor disease progression and response in patients during DrotAA treatment...
  20. ncbi Low-molecular weight heparin for deep vein thrombosis prophylaxis in hospitalized medical patients: results from a cost-effectiveness analysis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
    Blood Coagul Fibrinolysis 18:309-16. 2007
    ..We conclude that, despite their higher cost, LMWHs for thromboprophylaxis in medical patients result in savings...
  21. ncbi Venous thromboembolism after orthopedic surgery: implications of the choice for prophylaxis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC 20010, USA
    Thromb Res 121:17-24. 2007
    ..We retrospectively analyzed a large hospital discharge database to assess the occurrence of clinically detected VTE as a function of the injectable antithrombotic agent used for VTE prophylaxis in orthopedic surgery...
  22. ncbi Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs?
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Section, Washington Hospital Center, USA
    Crit Care Med 35:1257-62. 2007
    ..To determine the financial impact of a sepsis protocol designed for use in the emergency department...
  23. ncbi The pharmacoeconomics of deep vein thrombosis treatment
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, DC 20010, USA
    Am J Med 120:S35-41. 2007
    ..A recent cost-effective analysis demonstrated that fondaparinux use offers an attractive economic alternative to other agents for initial DVT therapy that could yield cost savings without compromising clinical outcomes or patient safety...
  24. ncbi Minimizing costs for treating deep vein thrombosis: the role for fondaparinux
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, 110 Irving St, NW, Washington, DC 20010, USA
    J Thromb Thrombolysis 23:229-36. 2007
    ....
  25. ncbi Comparison of cost, effectiveness, and safety of injectable anticoagulants used for thromboprophylaxis after orthopedic surgery
    Andrew F Shorr
    Pulmonary and Critical Care, Washington Hospital Center, Washington, DC 20010, USA
    Am J Health Syst Pharm 64:2349-55. 2007
    ..The cost, effectiveness, and safety of injectable anticoagulants used for thromboprophylaxis after orthopedic surgery were compared...
  26. ncbi Anemia in chronic obstructive pulmonary disease: epidemiology and economic implications
    Andrew F Shorr
    Washington Hospital Center, Washington, DC 20010, USA
    Curr Med Res Opin 24:1123-30. 2008
    ..Because no data studies have been performed either in a single center or a subpopulation of COPD patients, anemia's influence on the outcomes is not fully understood...
  27. ncbi Impact of antibiotic guideline compliance on duration of mechanical ventilation in critically ill patients with community-acquired pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Section, Department of Medicine, Room 2A 38D, Washington Hospital Center, Washington, DC 20010, USA
    Chest 130:93-100. 2006
    ..Our goal was to assess the impact of following these guidelines, such as those from the Infectious Disease Society of America (IDSA), on the duration of mechanical ventilation (MV)...
  28. pmc Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, District of Columbia, USA
    Crit Care 10:R97. 2006
    ....
  29. pmc Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care 10:R92. 2006
    ..The objective of this study was to determine whether early directional changes in protein C levels correlate with outcome...
  30. ncbi Levofloxacin 750-mg for 5 days for the treatment of hospitalized Fine Risk Class III/IV community-acquired pneumonia patients
    Andrew F Shorr
    Department of Medicine, Pulmonary and Critical Care Medicine, Room 2A 38D, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    Respir Med 100:2129-36. 2006
    ..This subgroup analysis attempted to compare the safety and efficacy of a short-course levofloxacin regimen with traditional levofloxacin dosing for PSI Class III/IV patients...
  31. ncbi Preventing pneumonia: the role for pneumococcal and influenza vaccines
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, NW, Washington, DC 20307, USA
    Clin Chest Med 26:123-34. 2005
    ..The pneumococcal and influenza vaccines are considered cost-effective options for pneumonia prevention...
  32. doi Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Section, Room 2A 38D, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    Arch Intern Med 168:2205-10. 2008
    ..The concept of health care-associated pneumonia (HCAP) attempts to capture this, but its predictive value is unclear...
  33. ncbi New choices for central venous catheters: potential financial implications
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 124:275-84. 2003
    ..To determine the cost-effectiveness of the newer antiseptic and antibiotic-impregnated central venous catheters (CVCs) relative to uncoated CVCs and to each other...
  34. pmc Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)
    Andrew F Shorr
    Washington Hospital Center, 110 Irving Street NW, Washington DC 20010, USA
    Crit Care 14:R229. 2010
    ..The purpose of this study was to evaluate the dose and duration of drotrecogin alfa (activated) treatment using serial measurements of protein C compared to standard therapy in patients with severe sepsis...
  35. ncbi An update on cost-effectiveness analysis in critical care
    Andrew F Shorr
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Curr Opin Crit Care 8:337-43. 2002
    ..With a framework for evaluating these studies, clinicians can better apply their findings to their own institutions...
  36. doi Diagnostics and epidemiology in ventilator-associated pneumonia
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Room 2A 68D, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
    Ther Adv Respir Dis 5:121-30. 2011
    ..Second, select cohorts of patients are at high risk for VAP, and patient case-mix clearly influences the epidemiology of VAP. Third, rates of VAP appear higher outside the US, irrespective of the diagnostic paradigm utilized...
  37. ncbi D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 121:1262-8. 2002
    ..To determine the relationship between d-dimer (DD) and both proinflammatory and anti-inflammatory cytokine levels, and to confirm the association between DD status and outcomes in critically ill patients...
  38. ncbi Endobronchial involvement and airway hyperreactivity in patients with sarcoidosis
    A F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 120:881-6. 2001
    ..To determine the relationship between airway hyperreactivity (AHR) and endobronchial involvement in patients with sarcoidosis...
  39. ncbi Endobronchial biopsy for sarcoidosis: a prospective study
    A F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 120:109-14. 2001
    ..To determine the yield of endobronchial biopsy (EBB) for suspected sarcoidosis, and to evaluate if EBB increases the diagnostic value of fiberoptic bronchoscopy (FOB) when added to transbronchial biopsy (TBB)...
  40. ncbi Continuous subglottic suctioning for the prevention of ventilator-associated pneumonia : potential economic implications
    A F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 119:228-35. 2001
    ..To determine the cost-effectiveness of continuous subglottic suctioning (CSS) as a strategy to decrease the incidence of ventilator-associated pneumonia (VAP)...
  41. ncbi Circulating D dimer in patients with sarcoidosis
    A F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 117:1012-6. 2000
    ..To determine the relationship between D dimer (DD) status and markers of disease activity in patients with sarcoidosis...
  42. doi Outcomes with micafungin in patients with candidaemia or invasive candidiasis due to Candida glabrata and Candida krusei
    Andrew F Shorr
    Pulmonary and Critical Care, Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA
    J Antimicrob Chemother 66:375-80. 2011
    ..Infection with Candida glabrata and Candida krusei represents a major challenge. We sought to describe outcomes for patients with candidaemia/invasive candidiasis (C/IC) due to these pathogens who were treated with micafungin...
  43. ncbi Predicting mortality in patients with sarcoidosis awaiting lung transplantation
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA
    Chest 124:922-8. 2003
    ..To identify factors associated with mortality in patients with sarcoidosis listed for lung transplantation, and to create a model for predicting intermediate-term mortality in these individuals...
  44. doi Ventilator-associated pneumonia: the clinical pulmonary infection score as a surrogate for diagnostics and outcome
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, DC, USA
    Clin Infect Dis 51:S131-5. 2010
    ..At present, the CPIS has a limited role both clinically and as a research tool...
  45. ncbi Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Clin Infect Dis 40:S123-9. 2005
    ..imipenem-cilastatin) was not predictive of outcomes, thus suggesting that the treatment regimens were equivalent. Both levofloxacin and imipenem-cilastatin regimens were well tolerated and had similar adverse event profiles...
  46. ncbi Quinolones for treatment of nosocomial pneumonia: a meta-analysis
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Clin Infect Dis 40:S115-22. 2005
    ..12 (95% confidence interval, 0.80-1.55). Neither microbiological eradication rates nor mortality rates varied on the basis of antimicrobial selection...
  47. ncbi Venous thromboembolism in critically ill patients. Observations from a randomized trial in sepsis
    Andrew F Shorr
    Pulmonary and Critical Care Department, Room 2A 38D, Washington Hospital Center, 110 Irving St, NW, Washington, DC 20010, USA
    Thromb Haemost 101:139-44. 2009
    ..Despite multiple guidelines, physicians do not uniformly prescribe VTE prophylaxis. Nonetheless, early VTE occurs even in persons given DAA. Most VTE in critically ill patients are clinically silent...
  48. ncbi Acute eosinophilic pneumonia among US Military personnel deployed in or near Iraq
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    JAMA 292:2997-3005. 2004
    ..Acute eosinophilic pneumonia (AEP) is a rare disease of unknown etiology characterized by respiratory failure, radiographic infiltrates, and eosinophilic infiltration of the lung...
  49. doi Guidelines and quality for community-acquired pneumonia: measures from the Joint Commission and the Centers for Medicare and Medicaid Services
    Andrew F Shorr
    Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Am J Health Syst Pharm 66:S2-7. 2009
    ..The rationales for and recent updates on quality measures for the treatment of community-acquired pneumonia (CAP) are reviewed...
  50. ncbi Depreotide scanning in sarcoidosis: a pilot study
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA
    Chest 126:1337-43. 2004
    ..To determine whether sarcoidosis results in uptake on (99m)Tc-labeled depreotide (DP) scintigraphy and to generate preliminary data to guide the development of future trials exploring this imaging modality in sarcoidosis patients...
  51. doi Quality pneumonia care: distinguishing community-acquired from health care-associated pneumonia
    Andrew F Shorr
    Washington Hospital Center, Washington, DC 20010, USA
    Am J Health Syst Pharm 66:S8-14. 2009
    ..Differences in the definition, demographics, risk factors, etiology, and treatment for health care-associated pneumonia (HCAP) versus community-acquired pneumonia (CAP) are discussed...
  52. pmc Candidemia on presentation to the hospital: development and validation of a risk score
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Washington Hospital Center, Washington, DC 20010, USA
    Crit Care 13:R156. 2009
    ..Candidemia results in substantial morbidity and mortality, especially if initial antifungal therapy is delayed or is inappropriate; however, candidemia is difficult to diagnose because of its nonspecific presentation...
  53. ncbi Sarcoidosis, race, and short-term outcomes following lung transplantation
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 125:990-6. 2004
    ..Patients with sarcoidosis, many of whom are African American, may require lung transplantation (LT). Little is known about survival following LT for sarcoidosis...
  54. ncbi Pulmonary infiltrates in the non-HIV-infected immunocompromised patient: etiologies, diagnostic strategies, and outcomes
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 125:260-71. 2004
    ..With the results of invasive testing, these treatments are then narrowed. Frustratingly, outcomes for immunocompromised patients with infiltrates remain poor...
  55. doi Impact of stageĀ 3B chronic kidney disease on thrombosis and bleeding outcomes after orthopedic surgery in patients treated with desirudin or enoxaparin: insights from a randomized trial
    A F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Thromb Haemost 10:1515-20. 2012
    ..Venous thromboembolism (VTE) remains a significant complication of major orthopedic surgery, and chronic kidney disease (CKD) is common among elderly patients undergoing total hip replacement (THR)...
  56. doi Evaluating the role for the optical density in the diagnosis of heparin-induced thrombocytopenia following cardiac surgery
    C M Chan
    Washington Hospital Center, Washington, DC 20010, USA
    Thromb Haemost 106:934-8. 2011
    ..A relatively modest elevation in the OD measurement, when it is already known to be greater than 0.4, does not reliably exclude the potential for a positive SRA in this setting...
  57. ncbi D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease
    A F Shorr
    Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Intensive Care Med 25:207-10. 1999
    ..To determine if D-dimer predicts outcomes in critically ill patients...
  58. ncbi Invasive approaches to the diagnosis of ventilator-associated pneumonia: a meta-analysis
    Andrew F Shorr
    Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 33:46-53. 2005
    ..g., bronchoscopy) remains unclear. We hypothesized that invasive testing would alter antibiotic management in patients with ventilator-associated pneumonia but would not necessarily alter mortality...
  59. ncbi Practical utility of clinical prediction rules for suspected acute pulmonary embolism in a large academic institution
    Lisa K Moores
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Building 2, WD 77, 6900 Georgia Avenue NW, Washington, DC 20307 5001, USA
    Thromb Res 113:1-6. 2004
    ..We sought to determine the utility of these algorithms in patients with suspected PE in a large, tertiary, academic medical center...
  60. ncbi Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 32:137-43. 2004
    ..To determine the incremental cost-effectiveness of linezolid compared with vancomycin for treatment of ventilator-associated pneumonia due to Staphylococcus aureus...
  61. ncbi Mechanical ventilation in hematopoietic stem cell transplantation: can We effectively predict outcomes?
    A F Shorr
    Division of Pulmonary and Critical Care Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 116:1012-8. 1999
    ....
  62. ncbi The yield of lumbar puncture to exclude nosocomial meningitis as aetiology for mental status changes in the medical intensive care unit
    W L Jackson
    Critical Care Medicine Service, Department of Surgery and the Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    Anaesth Intensive Care 34:21-4. 2006
    ..These findings should not be generalized to patients who have sustained head trauma, have undergone neurosurgical procedures, or may be immunosuppressed...
  63. ncbi Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use
    Stanley A Nasraway
    Division of Surgical Critical Care, Department of Surgery, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Clin Infect Dis 37:1609-16. 2003
    ..Clinically significant thrombocytopenia was uncommon in our analysis, and linezolid was not associated with a greater risk of thrombocytopenia in seriously ill patients than was vancomycin...
  64. doi Epidemiology of healthcare-associated pneumonia (HCAP)
    Marya D Zilberberg
    Department of Health Policy and Management, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts 01032, USA
    Semin Respir Crit Care Med 30:10-5. 2009
    ..More precise instruments are needed to heighten clinicians' index of suspicion for treating probable resistant pathogens with appropriate empirical antibiotic choices...
  65. ncbi Red blood cell transfusion and ventilator-associated pneumonia: A potential link?
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 32:666-74. 2004
    ..To determine the relationship between packed red blood cell transfusion practice and the development of ventilator-associated pneumonia (VAP)...
  66. doi Antimicrobial therapy escalation and hospital mortality among patients with health-care-associated pneumonia: a single-center experience
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
    Chest 134:963-8. 2008
    ..Initial inappropriate treatment has been shown to increase hospital mortality. It is not known whether escalation in response to culture results mitigates this risk...
  67. doi Association between a silver-coated endotracheal tube and reduced mortality in patients with ventilator-associated pneumonia
    Bekele Afessa
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905 0001, USA
    Chest 137:1015-21. 2010
    ..A silver-coated endotracheal tube (ETT) reduced the incidence of ventilator-associated pneumonia (VAP) compared with an uncoated ETT in the North American Silver-Coated Endotracheal Tube (NASCENT) study...
  68. doi Resistant pathogens in nonnosocomial pneumonia and respiratory failure: is it time to refine the definition of health-care-associated pneumonia?
    Matthew P Schreiber
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Chest 137:1283-8. 2010
    ..The concept of health-care-associated pneumonia (HCAP) exists to identify patients infected with highly resistant pathogens. It is unclear how precise this concept is and how well it performs as a screening tool for resistance...
  69. ncbi Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:2588-95. 2006
    ..To gain a better understanding of the epidemiology, microbiology, and outcomes of early-onset, culture-positive, community-acquired, healthcare-associated, and hospital-acquired bloodstream infections...
  70. ncbi Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:700-6. 2006
    ....
  71. ncbi Acute respiratory distress syndrome after kidney transplantation: epidemiology, risk factors, and outcomes
    A F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center Washington, DC, USA
    Crit Care Med 31:1325-30. 2003
    ....
  72. doi The validation and reproducibility of the pulmonary embolism severity index
    C M Chan
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Thromb Haemost 8:1509-14. 2010
    ..Rapid, accurate risk stratification is paramount in managing patients with acute pulmonary embolism (PE). The PE Severity Index (PESI) is a simple tool that risk stratifies patients with acute PE...
  73. ncbi Enoxaparin for thromboprophylaxis after major trauma: potential cost implications
    A F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Crit Care Med 29:1659-65. 2001
    ..Further studies are warranted to confirm the efficacy of enoxaparin...
  74. doi Prolonged acute mechanical ventilation: implications for hospital benchmarking
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Goshen, MA 01032, USA
    Chest 135:1157-62. 2009
    ....
  75. ncbi Outcomes for patients with sarcoidosis awaiting lung transplantation
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Chest 122:233-8. 2002
    ....
  76. doi Acute kidney injury and cardiovascular outcomes in acute severe hypertension
    Lynda A Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Circulation 121:2183-91. 2010
    ....
  77. doi Epidemiology and outcomes of clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Goshen, MA 01032, USA
    Chest 136:752-8. 2009
    ..We examined the rates and outcomes of CDAD among adult PAMV patients...
  78. doi Epidemiology and outcomes of hospitalizations with complicated skin and skin-structure infections: implications of healthcare-associated infection risk factors
    Marya D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA
    Infect Control Hosp Epidemiol 30:1203-10. 2009
    ..Because prompt appropriate treatment is associated with better outcomes, we studied the epidemiology of healthcare-associated complicated skin and skin-structure infections (cSSSIs)...
  79. ncbi Ventilator-associated pneumonia: insights from recent clinical trials
    Andrew F Shorr
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA
    Chest 128:583S-591S. 2005
    ..This review highlights selected areas of new clinical research on VAP treatment and prevention in order to place their significance in context...
  80. doi Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia
    Andrew F Shorr
    Washington Hospital Center, DC 20010, USA
    Infect Control Hosp Epidemiol 30:759-63. 2009
    ..To conduct a cost-effectiveness analysis of the economic outcomes of ventilator-associated pneumonia (VAP) prevention associated with silver-coated endotracheal tubes versus uncoated endotracheal tubes...
  81. doi Postdischarge oral versus injectable anticoagulation following major orthopedic surgery
    Andrew F Shorr
    Pulmonary and Critical Care, Washington Hospital Center, Georgetown University, Washington, DC 34685, USA
    Ann Pharmacother 42:1222-8. 2008
    ..Multiple clinical studies have shown postdischarge anticoagulation to be beneficial following major orthopedic surgery (MOS); however, outpatient prophylaxis is not widely practiced...
  82. doi Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit
    Andrew F Shorr
    Department of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington DC, USA
    Crit Care Med 37:1463-9. 2009
    ..To review studies addressing mortality, length of stay (LOS), and cost of resistant Gram-negative bacterial infections in the intensive care unit (ICU)...
  83. ncbi Epidemiology of staphylococcal resistance
    Andrew F Shorr
    Pulmonary and Critical Care Medicine and Pulmonary Clinic, Washington Hospital Center, Washington, DC 20010, USA
    Clin Infect Dis 45:S171-6. 2007
    ..Improvements in the preparation and dissemination of antibiograms, along with adequate public reporting of MRSA trends, are needed to address the challenge of choosing appropriate initial antibiotic treatment for MRSA infections...
  84. ncbi Epidemiology and economic impact of meticillin-resistant Staphylococcus aureus: review and analysis of the literature
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Pharmacoeconomics 25:751-68. 2007
    ..Current opinion favours rational prescribing to maximise therapeutic benefit and minimise the risk of further antibacterial resistance...
  85. ncbi Linezolid versus vancomycin for Staphylococcus aureus bacteraemia: pooled analysis of randomized studies
    Andrew F Shorr
    Pulmonary, Critical Care and Respiratory Services, Washington Hospital Center, 110 Irving Street NW, Room 2A38 D, Washington, DC 20010, USA
    J Antimicrob Chemother 56:923-9. 2005
    ..To compare outcomes in patients with Staphylococcus aureus bacteraemia treated with linezolid with those of vancomycin-treated patients...
  86. ncbi Cost-minimization analysis of two algorithms for diagnosing acute pulmonary embolism
    Christopher W Humphreys
    Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Thromb Res 113:275-82. 2004
    ..We hypothesized that an algorithmic approach to diagnosis of pulmonary embolism based upon clinical risk stratification and D-dimer testing would be less costly than a standard approach...
  87. doi Understanding cost-effectiveness
    M D Zilberberg
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
    Clin Microbiol Infect 16:1707-12. 2010
    ..This article provides a primer for understanding the methods and applications of cost-effectiveness and cost-utility analyses...
  88. ncbi The quick and the dead: the importance of rapid evaluation of infiltrates in the immunocompromised patient
    Andrew F Shorr
    Chest 122:9-12. 2002
  89. ncbi Resistance in the intensive care unit: whose problem is it and how can intensivists help?
    Andrew F Shorr
    Crit Care Med 35:299-301. 2007
  90. doi Not everything that can be counted counts
    Lee E Morrow
    Chest 133:336-7. 2008
  91. ncbi Is the implementation of research findings in the critically ill hampered by the lack of universal definitions of illness?
    Shannon S Carson
    Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7020, USA
    Curr Opin Crit Care 9:308-15. 2003
    ..More specific identifiers of critical illnesses using specific biochemical or genetic markers are being explored. This approach may also be useful for staging disease...
  92. pmc The protein C pathway: implications for the design of the RESPOND study
    Burkhard Vangerow
    Eli Lilly Critical Care Europe, Air Center, 1214 Vernier Geneva, Switzerland
    Crit Care 11:S4. 2007
    ....
  93. ncbi Dollars and sense in the intensive care unit: the costs of ventilator-associated pneumonia
    Andrew F Shorr
    Crit Care Med 31:1582-3. 2003
  94. doi There is no "cap" on the importance of community-acquired pneumonia in the ICU
    Andrew F Shorr
    Chest 133:590-2. 2008
  95. ncbi Making the wrong choice: Consequences for patients with infections due to methicillin-resistant Staphylococcus aureus
    Andrew F Shorr
    Crit Care Med 34:2239-41. 2006
  96. doi The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia
    Francois Lauzier
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 23:50-7. 2008
    ..The aim of the study was to assess the utility of pretest probability and modified clinical pulmonary infection score CPIS in the diagnosis of late-onset ventilator-associated pneumonia (VAP)...
  97. ncbi Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis
    Christopher J Lettieri
    Walter Reed Army Medical Center, Department of Pulmonary and Critical Care, 6900 Georgia Avenue NW, Washington, DC 20307, USA
    Chest 129:746-52. 2006
    ..We sought to characterize the prevalence of PAH and its impact on survival in patients with advanced IPF...
  98. doi Health care-associated pneumonia: identification and initial management in the ED
    Fredrick M Abrahamian
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Emerg Med 26:1-11. 2008
    ..The aim of this article is to create awareness of the entity known as HCAP and to provide knowledge of its identification and initial management in the emergency department...
  99. ncbi Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital, AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, Paris, France
    Crit Care Med 33:341-8. 2005
    ..To determine whether changes in coagulation biomarkers during the first day of severe sepsis correlate with progression from single to multiple organ failure and subsequent death...
  100. ncbi Transfusion practice in the ICU: when will we apply the evidence?
    Andrew F Shorr
    Chest 127:702-5. 2005
  101. ncbi Interferon gamma-1b as therapy for idiopathic pulmonary fibrosis. An intrapatient analysis
    Steven D Nathan
    Inova Transplant Center, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Respiration 71:77-82. 2004
    ..We report our results using this medication in a cohort of patients with a wide range of severity of IPF...