Leonard Rybak

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. pmc Cisplatin ototoxicity and protection: clinical and experimental studies
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, IL, USA
    Tohoku J Exp Med 219:177-86. 2009
  2. ncbi request reprint Ototoxicity: bioprotective mechanisms
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, Springfield 62794 9653, USA
    Curr Opin Otolaryngol Head Neck Surg 11:328-33. 2003
  3. ncbi request reprint Ototoxicity: therapeutic opportunities
    Leonard P Rybak
    Department of Surgery, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Drug Discov Today 10:1313-21. 2005
  4. ncbi request reprint Neurochemistry of the peripheral and central auditory system after ototoxic drug exposure: implications for tinnitus
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University School of Medicine, PO Box 19653, Springfield, IL 62794 9653, USA
    Int Tinnitus J 11:23-30. 2005
  5. ncbi request reprint Mechanisms of cisplatin-induced ototoxicity and prevention
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Hear Res 226:157-67. 2007
  6. ncbi request reprint Ototoxicity
    L P Rybak
    Department of Surgery, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9653, USA
    Kidney Int 72:931-5. 2007
  7. ncbi request reprint Mechanisms of cisplatin ototoxicity and progress in otoprotection
    Leonard P Rybak
    Division of Otolaryngology, Department of Surgery, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9653, USA
    Curr Opin Otolaryngol Head Neck Surg 15:364-9. 2007
  8. ncbi request reprint Time response of carboplatin-induced hearing loss in rat
    K Husain
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Hear Res 191:110-8. 2004
  9. ncbi request reprint Expression and function of adenosine receptors in the chinchilla cochlea
    M S Ford
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794, USA
    Hear Res 105:130-40. 1997
  10. ncbi request reprint Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin
    D Mukherjea
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9626, USA
    Neuroscience 139:733-40. 2006

Research Grants

  1. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard P Rybak; Fiscal Year: 2010
  2. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard Rybak; Fiscal Year: 2009
  3. ENDOGENOUS MODULATION OF COCHLEA INJURY
    Leonard Rybak; Fiscal Year: 2006
  4. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard Rybak; Fiscal Year: 2003

Collaborators

Detail Information

Publications35

  1. pmc Cisplatin ototoxicity and protection: clinical and experimental studies
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, IL, USA
    Tohoku J Exp Med 219:177-86. 2009
    ..The future strategies for limiting cisplatin ototoxicity will need to avoid interference with the therapeutic effect of cisplatin in order to enhance the quality of life of patients receiving this important anti-tumor agent...
  2. ncbi request reprint Ototoxicity: bioprotective mechanisms
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, Springfield 62794 9653, USA
    Curr Opin Otolaryngol Head Neck Surg 11:328-33. 2003
    ..This review discusses current research dealing with novel approaches to the prevention of ototoxicity caused by cisplatin and aminoglycoside antibiotics...
  3. ncbi request reprint Ototoxicity: therapeutic opportunities
    Leonard P Rybak
    Department of Surgery, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Drug Discov Today 10:1313-21. 2005
    ..Challenges and opportunities exist for appropriate drug delivery to the inner ear and for avoiding interference with the therapeutic efficacy of both categories of ototoxic drugs...
  4. ncbi request reprint Neurochemistry of the peripheral and central auditory system after ototoxic drug exposure: implications for tinnitus
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University School of Medicine, PO Box 19653, Springfield, IL 62794 9653, USA
    Int Tinnitus J 11:23-30. 2005
    ..Protective agents may prevent tinnitus by preventing damage to the cochlea, thereby obviating the development of disinhibition within central auditory pathways...
  5. ncbi request reprint Mechanisms of cisplatin-induced ototoxicity and prevention
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Hear Res 226:157-67. 2007
    ..This review summarizes recent data that shed new light on the mechanisms of cisplatin ototoxicity and its prevention...
  6. ncbi request reprint Ototoxicity
    L P Rybak
    Department of Surgery, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9653, USA
    Kidney Int 72:931-5. 2007
    ..This would provide a maximal dose of protective agent without systemic interference with the desired effect of the ototoxic agent...
  7. ncbi request reprint Mechanisms of cisplatin ototoxicity and progress in otoprotection
    Leonard P Rybak
    Division of Otolaryngology, Department of Surgery, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9653, USA
    Curr Opin Otolaryngol Head Neck Surg 15:364-9. 2007
    ..Cisplatin ototoxicity is a frequent and serious problem in patients. Strategies to ameliorate ototoxicity without interfering with the desired therapeutic effects are urgently needed...
  8. ncbi request reprint Time response of carboplatin-induced hearing loss in rat
    K Husain
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Hear Res 191:110-8. 2004
    ..The data suggest that carboplatin-induced hearing loss involves oxidative injury to the cochlea of the rat in a time-dependent manner...
  9. ncbi request reprint Expression and function of adenosine receptors in the chinchilla cochlea
    M S Ford
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794, USA
    Hear Res 105:130-40. 1997
    ..These results suggest a potential cytoprotective role of adenosine in the cochlea against oxidative damage...
  10. ncbi request reprint Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin
    D Mukherjea
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9626, USA
    Neuroscience 139:733-40. 2006
    ..Taken together, these data identify kidney injury molecule-1 as a novel cochlear injury molecule, whose expression is regulated by reactive oxygen species generated via the NADPH oxidase pathway...
  11. ncbi request reprint Migration of cochlear lateral wall cells
    George Dunaway
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 10629, Springfield, IL 62794 9629, USA
    Hear Res 177:1-11. 2003
    ..These observations are consistent with the hypothesis that marginal cells were replaced by underlying cells. Cell migration appears to be an important mechanism for preserving the function and structure of the stria vascularis...
  12. ncbi request reprint Carboplatin-induced oxidative stress in rat cochlea
    K Husain
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, 62794 9629, USA
    Hear Res 159:14-22. 2001
    ..The data suggest that carboplatin induced free radical generation and antioxidant depletion, and caused oxidative injury in the cochleae of rats...
  13. ncbi request reprint D-Methionine protects against cisplatin damage to the stria vascularis
    K C Campbell
    SIU School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Hear Res 138:13-28. 1999
    ..Protection of marginal cell cytoplasmic organelles was also noted. In summary, D-met partially or fully protects the stria vascularis from several types of CDDP-induced damage...
  14. ncbi request reprint Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: antioxidant defense system
    S M Somani
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794 9629, USA
    Pharmacol Toxicol 86:234-41. 2000
    ....
  15. ncbi request reprint Dose response of carboplatin-induced hearing loss in rats: antioxidant defense system
    K Husain
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794 9629, USA
    Hear Res 151:71-78. 2001
    ..The data suggest that higher doses of carboplatin (above 128 mg/kg) induce hearing loss as evidenced by significant changes in ABRs, lipid peroxidation and antioxidants in the cochlea of rats...
  16. ncbi request reprint Carboplatin-induced oxidative injury in rat inferior colliculus
    Kazim Husain
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Int J Toxicol 22:335-42. 2003
    ..The data suggest that carboplatin induced oxidative injury specifically in the inferior colliculus of the rat leading to hearing loss...
  17. ncbi request reprint Organic acid transport into the cochlear perilymph
    L P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, Springfield 62708
    Arch Otorhinolaryngol 244:204-8. 1987
    ..Furthermore, these studies show that, contrary to previous suggestions, non-ototoxic compounds can achieve marked concentration gradients within the perilymph...
  18. ncbi request reprint Round window pH manipulation alters the ototoxicity of systemic cisplatin
    Fujinobu Tanaka
    Department of Surgery, Southern Illinois University School of Medicine, P O Box 19638, Springfield, IL 62794 9638, USA
    Hear Res 187:44-50. 2004
    ..05). It appears that changes in cochlear pH can modulate the ototoxic effects of systemically applied cisplatin...
  19. ncbi request reprint Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney
    Satyanarayan G Bhat
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62974 1222, USA
    Eur J Pharmacol 442:251-64. 2002
    ..These data indicate that cisplatin can regulate the adenosine A(1) receptor in the kidney and suggest a cytoprotective role of this receptor subtype against cisplatin-induced nephrotoxicity...
  20. ncbi request reprint Round window application of D-methionine provides complete cisplatin otoprotection
    Kurtis D Korver
    Division of Otolaryngology, Southern Illinois University, Springfield, USA
    Otolaryngol Head Neck Surg 126:683-9. 2002
    ..Cisplatin is a widely used, very effective chemotherapeutic agent that can cause severe ototoxicity. In this study, D-methionine was tested as an otoprotectant via round window membrane (RWM) application in the chinchilla...
  21. ncbi request reprint Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats
    Xinyan Huang
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9662, USA
    Otol Neurotol 28:828-33. 2007
    ..A standardized Ginkgo biloba extract, EGb 761, may have protective effect against cisplatin-induced ototoxicity in rats...
  22. ncbi request reprint Noise in animal facilities: why it matters
    Jeremy G Turner
    Department of Surgery Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA
    J Am Assoc Lab Anim Sci 46:10-3. 2007
    ..This special issue will highlight the need for more thorough monitoring and will serve as an introduction to noise and its various effects on animals...
  23. ncbi request reprint Dose response of carboplatin-induced nephrotoxicity in rats
    Kazim Husai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794 9638, USA
    Pharmacol Toxicol 91:83-9. 2002
    ..The data suggested that carboplatin caused dose-dependent oxidative renal injury, as evidenced by renal antioxidant depletion, enhanced lipid peroxidation, platinum content, plasma creatinine and blood urea nitrogen levels in rats...
  24. ncbi request reprint Influence of pH on the ototoxicity of cisplatin: a round window application study
    Fujinobu Tanaka
    Department of Surgery, Southern Illinois University School of Medicine, PO Box 19638, Springfield, IL 62794 9638, USA
    Hear Res 177:21-31. 2003
    ..0, pH 6.0 PBS was applied to round window membrane. This acidic PBS solution did not cause any hearing impairment. These results demonstrate that pH can modulate the ototoxic effects of cisplatin...
  25. ncbi request reprint Glutathione ester but not glutathione protects against cisplatin-induced ototoxicity in a rat model
    Kathleen C M Campbell
    Southern Illinois University School of Medicine, Springfield, IL, USA
    J Am Acad Audiol 14:124-33. 2003
    ..GSH was not significantly protective. The best GSH ester protection was less than we have previously reported with D-methionine...
  26. ncbi request reprint The effect of D-methionine on cochlear oxidative state with and without cisplatin administration: mechanisms of otoprotection
    Kathleen C M Campbell
    Southern Illinois University School of Medicine, Springfield, IL, USA
    J Am Acad Audiol 14:144-56. 2003
    ..The excellent correlation of enzyme levels with hearing loss and weight loss suggests that antioxidant enzyme level protection may underlie, at least in part, D-met's otoprotective action...
  27. ncbi request reprint Partial protection by lipoic acid against carboplantin-induced ototoxicity in rats
    Kazim Husain
    Department of Surgery, Southern Illinois University, School of Medicine, Springfield, IL 62794, USA
    Biomed Environ Sci 18:198-206. 2005
    ..To investigate the alterations in auditory brainstem evoked responses (ABRs) and the changes of carboplatin-induced ototoxicity in the cochlear oxidant/antioxidant systems and otoprotection by an antioxidant lipoate...
  28. ncbi request reprint Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-mediated apoptosis
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    J Biol Chem 279:43157-67. 2004
    ....
  29. ncbi request reprint Time response of carboplatin-induced nephrotoxicity in rats
    Kazim Husain
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA
    Pharmacol Res 50:291-300. 2004
    ..The data suggested that carboplatin caused time-dependent oxidative renal injury, as evidenced by renal anti-oxidant depletion, enhanced lipid peroxidation, platinum content, plasma creatinine BUN, and blood urea levels in rats...
  30. ncbi request reprint Aminoguanidine reduces cisplatin ototoxicity
    Thomas C Kelly
    Southern Illinois University School of Medicine, Department of Surgery, P O Box 19638, Springfield, IL 62794 9653, USA
    Hear Res 186:10-6. 2003
    ..The iNOS pathway may play a role in the generation of free radicals and hearing loss resulting from cisplatin administration, but this conclusion was not supported by our data...
  31. ncbi request reprint Vitamin E reduces cisplatin ototoxicity
    James G Kalkanis
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 19653, USA
    Laryngoscope 114:538-42. 2004
    ..The purpose of the study was to determine the effectiveness of vitamin E as an otoprotectant...
  32. ncbi request reprint Protection against cisplatin ototoxicity by adenosine agonists
    Craig A Whitworth
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794 9230, USA
    Biochem Pharmacol 67:1801-7. 2004
    ..Our findings are consistent with the notion that the A(1)AR contributes significantly to cytoprotection in the cochlea, and thereby protects against hearing loss...
  33. ncbi request reprint Noise induces A1 adenosine receptor expression in the chinchilla cochlea
    Vickram Ramkumar
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19620, Springfield, IL 62794 9620, USA
    Hear Res 188:47-56. 2004
    ..We conclude that noise exposure induces A1AR expression, which might be mediated, in part, through generation of reactive oxygen species and activation of NF-kappaB...
  34. ncbi request reprint Activation of the adenosine A3 receptor in RAW 264.7 cells inhibits lipopolysaccharide-stimulated tumor necrosis factor-alpha release by reducing calcium-dependent activation of nuclear factor-kappaB and extracellular signal-regulated kinase 1/2
    Lynn Martin
    Dept of Pharmacology, Southern Illinois University School of Medicine, P O Box 19230, Springfield, IL 62794 1222, USA
    J Pharmacol Exp Ther 316:71-8. 2006
    ....
  35. ncbi request reprint Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Mol Pharmacol 72:856-67. 2007
    ..Taken together, our results demonstrate that the A(1)AR protects against HIV-1 toxicity by inhibiting NF-kappaB, thereby reducing the expression of iNOS and NO radicals and neuronal apoptosis...

Research Grants16

  1. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard P Rybak; Fiscal Year: 2010
    ..Cisplatin causes hearing loss in a large percentage of cancer patients who receive this drug to cure their cancer. ..
  2. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard Rybak; Fiscal Year: 2009
    ..Cisplatin causes hearing loss in a large percentage of cancer patients who receive this drug to cure their cancer. ..
  3. ENDOGENOUS MODULATION OF COCHLEA INJURY
    Leonard Rybak; Fiscal Year: 2006
    ..The results of these experiments should provide novel insights into the mechanisms of cisplatin-induced ototoxicity and new methods for chemoprevention. ..
  4. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard Rybak; Fiscal Year: 2003
    ..These studies should provide new insights into the mechanisms of cisplatin ototoxicity and mechanisms for protection from this dose-limiting side effect arising from use of this life-saving chemotherapeutic agent. ..