Debashree Mukherjea

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. doi request reprint Early investigational drugs for hearing loss
    Debashree Mukherjea
    Southern Illinois University School of Medicine, Department of Surgery, P O Box 19629, Springfield, IL 62794 9629, USA
    Expert Opin Investig Drugs 24:201-17. 2015
  2. pmc Pharmacogenomics of cisplatin-induced ototoxicity
    Debashree Mukherjea
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL, USA
    Pharmacogenomics 12:1039-50. 2011
  3. pmc Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9649, USA
    Antioxid Redox Signal 13:589-98. 2010
  4. ncbi request reprint Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Mol Pharmacol 72:856-67. 2007
  5. pmc Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Departments of Pharmacology and Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci 28:13056-65. 2008
  6. pmc NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss
    Debashree Mukherjea
    Department of Pharmacology, SIU School of Medicine, Springfield, Illinois 62794 9629, USA
    Antioxid Redox Signal 14:999-1010. 2011
  7. pmc Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery
    Sarvesh Jajoo
    PO Box 19629, SIU School of Medicine, Springfield, IL 62794, USA
    Am J Physiol Cell Physiol 298:C56-65. 2010
  8. pmc Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway
    Sandeep Sheth
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e51655. 2012
  9. pmc Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity
    Sarvesh Jajoo
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Neoplasia 11:1132-45. 2009
  10. doi request reprint siRNA-mediated knock-down of NOX3: therapy for hearing loss?
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL 62794 9649, USA
    Cell Mol Life Sci 69:2429-34. 2012

Collaborators

Detail Information

Publications18

  1. doi request reprint Early investigational drugs for hearing loss
    Debashree Mukherjea
    Southern Illinois University School of Medicine, Department of Surgery, P O Box 19629, Springfield, IL 62794 9629, USA
    Expert Opin Investig Drugs 24:201-17. 2015
    ..There are several different causes of sensorineural HL included in this review of new investigational drugs for HL. They are noise-induced, drug-induced, sudden sensorineural HL, presbycusis and HL due to cytomegalovirus infections...
  2. pmc Pharmacogenomics of cisplatin-induced ototoxicity
    Debashree Mukherjea
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL, USA
    Pharmacogenomics 12:1039-50. 2011
    ..This article addresses recent progress in clarifying the incidence of cisplatin ototoxicity and the risk factors and controversies regarding the identification of genetic variants associated with cisplatin-induced hearing loss...
  3. pmc Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9649, USA
    Antioxid Redox Signal 13:589-98. 2010
    ..This appears to be the first study of the efficacy of transtympanic delivery of siRNA attenuating cisplatin ototoxicity...
  4. ncbi request reprint Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Mol Pharmacol 72:856-67. 2007
    ..Taken together, our results demonstrate that the A(1)AR protects against HIV-1 toxicity by inhibiting NF-kappaB, thereby reducing the expression of iNOS and NO radicals and neuronal apoptosis...
  5. pmc Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Departments of Pharmacology and Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci 28:13056-65. 2008
    ..These data provide a link between NOX3 and TRPV1 in cisplatin-induced hearing loss and suggest that targeting these proteins for knockdown by siRNA could serve as a novel approach in treating cisplatin ototoxicity...
  6. pmc NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss
    Debashree Mukherjea
    Department of Pharmacology, SIU School of Medicine, Springfield, Illinois 62794 9629, USA
    Antioxid Redox Signal 14:999-1010. 2011
    ..Thus, these proteins represent reasonable targets for ameliorating hearing loss...
  7. pmc Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery
    Sarvesh Jajoo
    PO Box 19629, SIU School of Medicine, Springfield, IL 62794, USA
    Am J Physiol Cell Physiol 298:C56-65. 2010
    ..We propose that such a pathway ensures both the termination of the agonist signal and recovery by priming the cell for rapid de novo synthesis of A(1)AR once the drug is terminated...
  8. pmc Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway
    Sandeep Sheth
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e51655. 2012
    ..These data suggest that resveratrol's anti-tumor actions in prostate cancer could be explained, in part, through inhibition of Akt/miR-21 signaling pathway...
  9. pmc Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity
    Sarvesh Jajoo
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Neoplasia 11:1132-45. 2009
    ..We conclude that activation of the A(3)AR in prostate cancer cells reduces protein kinase A-mediated stimulation of ERK1/2, leading to reduced NADPH oxidase activity and cancer cell invasiveness...
  10. doi request reprint siRNA-mediated knock-down of NOX3: therapy for hearing loss?
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL 62794 9649, USA
    Cell Mol Life Sci 69:2429-34. 2012
    ..In this paper, we review recent publications dealing with the role of NOX3 in ototoxicity and the effects of siRNA against cisplatin-induced hearing loss...
  11. pmc Essential role of NADPH oxidase-dependent reactive oxygen species generation in regulating microRNA-21 expression and function in prostate cancer
    Sarvesh Jajoo
    1 Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois
    Antioxid Redox Signal 19:1863-76. 2013
    ....
  12. pmc The design and screening of drugs to prevent acquired sensorineural hearing loss
    Debashree Mukherjea
    Southern Illinois University, School of Medicine, Department of Surgery, P O Box 19653, Springfield, IL 62794 9653, USA
    Expert Opin Drug Discov 6:491-505. 2011
    ....
  13. pmc Cisplatin ototoxicity and protection: clinical and experimental studies
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, IL, USA
    Tohoku J Exp Med 219:177-86. 2009
    ..The future strategies for limiting cisplatin ototoxicity will need to avoid interference with the therapeutic effect of cisplatin in order to enhance the quality of life of patients receiving this important anti-tumor agent...
  14. ncbi request reprint Mechanisms of cisplatin-induced ototoxicity and prevention
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Hear Res 226:157-67. 2007
    ..This review summarizes recent data that shed new light on the mechanisms of cisplatin ototoxicity and its prevention...
  15. ncbi request reprint Induction of adenosine A1 receptor expression by pertussis toxin via an adenosine 5'-diphosphate ribosylation-independent pathway
    Sarvesh Jajoo
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Pharmacol Exp Ther 317:1-10. 2006
    ..We conclude that pertussis toxin promotes de novo A(1)AR synthesis by activating NF-kappaB through an ADP ribosylation-independent mechanism involving intracellular Ca(2+) release and PKC activation...
  16. pmc Adenosine receptors: expression, function and regulation
    Sandeep Sheth
    Department of Pharmacology and Neuroscience, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Int J Mol Sci 15:2024-52. 2014
    ..In addition, the importance of these receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined. ..
  17. pmc Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast
    Miao Chang
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Biol Reprod 78:841-51. 2008
    ....
  18. ncbi request reprint Essential role of Rac1/NADPH oxidase in nerve growth factor induction of TRPV1 expression
    Preeti Puntambekar
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurochem 95:1689-703. 2005
    ..We conclude that the Rac1/NADPH oxidase pathway regulates p38 activation and TRPV1 expression which aids in the maintenance of peripheral neuron integrity and pain perception...