Debashree Mukherjea

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi Pharmacogenomics of cisplatin-induced ototoxicity
    Debashree Mukherjea
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL, USA
    Pharmacogenomics 12:1039-50. 2011
  2. ncbi NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss
    Debashree Mukherjea
    Department of Pharmacology, SIU School of Medicine, Springfield, Illinois 62794 9629, USA
    Antioxid Redox Signal 14:999-1010. 2011
  3. ncbi Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9649, USA
    Antioxid Redox Signal 13:589-98. 2010
  4. ncbi siRNA-mediated knock-down of NOX3: therapy for hearing loss?
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL 62794 9649, USA
    Cell Mol Life Sci 69:2429-34. 2012
  5. ncbi Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Departments of Pharmacology and Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci 28:13056-65. 2008
  6. ncbi Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery
    Sarvesh Jajoo
    PO Box 19629, SIU School of Medicine, Springfield, IL 62794, USA
    Am J Physiol Cell Physiol 298:C56-65. 2010
  7. ncbi Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity
    Sarvesh Jajoo
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Neoplasia 11:1132-45. 2009
  8. ncbi The design and screening of drugs to prevent acquired sensorineural hearing loss
    Debashree Mukherjea
    Southern Illinois University, School of Medicine, Department of Surgery, P O Box 19653, Springfield, IL 62794 9653, USA
    Expert Opin Drug Discov 6:491-505. 2011
  9. ncbi Cisplatin ototoxicity and protection: clinical and experimental studies
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, IL, USA
    Tohoku J Exp Med 219:177-86. 2009
  10. ncbi Mechanisms of cisplatin-induced ototoxicity and prevention
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Hear Res 226:157-67. 2007

Collaborators

  • Vickram Ramkumar
  • Leonard P Rybak
  • Jeremy G Turner
  • Ronald J Torry
  • Sarvesh Jajoo
  • Miao Chang
  • Sandeep C Pingle
  • Preeti Puntambekar
  • Tejbeer Kaur
  • Sandeep Sheth
  • Sunny Kumar
  • Kounosuke Watabe
  • Kathleen A Groesch
  • Ryan M Gobble
  • Donald S Torry
  • Lynn F Sniderhan
  • Sanjay B Maggirwar
  • Adriana Marcuzzi
  • Krishna A Jhaveri
  • Yuko Sekino
  • Sandeep Pingle

Detail Information

Publications14

  1. ncbi Pharmacogenomics of cisplatin-induced ototoxicity
    Debashree Mukherjea
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL, USA
    Pharmacogenomics 12:1039-50. 2011
    ..This article addresses recent progress in clarifying the incidence of cisplatin ototoxicity and the risk factors and controversies regarding the identification of genetic variants associated with cisplatin-induced hearing loss...
  2. ncbi NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss
    Debashree Mukherjea
    Department of Pharmacology, SIU School of Medicine, Springfield, Illinois 62794 9629, USA
    Antioxid Redox Signal 14:999-1010. 2011
    ..Thus, these proteins represent reasonable targets for ameliorating hearing loss...
  3. ncbi Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9649, USA
    Antioxid Redox Signal 13:589-98. 2010
    ..This appears to be the first study of the efficacy of transtympanic delivery of siRNA attenuating cisplatin ototoxicity...
  4. ncbi siRNA-mediated knock-down of NOX3: therapy for hearing loss?
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL 62794 9649, USA
    Cell Mol Life Sci 69:2429-34. 2012
    ..In this paper, we review recent publications dealing with the role of NOX3 in ototoxicity and the effects of siRNA against cisplatin-induced hearing loss...
  5. ncbi Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
    Debashree Mukherjea
    Departments of Pharmacology and Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci 28:13056-65. 2008
    ..These data provide a link between NOX3 and TRPV1 in cisplatin-induced hearing loss and suggest that targeting these proteins for knockdown by siRNA could serve as a novel approach in treating cisplatin ototoxicity...
  6. ncbi Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery
    Sarvesh Jajoo
    PO Box 19629, SIU School of Medicine, Springfield, IL 62794, USA
    Am J Physiol Cell Physiol 298:C56-65. 2010
    ..We propose that such a pathway ensures both the termination of the agonist signal and recovery by priming the cell for rapid de novo synthesis of A(1)AR once the drug is terminated...
  7. ncbi Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity
    Sarvesh Jajoo
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Neoplasia 11:1132-45. 2009
    ..We conclude that activation of the A(3)AR in prostate cancer cells reduces protein kinase A-mediated stimulation of ERK1/2, leading to reduced NADPH oxidase activity and cancer cell invasiveness...
  8. ncbi The design and screening of drugs to prevent acquired sensorineural hearing loss
    Debashree Mukherjea
    Southern Illinois University, School of Medicine, Department of Surgery, P O Box 19653, Springfield, IL 62794 9653, USA
    Expert Opin Drug Discov 6:491-505. 2011
    ....
  9. ncbi Cisplatin ototoxicity and protection: clinical and experimental studies
    Leonard P Rybak
    Department of Surgery, Southern Illinois University School of Medicine, IL, USA
    Tohoku J Exp Med 219:177-86. 2009
    ..The future strategies for limiting cisplatin ototoxicity will need to avoid interference with the therapeutic effect of cisplatin in order to enhance the quality of life of patients receiving this important anti-tumor agent...
  10. ncbi Mechanisms of cisplatin-induced ototoxicity and prevention
    Leonard P Rybak
    Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, P O Box 19653, Springfield, IL 62794 9653, USA
    Hear Res 226:157-67. 2007
    ..This review summarizes recent data that shed new light on the mechanisms of cisplatin ototoxicity and its prevention...
  11. ncbi Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase
    Sandeep C Pingle
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Mol Pharmacol 72:856-67. 2007
    ..Taken together, our results demonstrate that the A(1)AR protects against HIV-1 toxicity by inhibiting NF-kappaB, thereby reducing the expression of iNOS and NO radicals and neuronal apoptosis...
  12. ncbi Essential role of Rac1/NADPH oxidase in nerve growth factor induction of TRPV1 expression
    Preeti Puntambekar
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurochem 95:1689-703. 2005
    ..We conclude that the Rac1/NADPH oxidase pathway regulates p38 activation and TRPV1 expression which aids in the maintenance of peripheral neuron integrity and pain perception...
  13. ncbi Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast
    Miao Chang
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Biol Reprod 78:841-51. 2008
    ....
  14. ncbi Induction of adenosine A1 receptor expression by pertussis toxin via an adenosine 5'-diphosphate ribosylation-independent pathway
    Sarvesh Jajoo
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9629, USA
    J Pharmacol Exp Ther 317:1-10. 2006
    ..We conclude that pertussis toxin promotes de novo A(1)AR synthesis by activating NF-kappaB through an ADP ribosylation-independent mechanism involving intracellular Ca(2+) release and PKC activation...