Research Topics
Genomes and Genes
| Yin Yuan MoSummaryAffiliation: Southern Illinois University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Targeting Ubc9 for cancer therapyYin Yuan Mo
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, PO Box 19626, Springfield, IL 62794, USA
Expert Opin Ther Targets 9:1203-16. 2005....- Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugsYin Yuan Mo
Department of Biopharmaceutical Sciences, and the Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA
Cancer Res 64:2793-8. 2004..Together, our results suggest a role for Ubc9 in tumor drug responsiveness... - A role for Ubc9 in tumorigenesisYin Yuan Mo
Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
Oncogene 24:2677-83. 2005..Together, these results suggest a role for Ubc9 in tumorigenesis at least partially through regulation of bcl-2 expression... - Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the proteinYin Yuan Mo
Department of Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
J Biol Chem 277:2958-64. 2002..Taken together, our results suggest that sumoylation of topo I might serve as an addressing tag for its nucleolar delocalization in response to topo I inhibitors... 
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthasePuspa R Pandey
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N Rutledge St, PO Box 19626, Springfield, IL 62794 9626, USA
Breast Cancer Res Treat 130:387-98. 2011....- N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasisWen Liu
Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL, USA
EMBO Mol Med 4:93-108. 2012..Collectively, we have identified NDRG1 as a novel negative master regulator of Wnt signalling during the metastatic progression, which opens an opportunity to define a potential therapeutic target for metastatic disease... 
MicroRNA-21 targets tumor suppressor genes in invasion and metastasisShuomin Zhu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
Cell Res 18:350-9. 2008..Therefore, suppression of mir-21 may provide a novel approach for the treatment of advanced cancers...- MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)Shuomin Zhu
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
J Biol Chem 282:14328-36. 2007..Thus, down-regulation of TPM1 by mir-21 may explain, at least in part, why suppression of mir-21 can inhibit tumor growth, further supporting the notion that mir-21 functions as an oncogene... - MicroRNA-mediated regulation of Ubc9 expression in cancer cellsFangting Wu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
Clin Cancer Res 15:1550-7. 2009..The aim of this study was to investigate the regulation of Ubc9 in cancer cells... - MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1Mohit Sachdeva
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
Cancer Res 70:378-87. 2010..Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis... - Targeting miR-205 in breast cancerHailong Wu
Southern Illinois University School of Medicine, Department of Medical Microbiology, Immunology and Cell Biology, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
Expert Opin Ther Targets 13:1439-48. 2009..These findings establish the tumor suppressive role of miR-205, which is probably through direct targeting of oncogenes such as ErbB3 and Zeb1. Therefore, miR-205 may serve as a unique therapeutic target for breast cancer... - Regulation of bcl-2 expression by Ubc9Zhaohui Lu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
Exp Cell Res 312:1865-75. 2006..Together, these results suggest that Ubc9 might regulate bcl-2 expression through the ER signaling pathway, which ultimately contributes to the alterations of drug responsiveness and tumor growth... - Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1Eiji Furuta
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
Cancer Res 68:1003-11. 2008.... - miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4Hiroshi Okuda
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
Cancer Res 73:1434-44. 2013..These results suggest that miR-7 and KLF4 may serve as biomarkers or therapeutic targets for brain metastasis of breast cancer... - Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brainFei Xing
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
EMBO Mol Med 5:384-96. 2013.... - Suppression of cell growth and invasion by miR-205 in breast cancerHailong Wu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
Cell Res 19:439-48. 2009..Together, these results suggest that miR-205 is a tumor suppressor in breast cancer... - Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathwayWen Liu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794 9626, USA
Breast Cancer Res Treat 128:57-68. 2011.... - SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4Jianmei W Leavenworth
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
J Immunol 183:1110-9. 2009..D2 mice, suggesting that increased c-Maf sumoylation contributes to immune deviation in T1D by reducing c-Maf access to and transactivation of the IL-4 gene... - c-Maf increases apoptosis in peripheral CD8 cells by transactivating Caspase 6Siying Peng
Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, 62794, USA
Immunology 127:267-78. 2009..Together these results indicated that c-Maf increases CD8 cell sensitivity to apoptotic stimuli, at least in part, by direct transactivation of Caspase 6, providing increased substrate for Caspase 6-dependent apoptosis pathways... - The human long non-coding RNA-RoR is a p53 repressor in response to DNA damageAli Zhang
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794 9621, USA
Cell Res 23:340-50. 2013..Together, these results suggest that the RoR-hnRNP I-p53 axis may constitute an additional surveillance network for the cell to better respond to various stresses... - Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cellsMohit Sachdeva
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Nucleic Acids Res 40:6683-92. 2012..Together, these results suggest a miR-145 regulatory system involving the Akt and C/EBP-β, which may contribute to the downregulation of miR-145 in cancer cells... - Ubiquitin-like protein modifications in prostate and breast cancerFangting Wu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, Springfield, IL 62794, USA
Front Biosci 12:700-11. 2007.... - Gam1-associated alterations of drug responsiveness through activation of apoptosisFangting Wu
Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Mol Cancer Ther 6:1823-30. 2007.... - Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsivenessCheng Fen Chen
Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
Mol Pharmacol 79:735-41. 2011..Ours is the first study to show that miR-485-3p mediates Top2α down-regulation in part by altered regulation of NF-YB... - Notch signaling and its role in breast cancerFangting Wu
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Front Biosci 12:4370-83. 2007..We will also highlight the therapeutic potential of targeting Notch for cancer treatment... - Systematic validation of predicted microRNAs for cyclin D1Qiong Jiang
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
BMC Cancer 9:194. 2009..However, only a relatively small number of these predicted microRNA/mRNA interactions are experimentally validated, and no systematic validation has been carried out using a reporter system... - Expression of a novel marker, Ubc9, in squamous cell carcinoma of the head and neckOhad Ronen
Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA
Head Neck 31:845-55. 2009..The objective of this study was to determine the expression of Ubc9 in squamous cell carcinoma of the head and neck (SCCHN)... - Stroma-mediated expression of estrogen and its role in cancerMohit Sachdeva
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine and Simmons Cooper Cancer Institute, Springfield, IL 62794, USA
Front Biosci 15:237-48. 2010..We also briefly touch on hormone therapy involving selective estrogen receptor modulators and aromatase inhibitors... - Detection of microRNAs in cultured cells and paraffin-embedded tissue specimens by in situ hybridizationAshim Gupta
Immunology and Cell Biology, Department of Medical Microbiology, School of Medicine, Southern Illinois University, Springfield, IL, USA
Methods Mol Biol 676:73-83. 2011..We have successfully used ISH to detect several microRNAs in paraffin-embedded tumor specimens or cells-cultured in vitro... - miR-145-mediated suppression of cell growth, invasion and metastasisMohit Sachdeva
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine Springfield, IL, USA
Am J Transl Res 2:170-80. 2010..This unique feature of miR-145-mediaed gene silencing may suggest that miR-145 is a potential cancer biomarker and serves as a novel target for cancer therapy... - p53 represses c-Myc through induction of the tumor suppressor miR-145Mohit Sachdeva
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Proc Natl Acad Sci U S A 106:3207-12. 2009.... - Role of SUMO/Ubc9 in DNA damage repair and tumorigenesisStergios J Moschos
Department of Medicine, Division of Hematology-Oncology, Hillman Cancer Research Pavilion, University of Pittsburgh Medical Center, 5117 Centre Avenue, Suite 1.32e, Pittsburgh, PA 15213, USA
J Mol Histol 37:309-19. 2006..This review summarizes the most important DNA damage repair pathways which are potentially affected by Ubc9/SUMO and their role in regulating the function of several proteins involved in the DNA damage repair machinery... - Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecinPrasad Rallabhandi
Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
J Biol Chem 277:40020-6. 2002.... - Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cellsShelagh E L Mirski
Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, ON, Canada K7L 3N6
Exp Cell Res 313:627-37. 2007..We conclude that topo II alpha and beta nuclear export is inhibited in proliferating cells so that these proteins do not shuttle... - Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosisPenny A Tavormina
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Cell Biol 158:23-9. 2002..Rapid mobility of topoII alpha in chromosomes may be essential to resolve strain imparted during chromosome condensation and segregation...
Research Grants
- Ubc9 as a novel target for cancer therapyYin Yuan Mo; Fiscal Year: 2006..As a result, we will be able to develop valuable Ubc9-based anticancer agents ..