Yin Yuan Mo

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. pmc Suppression of cell growth and invasion by miR-205 in breast cancer
    Hailong Wu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Cell Res 19:439-48. 2009
  2. pmc Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner
    S Zhu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Oncogene 29:1763-72. 2010
  3. ncbi Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs
    Yin Yuan Mo
    Department of Biopharmaceutical Sciences, and the Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA
    Cancer Res 64:2793-8. 2004
  4. ncbi A role for Ubc9 in tumorigenesis
    Yin Yuan Mo
    Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Oncogene 24:2677-83. 2005
  5. ncbi Targeting Ubc9 for cancer therapy
    Yin Yuan Mo
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, PO Box 19626, Springfield, IL 62794, USA
    Expert Opin Ther Targets 9:1203-16. 2005
  6. pmc Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
    Fei Xing
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    EMBO Mol Med 5:384-96. 2013
  7. ncbi Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein
    Yin Yuan Mo
    Department of Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 277:2958-64. 2002
  8. pmc miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4
    Hiroshi Okuda
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Cancer Res 73:1434-44. 2013
  9. pmc Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
    Puspa R Pandey
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N Rutledge St, PO Box 19626, Springfield, IL 62794 9626, USA
    Breast Cancer Res Treat 130:387-98. 2011
  10. doi MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    Shuomin Zhu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Cell Res 18:350-9. 2008

Research Grants

  1. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2006
  2. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2003
  3. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2004
  4. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2005

Collaborators

Detail Information

Publications41

  1. pmc Suppression of cell growth and invasion by miR-205 in breast cancer
    Hailong Wu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Cell Res 19:439-48. 2009
    ..Together, these results suggest that miR-205 is a tumor suppressor in breast cancer...
  2. pmc Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner
    S Zhu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Oncogene 29:1763-72. 2010
    ..Together, these results show a molecular link between Ubc9 and the metastasis genes such as CDC42 and CXCR4, and thus provide new insight into the mechanism by which Ubc9 promotes tumor invasion and metastasis...
  3. ncbi Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs
    Yin Yuan Mo
    Department of Biopharmaceutical Sciences, and the Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA
    Cancer Res 64:2793-8. 2004
    ..Together, our results suggest a role for Ubc9 in tumor drug responsiveness...
  4. ncbi A role for Ubc9 in tumorigenesis
    Yin Yuan Mo
    Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Oncogene 24:2677-83. 2005
    ..Together, these results suggest a role for Ubc9 in tumorigenesis at least partially through regulation of bcl-2 expression...
  5. ncbi Targeting Ubc9 for cancer therapy
    Yin Yuan Mo
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, PO Box 19626, Springfield, IL 62794, USA
    Expert Opin Ther Targets 9:1203-16. 2005
    ....
  6. pmc Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
    Fei Xing
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    EMBO Mol Med 5:384-96. 2013
    ....
  7. ncbi Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein
    Yin Yuan Mo
    Department of Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 277:2958-64. 2002
    ..Taken together, our results suggest that sumoylation of topo I might serve as an addressing tag for its nucleolar delocalization in response to topo I inhibitors...
  8. pmc miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4
    Hiroshi Okuda
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Cancer Res 73:1434-44. 2013
    ..These results suggest that miR-7 and KLF4 may serve as biomarkers or therapeutic targets for brain metastasis of breast cancer...
  9. pmc Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
    Puspa R Pandey
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N Rutledge St, PO Box 19626, Springfield, IL 62794 9626, USA
    Breast Cancer Res Treat 130:387-98. 2011
    ....
  10. doi MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    Shuomin Zhu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Cell Res 18:350-9. 2008
    ..Therefore, suppression of mir-21 may provide a novel approach for the treatment of advanced cancers...
  11. pmc N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis
    Wen Liu
    Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL, USA
    EMBO Mol Med 4:93-108. 2012
    ..Collectively, we have identified NDRG1 as a novel negative master regulator of Wnt signalling during the metastatic progression, which opens an opportunity to define a potential therapeutic target for metastatic disease...
  12. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
    ..Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis...
  13. ncbi MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    Shuomin Zhu
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Biol Chem 282:14328-36. 2007
    ..Thus, down-regulation of TPM1 by mir-21 may explain, at least in part, why suppression of mir-21 can inhibit tumor growth, further supporting the notion that mir-21 functions as an oncogene...
  14. pmc LncRNA loc285194 is a p53-regulated tumor suppressor
    Qian Liu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Nucleic Acids Res 41:4976-87. 2013
    ..Together, these results suggest that loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211...
  15. pmc MicroRNA-mediated regulation of Ubc9 expression in cancer cells
    Fangting Wu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Clin Cancer Res 15:1550-7. 2009
    ..The aim of this study was to investigate the regulation of Ubc9 in cancer cells...
  16. ncbi Regulation of bcl-2 expression by Ubc9
    Zhaohui Lu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Exp Cell Res 312:1865-75. 2006
    ..Together, these results suggest that Ubc9 might regulate bcl-2 expression through the ER signaling pathway, which ultimately contributes to the alterations of drug responsiveness and tumor growth...
  17. doi Targeting miR-205 in breast cancer
    Hailong Wu
    Southern Illinois University School of Medicine, Department of Medical Microbiology, Immunology and Cell Biology, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Expert Opin Ther Targets 13:1439-48. 2009
    ..These findings establish the tumor suppressive role of miR-205, which is probably through direct targeting of oncogenes such as ErbB3 and Zeb1. Therefore, miR-205 may serve as a unique therapeutic target for breast cancer...
  18. pmc The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage
    Ali Zhang
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794 9621, USA
    Cell Res 23:340-50. 2013
    ..Together, these results suggest that the RoR-hnRNP I-p53 axis may constitute an additional surveillance network for the cell to better respond to various stresses...
  19. doi Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
    Eiji Furuta
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
    Cancer Res 68:1003-11. 2008
    ....
  20. doi Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway
    Wen Liu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794 9626, USA
    Breast Cancer Res Treat 128:57-68. 2011
    ....
  21. pmc p53 represses c-Myc through induction of the tumor suppressor miR-145
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Proc Natl Acad Sci U S A 106:3207-12. 2009
    ....
  22. pmc SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4
    Jianmei W Leavenworth
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    J Immunol 183:1110-9. 2009
    ..D2 mice, suggesting that increased c-Maf sumoylation contributes to immune deviation in T1D by reducing c-Maf access to and transactivation of the IL-4 gene...
  23. pmc c-Maf increases apoptosis in peripheral CD8 cells by transactivating Caspase 6
    Siying Peng
    Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, 62794, USA
    Immunology 127:267-78. 2009
    ..Together these results indicated that c-Maf increases CD8 cell sensitivity to apoptotic stimuli, at least in part, by direct transactivation of Caspase 6, providing increased substrate for Caspase 6-dependent apoptosis pathways...
  24. ncbi Roles of microRNAs in cancer stem cells
    Nanjiang Zhou
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Front Biosci (Schol Ed) 4:810-8. 2012
    ..In this review, we will update recent advances in microRNAs involved in cancer stem cells and their gene regulations in these cells...
  25. pmc Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Nucleic Acids Res 40:6683-92. 2012
    ..Together, these results suggest a miR-145 regulatory system involving the Akt and C/EBP-β, which may contribute to the downregulation of miR-145 in cancer cells...
  26. pmc Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness
    Cheng Fen Chen
    Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Pharmacol 79:735-41. 2011
    ..Ours is the first study to show that miR-485-3p mediates Top2α down-regulation in part by altered regulation of NF-YB...
  27. pmc Systematic validation of predicted microRNAs for cyclin D1
    Qiong Jiang
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    BMC Cancer 9:194. 2009
    ..However, only a relatively small number of these predicted microRNA/mRNA interactions are experimentally validated, and no systematic validation has been carried out using a reporter system...
  28. ncbi Expression of a novel marker, Ubc9, in squamous cell carcinoma of the head and neck
    Ohad Ronen
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Head Neck 31:845-55. 2009
    ..The objective of this study was to determine the expression of Ubc9 in squamous cell carcinoma of the head and neck (SCCHN)...
  29. ncbi Ubiquitin-like protein modifications in prostate and breast cancer
    Fangting Wu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, Springfield, IL 62794, USA
    Front Biosci 12:700-11. 2007
    ....
  30. ncbi Gam1-associated alterations of drug responsiveness through activation of apoptosis
    Fangting Wu
    Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Mol Cancer Ther 6:1823-30. 2007
    ....
  31. ncbi Notch signaling and its role in breast cancer
    Fangting Wu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Front Biosci 12:4370-83. 2007
    ..We will also highlight the therapeutic potential of targeting Notch for cancer treatment...
  32. ncbi Role of microRNAs in leukemia stem cells
    Jianguo Huang
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Front Biosci (Schol Ed) 4:799-809. 2012
    ..The purpose of this review is to provide updates on the role of microRNAs in HSCs and LSCs and to highlight their potential in differentiation therapy of leukemias...
  33. doi Detection of microRNAs in cultured cells and paraffin-embedded tissue specimens by in situ hybridization
    Ashim Gupta
    Immunology and Cell Biology, Department of Medical Microbiology, School of Medicine, Southern Illinois University, Springfield, IL, USA
    Methods Mol Biol 676:73-83. 2011
    ..We have successfully used ISH to detect several microRNAs in paraffin-embedded tumor specimens or cells-cultured in vitro...
  34. ncbi Stroma-mediated expression of estrogen and its role in cancer
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine and Simmons Cooper Cancer Institute, Springfield, IL 62794, USA
    Front Biosci (Landmark Ed) 15:237-48. 2010
    ..We also briefly touch on hormone therapy involving selective estrogen receptor modulators and aromatase inhibitors...
  35. ncbi Alternative approach to generate shRNA from cDNA
    Anh Dinh
    Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Biotechniques 38:629-32. 2005
    ..Such shRNA libraries can be used to identify potential siRNA target sequences and study gene functions by a variety of selection methods...
  36. pmc Role of the lncRNA-p53 regulatory network in cancer
    Ali Zhang
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Mol Cell Biol 6:181-91. 2014
    ..As a result, lncRNAs may prove to be valuable biomarkers for cancer diagnosis or potential targets for cancer therapy. ..
  37. pmc miR-145-mediated suppression of cell growth, invasion and metastasis
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine Springfield, IL, USA
    Am J Transl Res 2:170-80. 2010
    ..This unique feature of miR-145-mediaed gene silencing may suggest that miR-145 is a potential cancer biomarker and serves as a novel target for cancer therapy...
  38. ncbi Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells
    Shelagh E L Mirski
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, ON, Canada K7L 3N6
    Exp Cell Res 313:627-37. 2007
    ..We conclude that topo II alpha and beta nuclear export is inhibited in proliferating cells so that these proteins do not shuttle...
  39. ncbi Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis
    Stergios J Moschos
    Department of Medicine, Division of Hematology Oncology, Hillman Cancer Research Pavilion, University of Pittsburgh Medical Center, 5117 Centre Avenue, Suite 1 32e, Pittsburgh, PA 15213, USA
    J Mol Histol 37:309-19. 2006
    ..This review summarizes the most important DNA damage repair pathways which are potentially affected by Ubc9/SUMO and their role in regulating the function of several proteins involved in the DNA damage repair machinery...
  40. ncbi Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin
    Prasad Rallabhandi
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Biol Chem 277:40020-6. 2002
    ....
  41. pmc Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosis
    Penny A Tavormina
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Biol 158:23-9. 2002
    ..Rapid mobility of topoII alpha in chromosomes may be essential to resolve strain imparted during chromosome condensation and segregation...

Research Grants4

  1. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2006
    ..As a result, we will be able to develop valuable Ubc9-based anticancer agents ..
  2. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2003
    ..As a result, we will be able to develop valuable Ubc9-based anticancer agents ..
  3. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2004
    ..As a result, we will be able to develop valuable Ubc9-based anticancer agents ..
  4. Ubc9 as a novel target for cancer therapy
    Yin Yuan Mo; Fiscal Year: 2005
    ..As a result, we will be able to develop valuable Ubc9-based anticancer agents ..