MICHAL MATEUSZ MASTERNAK

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi Divergent effects of caloric restriction on gene expression in normal and long-lived mice
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 59:784-8. 2004
  2. pmc Insulin sensitivity as a key mediator of growth hormone actions on longevity
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Gerontol A Biol Sci Med Sci 64:516-21. 2009
  3. pmc The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice
    Michal M Masternak
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, 801 N Rutledge, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 65:24-30. 2010
  4. pmc Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 41:417-29. 2006
  5. ncbi Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice
    Michal M Masternak
    Southern Illinois University, School of Medicine, Geriatrics Research, Department of Internal Medicine, 801 N Rutledge St, Room 4389, P O Box 19628, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 60:1394-8. 2005
  6. ncbi Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice
    Michal M Masternak
    Department of Internal Medicine, Geriatrics Research, Southern Illnois University School of Medicine, Springfield, 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 60:1238-45. 2005
  7. ncbi Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice
    Michal M Masternak
    Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, P O Box 19628, Springfield, IL 62794 9628, USA
    Exp Gerontol 40:679-84. 2005
  8. ncbi Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice
    Michal M Masternak
    Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 40:491-7. 2005
  9. pmc Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice
    Audreen Louis
    Department of Internal Medicine, Division of Geriatric Research, School of Medicine, Southern Illinois University, 801 N Rutledge, Room 4389, PO Box 19628, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 65:344-52. 2010
  10. ncbi Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice
    Zhihui Wang
    Division of Diabetes, Endocrinology, and Metabolism, School of Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232 6303, USA
    Endocrinology 148:2845-53. 2007

Research Grants

  1. Dietary fat, visceral fat depots and aging
    MICHAL MATEUSZ MASTERNAK; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi Divergent effects of caloric restriction on gene expression in normal and long-lived mice
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 59:784-8. 2004
    ..Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics...
  2. pmc Insulin sensitivity as a key mediator of growth hormone actions on longevity
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Gerontol A Biol Sci Med Sci 64:516-21. 2009
    ..We also report that the effects of GH treatment on insulin sensitivity may be limited to the period of GH administration...
  3. pmc The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice
    Michal M Masternak
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, 801 N Rutledge, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 65:24-30. 2010
    ..This suggests that improving growth of these animals may negatively affect both their healthspan and longevity by causing insulin resistance...
  4. pmc Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 41:417-29. 2006
    ....
  5. ncbi Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice
    Michal M Masternak
    Southern Illinois University, School of Medicine, Geriatrics Research, Department of Internal Medicine, 801 N Rutledge St, Room 4389, P O Box 19628, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 60:1394-8. 2005
    ..The results also indicate that CR may increase insulin sensitivity through a different mechanism...
  6. ncbi Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice
    Michal M Masternak
    Department of Internal Medicine, Geriatrics Research, Southern Illnois University School of Medicine, Springfield, 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 60:1238-45. 2005
    ..This suggested metabolic change clearly does not affect whole-body insulin action. These findings suggest that whole-animal insulin sensitivity is not regulated through skeletal muscle insulin action...
  7. ncbi Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice
    Michal M Masternak
    Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, P O Box 19628, Springfield, IL 62794 9628, USA
    Exp Gerontol 40:679-84. 2005
    ..The results also show that improved insulin sensitivity in response to CR is not due to increased mRNA expression of the above genes in either normal or GHR-KO animals...
  8. ncbi Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice
    Michal M Masternak
    Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 40:491-7. 2005
    ..The results indicate that EOD produces some changes in the insulin and IGF1 signaling pathways, and that these changes are consistent with EOD increasing insulin sensitivity...
  9. pmc Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice
    Audreen Louis
    Department of Internal Medicine, Division of Geriatric Research, School of Medicine, Southern Illinois University, 801 N Rutledge, Room 4389, PO Box 19628, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 65:344-52. 2010
    ..These results indicate that GH and T4 treatment has differential impact on insulin signaling during development and adulthood...
  10. ncbi Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice
    Zhihui Wang
    Division of Diabetes, Endocrinology, and Metabolism, School of Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232 6303, USA
    Endocrinology 148:2845-53. 2007
    ..An increase in plasma adiponectin and decrease in plasma IL-6, triglycerides, and cholesterol levels in response to CR may improve insulin sensitivity...
  11. ncbi Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction
    Khalid A Al-Regaiey
    Department of Physiology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9628, USA
    Endocrinology 146:851-60. 2005
    ..These results also add to the evidence that targeted disruption of the GH receptor/GH-binding protein gene and CR act via overlapping, but distinct, mechanisms...
  12. pmc Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?
    Jacob A Panici
    Department of Internal Medicine, Geriatrics Research, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 64:1126-33. 2009
    ....
  13. ncbi Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle
    Khalid A Al-Regaiey
    Departments of Internal Medicine, Southern Illinois University, School of Medicine, Springfield, USA
    J Gerontol A Biol Sci Med Sci 62:18-26. 2007
    ..These changes may be related to mechanisms of improving insulin sensitivity and life expectancy...
  14. pmc Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
    Michael S Bonkowski
    Department of Internal Medicine Geriatrics Research, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Proc Natl Acad Sci U S A 103:7901-5. 2006
    ..The present findings also support the notion that enhanced sensitivity to insulin plays a prominent role in the actions of CR and GH resistance on longevity...
  15. pmc Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity
    Michael S Bonkowski
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 4:e4567. 2009
    ....
  16. ncbi Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice
    Andrzej Bartke
    Geriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, PO Box 19628, Springfield, IL 62794, USA
    Interdiscip Top Gerontol 35:69-82. 2007
    ..This last category is of particular interest since genes affected in normal but not GHRKO mice may be related to mechanisms by which DR extends longevity...
  17. ncbi Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics
    Michael S Bonkowski
    Department of Physiology and Internal Medicine Geriatrics Research, Southern Illinois University School of Medicine, Springfield IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 61:562-7. 2006
    ..These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice...
  18. ncbi Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice
    Zhihui Wang
    Geriatrics Research, Department of Physiology and Internal Medicine, School of Medicine, Southern Illinois University, 801 N Rutledge, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 61:323-31. 2006
    ..However, CR may reduce rather than enhance some of the insulin effects in the highly insulin-sensitive dwarf mice...
  19. ncbi Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
    Liou Y Sun
    Geriatrics Research, Department of Medicine, Southern Illinois University, Springfield, IL 62794, USA
    Neurobiol Aging 26:929-37. 2005
    ....
  20. pmc Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice
    Jacob A Panici
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    FASEB J 24:5073-9. 2010
    ..We conclude that the remarkable life-span extension of Ames dwarf mice, and the stress resistance of cells from these mice, depends on low levels of GH exposure in juvenile and very young adult mice...
  21. ncbi Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction
    Jorge F Giani
    Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Química y Fisicoquímica Biológicas IQUIFIB, Buenos Aires, Buenos Aires 1113, Argentina
    J Gerontol A Biol Sci Med Sci 63:788-97. 2008
    ..This change may be cardioprotective and thus contribute to increased longevity in response to CR. Interestingly, the insulin signaling cascade in the heart of GHRKO mice was unaffected by CR...
  22. pmc Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation
    Joseph Dhahbi
    BioMarker Pharmaceuticals Inc, 5941 Optical Court, San Jose, CA 95138, USA
    Exp Gerontol 42:772-88. 2007
    ..However, whole leukocytes population represents the function of immune system in these organisms...
  23. doi Effects of every-other-day feeding on prolactin regulatory mechanism in transgenic human growth hormone mice
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Exp Biol Med (Maywood) 233:434-8. 2008
    ..These parameters were not affected by the EOD feeding pattern. These data may suggest an autocrine or paracrine effect of dopamine at the hypophyseal level on prolactin secretion that is independent of the feeding pattern...

Research Grants1

  1. Dietary fat, visceral fat depots and aging
    MICHAL MATEUSZ MASTERNAK; Fiscal Year: 2010
    ..Do these mechanisms involve genetics, lifestyle or dietary choices? If one could identify the mechanisms involved, future research would have targets to extend lifespan and improve the "healthspan" of the human race. ..