Yonghe Li

Summary

Affiliation: Southern Research Institute
Country: USA

Publications

  1. ncbi request reprint Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)
    Hua Poo Su
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11772-9. 2002
  2. ncbi request reprint LRP5/6 in Wnt signaling and tumorigenesis
    Yonghe Li
    Southern Research Institute, Biochemistry and Molecular Biology Department, Drug Discovery Division, Birmingham, AL 35255, USA
    Future Oncol 1:673-81. 2005
  3. ncbi request reprint Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 118:5305-14. 2005
  4. pmc Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation
    Yonghe Li
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA
    PLoS ONE 5:e11014. 2010
  5. pmc Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, Alabama 35255 5305, USA
    Biochemistry 49:4635-43. 2010
  6. pmc The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells
    Cuihong Lin
    Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, United States of America
    PLoS ONE 8:e58102. 2013
  7. ncbi request reprint Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:15464-70. 2005
  8. pmc Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
    Heesang Song
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:879-86. 2009
  9. pmc A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity
    Jason D Whitt
    Department of Pharmacology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Prev Res (Phila) 5:822-33. 2012
  10. pmc Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway
    Wenyan Lu
    Drug Discovery Division, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, Alabama, United States of America
    PLoS ONE 6:e29290. 2011

Research Grants

  1. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2009
  2. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2010
  3. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2009
  4. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)
    Hua Poo Su
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11772-9. 2002
    ..These studies suggest a physical link between CED-1 or CD91/LRP and the adapter protein CED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies...
  2. ncbi request reprint LRP5/6 in Wnt signaling and tumorigenesis
    Yonghe Li
    Southern Research Institute, Biochemistry and Molecular Biology Department, Drug Discovery Division, Birmingham, AL 35255, USA
    Future Oncol 1:673-81. 2005
    ..Furthermore, it has been demonstrated that LRP5 and 6 are potential oncogenic proteins. Thus, blockade of LRP56 function may lead to new strategies in cancer treatment...
  3. ncbi request reprint Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 118:5305-14. 2005
    ..Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6...
  4. pmc Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation
    Yonghe Li
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA
    PLoS ONE 5:e11014. 2010
    ..Previous studies have demonstrated that Dkk1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen...
  5. pmc Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, Alabama 35255 5305, USA
    Biochemistry 49:4635-43. 2010
    ..Our results indicate that recombinant Mesd protein is a useful tool for studying Wnt/beta-catenin signaling on the cell surface and has a potential therapeutic role in Wnt-dependent cancers...
  6. pmc The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells
    Cuihong Lin
    Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, United States of America
    PLoS ONE 8:e58102. 2013
    ..Together, our results suggest that Mesd C-terminal region constitutes the major LRP5/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer...
  7. ncbi request reprint Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:15464-70. 2005
    ..Together, these data establish a relationship between LRP rapid endocytosis and APP trafficking and proteolytic processing to generate Abeta...
  8. pmc Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
    Heesang Song
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:879-86. 2009
    ..Together, our data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway...
  9. pmc A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity
    Jason D Whitt
    Department of Pharmacology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Prev Res (Phila) 5:822-33. 2012
    ..We conclude that PDE5 and possibly other cGMP degrading isozymes can be targeted to develop safer and more efficacious NSAID derivatives for colorectal cancer chemoprevention...
  10. pmc Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway
    Wenyan Lu
    Drug Discovery Division, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, Alabama, United States of America
    PLoS ONE 6:e29290. 2011
    ....
  11. pmc Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway
    Lora Melman
    Department of Pediatrics, Washington University School of Medicine, CB 8208, St Louis Children s Hospital, Missouri 63110, USA
    Mol Biol Cell 13:3325-35. 2002
    ..e., LRP, is regulated by the proteasomal system, suggesting a broader function of the proteasome in regulating the trafficking of receptors into the degradation pathway...
  12. ncbi request reprint Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    FEBS Lett 555:346-50. 2003
    ..More important, we found that platelet-derived growth factor-dependent cell migration was inhibited in cells transfected with LRP siRNA. These results demonstrate an important role of LRP in smooth muscle cell migration...
  13. pmc Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation
    Jane M Knisely
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 313:3298-307. 2007
    ..From these data, we propose that both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate...
  14. ncbi request reprint LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 23:9129-35. 2004
    ..Finally, we demonstrate that LRP6 expression promotes tumorigenesis in vivo. These results thus indicate that LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling...
  15. ncbi request reprint Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 45:1084-91. 2004
    ..Taken together, these data demonstrate that the proteasome is the principal degradation pathway for LDLR class 2 mutants...
  16. pmc Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases
    Guojun Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Int J Cancer 123:1034-42. 2008
    ..Taken together, these results suggest that breast cancer-produced Dkk1 may be an important mechanistic link between primary breast tumors and secondary osteolytic bone metastases...
  17. pmc Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    Cell Signal 24:2291-6. 2012
    ....
  18. pmc Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo
    Cuihong Lin
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, United States
    FEBS Lett 585:3120-5. 2011
    ..Our results indicate that Mesd is a universal inhibitor of Wnt/LRP signaling on the cell surface...
  19. ncbi request reprint Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, MO 63110, USA
    FEBS Lett 580:5423-8. 2006
    ..Our results present novel mechanisms by which Mesd and LRP6 modulate Wnt signaling...
  20. ncbi request reprint The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:29639-46. 2004
    ..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease...
  21. pmc Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells
    Heather N Tinsley
    Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA
    Cancer Prev Res (Phila) 4:1275-84. 2011
    ..We conclude that PDE5 represents a novel molecular target for the discovery of safer and more efficacious drugs for breast cancer chemoprevention...
  22. ncbi request reprint Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 277:42366-71. 2002
    ..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration...
  23. doi request reprint R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
    FEBS Lett 582:643-50. 2008
    ..Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling...
  24. ncbi request reprint Striking differences of LDL receptor-related protein 1B expression in mouse and human
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 333:868-73. 2005
    ..The broader expression pattern of LRP1B in human tissues suggests that this putative tumor suppressor may play roles in several types of human cancer...
  25. ncbi request reprint Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
    Yonghe Li
    Drug Discovery Division, Southern Research Institute, Birmingham, AL, United States Electronic address
    Cancer Lett 349:8-14. 2014
    ..This article reviews various aspects of niclosamide as they relate to its efficacy against cancer and associated molecular mechanisms...
  26. doi request reprint Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats
    Deepthi Alapati
    Department of Pediatrics, Division of Neonatology, Batchelor Children s Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Pediatr Res 73:719-25. 2013
    ..We hypothesized that inhibition of LRP5/6 by their universal inhibitor, Mesd, would attenuate hyperoxia-induced lung injury...
  27. pmc A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity
    Gary A Piazza
    Drug Discovery and Development Divisions, Southern Research Institute, Birmingham, Alabama 35205, USA
    Cancer Prev Res (Phila) 2:572-80. 2009
    ..These results indicate that SSA has potential safety and efficacy advantages for colon cancer chemoprevention as well as utility for treating malignant disease if combined with chemotherapy...
  28. pmc Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation
    Wenyan Lu
    Department of Biochemistry, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35255 5305, United States
    Eur J Pharmacol 602:8-14. 2009
    ..Together, these results suggest that small molecules that inhibit Wnt/beta-catenin signaling have therapeutic potential for the prevention or treatment of prostate cancer...
  29. ncbi request reprint Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants
    Yonghe Li
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 41:4921-8. 2002
    ..Taken together, our results show that the folding, trafficking, and maturation of the LDLR and its class 2 mutants are promoted by RAP...
  30. pmc Frizzled7 as an emerging target for cancer therapy
    Taj D King
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA
    Cell Signal 24:846-51. 2012
    ..Therefore, targeted inhibition of Fzd7 represents a rational and promising new approach for cancer therapy...
  31. doi request reprint The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer
    Taj D King
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA
    J Cell Biochem 113:13-8. 2012
    ..Therefore, the Wnt/β-catenin signaling pathway and particularly the Wnt receptors on the cell surface may serve as novel therapeutic targets for the treatment of TNBC...
  32. ncbi request reprint Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35255, USA
    Cell Signal 26:1303-9. 2014
    ..Our data indicate that rottlerin is a novel LRP6 inhibitor and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells, and that LRP6 represents a potential therapeutic target for cancers...
  33. ncbi request reprint LRP5, a multifunctional cell surface receptor
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Lipidol 15:361-3. 2004
  34. ncbi request reprint Effect of Niclosamide on Basal-like Breast Cancers
    Angelina I Londoño-Joshi
    Authors Affiliations Departments of Pathology, Biology, Biostatistics, Medicine, and Radiation Oncology Division of Gynecologic Oncology Southern Research Institute and Division of Hematology and Onocology, University of Alabama at Birmingham, Birmingham, Alabama
    Mol Cancer Ther 13:800-11. 2014
    ..These results suggest that niclosamide or congeners of this agent may be useful for the treatment of BLBC. Mol Cancer Ther; 13(4); 800-11. ©2014 AACR. ..

Research Grants5

  1. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2009
    ..The research proposal may lead to a novel strategy for cancer treatment. ..
  2. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2010
    ..The research proposal may lead to a novel strategy for cancer treatment. ..
  3. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2009
    ..The research proposal may lead to a novel strategy for cancer treatment. ..
  4. Wnt co-receptor LRP6 turnover and cancer
    Yonghe Li; Fiscal Year: 2010
    ..The research proposal may lead to a novel strategy for cancer treatment. ..