Research Topics
Genomes and Genes
| Yonghe LiSummaryAffiliation: Southern Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)Hua Poo Su
Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 277:11772-9. 2002..These studies suggest a physical link between CED-1 or CD91/LRP and the adapter protein CED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies...
Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulationYonghe Li
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA
PLoS ONE 5:e11014. 2010..Previous studies have demonstrated that Dkk1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen...- LRP5/6 in Wnt signaling and tumorigenesisYonghe Li
Southern Research Institute, Biochemistry and Molecular Biology Department, Drug Discovery Division, Birmingham, AL 35255, USA
Future Oncol 1:673-81. 2005..Furthermore, it has been demonstrated that LRP5 and 6 are potential oncogenic proteins. Thus, blockade of LRP56 function may lead to new strategies in cancer treatment... - Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand bindingYonghe Li
Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Cell Sci 118:5305-14. 2005..Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6... - Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cellsWenyan Lu
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, Alabama 35255 5305, USA
Biochemistry 49:4635-43. 2010..Our results indicate that recombinant Mesd protein is a useful tool for studying Wnt/beta-catenin signaling on the cell surface and has a potential therapeutic role in Wnt-dependent cancers... - Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor proteinJudy A Cam
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 280:15464-70. 2005..Together, these data establish a relationship between LRP rapid endocytosis and APP trafficking and proteolytic processing to generate Abeta... - Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9Heesang Song
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 69:879-86. 2009..Together, our data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway... - A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activityJason D Whitt
Department of Pharmacology, The University of Alabama at Birmingham, Birmingham, AL, USA
Cancer Prev Res (Phila) 5:822-33. 2012..We conclude that PDE5 and possibly other cGMP degrading isozymes can be targeted to develop safer and more efficacious NSAID derivatives for colorectal cancer chemoprevention... - Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathwayWenyan Lu
Drug Discovery Division, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, Alabama, United States of America
PLoS ONE 6:e29290. 2011.... - Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathwayLora Melman
Department of Pediatrics, Washington University School of Medicine, CB 8208, St. Louis Children's Hospital, Missouri 63110, USA
Mol Biol Cell 13:3325-35. 2002..e., LRP, is regulated by the proteasomal system, suggesting a broader function of the proteasome in regulating the trafficking of receptors into the degradation pathway... - Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migrationYonghe Li
Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
FEBS Lett 555:346-50. 2003..More important, we found that platelet-derived growth factor-dependent cell migration was inhibited in cells transfected with LRP siRNA. These results demonstrate an important role of LRP in smooth muscle cell migration... 
Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastasesGuojun Bu
Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
Int J Cancer 123:1034-42. 2008..Taken together, these results suggest that breast cancer-produced Dkk1 may be an important mechanistic link between primary breast tumors and secondary osteolytic bone metastases...- LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distributionYonghe Li
Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
Oncogene 23:9129-35. 2004..Finally, we demonstrate that LRP6 expression promotes tumorigenesis in vivo. These results thus indicate that LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling... - Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathwayYonghe Li
Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
J Lipid Res 45:1084-91. 2004..Taken together, these data demonstrate that the proteasome is the principal degradation pathway for LDLR class 2 mutants... - Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformationJane M Knisely
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Exp Cell Res 313:3298-307. 2007..From these data, we propose that both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate... - Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cellsWenyan Lu
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
Cell Signal 24:2291-6. 2012.... - Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivoCuihong Lin
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, United States
FEBS Lett 585:3120-5. 2011..Our results indicate that Mesd is a universal inhibitor of Wnt/LRP signaling on the cell surface... - Modulation of LRP6-mediated Wnt signaling by molecular chaperone MesdYonghe Li
Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, MO 63110, USA
FEBS Lett 580:5423-8. 2006..Our results present novel mechanisms by which Mesd and LRP6 modulate Wnt signaling... - Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cellsHeather N Tinsley
Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA
Cancer Prev Res (Phila) 4:1275-84. 2011..We conclude that PDE5 represents a novel molecular target for the discovery of safer and more efficacious drugs for breast cancer chemoprevention... - The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide productionJudy A Cam
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 279:29639-46. 2004..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease... - Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migrationYonghe Li
Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
J Biol Chem 277:42366-71. 2002..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration... - Striking differences of LDL receptor-related protein 1B expression in mouse and humanYonghe Li
Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
Biochem Biophys Res Commun 333:868-73. 2005..The broader expression pattern of LRP1B in human tissues suggests that this putative tumor suppressor may play roles in several types of human cancer... - R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expressionWenyan Lu
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
FEBS Lett 582:643-50. 2008..Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling... - The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cellsCuihong Lin
Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, United States of America
PLoS ONE 8:e58102. 2013..Together, our results suggest that Mesd C-terminal region constitutes the major LRP5/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer... - A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activityGary A Piazza
Drug Discovery and Development Divisions, Southern Research Institute, Birmingham, Alabama 35205, USA
Cancer Prev Res (Phila) 2:572-80. 2009..These results indicate that SSA has potential safety and efficacy advantages for colon cancer chemoprevention as well as utility for treating malignant disease if combined with chemotherapy... - Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferationWenyan Lu
Department of Biochemistry, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35255 5305, United States
Eur J Pharmacol 602:8-14. 2009..Together, these results suggest that small molecules that inhibit Wnt/beta-catenin signaling have therapeutic potential for the prevention or treatment of prostate cancer... - Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutantsYonghe Li
Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Biochemistry 41:4921-8. 2002..Taken together, our results show that the folding, trafficking, and maturation of the LDLR and its class 2 mutants are promoted by RAP... - The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancerTaj D King
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA
J Cell Biochem 113:13-8. 2012..Therefore, the Wnt/β-catenin signaling pathway and particularly the Wnt receptors on the cell surface may serve as novel therapeutic targets for the treatment of TNBC... - Frizzled7 as an emerging target for cancer therapyTaj D King
Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA
Cell Signal 24:846-51. 2012..Therefore, targeted inhibition of Fzd7 represents a rational and promising new approach for cancer therapy... - LRP5, a multifunctional cell surface receptorYonghe Li
Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA
Curr Opin Lipidol 15:361-3. 2004
Research Grants
- Wnt co-receptor LRP6 turnover and cancerYonghe Li; Fiscal Year: 2010..The research proposal may lead to a novel strategy for cancer treatment. ..
- Wnt co-receptor LRP6 turnover and cancerYonghe Li; Fiscal Year: 2010..The research proposal may lead to a novel strategy for cancer treatment. ..