C Faingold

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1418:104-10. 2011
  2. ncbi Integrative neurobiology of the alcohol withdrawal syndrome--from anxiety to seizures
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Alcohol Clin Exp Res 28:268-78. 2004
  3. ncbi Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Prog Neurobiol 72:55-85. 2004
  4. ncbi Electrical stimulation therapies for CNS disorders and pain are mediated by competition between different neuronal networks in the brain
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Med Hypotheses 71:668-81. 2008
  5. ncbi DBA/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Epilepsy Behav 17:436-40. 2010
  6. ncbi Role of GABA abnormalities in the inferior colliculus pathophysiology - audiogenic seizures
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Hear Res 168:223-37. 2002
  7. ncbi Teaching pharmacology within a multidisciplinary organ system-based medical curriculum
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine SIUSM, P O Box 19629, Springfield, IL 62794 9629, USA
    Naunyn Schmiedebergs Arch Pharmacol 366:18-25. 2002
  8. ncbi Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Epilepsy Behav 22:186-90. 2011
  9. ncbi Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures
    C Faingold
    Departments of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 868:287-95. 2000
  10. ncbi Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures
    Manish Raisinghani
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794-9629, USA
    Brain Res 1048:193-201. 2005

Research Grants

  1. INTEGRATIVE NEUROBIOLOGY OF ALCOHOL WITHDRAWAL SEIZURES
    Carl Faingold; Fiscal Year: 2002

Collaborators

Detail Information

Publications26

  1. ncbi Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1418:104-10. 2011
    ..mCPP blocked RA in DBA/2 mice and concomitantly reduced tonic seizures, which also occurs. Fluoxetine is the only agent tested that blocks RA selectively in these SUDEP models, which may be clinically relevant...
  2. ncbi Integrative neurobiology of the alcohol withdrawal syndrome--from anxiety to seizures
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Alcohol Clin Exp Res 28:268-78. 2004
    ....
  3. ncbi Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Prog Neurobiol 72:55-85. 2004
    ..Thus, the MK-801-induced firing increases in SNR neurons observed in vivo may involve an indirect effect via disinhibition, involving an action on the emergent properties of this seizure network...
  4. ncbi Electrical stimulation therapies for CNS disorders and pain are mediated by competition between different neuronal networks in the brain
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Med Hypotheses 71:668-81. 2008
    ..This network interaction hypothesis has value for future research in CNS disease mechanisms and also for identifying therapeutic targets in specific brain networks for more selective stimulation and pharmacological therapies...
  5. ncbi DBA/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Epilepsy Behav 17:436-40. 2010
    ..These mice die suddenly from respiratory arrest after generalized convulsive seizures until reaching PND >or=100, allowing testing of chronic preventive treatments for SUDEP...
  6. ncbi Role of GABA abnormalities in the inferior colliculus pathophysiology - audiogenic seizures
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Hear Res 168:223-37. 2002
    ..These neurotransmitter abnormalities result in excessive firing of ICc neurons that acts as the critical initiation mechanism for triggering seizures in response to intense acoustic stimuli...
  7. ncbi Teaching pharmacology within a multidisciplinary organ system-based medical curriculum
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine SIUSM, P O Box 19629, Springfield, IL 62794 9629, USA
    Naunyn Schmiedebergs Arch Pharmacol 366:18-25. 2002
    ..The multidisciplinary, case-based sessions were perceived to be instructive, valuable learning experiences, based on formal and informal student and faculty feedback...
  8. ncbi Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Epilepsy Behav 22:186-90. 2011
    ..Epilepsia 2010;51:2211-4]. These findings suggest that treatment with SSRIs should be evaluated for reducing the incidence of SUDEP in patients...
  9. ncbi Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures
    C Faingold
    Departments of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 868:287-95. 2000
    ..The common changes in IC neurotransmission in these AGS forms may be general mechanisms subserving AGS and other forms of auditory system pathophysiology in which the IC is implicated...
  10. ncbi Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures
    Manish Raisinghani
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794-9629, USA
    Brain Res 1048:193-201. 2005
    ..These data are the first indication that PRh participates importantly in the neuronal network for AGS as a result of AGS kindling and demonstrate a previously unknown involvement of PRh in generalized onset seizures...
  11. ncbi The effects of chronic ethanol administration on amygdala neuronal firing and ethanol withdrawal seizures
    Hua Jun Feng
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Neuropharmacology 55:648-53. 2008
    ....
  12. ncbi Neurons in the amygdala play an important role in the neuronal network mediating a clonic form of audiogenic seizures both before and after audiogenic kindling
    Manish Raisinghani
    Department of Pharmacology, Southern Illinois University School of Medicine, P.O. Box 19629, Springfield, IL 62794-9629, United States
    Brain Res 1032:131-40. 2005
    ....
  13. ncbi Glutamatergic activation of the amygdala differentially mimics the effects of audiogenic seizure kindling in two substrains of genetically epilepsy-prone rats
    M Raisinghani
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794-9629, USA
    Exp Neurol 183:516-22. 2003
    ..However, the behavioral effect of the treatment was different in the two AGS substrains, suggesting interrelated but not identical pathophysiological mechanisms in these closely related epilepsy models...
  14. ncbi Abnormal serotonin receptor expression in DBA/2 mice associated with susceptibility to sudden death due to respiratory arrest
    Victor V Uteshev
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Epilepsy Res 88:183-8. 2010
    ..Preliminary studies indicate that 5-HT(2C) receptors may be particularly important, since a 5-HT(2C) agonist is very effective in blocking RA in DBA/2 mice...
  15. ncbi Role of the amygdala in ethanol withdrawal seizures
    Hua Jun Feng
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1141:65-73. 2007
    ..These findings suggest a critical role of the amygdala in the ETX seizure network in generating tonic convulsions during AGS...
  16. ncbi Sleep, temperature, activity, and prolactin phenotypes of genetically epilepsy-prone rats
    Linda A Toth
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Comp Med 56:402-15. 2006
    ..Our detection of concurrent alterations in sleep, temperature, and prolactin in these 2 GEPR strains implicates the hypothalamus as a likely site for anatomic or physiologic variation in the control of these homeostatic processes...
  17. ncbi Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice
    Srinivasan Tupal
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9629, USA
    Epilepsia 47:21-6. 2006
    ..The data raise concern about the use of serotonin antagonists in this patient population...
  18. ncbi Pontine reticular formation neurons are implicated in the neuronal network for generalized clonic seizures which is intensified by audiogenic kindling
    Manish Raisinghani
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794-9629, USA
    Brain Res 1064:90-7. 2005
    ..This study also suggests that cPRF neurons may be involved in F and F clonus, which was unexpected since F and F clonus is thought to originate primarily in forebrain structures...
  19. ncbi Modulation of the audiogenic seizure network by noradrenergic and glutamatergic receptors of the deep layers of superior colliculus
    C Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 821:392-9. 1999
    ..These data support recent neuronal recording data, which indicate that DLSC neurons play a critical role in AGS...
  20. ncbi The Majchrowicz binge alcohol protocol: an intubation technique to study alcohol dependence in rats
    Carl L Faingold
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Curr Protoc Neurosci . 2008
    ..One specific behavior observed during ethanol withdrawal and described here is sound-induced (audiogenic) convulsive seizure...
  21. ncbi Identification of the requisite brain sites in the neuronal network subserving generalized clonic audiogenic seizures
    Manish Raisinghani
    Department of Pharmacology, Southern Illinois University, School of Medicine, P.O. Box 19629, Springfield 62794-9629, USA
    Brain Res 967:113-22. 2003
    ..However, the requisite involvement of AMG in the clonic AGS network, which is not seen in tonic AGS, is surprising and suggests important mechanistic differences between clonic and tonic forms of AGS...
  22. ncbi Repeated generalized audiogenic seizures induce plastic changes on acoustically evoked neuronal firing in the amygdala
    Hua Jun Feng
    Department of Pharmacology, School of Medicine, Southern Illinois University, P.O. Box 19629, Springfield, IL 62794-9629, USA
    Brain Res 932:61-9. 2002
    ....
  23. ncbi Precipitous induction of audiogenic kindling by activation of adenylyl cyclase in the amygdala
    Srinivasan Tupal
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Epilepsia 51:354-61. 2010
    ..This study attempted to mimic AGS kindling persistently in nonkindled GEPR-9s by one-time activation of AC in LA...
  24. ncbi Synaptic plasticity in the pathway from the medial geniculate body to the lateral amygdala is induced by seizure repetition
    Hua-Jun Feng
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-9629, USA
    Brain Res 946:198-205. 2002
    ....
  25. ncbi Excitatory amino acid receptor-mediated responses in periaqueductal gray neurons are increased during ethanol withdrawal
    Cheng Long
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Neuropharmacology 52:802-11. 2007
    ..This dichotomy may be related to the different role played by IC and PAG in the ETX seizure network...
  26. ncbi Development of a therapeutics curriculum to enhance knowledge of fourth-year medical students about clinical uses and adverse effects of drugs
    Dean K Naritoku
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Teach Learn Med 21:148-52. 2009
    ..However, many medical schools lack sufficient clinical pharmacologists to teach such courses. The Southern Illinois University Medical School faculty implemented an Advanced Therapeutics course to address these issues...

Research Grants5

  1. INTEGRATIVE NEUROBIOLOGY OF ALCOHOL WITHDRAWAL SEIZURES
    Carl Faingold; Fiscal Year: 2002
    ..We expect these approaches to yield novel insights into the neurobiological mechanisms controlling seizure susceptibility during ethanol withdrawal and suggest improved approaches to the therapy of alcoholism. ..