James E Cummins

Summary

Affiliation: Southern Research Institute
Country: USA

Publications

  1. pmc Detection of infectious human immunodeficiency virus type 1 in female genital secretions by a short-term culture method
    James E Cummins
    Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4081-8. 2003
  2. pmc Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection
    Rhonda D Cardin
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Virol J 6:214. 2009
  3. ncbi request reprint Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine
    James E Cummins
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 23:748-54. 2007
  4. pmc Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 51:1770-9. 2007
  5. ncbi request reprint Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 22:788-95. 2006
  6. pmc Mucosal and systemic antibody responses in humans infected with simian foamy virus
    James E Cummins
    HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:13186-9. 2005
  7. ncbi request reprint A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection
    Sheila R Abner
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, and Surgical Service, Emory University School of Medicine, Decatur, Georgia, USA
    J Infect Dis 192:1545-56. 2005
  8. pmc In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories
    Brigitte E Beer
    Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antimicrob Agents Chemother 50:713-23. 2006
  9. pmc Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides
    Carol Lackman-Smith
    Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, USA
    Antimicrob Agents Chemother 52:1768-81. 2008
  10. ncbi request reprint Inhibition of HIV-1 replication by amphotericin B methyl ester: selection for resistant variants
    Abdul A Waheed
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    J Biol Chem 281:28699-711. 2006

Collaborators

Detail Information

Publications11

  1. pmc Detection of infectious human immunodeficiency virus type 1 in female genital secretions by a short-term culture method
    James E Cummins
    Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4081-8. 2003
    ..Accurate measurements of infectious virus in genital secretions will improve studies that evaluate sexual transmission of HIV-1...
  2. pmc Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection
    Rhonda D Cardin
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Virol J 6:214. 2009
    ..The activity of these agents against animal cytomegalovirus (CMV) infections in vitro and in vivo was therefore investigated...
  3. ncbi request reprint Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine
    James E Cummins
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 23:748-54. 2007
    ..Because of the importance of innate immunity in host defense, evaluation of the mucosal innate immune system should be included in future HIV prevention trials...
  4. pmc Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 51:1770-9. 2007
    ..Collectively, these data suggest that this culture system can be used for evaluating the safety and efficacy of topical microbicides designed for vaginal use...
  5. ncbi request reprint Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 22:788-95. 2006
    ..In this group of women, these results suggest that the levels of certain innate immune factors are more closely associated with HIV-1 shedding in the genital mucosa than plasma virus concentrations...
  6. pmc Mucosal and systemic antibody responses in humans infected with simian foamy virus
    James E Cummins
    HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:13186-9. 2005
    ..These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response...
  7. ncbi request reprint A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection
    Sheila R Abner
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, and Surgical Service, Emory University School of Medicine, Decatur, Georgia, USA
    J Infect Dis 192:1545-56. 2005
    ..These results suggest that this model is useful for evaluating the safety and efficacy of topical microbicides when used rectally...
  8. pmc In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories
    Brigitte E Beer
    Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antimicrob Agents Chemother 50:713-23. 2006
    ..This comparative work can be used to develop standardized microbicide testing protocols that will help advance potential microbicides to clinical trials...
  9. pmc Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides
    Carol Lackman-Smith
    Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, USA
    Antimicrob Agents Chemother 52:1768-81. 2008
    ....
  10. ncbi request reprint Inhibition of HIV-1 replication by amphotericin B methyl ester: selection for resistant variants
    Abdul A Waheed
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    J Biol Chem 281:28699-711. 2006
    ..Our data define the target and mechanism of action of AME and provide support for the concept that cholesterol-binding compounds should be pursued as antiretroviral drugs to disrupt HIV-1 replication...
  11. pmc Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study
    Raina N Fichorova
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anal Chem 80:4741-51. 2008
    ..This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface...