Thomas J Brozoski

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Gap detection deficits in rats with tinnitus: a potential novel screening tool
    Jeremy G Turner
    Department of Surgery OtolaryngologySouthern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Behav Neurosci 120:188-95. 2006
  2. pmc Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model
    Thomas J Brozoski
    Division of Otolaryngology, Southern Illinois University School of Medicine, 801 N Rutledge St, Rm 3205, P O Box 19629, Springfield, IL 62794 9629, USA
    J Assoc Res Otolaryngol 8:105-18. 2007
  3. ncbi request reprint Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI)
    Thomas J Brozoski
    Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Hear Res 228:168-79. 2007
  4. pmc The effect of supplemental dietary taurine on tinnitus and auditory discrimination in an animal model
    Thomas J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Hear Res 270:71-80. 2010
  5. ncbi request reprint Marking multi-channel silicon-substrate electrode recording sites using radiofrequency lesions
    Thomas J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Neurosci Methods 150:185-91. 2006
  6. ncbi request reprint The effect of dorsal cochlear nucleus ablation on tinnitus in rats
    Thomas J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Hear Res 206:227-36. 2005
  7. ncbi request reprint Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus
    T J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    J Neurosci 22:2383-90. 2002
  8. pmc Bilateral dorsal cochlear nucleus lesions prevent acoustic-trauma induced tinnitus in an animal model
    Thomas Jeffrey Brozoski
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Assoc Res Otolaryngol 13:55-66. 2012
  9. pmc Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci Res 86:2564-78. 2008
  10. ncbi request reprint Primary afferent dendrite degeneration as a cause of tinnitus
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    J Neurosci Res 85:1489-98. 2007

Detail Information

Publications24

  1. ncbi request reprint Gap detection deficits in rats with tinnitus: a potential novel screening tool
    Jeremy G Turner
    Department of Surgery OtolaryngologySouthern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Behav Neurosci 120:188-95. 2006
    ..The results suggest that gap detection reflex procedures might be effective for rapid tinnitus screening in rats...
  2. pmc Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model
    Thomas J Brozoski
    Division of Otolaryngology, Southern Illinois University School of Medicine, 801 N Rutledge St, Rm 3205, P O Box 19629, Springfield, IL 62794 9629, USA
    J Assoc Res Otolaryngol 8:105-18. 2007
    ..Although vigabatrin has serious negative side effects that have prevented its clinical use in the USA, it is nevertheless a potentially useful tool in unraveling tinnitus pathophysiology...
  3. ncbi request reprint Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI)
    Thomas J Brozoski
    Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Hear Res 228:168-79. 2007
    ..It was concluded that chronic tinnitus in rats is associated with focal activity elevation in the auditory brainstem and increased activity in the paraflocculus that may be unique to tinnitus...
  4. pmc The effect of supplemental dietary taurine on tinnitus and auditory discrimination in an animal model
    Thomas J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Hear Res 270:71-80. 2010
    ..These results are consistent with the hypothesis that taurine attenuates tinnitus and improves auditory discrimination by increasing inhibitory tone and decreasing noise in the auditory pathway...
  5. ncbi request reprint Marking multi-channel silicon-substrate electrode recording sites using radiofrequency lesions
    Thomas J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Neurosci Methods 150:185-91. 2006
    ..Advantages of the rf method include well-documented methods of in vitro calibration as well as low impact on probe integrity. The rf method of marking individual-channel sites should be useful in a variety of applications...
  6. ncbi request reprint The effect of dorsal cochlear nucleus ablation on tinnitus in rats
    Thomas J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Hear Res 206:227-36. 2005
    ..In addition to serving as a trigger, the DCN may also modify the experience of tinnitus, since the evidence of tinnitus was enhanced by ipsilateral DCN ablation...
  7. ncbi request reprint Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus
    T J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    J Neurosci 22:2383-90. 2002
    ..These parallel psychophysical and electrophysiological results are consistent with the hypothesis that chronic tonal tinnitus is associated with, and may result from, trauma-induced elevation of activity of DCN fusiform cells...
  8. pmc Bilateral dorsal cochlear nucleus lesions prevent acoustic-trauma induced tinnitus in an animal model
    Thomas Jeffrey Brozoski
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Assoc Res Otolaryngol 13:55-66. 2012
    ..The increased drive could produce persistent pathological changes in the rostral areas, such as high-frequency bursting and decreased interspike variance, that comprise the chronic tinnitus signal...
  9. pmc Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci Res 86:2564-78. 2008
    ..Particularly affected was a subpopulation ensemble of IC neurons with the described unique triad of features...
  10. ncbi request reprint Primary afferent dendrite degeneration as a cause of tinnitus
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    J Neurosci Res 85:1489-98. 2007
    ..However, a significant loss of large-diameter fibers in the osseous spiral lamina of exposed cochleas of trauma subjects was observed. The significance of this finding in the context of a model of tinnitus is discussed...
  11. pmc The cerebellum as a novel tinnitus generator
    Carol A Bauer
    Southern Illinois University School of Medicine, P O Box 19662, Springfield, IL 62794 9662, USA
    Hear Res 295:130-9. 2013
    ..In a rat model of noise-induced chronic tinnitus, the cerebellar PFL may serve as a sufficient but non-obligatory generator of tinnitus...
  12. pmc Inhibitory neurotransmission in animal models of tinnitus: maladaptive plasticity
    Hongning Wang
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Hear Res 279:111-7. 2011
    ..A clear understanding of tinnitus-related plasticity in the central auditory system and its associated neurochemistry may help define unique targets for therapeutic drug development...
  13. ncbi request reprint Acoustic injury and TRPV1 expression in the cochlear spiral ganglion
    Carol A Bauer
    Southern Illinois University School of Medicine, Division of Otolaryngology Head and Neck Surgery, Springfield, IL 62794, USA
    Int Tinnitus J 13:21-8. 2007
    ..These results suggest that TRPV1 may participate after cochlear injury in a signal cascade that is responsible for the neuroplastic events leading to tinnitus and hyperacusis...
  14. pmc Tinnitus, unipolar brush cells, and cerebellar glutamatergic function in an animal model
    Carol A Bauer
    Department of Otolaryngology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 8:e64726. 2013
    ..These results are consistent with the hypothesis that UBC up regulation and enhanced glutamatergic transmission in the cerebellum contribute to the pathophysiology of tinnitus...
  15. ncbi request reprint Gabapentin
    Carol A Bauer
    Southern Illinois University School of Medicine, Division of Otolaryngology Head and Neck Surgery, Springfield, IL 62794, USA
    Prog Brain Res 166:287-301. 2007
    ..Both animal studies and human clinical trials implicate loss of inhibition, and specifically loss of GABA function, in the development of acoustic trauma-induced tinnitus...
  16. pmc Targeting inhibitory neurotransmission in tinnitus
    Ben D Richardson
    Department of Pharmacology, Southern Illinois University School of Medicine, 801 N Rutledge St, Rm 3234, PO Box 19629, Springfield, IL 62794, USA
    Brain Res 1485:77-87. 2012
    ..These pharmacological interventions are examined in terms of their mechanism of action and why these agents may be effective in tinnitus treatment. This article is part of a Special Issue entitled: Tinnitus Neuroscience...
  17. doi request reprint Effect of tinnitus retraining therapy on the loudness and annoyance of tinnitus: a controlled trial
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Ear Hear 32:145-55. 2011
    ..The aim of this study was to compare the effect of tinnitus retraining therapy on the loudness and annoyance of tinnitus with a control group...
  18. pmc Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus
    H Wang
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Neuroscience 164:747-59. 2009
    ..Tinnitus related GlyR changes could provide a unique receptor target for tinnitus pharmacotherapy or blockade of tinnitus initiation...
  19. ncbi request reprint Effects of chronic salicylate on GABAergic activity in rat inferior colliculus
    C A Bauer
    Southern Illinois University School of Medicine, Springfield, IL 62794 9662, USA
    Hear Res 147:175-82. 2000
    ..This suggests that GAD expression and GABA(A) receptor binding characteristics may be altered with chronic exposure to sodium salicylate and these changes may represent aberrant plasticity clinically experienced as tinnitus...
  20. pmc Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model
    C A Bauer
    Department of Surgery, Southern Illinois University School of Medicine, Springfield 62794, USA
    J Assoc Res Otolaryngol 2:54-64. 2001
    ....
  21. doi request reprint Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?
    Rui Cai
    Southern Illinois University School of Medicine, Department of Pharmacology, Springfield, Illinois and
    J Neurophysiol 111:229-38. 2014
    ..This increased GABA sensitivity likely underpins the vital filtering role of auditory thalamus. ..
  22. pmc Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model
    Thomas J Brozoski
    Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 8:e77674. 2013
    ..Additionally, it was confirmed that in this model, elevated spontaneous activity in the cerebellar paraflocculus and auditory brainstem is associated with tinnitus. ..
  23. ncbi request reprint Effect of gabapentin on the sensation and impact of tinnitus
    Carol A Bauer
    Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9662, USA
    Laryngoscope 116:675-81. 2006
    ..The hypothesis was that gabapentin would decrease both subjective and objective features of tinnitus in the trauma group but would be less effective in the nontrauma group...
  24. ncbi request reprint Cochlear structure and function after round window application of ototoxins
    Carol A Bauer
    Division of Otolaryngology, School of Medicine, Southern Illinois University, P O Box 19662, Springfield, IL 62794 9662, USA
    Hear Res 201:121-31. 2005
    ..Limitations of direct round window ototoxin treatments are discussed, in addition to their potential application in the study of tinnitus...