Affiliation: Southern Illinois University School of Medicine
Brewer G, Reichensperger J, Brinton R. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol Aging. 2006;27:306-17 pubmed
..These results demonstrate age-associated dysregulation of [Ca2+]i homeostasis which was largely prevented by 17beta-estradiol with implications for estrogen/hormone therapy. ..
Brewer G. Effects of acidosis on the distribution of processing of the beta-amyloid precursor protein in cultured hippocampal neurons. Mol Chem Neuropathol. 1997;31:171-86 pubmed
..If a similar process occurs in the presence of other cell types in the aging brain, acidosis may stimulate an extracellular deposition of amyloid and contribute to the pathogenesis of Alzheimer disease. ..
Brewer G. Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons. Neurobiol Aging. 1998;19:561-8 pubmed
..Similar results were found for A beta (1-40) (LD50 = 2 microM). These results suggest that aging imparts to individual cells an increased susceptibility to toxic substances relevant to neurodegenerative diseases. ..
Brewer G, Boehler M, Jones T, Wheeler B. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008;170:181-7 pubmed publisher
..These results show that NbActiv4 is an improvement to Neurobasal/B27 for cultured networks with an increased density of synapses and transmitter receptors which produces higher spontaneous spike rates in neuron networks. ..