Sukesh R Bhaumik

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. pmc Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illnois University School of Medicine, Carbondale, IL 62901, USA
    Biochim Biophys Acta 1809:97-108. 2011
  2. ncbi request reprint Analysis of in vivo targets of transcriptional activators by fluorescence resonance energy transfer
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Methods 40:353-9. 2006
  3. ncbi request reprint Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Crit Rev Biochem Mol Biol 43:419-33. 2008
  4. pmc Rad26p regulates the occupancy of histone H2A-H2B dimer at the active genes in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Nucleic Acids Res 40:3348-63. 2012
  5. pmc Regulation of chromatin assembly/disassembly by Rtt109p, a histone H3 Lys56-specific acetyltransferase, in vivo
    Geetha Durairaj
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 285:30472-9. 2010
  6. pmc Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo
    Rwik Sen
    Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 288:9619-33. 2013
  7. pmc The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo
    Shweta Lahudkar
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Nucleic Acids Res 39:2188-209. 2011
  8. pmc Rad26p, a transcription-coupled repair factor, is recruited to the site of DNA lesion in an elongating RNA polymerase II-dependent manner in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, 1245 Lincoln Drive, Carbondale, IL 62901, USA
    Nucleic Acids Res 38:1461-77. 2010
  9. pmc Rad26p, a transcription-coupled repair factor, promotes the eviction and prevents the reassociation of histone H2A-H2B dimer during transcriptional elongation in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biochemistry 51:5873-5. 2012
  10. pmc Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo
    Abhijit Shukla
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, United States
    Biochemistry 51:706-14. 2012

Collaborators

  • Tej K Pandita
  • Shivani Malik
  • Geetha Durairaj
  • Shweta Lahudkar
  • Priyasri Chaurasia
  • Abhijit Shukla
  • Rwik Sen
  • Bhawana Uprety
  • Sarah Frankland-Searby
  • Zhen Duan
  • Nadia Stanojevic
  • Pratibha Bajwa
  • Pooja Garg
  • Payel Sen
  • Thomas Shadle
  • Jessica Schneider
  • Shruti Bagla

Detail Information

Publications22

  1. pmc Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illnois University School of Medicine, Carbondale, IL 62901, USA
    Biochim Biophys Acta 1809:97-108. 2011
    ..The regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID are discussed here. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough!..
  2. ncbi request reprint Analysis of in vivo targets of transcriptional activators by fluorescence resonance energy transfer
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Methods 40:353-9. 2006
    ..Here, we describe the FRET assay in general for analysis of the targets of transcriptional activators in living yeast cells. Such an assay can also be used as a general method to monitor protein-protein interactions in vivo...
  3. ncbi request reprint Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Crit Rev Biochem Mol Biol 43:419-33. 2008
    ..Here, we discuss the intricate mechanisms of such proteasomal regulation of eukaryotic gene activation via multiple pathways...
  4. pmc Rad26p regulates the occupancy of histone H2A-H2B dimer at the active genes in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Nucleic Acids Res 40:3348-63. 2012
    ..Similar results are also found at other inducible non-GAL genes. Collectively, our results define a new role of Rad26p in orchestrating chromatin structure and hence transcription in vivo...
  5. pmc Regulation of chromatin assembly/disassembly by Rtt109p, a histone H3 Lys56-specific acetyltransferase, in vivo
    Geetha Durairaj
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 285:30472-9. 2010
    ....
  6. pmc Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo
    Rwik Sen
    Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 288:9619-33. 2013
    ..Similar results are also obtained at other genes. Collectively, our results implicate both the stimulatory and repressive roles of Bre1p in regulation of RNA polymerase II association with active genes (and hence transcription) in vivo...
  7. pmc The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo
    Shweta Lahudkar
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Nucleic Acids Res 39:2188-209. 2011
    ....
  8. pmc Rad26p, a transcription-coupled repair factor, is recruited to the site of DNA lesion in an elongating RNA polymerase II-dependent manner in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, 1245 Lincoln Drive, Carbondale, IL 62901, USA
    Nucleic Acids Res 38:1461-77. 2010
    ....
  9. pmc Rad26p, a transcription-coupled repair factor, promotes the eviction and prevents the reassociation of histone H2A-H2B dimer during transcriptional elongation in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biochemistry 51:5873-5. 2012
    ..Thus, the absence of Rad26p leads to the generation of an atypical histone H2A-H2B dimer-enriched chromatin at the active coding sequence in vivo...
  10. pmc Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo
    Abhijit Shukla
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, United States
    Biochemistry 51:706-14. 2012
    ..Taken together, these results support the idea that SAGA-associated Sgf29p facilitates the recruitment of TBP (and hence transcription) without altering the global structural integrity of SAGA in vivo...
  11. pmc Mechanisms of antisense transcription initiation from the 3' end of the GAL10 coding sequence in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA
    Mol Cell Biol 33:3549-67. 2013
    ..Taken together, our results reveal that GAL10 sense and antisense transcriptions are regulated differently and shed much light on the mechanisms of antisense transcription initiation. ..
  12. pmc Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo
    Priyasri Chaurasia
    Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 288:793-806. 2013
    ..Collectively, our results unveil a new role of Rad14p in stimulating transcription in addition to its well-known function in nucleotide excision repair...
  13. pmc The 19S proteasome subcomplex promotes the targeting of NuA4 HAT to the promoters of ribosomal protein genes to facilitate the recruitment of TFIID for transcriptional initiation in vivo
    Bhawana Uprety
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Nucleic Acids Res 40:1969-83. 2012
    ....
  14. pmc The 19 s proteasome subcomplex establishes a specific protein interaction network at the promoter for stimulated transcriptional initiation in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 284:35714-24. 2009
    ..Together, these results provide significant insights as to how the 19 S proteasome subcomplex regulates the formation of the active transcription complex assembly (and, hence, transcriptional initiation) at the promoter in vivo...
  15. pmc A Novel Role for Cet1p mRNA 5'-Triphosphatase in Promoter Proximal Accumulation of RNA Polymerase II in Saccharomyces cerevisiase
    Shweta Lahudkar
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901
    Genetics 196:161-76. 2014
    ..Collectively, our results demonstrate a novel role of Cet1p in regulation of promoter proximal accumulation of RNA polymerase II independently of mRNA capping activity, and hence transcription in vivo. ..
  16. pmc Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    FEBS J 277:1805-21. 2010
    ..These studies revealed a set of histone H3 lysine 4 methyltransferases with important cellular functions in different eukaryotes, as discussed here...
  17. pmc Preferential repair of DNA double-strand break at the active gene in vivo
    Priyasri Chaurasia
    Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 287:36414-22. 2012
    ..We found a fast DSB repair at the active PHO5 gene in comparison to its inactive state. Collectively, our results demonstrate a preferential DSB repair at the active gene, thus supporting transcription-coupled DSB repair in living cells...
  18. doi request reprint Stimulation of mRNA export by an F-box protein, Mdm30p, in vivo
    Abhijit Shukla
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, 1245 Lincoln Drive, Carbondale, IL 62901, USA
    J Mol Biol 389:238-47. 2009
    ..Together, our data demonstrate that Mdm30p selectively controls mRNA export independently of mitochondrial fusion, revealing a novel function of an F-box protein in mRNA export...
  19. ncbi request reprint Nuclear export of mRNA and its regulation by ubiquitylation
    Geetha Durairaj
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL, USA
    RNA Biol 6:531-5. 2009
    ..Here, we highlight the recent advances of mRNA export and its regulation by ubiquitylation or the enzymes controlling this posttranslational modification...
  20. pmc The 26S proteasome complex: an attractive target for cancer therapy
    Sarah Frankland-Searby
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biochim Biophys Acta 1825:64-76. 2012
    ..Here, we discuss the 26S proteasome complex in carcinogenesis and different proteasome inhibitors with their potential therapeutic applications in treatment of numerous cancers...
  21. doi request reprint Elongating RNA polymerase II is disassembled through specific degradation of its largest but not other subunits in response to DNA damage in vivo
    Shivani Malik
    Department of Biochemistry and Molecular Biology, Southern Illinois University, School of Medicine, Carbondale, Illinois 62901, USA
    J Biol Chem 283:6897-905. 2008
    ....
  22. pmc In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer
    Sukesh R Bhaumik
    Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 18:333-43. 2004
    ..The FRET assay we describe is a general method that can be used to identify the in vivo targets of other activators...